34 research outputs found
Preliminary Investigation towards the Use of Infrared Technology for Raw Milk Treatment
No full textInfrared (IR) technology offers a promising solution for reducing microbiological loads in various food types while preserving their quality traits, such as flavour. However, research on IR's application in complex matrices is limited. Therefore, our preliminary study aimed to evaluate its effectiveness in sanitizing bovine raw milk. We assessed the bacterial count before and after IR treatment by comparing volatile organic compound profiles via headspace extraction and GC/MS analysis. Our findings showed that higher energy levels led to a greater bacterial reduction. IR85 was the most effective in reducing Coliforms and Enterobacteriaceae in non-homogenised samples, with a reduction ranging from -1.01 to >-2.99 and from -1.66 to -3.09 Log CFU/mL, respectively. IR60 and 70 showed no efficacy, while IR80 had intermediate but still satisfactory effect. IR85 notably affected volatile compounds, particularly increasing hexanal (from 0.08 to 4.21 ng g(-1)) and dimethyl sulphone (from 10.76 to 26.40 ng g(-1)), while IR80 better preserved the aroma profile. As a result, only IR80 was tested with homogenised raw milk, demonstrating significant bacterial reduction (from >2.39 to 3.06 Log CFU/mL for Coliforms and from 1.90 to >2.45 Log CFU/mL for Enterobacteriaceae) and maintaining the aroma profile quality
L'attività commerciale nel settore della logistica conto terzi : il caso Interlaziale
No full textLAUREA MAGISTRAL
Compliance between Food and Feed Safety: Eight-Year Survey (2013–2021) of Aflatoxin M1 in Raw Milk and Aflatoxin B1 in Feed in Northern Italy
No full textAflatoxins (AFs) are fungal metabolites that are found in feed and food. When ruminants eat feed contaminated with aflatoxin B1 (AFB1), it is metabolised and aflatoxin M1 (AFM1) is excreted in the milk. Aflatoxins can result in hepatotoxic, carcinogenic, and immunosuppressive effects. The European Union thus set a low threshold limit (50 ng/L) for presence of AFM1 in milk. This was in view of its possible presence also in dairy products and that quantification of these toxins is mandatory for milk suppliers. In the present study, a total of 95,882 samples of whole raw milk, collected in northern Italy between 2013 and 2021, were evaluated for presence of AFM1 using an ELISA (enzyme-linked immunosorbent assay) method. The study also evaluated the relationship between feed materials collected from the same farms in the same area during the same period (2013–2021) and milk contamination. Only 667 milk samples out of 95,882 samples analysed (0.7%) showed AFM1 values higher than the EU threshold limit of 50 ng/L. A total of 390 samples (0.4%) showed values between 40 and 50 ng/L, thus requiring corrective action despite not surpassing the regulatory threshold. Combining feed contamination and milk contamination data, some feedingstuffs seem to be more effective in defying potential carryover of AFs from feed to milk. Combining the results, it can be concluded that a robust monitoring system that covers both feed, with a special focus on high risk/sentinel matrices, and milk is essential to guarantee high quality and safety standards of dairy products
An Antibiotic Stewardship Program in Pancreatic Surgery
No full textImportance: Antimicrobial stewardship (AMS) programs optimize antibiotic use and mitigate antimicrobial resistance. The literature on the efficacy of AMS programs in pancreatic surgery is limited. Objective: To investigate the association of a multifaceted AMS intervention targeting surgical antibiotic prophylaxis (SAP) with the rate of surgical site infections (SSIs) following pancreatic surgery. Design, setting, and participants: This cross-sectional study was a multicenter, before-and-after analysis conducted at 3 Italian centers. The intervention cohort included adult patients aged 18 years or older who underwent pancreatectomy between January 1, 2020, and December 31, 2022, while the historical cohort included patients from January 1, 2015, to December 31, 2019. Exposure: A multiprofessional, multidimensional ASM program that included a bundle of interventions and pivoted on preoperative rectal screening for multidrug-resistant bacteria and targeted SAP. Main outcomes and measures: The primary outcomes were SSI incidence and SAP appropriateness, assessed through the coverage rate of rectal and biliary isolates. Data were analyzed using propensity score weighting. Secondary outcomes evaluated were other postoperative outcomes (eg, pancreatic fistula rate, length of stay), antibiotic use, and costs. Results: A total of 3387 patients (median [IQR] age, 66 [66-73] years; 1788 male [52.8%]) were included, with 1219 in the intervention cohort and 2168 in the historical cohort. After implementing the AMS program, a statistically significant reduction was found in rates of overall (30.1% vs 20.6%), superficial (5.8% vs 2.5%), deep (0.9% vs 0.3%), and organ-space (26.3% vs 19.3%) SSIs. After propensity score weighting, the odds ratios for the estimated mean treatment effect were 0.92 (95% CI, 0.89-0.96) for overall, 0.85 (95% CI, 0.78-0.93) for superficial, and 0.95 (95% CI, 0.92-0.99) for organ-space SSIs. Surgical antibiotic prophylaxis coverage increased significantly for rectal screening (87.2% vs 100%) and biliary bacterial colonization (59.7% vs 68.7%). Complications, infections, length of stay, and antibiotic consumption also decreased, with an overall cost savings of 247 460 euros. Conclusions and relevance: These findings suggest that a multifaceted, pancreatic surgery-specific AMS program is associated with decreased rates of SSIs, increased coverage of isolated bacteria, improved clinical outcomes, more judicious antibiotic use, and lower costs
Cerebrospinal fluid cyclase-associated protein 2 is increased in Alzheimer’s disease and correlates with tau pathology
No full textSynaptic dysfunction represents an early pathological event that precedes neurodegeneration in Alzheimer’s disease (AD), even though the molecular mechanisms that underlie synaptic dysfunction remain to be completely understood. Nonetheless, in vivo synaptic biomarkers are highly relevant as they have the potential to reveal early-stage changes and to track target engagement of specific disease-modifying strategies
Lilus Kikus, de Elena Poniatowska: estrangeiridades, multiplicidade Linguístico-cultural e Tradução
No full textTese apresentada como requisito parcial à
obtenção do título de Doutora, Curso de Pós-
Graduação em Letras, Setor de Ciências
Humanas da Universidade Federal do Paraná.
