111,139 research outputs found
ACA inhibited cell viability of A549 and SK-LU-1 cell lines.
No full text(A) Chemical structure of 1’S-1’-acetoxychavicol acetate (ACA). (B) The cell viability of MCF 10A, A549 and SK-LU-1 cells lines after exposure to ACA (0–30 μM) for 24 h was assessed using MTT assay. Data represented as mean percentage of cell viability ± SD for three independent experiments. (C) The cell viability of A549 and SK-LU-1 cells lines after exposure to IC50 of ACA (25 μM for SK-LU-1 and 30 μM for A549 cells) on respective cell lines for 0–24 h was assessed using MTT assay. Data represented as mean percentage of cell viability ± SD for three independent experiments. * p p < 0.01 statistically different in comparison to 0 h (D) Representative photomicrograph (200 × magnification) of A549 and SK-LU-1 cell lines upon ACA treatment. Arrow indicates the cytoplasmic vacuole.</p
Autophagy effect of ACA on A549 and SK-LU-1 cell lines.
No full text(A) Representative fluorescence photomicrograph (400 × magnification) illustrating the acidic vesicular organelles in A549 and SK-LU-1 cell lines after treated with ACA for 0, 3, 6, 12, and 24 h. Data were presented as relative fluorescence intensity in comparison to untreated cells ± SD. * p p p p p p p p p < 0.001 statistically different in comparison to untreated.</p
Efficient p-Multigrid Based Solvers for Isogeometric Analysis on Multipatch Geometries
No full textIsogeometric Analysis can be considered as the natural extension of the Finite Element Method (FEM) to higher-order spline based discretizations simplifying the treatment of complex geometries with curved boundaries. Finding a solution of the resulting linear systems of equations efficiently remains, however, a challenging task. Recently, p-multigrid methods have been considered [18], in which a multigrid hierarchy is constructed based on different approximation orders p instead of mesh widths h as it would be the case in classical h-multigrid schemes [8]. The use of an Incomplete LU-factorization as a smoother within the p-multigrid method has shown to lead to convergence rates independent of both h and p for single patch geometries [19]. In this paper, the focus lies on the application of the aforementioned p-multigrid method on multipatch geometries having a C0-continuous coupling between the patches. The use of ILUT as a smoother within p-multigrid methods leads to convergence rates that are essentially independent of h and p, but depend mildly on the number of patches.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Numerical Analysi
A 2 h periodic variation in the low-mass X-ray binary Ser X-1
No full textSpectroscopy of the low-mass X-ray binary Ser X-1 using the Gran Telescopio Canarias have revealed a ?2 h periodic variability that is present in the three strongest emission lines. We tentatively interpret this variability as due to orbital motion, making it the first indication of the orbital period of Ser X-1. Together with the fact that the emission lines are remarkably narrow, but still resolved, we show that a main-sequence K dwarf together with a canonical 1.4 M? neutron star gives a good description of the system. In this scenario, the most likely place for the emission lines to arise is the accretion disc, instead of a localized region in the binary (such as the irradiated surface or the stream-impact point), and their narrowness is due instead to the low inclination (?10°) of Ser X-1
Search for new hadronic decays of h c and observation of h c → p p ¯ η
No full textAbstract A search for the hadronic decays of the h c meson to the final states p p ¯ π + π − π 0, p p ¯ η , and p p ¯ π 0 via the process ψ(3686) → π 0 h c is performed using (4.48 ± 0.03) × 108 ψ(3686) events collected with the BESIII detector. The decay channel h c → p p ¯ η is observed for the first time with a significance greater than 5σ and a branching fraction of (6.41 ± 1.74 ± 0.53 ± 1.00) × 10 −4, where the uncertainties are statistical, systematic, and that from the branching fraction of ψ(3686) → π 0 h c . Strong evidence for the decay h c → p p ¯ π + π − π 0 is found with a significance of 4.9σ and a branching fraction of (3.84 ± 0.83 ± 0.69 ± 0.58) × 10 −3. The significances include systematic uncertainties. No clear signal of the decay h c → p p ¯ π 0 is found, and an upper limit of 6.59 × 10 −4 on its branching fraction is set at the 90% confidence level
Isocyanide-Mediated C-H Activation, C-C Coupling, and Transformation of a Bis(diphenylphosphino)methane Ligand in Triosmium Clusters
No full textKidney absorbed radiation doses for [ 177 Lu]Lu-PSMA-617 and [ 177 Lu]Lu-PSMA-I&T determined by 3D clinical dosimetry.
