1,391 research outputs found
Study of Interaction Between Lu(III)-ARS Complex and Herring Sperm DNA
No full textThe authors synthesized an ARS-Lu(III) complex and focused on the interaction between the complex and herring sperm DNA using UV-vis absorption, fluorescence, and viscosity methods. The results indicated that the partial or nonclassical intercalation and groove binding are the major mode for interaction between the Lu(ARS)3 complex and herring sperm DNA. The binding ratio is n Lu(ARS)3:n DNA = 5:1, and the binding constant is K 27 degrees C = 2.23 x 105 L/mol. By double-reciprocal method and thermodynamic calculation, the driving force of the interaction is entropy
Effect of propionate on the production of natamycin with Streptomyces gilvosporeus XM-172
No full textThis study described the influence of feeding short-chain fatty acids and alcohols on natamycin production in the glucose basal medium, produced by Streptomyces gilvosporeus XM-172. The highest natamycin production was obtained with feeding propionate as compared to other precursors. The optimal propionate concentration and feeding time were 6 g L-1 and early log phase, respectively. This optimal propionate feeding strategy led to a natamycin production of 6.72 g L-1, which was nearly 85% higher than that of the control. It was firstly revealed that propionate could greatly promote natamycin biosynthesis by S. gilvosporeus.Key words: Precursor, propionate, natamycin production, Streptomyces gilvosporeus XM-172
CANONICAL ABERRATION THEORY IN ELECTROMAGNETIC MULTIPOLES
No full textIn a 2N-pole electromagnetic system, defining the electron optical Hamiltonian function, we have derived both general algebraic expressions (arbitrary N) and special numerical formulas (N = 3,4,5,6,7) for different aberrations from lower to higher order (i.e., the order of N - 1, N + 1, 2N - 3, 2N - 1, 3N - 5). The so-called canonical aberration theory in electromagnetic multipoles has thus been developed, which allows us to deduce angular dependencies of different aberrations and to examine the possibility for spherical correction of a round lens by using multipoles.Physics, AppliedSCI(E)0ARTICLE125968-59756
Effect of propionate on the production of natamycin with Streptomyces gilvosporeus XM-172
No full textThis study described the influence of feeding short-chain fatty acids and alcohols on natamycin production in the glucose basal medium, produced by Streptomyces gilvosporeus XM-172. The highest natamycin production was obtained with feeding propionate as compared to other precursors. The optimal propionate concentration and feeding time were 6 g L(-1) and early log phase, respectively. This optimal propionate feeding strategy led to a natamycin production of 6.72 g L(-1), which was nearly 85% higher than that of the control. It was firstly revealed that propionate could greatly promote natamycin biosynthesis by S. gilvosporeus
Profile of conbercept in the treatment of neovascular age-related macular degeneration
No full textXinmin Lu,1 Xiaodong Sun1–31Department of Ophthalmology, Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 2Eye Research Institute of Shanghai Jiao Tong University, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Fundus Disease, Shanghai, People’s Republic of China Abstract: In developed countries, age-related macular degeneration (AMD) is the leading cause of irreversible blindness in individuals over the age of 65 years. Vascular endothelial growth factor (VEGF) plays a vital role in the formation of neovascular AMD. VEGF regulates angiogenesis, enhances vascular permeability, and drives the formation of choroidal neovascularization. As a result of the introduction of anti-VEGF drugs, the incidence of blindness from neovascular AMD has greatly reduced. Anti-VEGF drugs are used as a first-line treatment for neovascular AMD. The most recent anti-VEGF drug is conbercept, also named KH902, which was approved for the treatment of neovascular AMD by the China Food and Drug Administration in December 2013. In this review, recent clinical information regarding the use of conbercept to treat neovascular AMD is summarized. Conbercept is a soluble receptor decoy that blocks all isoforms of VEGF-A, VEGF-B, VEGF-C, and PlGF, which has a high binding affinity to VEGF and a long