3,243 research outputs found
IPOs of Chinese Private Companies in U.S. and HK: the Choice of Listing Venue and Long-Run Performance
No full textFull text is available to authenticated members of The University of Auckland only.I investigate the determinants for Chinese private companies to list in either the U.S. or HK during period of 2000 to 2014. Chinese private companies with higher asset growth, lower leverage, classified as high-tech companies, with negative earnings before listing, and with venture capitalists supporting them are more likely to list in the U.S. HK IPO issuers are generally larger than U.S. IPO issuers in terms of pre-listing total assets. In addition, Chinese private companies are more likely to list where they have a better information environment that is measured by analyst coverage and the number of recent IPOs in the same industry. Subsequent to the listing event, Chinese private companies listed in both the U.S. and HK experience a significant drop in operating performance measures one, two, and three years after the IPO year. Some of the operating performance measures of the Chinese private companies that are listed in the U.S. decline significantly more than those listed in HK. In terms of stock performance, Chinese private companies listed in the U.S. significantly underperform their matching firms one, two, and three years after the IPO year, while Chinese private companies listed in HK only exhibit underperformance in the first year after IPO
Case Study for Holylight(HK)
Full text linkIn this thesis the case company – Holylight (HK) was thoroughly studied. The company structure, business strategic management and Marketing mix (4ps) were analyzed using SWOT analysis. It was found that Holylight (HK) had huge poten-tial in the business its stable supplies from the United States of America, Europe and Australia; Alliance partnership company ensure the steady sales channel in potential market – China that further development and expansion are highly feasible.
However there are issues, both internal and external. T prudent strategies and lack of manpower that might hinder a smooth growth of the business. Advises and recommendations were given to tackle the issues mentioned, such as bring up a successor and entering to a new market which related to Marine industry. Hopefully the applications of them would help Holylight (HK) in the future.
Author used interview as the main researching Method. Author collected the Information which needed in this case study from the CEO directly. Observational research also apply in this case study, author worked for the case company for a not short period and it provided the information in more objective way
HK-ASAP study
No full textBackground: The changes of circadian rhythm are very common in senior adults, which can lead to decreased quality of life and jeopardize the brain health in the long run. Among all the types of sleep disturbances, poor sleep quality, as a modifiable condition, can greatly affect the daily activities, cognitive functions, quality of life, and even be implicated as a key potential contributing factor in the development of accelerated cognitive decline and prodromal dementia. Consequently, research efforts to understand, and thus potentially model, the effects of sleep quality on cognition and brain during ageing are of great pragmatic values.
Methods: The Hong Kong Cohort of Abnormal Sleep in Ageing Population (HK-ASAP) project is a prospective cohort study recruiting 244 older adults with sleep disturbances. The HK-ASAP study plans to measure sleep quality, brain reserve and cognition at baseline and 2 years. Subjective sleep quality will be assessed by the Pittsburgh Sleep Quality Index (PSQI). Global cognition and domain-specific cognitive functions will be assessed by a comprehensive neuropsychological battery. High-resolution structural magnetic resonance imaging (MRI) data will be acquired and used to quantify the brain reserve, including gray matter volume, cortical thickness, folding and brain age matrices. Saliva samples will be collected for measuring the levels of Aβ40 and Aβ42. Using the data, we will estimate and compare the sleep quality and its associations with cognition, Aβ, and brain reserve in senior adults.
Discussion: The bidirectional relationship between sleep quality and cognitive impairments in late adulthood presents an urgent need to understand how poor sleep quality affects cognition and its potential relationship to brain reserve and neuropathological factors. The HK-ASAP study will be a valuable resource for both epidemiological and clinical research, as it will provide fundamental information to identify at-risk individuals. Results from the HK-ASAP study will enable to develop interventions to improve the sleep quality, cognition and healthy longevity in old adults
Clinical outcome following DIAM implantation for symptomatic lumbar internal disk disruption: a 3-year retrospective analysis [Corrigendum]
No full textLu K, Liliang PC, Wang HK, Chen JS, Chen TY, Huang R, Chen HJ. J Pain Res. 2016;9:917–924. Page 917, author affiliation list, the authors have requested for the affiliations to be listed as shown below. Kang Lu1Po-Chou Liliang1Hao-Kuang Wang1Jui-Sheng Chen1Te-Yuan Chen1Ruyi Huang2Han-Jung Chen1,3 1Department of Neurosurgery, E-Da Hospital, I-Shou University, 2Department of Family Medicine, E-Da Hospital, I-Shou University, 3Department of Neurosurgery, E-Da Cancer Hospital, College of Medicine, I-Shou University, Kaohsiung, TaiwanRead the original articl
STRATEGI BAURAN PEMASARAN AIR MINERAL HK DIKABUPATEN FAKFAK
Full text linkEngaged in the industrial sector to meet the needs of the majority of society. The HK Mineral Water Industry was founded in 2011 until now. The marketing mix in the HK mineral water business is already good enough so that the marketing process with the 4P concept applied can run according to the market conditions at the sales location. The purpose of writing the Assignment report The end is to find out the marketing mix strategy for HK Mineral Water by the HK Mineral Water business in Fakfak district. The author uses a descriptive analysis method that compares existing data with various theories that support existing data with various theories that support and are explanatory and expounding. Measurement of variables This is done using the Libert scale, which is used for the attitudes, opinions and perceptions of a person or group of people. This research involved 50 respondents from the population of HK mineral water consumers in the city of Fakfak. The questionnaires distributed have all been distributed and can be used as data in this research. Regarding Air HK product quality, regarding the packaging of Air HK products it is in the good category. A product is anything that a producer can offer to the market to fulfill the market's desires or needs to fulfill desire or need. In this research, the implementation of the marketing strategy used by HK Mineral Water is quite good because it always focuses on fulfilling the needs and desires of consumers. From the results of the research carried out, it can be concluded that the research results are the marketing mix strategy for HK Mineral Water in Fakfak district from all product variables with respondents who said that the Air Mineral HK product was in the good category with 1559 points, it could be concluded that the Air HK product was running well.