No full textPURPOSE: For prostate-specific membrane antigen-directed radioligand therapy (PSMA-RLT), [ 177 Lu]Lu-PSMA-617 and [ 177 Lu]Lu-PSMA-I&T are the currently preferred compounds. Recent preclinical studies suggested ~30x higher kidney absorbed dose for [ 177 Lu]Lu-PSMA-I&T compared to [ 177 Lu]Lu-PSMA-617, which may lead to an increased risk of kidney toxicity. We performed two single-centre, prospective dosimetry studies with either [ 177 Lu]Lu-PSMA-617 or [ 177 Lu]Lu-PSMA-I&T, using an identical dosimetry protocol. We evaluated the absorbed doses of both 177 Lu-labelled radioligands in human kidneys. METHODS: 3D SPECT/computed tomography (CT) imaging of the kidneys was performed after PSMA-RLT in cancer patients with PSMA-positive disease and an adequate glomerular filtration rate (≥50 mL/min). Ten metastatic hormone-sensitive prostate cancer patients (mHSPC) were treated with [ 177 Lu]Lu-PSMA-617 and 10 advanced salivary gland cancer (SGC) patients were treated with [ 177 Lu]Lu-PSMA-I&T. SPECT/CT imaging was performed at five timepoints (1 h, 24 h, 48 h, 72 h, and 168 h post-injection). In mHSPC patients, SPECT/CT imaging was performed after cycles 1 and 2 (cumulative activity: 9 GBq) and in SGC patients only after cycle 1 (activity: 7.4 GBq). Kidney absorbed dose was calculated using organ-based dosimetry. RESULTS: The median kidney absorbed dose was 0.49 Gy/GBq (range: 0.34-0.66) and 0.73 Gy/GBq (range: 0.42-1.31) for [ 177 Lu]Lu-PSMA-617 and [ 177 Lu]Lu-PSMA-I&T, respectively (independent samples t test; P = 0.010). CONCLUSION: This study shows that the kidney absorbed dose for [ 177 Lu]Lu-PSMA-617 and [ 177 Lu]Lu-PSMA-I&T differs, with a ~1.5x higher median kidney absorbed dose for [ 177 Lu]Lu-PSMA-I&T. This difference in the clinical setting is considerably smaller than observed in preclinical studies and may not hamper treatments with [ 177 Lu]Lu-PSMA-I&T
Lu-177-PSMA dosimetry for kidneys and tumors based on SPECT images at two imaging time points.
No full textBACKGROUND
Personalized dosimetry for Lu-177-PSMA treatment requires multiple-time-point SPECT/CT scans to calculate time-integrated activity (TIA). This study evaluates two-time-point (TTP) methods for TIA calculation for kidneys and tumors.
METHODS
A total of 18 patients treated with 3.7-7.4 GBq Lu-177 PSMA-617 were analyzed retrospectively, including 18 sets of left and right kidneys, as well as 45 tumors. Four quantitative SPECT/CT (4TP) were acquired at 2 h, 20 h, 40 h, 60 h (n = 11), or 200 h (n = 7) after treatment, and they were fit bi-exponentially as reference. The TTP method was fitted by a mono-exponential washout function using two selected imaging time points for kidneys. For tumors, one uptake and one washout phase were modeled, assuming linear (type I) and same (type II) uptake phase between 0 h to the first time point and mono-exponential washout thereafter. Two single-time-point (STP) methods were also implemented for comparison. TIA calculated by TTP and STP methods were compared with reference to the 4TP TIA.
RESULTS
For the kidneys, the TTP methods using 20 h-60 h and 40 h-200 h had smaller mean absolute errors of 8.05 ± 6.05% and 4.95 ± 3.98%, respectively, as compared to other combinations of time points and STP methods. For tumors, the type I and type II TTP methods using 20h-60 h and 40-200 h had smaller mean absolute errors of 6.14 ± 5.19% and 12.22 ± 4.44%, and 8.31 ± 7.16% and 4.48 ± 7.10%, respectively, as compared to other TTP and STP methods.
CONCLUSION
The TTP methods based on later imaging time demonstrated fewer errors than the STP methods in kidney and tumor TIA. Imaging at 20 h-60 h and 40 h-200 h could simplify the dosimetry procedures with fewer TIA estimation errors
Studies on the dynamic model of plant adaptation of quantitative characters. III. Diallel analysis
No full text- …
