2,386 research outputs found
Control of cell fate determination by p21ras/Ras1, an essential component of torso signaling in Drosophila.
No full textEthanol ablation of hepatocellular carcinoma Up to 5.0 cm by using a multipronged injection needle with high-dose strategy
No full textPURPOSE: To investigate whether ethanol ablation by using a multipronged needle delivery system (multipronged ethanol ablation) could eradicate hepatocellular carcinoma (HCC) up to 5.0 cm in diameter with a single-session high-dose strategy.
MATERIALS AND METHODS: The hospital ethics committee approved the prospective study, and each patient provided written informed consent. One hundred forty-one patients (125 men, 16 women; mean age, 53 years; range, 27-76 years) with 164 primary or recurrent HCC ranging from 1.3 to 5.0 cm in diameter (mean, 2.9 cm +/- 0.9) were treated with high-dose multipronged ethanol ablation. Patients were unsuitable for surgery, declined surgery and radiofrequency ablation, or had tumors located at unfavorable sites. Primary technique effectiveness (PTE) (complete ablation within two sessions), local tumor progression (LTP), and complications after the treatment were observed. Twenty risk factors of local effectiveness and complications were analyzed by means of univariate and multivariate analysis.
RESULTS: Mean number of treatment sessions was 1.1. The mean volume of ethanol per tumor was 31 mL (range, 8-68 mL). PTE was achieved in 134 (95%) of 141 patients and was significantly associated with tumor pattern (capsulated vs noncapsulated, P = .018). After a mean follow-up period of 25 months, LTP was observed in 16 (12%) of 134 patients, and in nine (56%) patients, LTP occurred in tumors 3.1-5.0 cm in diameter. Alanine aminotransferase level (P = .023) was the independent risk factor for LTP. Three (2%) of 141 patients had major complications.
CONCLUSION: Multipronged ethanol ablation with a high-dose strategy can be used to treat HCC up to 5.0 cm in diameter effectively and safely, often in a single sessio
XY displacement device
No full textAn XY-displacement device (1) with a four-fold symmetry comprises a reference frame (10); an object mount (20) for holding an object (22) to be displaced; an X-manipulator (100) coupled between the reference frame (10) and the object mount (20), which provides a rigid coupling between the object mount (20) and a piezoelectric X-actuator (140), allows a Y-displacement of the object mount (20) relative to the reference frame (10), and counteracts a Z-displacement of the object mount (20) relative to the reference frame (10); ; and a Y-manipulator (200) coupled between the reference frame (10) and the object mount (20), which provides a rigid coupling between the object mount (20) and a piezoelectric Y-actuator (240), allows an X-displacement of the object mount (20) relative to the reference frame (10), and counteracts a Z-displacement of the object mount (20) relative to the reference frame (10).Applied Science
Silicon nanostructured films formed by pulsed-laser deposition in inert gas and reactive gas
No full textDraft of Marketing Strategy for XY Company in Specialisation of Industrial Cooling
No full textAutorka diplomové práce si jako téma vybrala Návrh marketingové strategie pro společ-nost XY v oboru průmyslového chlazení. V teoretické části na základě rešerše odborné literatury autorka práce si objasní pojmy, které souvisí s tématem diplomové práce. V praktické části provede analýzy vnitřního a vnějšího prostředí firmy XY pomocí kvalitativního výzkumu a vlastního sběru dat. V projektové části se o závěry z těchto analýz bude opírat při zpracování marketingové strategie firmy XY. Vzhledem k tomu, že se jedná o velmi citlivé informace, bude místo názvu firmy používat označení společnost XY.The author of the thesis chose as the topic the draft of Marketing strategy for the XY company in the field of industrial cooling. The author of the work explains terms related to the topic of the thesis in the theoretical part, which is based on technical literature. In the practical part the analysis of internal and external environment of the XY company is acomplished by means of qualitative research and author's own data collection. There is also the conclusion of these analyzes based on the marketing strategy of the XY company in the project part of the work. Taking into consideration using very sensitive information, author uses in the dissertation the XY name for the original company which the work si based on.Ústav marketingových komunikac
Comparative analysis of LLM capabilities and their implementation potential in business workflows
No full textCompany XY is still growing and the processes have changed over the last few years. Therefore, they have never been drawn and analyzed systematically to see if there is any potential for optimization. For this reason, the author was commissioned to do so, and the following research questions have emerged: Are large language models capable of optimizing internal processes? What processes can be optimized? How can they be implemented? And what is the impact of set implementations? The goal of this paper is to get insights into the state of the processes and possible optimizations with a LLM
Marketing Communications of the Firm XY, s.r.o.
No full textThis thesis helps to understand the problems of marketing communication in business-to-business market. The main intention is to show the theoretical background on the example of real company called XY, s. r. o. The author tried to get familiar with the current company marketing communications and applied the theoretical knowledge, especially in the proposals to improve this communication
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