1,721,107 research outputs found
CpG and non-CpG methylation in the diet-epigenetics-neurodegeneration connection
No full textPURPOSE OF REVIEW: Unraveling the diet-epigenetics-neurodegeneration connection may disclose associated mechanisms and novel approaches to the neurodegenerative diseases. This review summarizes the basic concepts and the innovative results in this field focusing on the relevance of non-CpG methylation. RECENT FINDINGS: Many multifactorial neurodegenerative diseases are associated with epigenetic changes, and the brain seems more prone to epigenetic changes than other tissues. Several environmental factors induce epigenetic modulation in the organisms: diet and nutrition retain a high capacity to modulate the epigenetic traits. Finally, unexpected, specific, and functional non-CpG methylation in the brain was identified. Non-CpG methylation modulates brain expression of genes especially in promoters characterized by low-density CpGs distribution. These genes appear more prone to the epigenetic effect of environmental factors, i.e., diet, possibly inducing neurodegenerative processes. Understanding these processes could help in setting nutritional intervention aimed at contrasting neurodegenerative diseases
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Less Energy, More Quality. From Leipzig Charta to 2010/31/Ue Directive
No full textTechnology is all geared to "Zero Energy Building " (in accordance with the EPBD Recast: 2010/31/UE Directive) acting especially on the envelope: less energy and other resources's needs and more use of eco-friendly materials, in order to guarantee appropriate performance (without energy sacrifice!) for heating, domestic hot water, cooling, natural ventilation and lighting. All because: "Europe needs cities where life is good!".
The contribute illustrates a design experience begun during the “Archisostenibile 2010” Workshop organized by the Mediterranean University of Reggio Calabria (urban design phase) and completed at the SUN (building design phase)
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Resilience and technological culture of design: the centrality of method
Full text linkThe article aims at depicting the main scientific points of the resilience debate within the field of the Architecture Tecnology. The contribution identifies into the formula “the method-as-research question" the theoretical roots of the technological culture specific, that is a prime condition for architecture, and a milestone for governing the common scientific results. According to this premise, the article aims at demonstrating the existence of a strongly consolidated design praxis within the disciplinary tradition that allows to continuously review research objectives and cognitive tools, effectively updating the theoretical apparatus. In order to enhance such approach, the article claims the advanced position of architecture technology with respect to the concept of resilience, and it focuses on the disciplinary capacity of adapting research questions to the design responses. Notably, the contribution emphasizes the performance-based design approach as a further methodological skill, typically referable to the discipline, that is a logical key to frame the resilience demand within the systemic condition of the design adaptation and / or mitigation projects
Régionalisme italien et régionalisme francais. Aspects constitutionnels, administartifs et fiscaux
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