Keywords: Water, Marketing Mix Strategy, Fakfak Regenc
Relations between chest wall motion and diaphragmatic excursion in healthy adults in supine position.
No full text
C-Reactive Protein Induces Interleukin-6 and Thrombospondin-1 Protein and mRNA Expression through Activation of Nuclear Factor-kappa B in HK-2 Cells
No full textBackground: Although C-reactive protein (CRP) is significantly increased in patients with diabetic nephropathy, whether CRP exerts direct proinflammatory effects on human renal tubular epithelial cells (HK-2 cells) is still unclear. Methods: HK-2 cells were incubated with purified CRP at clinically relevant concentrations (0, 5, 10, 20 and 40 mu g/ml). The protein and transcript levels of thrombospondin-1 (TSP-1) and interleukin-6 (IL-6) were determined by ELISA and RT-PCR. Phosphorylation of p38MAPK was investigated through Western blot analysis in HK-2 cells induced by CRP. The activation of nuclear factor-kappa B (NF-kappa B) was studied via EMSA. A specific p38MAPK inhibitor (SB203580) and an NF-kappa B inhibitor (PDTC; pyrrolidine dithiocarbamate) were used to analyze the signal transduction in CRP induction. To explore the direct or indirect role of CRP in HK-2 cells, IL-6 or TSP-1 antibodies were used. The expression of IL-6, TSP-1 and transforming growth factor-beta(1) (TGF-beta(1)) were determined through Western blot analysis in HK-2 cells. Results: In HK-2 cells, purified CRP significantly induced protein release and mRNA expression of IL-6 and TSP-1 in a dose- and time-dependent manner. TGF-beta(1) protein was overexpressed in HK-2 cells induced by CRP, which cannot be inhibited by IL-6 or TSP-1 antibodies. CRP triggered phosphorylation of p38MAPK and activation of NF-kappa B-mediated signal transduction. SB203580 (5 mu m) and PDTC (50 mu m) efficiently suppressed those effects of CRP in HK-2 cells. Conclusions: CRP induces IL-6 and TSP-1 protein release and mRNA expression from HK-2 cells via activation of the p38MAPK and NF-kappa B signaling pathways and TGE-beta(1) was highly expressed in HK-2 cells, suggesting that CRP plays an important role in the propagation and prolongation of inflammation in renal fibrosis. Copyright (C) 2012 S. Karger AG, BaselBackground: Although C-reactive protein (CRP) is significantly increased in patients with diabetic nephropathy, whether CRP exerts direct proinflammatory effects on human renal tubular epithelial cells (HK-2 cells) is still unclear. Methods: HK-2 cells were incubated with purified CRP at clinically relevant concentrations (0, 5, 10, 20 and 40 mu g/ml). The protein and transcript levels of thrombospondin-1 (TSP-1) and interleukin-6 (IL-6) were determined by ELISA and RT-PCR. Phosphorylation of p38MAPK was investigated through Western blot analysis in HK-2 cells induced by CRP. The activation of nuclear factor-kappa B (NF-kappa B) was studied via EMSA. A specific p38MAPK inhibitor (SB203580) and an NF-kappa B inhibitor (PDTC; pyrrolidine dithiocarbamate) were used to analyze the signal transduction in CRP induction. To explore the direct or indirect role of CRP in HK-2 cells, IL-6 or TSP-1 antibodies were used. The expression of IL-6, TSP-1 and transforming growth factor-beta(1) (TGF-beta(1)) were determined through Western blot analysis in HK-2 cells. Results: In HK-2 cells, purified CRP significantly induced protein release and mRNA expression of IL-6 and TSP-1 in a dose- and time-dependent manner. TGF-beta(1) protein was overexpressed in HK-2 cells induced by CRP, which cannot be inhibited by IL-6 or TSP-1 antibodies. CRP