half-life in vitreous. Preclinical studies have demonstrated its anti-angiogenesis activity in both ocular neovascular disease models and tumor models. Clinical trials of conbercept have shown its superior efficacy and safety. Patients respond well even with 3-month treatment intervals following loading doses once a month for 3 months. The potential therapeutic effect of conbercept on the treatment of polypoidal choroidal vasculopathy, a special type of neovascular AMD, is also promising. In summary, conbercept is a new treatment option for ophthalmologists and their patients and may help address the limitations of current anti-VEGF drugs.Keywords: conbercept, KH902, age-related macular degeneration, vascular endothelial growth factor, neovascularizatio
The effect of benzodiazepines on insomnia in patients with chronic obstructive pulmonary disease: a meta-analysis of treatment efficacy and safety
No full textXiao-Min Lu,* Ji-Ping Zhu,* Xian-Mei Zhou Department of Respiratory Medicine, Affiliated Jiangsu Province Hospital of Traditional Chinese Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, People’s Republic of China *These authors contributed equally to this work Background: Insomnia is a common comorbidity associated with COPD. Although benzodiazepines (BZDs) can have adverse effects on respiratory response in COPD patients, these are the most common hypnotics. The aim of this study was to examine by meta-analysis the efficacy and safety of BZD to treat insomnia in COPD patients. Materials and methods: Electronic databases (PubMed, China National Knowledge Infrastructure, Cochrane clinical trials database) were searched. Studies were eligible if they compared the effects of BZD versus placebo on insomnia in COPD patients. Two reviewers extracted data independently. Disagreements were resolved by discussion with another reviewer until a consensus was achieved. Data that included objective and subjective sleep evaluation and respiratory function variables were extracted. Data were analyzed by the methods recommended by Review Manager 5.3 software. Results: A total of 233 records were identified through the initial search; of these, five studies were included in the meta-analysis. When BZD was compared with placebo, objective sleep quality was significantly improved, including total sleep time (95% confidence interval [CI] 0.54–1.14, P<0.00001), sleep efficiency (95% CI 0.48–1.16, P<0.00001), sleep latency (95% CI -18.24 to -4.46, P=0.001), and number of arousals/hour of sleep (95% CI -0.72 to -0.07, P=0.02). Otherwise, subjective sleep quality was not improved remarkably. Apart from maximum transcutaneous carbon dioxide pressure increase during sleep (95% CI 0.05–0.28, P=0.006), BZD administration had no effect on respiratory assessment. Conclusion: In this meta-analysis, the results suggested BZDs might be efficient and safe hypnotics. Compared with placebo, BZD improved sleep quality partly, and significantly increased maximum transcutaneous carbon dioxide pressure during sleep. More randomized controlled trials are necessary to determine the potential effect of BZD in COPD patients with insomnia. Keywords: benzodiazepine, COPD, insomnia, efficacy, safety, meta-analysi
Airapus rakovici Kral & Lu 2021, new species
No full textAirapus rakovici Král & Lu, new species [XMŧūøƃ] (Figs. 1–9) Type locality. China, Fujian, Nanping, Wu Yi Shan Mts., Sangang, Forest Ecological Station, 890 m, 27°42'23.6"N, 117°45'15.9"E (see Figs. 6–9). Type material. China, Fujian: Holotype, ♂, “ ēs.Ŧfflẋƛm | ÷ ƗÈ ữü | 2009.VI.30 | Nħflx | • Bn'+Ľëssffi || Fujian, Nanping, Wu Yi Shan | Sangang, Forest Ecological Station | 2009.VI.30 | Xiushuai Yang lgt. [printed]”. Deposited in the Institute of Zoology, Chinese Academy of Sciences, Beijing, China. Description of holotype (♂). Oblong oval, subparallel, only slightly broader posteriad, moderately convex, moderately shining, dark blackish brown, anterior clypeus margin, anterior pronotal angles and sutural interval of elytra brown. Dorsal surface almost bare, microscopical setae only in approximately apical third (Figs. 1–3). Head (Figs. 1, 3) moderately convex, without visible frontoclypeal suture; head surface with mostly longitudinal punctures. Clypeus dentate each side of wide anteromedian emargination, its