71 research outputs found
Il ruolo del fumo di tabacco nella cancerogenesi di campo delle neoplasie del distretto testa-collo
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The Many Faces of Head and Neck Surgery in 2022 and Looking Ahead!
No full textHead and neck (HN) cancer, which mainly presents in the form of squamous cell carcinoma, was the seventh most common cancer worldwide in 2018, with approximately 890,000 new cases and 450,000 deaths [...
Update on the biological and clinical relevance of mast cells in chronic rhinosinusitis with nasal polyps
No full textA systematic review of PubMed and Google Scholar registries of all the pertinent articles regarding the role of mast cells in chronic rhinosinusitis with nasal polyps in the last 10 year
The risks and benefits of salvage surgery for radiorecurrent head and neck cancer: a retrospective clinical study
No full textIMPORTANCE The risks associated with salvage surgery of head and neck squamous cell carcinoma (SCC) in a previously irradiated field needs to be balanced against the expected survival benefits.
OBJECTIVE To identify preoperative predictive factors for overall and disease-specific survival (OS/DSS) and for the development of serious (Clavien-Dindo, CD≥III) complications following salvage surgery for radiorecurrent SCC to help surgeons, patients, and caregivers in the decision-making process in this setting.
DESIGN, SETTING, AND PARTICIPANTS The records of 234 patients presenting to the Lorraine Cancer Institute with locoregional radiorecurrent SCC between January 1, 1990, and March 31, 2020, were retrospectively reviewed. The primary endpoint was OS from salvage treatment to last follow-up or death. Secondary endpoints were DSS, OS without tracheostomy/gastrostomy, and the risk of CD≥III complications. Univariate and multivariate analyses were carried out to explore preoperative factors associated with survival and the risk of postoperative complications.
RESULTS With a median follow-up time of 19 months, 5-year OS since the first salvage surgery was 28.3%, 5-year DSS was 38.9%. 2- and 5-year functional OS were 45.6% and 27.2%. rcT-rcN, and WUNHCI ≥4 were both independent significant preoperative predictors of OS and DSS. 30-days postoperative complications occurred in 44.4% of patients (28 CD I, 24 CD II, 34 CD III, 11 CD IV, 7 CD V). A salvage procedure involving T+N plus the presence of a WUHNCI ≥4 was the only independent predictor of CD≥III complication.
CONCLUSIONS AND RELEVANCE When discussing with the patients and the caregivers salvage surgery for radiorecurrent head and neck SCC, a careful evaluation of the preoperative comorbidities by the WUHNCI tool can reliably predict the expected risks and benefits from the procedure
Head and Neck Surgery: Clinical Updates and Perspectives
No full textAs Guest Editors, we are very delighted to see the reprint of our Special Issue, “Head and Neck Surgery: Clinical Updates and Perspectives", which is published in the Otolaryngology section of the Journal of Clinical Medicine. These papers are the joint effort of many excellent colleagues who have devoted their lives and careers to the exciting field of Otorhinolaryngology. As both clinicians and surgeons, we are actively advancing the diagnosis and management of the myriad of conditions affecting the head and neck region. Unprecedented discoveries in the field of genetics and molecular biology are always integrated with sound knowledge of the intricate anatomy of our discipline, while technological advancements now permit us to provide tailored and minimally invasive treatments for our patients. We wish to thank all the authors who contributed to this publication and we hope you enjoy reading it
Surgical approaches to the management of the intrathoracic goiter - A systematic review
No full textAbstract
Objective: Intrathoracic goiters (ITGs) pose numerous challenges to head and neck surgeons due to the intricate relationships with major vessels and other mediastinal structures. Surgical excision remains the mainstay of treatment and we herein present an update on this topic.
Methods: A systematic review from 2017 to date was performed in the PubMed database and a total of 93 articles were identified and discussed, along with methodological issues and future directions in the research on ITGs.
Results: Transcervical excision is the commonest approach for treating ITGs, yet the potential need for a transthoracic approach must be always kept in mind. An acceptable rate of postoperative complications is expected if surgeries are carried out by experienced and dedicated surgical teams.
Conclusions: Surgical excision remains the principal treatment for ITGs and new less invasive techniques are being developed. Surgery for ITGs should be always carried out in specialist centres with experienced multidisciplinary teams
All that glitters is not gold: Clinical implications from the genetic analysis of head and neck cancer recurrences
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