258 research outputs found
A Maltese neurosurgeon in London
No full textThere is nothing positive about a tragedy, or so it may seem. But a
tragedy ignited a young boy's desire to emulate his father and become a
neurosurgeon. This is the story of Ludvvic Zrinzo. Mr Ludvic Zrinzo was interviewed by Marika Azzopardi when he was in Malta to give a talk on 'Surgical Neuromodulation - Helping patients, advancing knowledge' at the 7th Malta Medical Conference held in November 2009peer-reviewe
Method for patient-specific finite element modeling and simulation of deep brain stimulation
No full textDeep brain stimulation (DBS) is an established treatment for Parkinsons disease. Success of DBS is highly dependent on electrode location and electrical parameter settings. The aim of this study was to develop a general method for setting up patient-specific 3D computer models of DBS, based on magnetic resonance images, and to demonstrate the use of such models for assessing the position of the electrode contacts and the distribution of the electric field in relation to individual patient anatomy. A software tool was developed for creating finite element DBS-models. The electric field generated by DBS was simulated in one patient and the result was visualized with isolevels and glyphs. The result was evaluated and it corresponded well with reported effects and side effects of stimulation. It was demonstrated that patient-specific finite element models and simulations of DBS can be useful for increasing the understanding of the clinical outcome of DBS.The original publication is available at www.springerlink.com: Mattias Åström, Ludvic U Zrinzo, Stephen Tisch, Elina Tripoliti, Marwan I Hariz and Karin Wårdell , Method for patient-specific finite element modeling and simulation of deep brain stimulation, 2009, Medical and Biological Engineering and Computing, (47), 1, 21-28. http://dx.doi.org/10.1007/s11517-008-0411-2 Copyright: Springer Science Business Media http://www.springerlink.com/</p
Patient-specific models and simulations of deep brain stimulation for postoperative follow-up
No full textDeep brain stimulation (DBS) is an established treatment for Parkinson’s disease (PD). The success of DBS is highly dependent on electrode location and electrical parameter settings. In this study patient-specific computer models of DBS were used for postoperative follow-up in three PD patients who suffered from stimulation induced hypomania, dysarthria, and uncontrollable laughter respectively. The overall aim of the study was to relate the anatomical aspect of the electric field to the effects and side effects of stimulation. The simulations showed the anatomical distribution of the electric field for all the patients and the results were in agreement with previous reports regarding these side effects of stimulation. It was demonstrated that patient-specific models and simulations of DBS may be useful for postoperative follow-up of DBS.Original Publication: Mattias Åström, Elina Tripoliti, Irene Martinez-Torres, Ludvic U. Zrinzo, Patricia Limousin, Marwan I. Hariz and Karin Wårdell, Patient-specific models and simulations of deep brain stimulation for postoperative follow-up, 2009, World Congress on Medical Physics and Biomedical Engineering, 331-334. http://dx.doi.org/10.1007/978-3-642-03889-1_89 Copyright: Springer http://www.springerlink.com/</p
Deep brain stimulation: a tale of two targets … and closing the loop
No full textThis scientific commentary refers to ‘At home adaptive dual target deep brain stimulation in Parkinson disease with proportional control’ by Schmidt et al. (https://doi.org/10.1093/brain/awad429)
Severe Refractory Obsessive Compulsive Disorder and Depression: Should We Consider Stereotactic Neurosurgery?
No full textFunctional neurosurgery involves modulation of activity within neural circuits that drive pathological activity. Neurologists and neurosurgeons have worked closely together, advancing the field for over a century, such that neurosurgical procedures for movement disorders are now accepted as "standard of care", benefiting hundreds of thousands of patients. As with movement disorders, some neuropsychiatric illnesses, including obsessive compulsive disorder and depression, can be framed as disorders of neural networks. Over the past two decades, evidence has accumulated that stereotactic neurosurgery can help some patients with mental disorders. Nevertheless, despite the availability of class I evidence for some interventions, there is a huge mismatch between the prevalence of severe refractory mental disorders and the number of referrals made to specialised functional neurosurgery services. This paper examines the historical trajectory of neurosurgery for movement and mental disorders. A review of neurosurgical techniques, including stereotactic radiofrequency ablation, gamma knife, deep brain stimulation, and magnetic resonance imaging guided focused ultrasound, explains the high degree of safety afforded by technological advances in the field. Evidence from clinical trials supporting functional neurosurgery for mental disorders, including obsessive compulsive disorder and depression, is presented. An improved understanding of modern functional neurosurgery should foster collaboration between psychiatry and neurosurgery, providing hope to patients whose symptoms are refractory to all other treatments
Radiofrequency Ablation in the MRI Era: Back to Our Roots - Commentary on Kostiuk: "Stereotactic Staged Asymmetric Bilateral Radiofrequency Lesioning for Parkinson's Disease".
No full textLetter: Systematic Stereotactic Error Reduction Using a Calibration Technique in Single-Brain-Pass and Multitrack Deep Brain Stimulations
No full textThalamotomy using MRI-guided focused ultrasound significantly improves contralateral symptoms and quality of life in essential tremor
No full text
- …
