1,721,101 research outputs found
Biofabrication of Electrospun Scaffolds for the Regeneration of Tendons and Ligaments
Full text linkTendon and ligament tissue regeneration and replacement are complex since scaffolds need to guarantee an adequate hierarchical structured morphology, and non-linear mechanical properties. Moreover, to guide the cells’ proliferation and tissue re-growth, scaffolds must provide a fibrous texture mimicking the typical of the arrangement of the collagen in the extracellular matrix of these tissues. Among the different techniques to produce scaffolds, electrospinning is one of the most promising, thanks to its ability to produce fibers of nanometric size. This manuscript aims to provide an overview to researchers approaching the field of repair and regeneration of tendons and ligaments. To clarify the general requirements of electrospun scaffolds, the first part of this manuscript presents a general overview concerning tendons’ and ligaments’ structure and mechanical properties. The different types of polymers, blends and particles most frequently used for tendon and ligament tissue engineering are summarized. Furthermore, the focus of the review is on describing the different possible electrospinning setups and processes to obtain different nanofibrous structures, such as mats, bundles, yarns and more complex hierarchical assemblies. Finally, an overview concerning how these technologies are exploited to produce electrospun scaffolds for tendon and ligament tissue applications is reported together with the main findings and outcomes
Biomechanical evaluation of innovative treatments of fractures of the proximal humerus with a limited number of screws and acrylic-based cement.
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Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
HIERARCHICAL MULTISCALE ELECTROSPUN SCAFFOLD FOR THE REGENERATION AND/OR REPLACEMENT OF THE TENDINOUS/LIGAMENTOUS TISSUE AND A METHOD FOR ITS PRODUCTION
No full textThe present invention relates to a support or a multiscale hierarchical scaffold for the tissue regeneration, in particular for the regeneration or replacement of the tendinous and/or ligamentous and/or muscular and/or nervous tissue. The present invention further relates to the processes for obtaining such support and the uses thereof
Electrospun nanofibrous multiscale scaffold for tendon and ligament tissue regeneration and replacement
No full textVariations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
In vitro full-field strain investigation in intact spine and spinal fixator by means of DIC
No full textSpine is one of the most studied systems of the human skeleton because of the several types of problems that can injure it (accidents, pathologies, stresses). Many studies evaluated the range of motion, stiffness and strain on hard tissues under different loading conditions. To integrate the study with the deformation of the soft tissues (intervertebral discs and ligaments), Digital Image Correlation (DIC) can measure the distribution of deformation in a contact-less way and provide a full-field view of the examined surface under load.
This study was performed using segment of human spine loaded in anterior bending with the use of loading machine and DIC. All tests showed the different deformation of the specimen in the vertebral body, intervertebral discs, ligaments and in the posterior rods.
This work showed the feasibility and importance of investigating the spine in a full-field way, due to the high strain inhomogeneity in the vertebrae and intervertebral discs. Therefore it can give useful information to design medical devices and to surgeons to implant them
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