347 research outputs found
SUPPORTIVE TREATMENT OF VASCULAR DYSFUNCTION IN PEDIATRIC SUBJECTS WITH OBESITY: THE OBELIX STUDY
No full textINTRODUCTION: Overweight and obese children develop abnormal endothelial cell dysfunction with increased vasomotor tone and inflammation. Curcumin, resveratrol, zinc, magnesium, selenium, soy, folic acid, and Vitamin D have shown potential beneficial effects on endothelial function. We test, among overweight and obese pediatric subjects, the effects on the endothelium of a combination of curcumin, resveratrol, zinc, magnesium, soy, folic acid, selenium, and Vitamin D. METHODS: 48 subjects (6-17 years) were randomized into two groups (placebo Vs treatment) and attended three visits at 0, 3, and 6 months (+/- 15 days). Endothelial function was assessed through the Laser Doppler Flowmetry technique using “post occlusive release hyperemic test” (PORH) for estimation of Delta Flow (DF) and Hyperemic Area under Curve index (Hyperemic AUC index) and “heat provocation test” (HPT) to measure Delta Flow HPT” (DFHPT). RESULTS: DF, Hyperemic AUC index and DFHPT represent recognized parameters for estimating endothelial dysfunction in both pediatric and adult age. Significant DF difference was noted at time-6-month in both groups (p<0.001). Overall time trend was significantly different between baseline, time-3-months, and 6-months both in Placebo (p<0.05) and Treatment (p< 0.001) groups and their comparison (p < 0.001). No differences were noted in Hyperemic AUC index (3 and 6 months), while there were significant differences in time trends of Treatment (p< 0.001) and Placebo (p<0.05) groups and their comparison (p < 0.001). DFHPT difference between groups was significant at 3 months and 6 months (p<0.05). The overall time trend was significant exclusively in "Treatment group" between time-3-month and 6-months (p<0.05). Correlation with anthropometrics was found for DF and BMI (r=0.677 at 6 months; p<0.05), as well as for Hyperemic AUC index and males (r= 0.348, p<0.05), while DFHPT showed no correlation. CONCLUSIONS: Curcumin, resveratrol, zinc, magnesium, soy, folic acid, selenium, and Vitamin D appear to be promising in enhancing endothelial function by improvement of both DF in post-occlusive release hyperemia test and DF in the heat provocation test, potentially lowering the risk of developing cardiovascular diseases in overweight and obese pediatric subjects
Ebastine overdose in a child
No full textThe lack of side effects after acute ingestion of a high dose of ebastine in our child aging 44 months suggests an overall safety profile of ebastine; it could suggest less time of hospitalization for children who are subjected to this event
The regional early warning system for rainfall-induced landslides operating in Campania (Italy): performance evaluation of two warning strategies
No full textLandslide monitoring for warning purposes: comparison of systems operating at slope scale
No full textBehind human milk and breastfeeding: not only food
No full textAfter birth, breastfeeding should not be considered only a normal and physiological event; in fact, it encloses both physical and the psychological aspects. Human milk cannot be compared to any formula milk. Specifically, human milk has immunological and nutritional properties and it is considered the best available option which guarantees an adequate growth and an optimal development of a child. Differences in term of mediators and hormones have been shown between infants who were breastfed and ones who were not. A key point is represented by unmeasurable environmental and psycho-affective factors. So, it may be simplistic to consider human milk only as a nutrient; since it encompasses much more. The aim of our commentary is to review clinical studies about breastfeeding, analysing its consequences on the neuro-developmental achievement, growth and risk of obesity within a holistic view
Monitoring strategies for local landslide early warning systems
No full textThe main aim of this study is the description and the analysis of the monitoring strategies implemented within local landslide early warning systems (Lo-LEWS) operational all around the world. Relevant information on 29 Lo-LEWS have been retrieved from peer-reviewed articles published in scientific journals and proceedings of technical conferences, books, reports, and institutional web pages. The first part of the paper describes the characteristics of these early warning systems considering their different components. The main characteristics of each system are summarized using tables with the aim of providing easily accessible information for technicians, experts, and stakeholders involved in the design and operation of Lo-LEWSs. The second part of the paper describes the monitoring networks adopted within the considered systems. Monitoring strategies are classified in terms of monitored activities and methods detailing the parameters and instruments adopted. The latter are classified as a function of the type of landslide being monitored. The discussion focuses on issues relevant for early warning, including appropriateness of the measurements, redundancy of monitoring methods, data analysis, and performance. Moreover, a description of the most used monitoring parameters and instruments for issuing warnings is presented.Monitoring strategies for local landslide early warning systemsacceptedVersio
Regional Landslide Early Warning Systems: Comparison of Warning Strategies by Means of a Case Study
No full textSweet at birth, bitter in growth
No full textComplementary feeding plays a primary role in the life of an infant, as long as the correct assumption of nutrients in terms of timing and quality is the key to a healthy growth. Since infants are totally dependent on their parents during complementary feeding, educational programmes and intervention plans are needed to educate parents and caregivers. As to this, children's sugar consumption throughout their life has been specifically investigated and several critical points have been detected, demonstrating how sugar intake should not be higher than necessary in children and should not include sweetened beverages in daily nutrition. The association between children's diet and the subsequent consequences in their later life has been extensively studied, pointing out how countries should invest in policies that aim at decreasing sugar intake and encouraging parents, as well as children, to a healthier behaviour. The aim of this article is to look at the problem from three different perspectives, the parents' one, the scientific one, and the paediatrician one, in order to offer a new insight on the future of complementary feeding
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