triggered phosphorylation of p38MAPK and activation of NF-kappa B-mediated signal transduction. SB203580 (5 mu m) and PDTC (50 mu m) efficiently suppressed those effects of CRP in HK-2 cells. Conclusions: CRP induces IL-6 and TSP-1 protein release and mRNA expression from HK-2 cells via activation of the p38MAPK and NF-kappa B signaling pathways and TGE-beta(1) was highly expressed in HK-2 cells, suggesting that CRP plays an important role in the propagation and prolongation of inflammation in renal fibrosis. Copyright (C) 2012 S. Karger AG, Base
The Promoting Role of HK II in Tumor Development and the Research Progress of Its Inhibitors
No full textIncreased glycolysis is a key characteristic of malignant cells that contributes to their high proliferation rates and ability to develop drug resistance. The glycolysis rate-limiting enzyme hexokinase II (HK II) is overexpressed in most tumor cells and significantly affects tumor development. This paper examines the structure of HK II and the specific biological factors that influence its role in tumor development, as well as the potential of HK II inhibitors in antitumor therapy. Furthermore, we identify and discuss the inhibitors of HK II that have been reported in the literature
Risāle-i Muzaffer Şāh-nāme; رسالۀ مظفر شاه نامه; Manzūme-i Ferāiz; منظومۀ فرائض; Muhtasar Tercümānü’l-Ümem [Risāle fì-İcmāl Ahvāli’l-Mezāhibi’l Muhtelife li-Tavālifi’l-Ümem; رساله فى اجمال احوال المذاهب المختلفه لطوايف الامم; Risāle-i Cifr ve Ed'iye; رسالۀ جفر و ادعيه; Risāle-i Hadìs-i Erba'in; رسالۀ حديث اربعين; Hikāye-i Ahvāl-i Sırāt; حكايۀ احوال صراط; Risāle-i Manzūme berāy-ı Zenān; رسالۀ منظومه براىزنان; Risāle-i Şerh-i Rūz-nāme; رسالۀ شرح روزنامه; Manzūme-i Salāt-ı Şerife; منظومۀ صلوت شريفه; Risāle-i Cennetü’l-Esmā ve Ed'iye; رسالۀ جنت الاسما
No full text1. eser : İçindekiler : Ia: Yazma içindeki bütün risalaler ait genel fihrist; 1a-11b: Fezail-i Leyle-i Kadr; 12a-20b: Fezail-i Mah-ı Receb; 21a-28b: Fezail-i Mah-ı Şaban; 28b-55b: Fezail-i Mah-ı Ramazan.; 2. eser : İçindekiler : Eser, çeşitli peygamberlerin, filozofların, mutasavvıfların ve devlet adamlarının hikmetli sözlerinden oluşan bir derlemedir.; 4. eser : İçindekiler : Eserde çeşitli İslam mezhep ve fırkaları birkaç satırla tanıtılmaktadır. Eser bittikten sonra 73a’da Arapça olarak İmam Şafii’den bir alıntı; 73b: Hz. Ali’den Arapça beyitler.; 5. eser : İçindekiler : 74b-76a: Türkçe Risâle-i Cifr; 76b-86b: Çeşitli zamanlarda okunacak Arapça dualar; 87a-97b: Risâle-i nâd-ı necât; 98a’da Osmanlı sultanlarının sırasıyla tahtta kalış yıllarını gösteren tablo; 99a-100b: Fâtiha tefsiri.; 6. eser : İçindekiler : Eser sırat köprüsünün nasıl geçileceği hk. mesnevi nazım biçimiyle yazılmış bir manzumedir.; 8. eser : İçindekiler : Eser, kadınlara hitaben yazılmış mesnevi biçiminde bir manzumedir. Bu manzume bittikten sonra 118a-b arasında peygamberler, ebced harfleri hk. Türkçe ve Kuranda yer alan namazla ilgili hükümler hk. Arapça notlar.; 9. eser : İçindekiler : Eser, hicri ayların ve mevsimlerin asıl tayin edilebileceği ve özellikleri hk.; 10. eser : İçindekiler : Şiir dörtlüklerle yazılmıştır. Kenarda da dörtlükler vardır.; 11. eser : İçindekiler : Risale dualardan oluşmaktadır. Eserin sonunda 143b-151b arasında çeşitli rüya tabirleri, manzumeler ve boş sayfalar bulunmaktadır. 151b-154b arasında ise küçük bir satır arası Arapça-Türkçe sözlük vardır.Original scanned with Zeutschel OS 12000C A2 scanner and saved as 300 ppi uncompressed tiffs. Display images generated in CONTENTdm as JP200011 vol. in 1; 15,5x10,5 c
- …