lateral sides nearly aligned with anterior margins of genae. Genae rounded, large, considerably exceeding eyes. Pronotum (Figs. 1, 3) transversal, considerably wider than head, widest before posterior angles, with nearly straight sides, rounded anterior angles and moderately rounded posterior angles. Pronotum surface regularly coarsely and densely punctate; punctures largest basally and stepwise decreasing in size toward anterior margin. Pronotum lateral margins smooth, glabrous. Scutellum small, narrow, triangular (Fig. 1). Elytra (Figs. 1, 3) with 10 striae and 10 intervals, with distinct humeral denticles, elongate, only slightly broader posteriad (broadest point behind half elytra length). Striae narrow, with punctures distinctly observable under high magnification only, but crenating intervals. Intervals wider, weakly costate, reticulate. Legs in dorsal view (Figs. 1–3): protibia with three large teeth in anterior part of outer margin, not denticulate in basal part, its upper surface smooth impunctate, apical spur about as long as basal protarsomere; basal meso- and metatarsomeres long, longer than superior terminal spurs of mesotibia and metatibia, respectively. Ventral surfaces (Fig. 2) shining, remarkably coarsely punctate, punctures on femora smaller than those on mesometaventum and abdominal ventrites. Median furrow of meso-metaventral plate nearly complete as shown in Fig. 2. Abdominal ventrites fluted anteriorly and/or posteriorly as in Fig. 2. Aedeagus as in Figs. 4–5. Measurements. Total body length of 5.8 mm. Name derivation. Patronymic; named in honour of our colleague Miloslav Rakovič (Dobřichovice, Czech Republic), an outstanding specialist on Aphodiinae, especially on Psammodiini. Collecting events. Collected from a light trap in the Forest Ecological Station in Wuyishan, which is surrounded by naturally growing vegetation with dominant trees of Castanopsis carlesii, C. eyrei and C. fargesii (Fagaceae). The nearby mountain ridge is covered with mostly coniferous forest. The soil nearby is composed from red and yellowish red soils (Figs. 6–9). Differential diagnosis. The new species is classified in the genus Airapus by the following set of synapomorphies: pronotal sides distinctly explanate; meso-metaventrum weakly convex or flat with variously shaped callosities; mesocoxae widely separated, flattened, parallel or subparallel; elytral intervals smooth or irregularly swollen; meso- and metatibiae straight with longitudinal lines (for details see also Stebnicka & Howden 1996 and Rakovič et al. 2019). It is distinguished from other south-eastern Asian species mainly by different sculpture of dorsal surface. In the key to Airapus species (Král et al. 2019), A. rakovici Král & Lu, new species will key to the couplet with A. jenisi Král, Mencl & Rakovič, 2019 and A. sumatrae (Fairmaire, 1896) but can be separated from the the fromer by pronotum remarkably simply and coarsely punctate, absence of oblique prontal impressions and elytral intervals impunctate (Figs. 1, 3) (pronotum with medium-sized punctures intermixed with fine ones, pronotal oblique impressions present and elytral punctures fine but distinct in A. jenisi, see Král et al. 2019, figs. 20–21 and 23–26) and from the latter by absence of oblique prontal impressions and posterior pronotal angles rather rounded (Figs. 1, 3) (oblique prontal impressions present and posterior pronotal angles truncate in A. sumatrae). Distribution. China: Fujian.Published as part of Král, David, Lu, Yuanyuan & Bai, Ming, 2021, Airapus rakovici (Coleoptera: Scarabaeidae: Aphodiinae: Eupariini), a new species from Fujian, China, pp. 140-144 in Zootaxa 4920 (1) on pages 140-144, DOI: 10.11646/zootaxa.4920.1.8, http://zenodo.org/record/447237
Synthesis, characterisation and magnetic behaviour of ionic metalloporphyrins: metal-tetrakis(N-octyl-4-pyridinium)-porphyrins with tetrabromoferrate(III) anions
No full textA series of magnetic, ionic-substituted tetrapyridyl metalloporphyrins, [tetrakis(N-octyl-4-pyridinium)-metal-porphyrin][tetrabromoferrate(III)] 4 (metal=iron, cobalt, manganese, copper or zinc), have been synthesised. All compounds show weak ferromagnetic behaviour at room temperature and respond to an external neodymium magnet
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