Linha de pesquisa: Alteridade, mobilidade e
tradução.
Orientadora: Profa. Dra. Isabel JasinskiA presente investigação parte do pressuposto de que o texto é resultado individual de uma experiência intercultural. Do mesmo modo, levando em consideração a percepção de Berman (2007) sobre o texto traduzido como o lugar onde se manifesta a cultura do outro, objetivamos, em nosso projeto de tradução de Lilus Kikus (1954), de Elena Poniatowska cultivar elementos que direta ou indiretamente enunciam questões que constituem a sociedade e cultura mexicana. Desse modo, a partir de um olhar atento à multiplicidade linguístico-cultural que acompanha a vida e obra da autora, trilhamos o seguinte caminho: 1. realizamos uma aproximação literária que contempla reflexões que norteiam a autora, sua escrita e a obra Lilus Kikus; 2. refletimos sobre o fazer tradutório enquanto experiência-reflexão elucidando os desafios na elaboração do projeto; 3. analisamos as escolhas que se delinearam no processo tradutório de Lilus Kikus a partir de elementos fonéticos, lexicais e morfossintáticos a fim de acolher a obra na língua de chegada e explorar suas possibilidades de (re)criar efeitos de sentido similares ou análogos. Portanto, com este trabalho pretendemos proporcionar ao leitor uma experiência análoga à leitura de Elena Poniatowska em espanhol mexicano, ao passo em que evidenciamos como a letra e o significado do texto fonte se plasmam em nossa tradução a fim de albergar esse estrangeiro.The present research is based on the assumption that the text is an individual result of
an intercultural experience. Likewise, taking into consideration the Berman's (2007)
perception of the translated text the place where the culture of the other is manifested, we
objectify, in our translation project of Lilus Kikus (1954) by Elena Poniatowska, to cultivate
elements that state directly or indirectly issues that constitute Mexican society and culture.
Thus, from a careful look at the linguistic-cultural multiplicity that accompanies the life and
work of the author, we track the following path: 1. We carry out a literary approach that
contemplates reflections that guide the author, her writing and the work Lilus Kikus; 2. we
reflect about doing translation as experience-reflection elucidating the challenges in the
elaboration of the project; 3. We analyze the choices that have been outlined in the translation
process of Lilus Kikus from phonetic, lexical and morphosyntactic elements in order to
accommodate the work in the target language and explore its possibilities of (re) creating
similar or analogous meaning effects. Therefore, with this work we intend to give the reader
an analogous experience to the reading of Elena Poniatowska in Mexican Spanish, while we
show how the letter and the meaning of the source text are reflected in our translation in order
to accommodate this foreigne
Cerebrospinal fluid cyclase-associated protein 2 is increased in Alzheimer’s disease and correlates with tau pathology
No full textThe pan - COVID - AGICT study. The impact of COVID-19 pandemic on surgically treated pancreatic cancer patients. A multicentric Italian study
No full textPrognostic Impact of Aspartate Aminotransferase-to-Platelet Ratio Index and Prognostic Nutrition Index in Hepatocellular Carcinoma Patients Undergoing Resection
No full textBackground/Objectives: Tumor-associated inflammation plays a crucial role in supporting tumorigenesis and the progression of oncological diseases. This study aimed to evaluate whether systemic inflammatory indices are associated with overall survival (OS) in patients with hepatocellular carcinoma (HCC) undergoing surgery. Methods: A retrospective cohort study was conducted on consecutive patients with HCC who underwent hepatic resection. Data were prospectively collected and retrospectively reviewed. The 5-year OS rate was used as the primary endpoint to stratify the values of inflammatory indices, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), aspartate aminotransferase-to-neutrophil ratio index (ANRI), fibrinogen-to-albumin ratio (Fib-Alb), the systemic immune-inflammation index (SII), prognostic nutritional index (PNI), and aspartate aminotransferase-to-platelet ratio index (APRI), through receiver operating characteristic (ROC) curve analysis. The optimal albumin–bilirubin (ALBI) and platelet–ALBI (PALBI) cut-off points from the literature were also applied. Results: Patients included in the study were 153. The 1-, 3-, and 5-year OS rates were 81.7%, 65.2%, and 40.7%, respectively. Univariate Cox proportional hazards analysis showed that, in addition to several patient- and tumor-related characteristics and postoperative complications, elevated values of PLR, ANRI, Fib-Alb, SII, APRI, ALBI, and PALBI, as well as low PNI, were significantly associated with poorer overall survival (OS). Among these, only APRI and PNI emerged as independent prognostic factors in the multivariate analysis. Conclusions: PNI and APRI could serve as valuable inflammatory indices for predicting OS, helping to identify HCC patients who might benefit from hepatic resection. However, further prospective studies with larger cohorts are needed to validate the prognostic role of PNI and APRI
