17,147 research outputs found
TACC3-ch-TOG track the growing tips of microtubules independently of clathrin and Aurora-A phosphorylation
Full text linkThe interaction between TACC3 (transforming acidic coiled coil protein 3) and the microtubule polymerase ch-TOG (colonic, hepatic tumor overexpressed gene) is evolutionarily conserved. Loading of TACC3–ch-TOG onto spindle microtubules requires the phosphorylation of TACC3 by Aurora-A kinase and the subsequent interaction of TACC3 with clathrin to form a microtubule binding surface. Whether there is a pool of TACC3–ch-TOG that is independent of clathrin in human cells, and what is the function of this pool, are open questions. Here, we report that TACC3 is recruited to the plus-ends of microtubules by its association with ch-TOG and that this pool is independent of phosphorylation and binding to clathrin. The plus-end binding of TACC3–ch-TOG persists in interphase and we propose that one cellular function of TACC3–ch-TOG is to modulate cell migration. We also describe the distinct subcellular pools of TACC3, ch-TOG and clathrin. TACC3 is often described as a centrosomal protein, but we show that there is no significant population of TACC3 at centrosomes. The delineation of distinct protein pools reveals a simplified view of how these proteins are organized and controlled by post-translational modification
Research on Lu-ch'iao's novels
No full textSince their publication in Taiwan, \ue2Wei-yang Ko\ue2(Song Never to End), and \ue2Jen-tzu\ue2(the Human Child and Legend Stories) authored by Lu-ch\ue2iao have not only had buoyant sales, but also long-term steady sales. It is especially so for \ue2Wei-yang Ko\ue2. By reading it, so many youths weave picturesque campus life. Although perceptual articles have often been released to comment on the two novels, there are very few academic critiques. As it is, this paper gathers the historic commentaries related to \ue2Wei-yang Ko\ue2 and \ue2Jen-tzu\ue2, analyzes and investigates them. On one hand they are used as the basis for this paper to elucidate, on the other, they provide detailed data for other researchers to research on Lu-ch\ue2iao\ue2s works in the future.
\ue2Wei-yang Ko\ue2 and \ue2Jen-tzu\ue2 have a large number of readers, but very few of them are aware Lu-ch\ue2iao\ue2s life. As is the case, the author makes reference to \ue2Lu-ch\ue2iao\ue2s Song Never To End\ue2 authored by Ms. Pu Yue as the major source and divides Lu-ch\ue2iao\ue2s life into four stages, growth, school attendance, having a family and his old age. At the same time, Lu-ch\ue2iao\ue2s biographic accounts are depicted from four aspects, his emotions, life dedication, sentiment for farming life and writing concept, in attempt to provide a vivid image about Lu-ch\ue2iao.
For \ue2Wei-yang Ko\ue2, this paper elucidates how it promotes the virtue of human nature and highlights the youth\ue2s enthusiasm and expectations through the analyses made by four major personages, Bao-sheng Wu, Meng-qin Yu, Yan-mei Lin and Xiao-xian Tong along with the investigation on friendship, love, gender, and sentiment.
For \ue2Jen-tzu\ue2, while the thinking of Lao-tzu and Zhuang-tzu is the major basis for interpretation, the Confucianism is used in some sections to assist in interpretation. In addition, Buddhism, mythology/legends, psychological analysis, gender discourse and western philosophical thinking, etc, are also used to explore the implication of the 13 stories. In the end, they are integrated as the context of \ue2a life course\ue2, in the hope of presenting an intact writing structure to the readers.
As a whole, \ue2Wei-yang Ko\ue2 uses the campus life in the university during the war of resistance against Japan as the background, in which the youth\ue2s pursuit of virtue and optimism about their lives are well presented through the exploration of friendship depiction, love illustrations and campus spirits. For \ue2Jen-tzu\ue2, it recounts fable-like stories to imply common philosophy and provide thinking stimulant which are strong enough to trigger readers\ue2 pondering and arguing temptation. If \ue2Wei-yang Ko\ue2 is described as an uncut jade to represent Lu-ch\ue2iao\ue2s thinking in his youthhood, then \ue2Jen-tzu\ue2 is like a sage to show Lu-ch\ue2iao\ue2s thinking brainchild resulting from his contemplation
Luminescence characteristics of sol-gel derived Y3Al5O12 : Eu3+ phosphors excited with vacuum ultraviolet
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Influence of alkaline sources on the structural and morphological properties of hydrothermally derived zinc oxide powders
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Ultrastructure of white spot syndrome virus development in primary lymphoid organ cell cultures.
No full textThe Short-term Effect of Acupuncture on Cortical Excitability in Patients with Parkinson’s Disease.
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