46,585 research outputs found
Shanghai Yü ying tang zheng xin lu.
No full textCaption title.; Special collection from London Missionary Society.; On double leaves, oriental style, in case.; Also available in an electronic version via the Internet at http://nla.gov.au/nla.gen-vn389180.880-02 Yü ying tang zheng xin lu
Lu ying jie mu
No full text1. 中國戲曲演唱交流 -- 2. 河南墜子 : 穆桂英指路 / 馬玉萍 -- 3. 雙唱京韻大鼓 : 鬧江州 / 種玉杰, 王玉蘭 -- 4. 北京琴書 : 楊八姐遊春 / 關學曾. Detailed contents in vernacular field only.Detailed contents in vernacular field only.Part title supplied by cataloguer.Live recording.Electronic reproduction from Rulan Chao Pian U-matic collection.Various performers.Sung and spoken in Chinese
Simple Modifications of Branched PEI Lead to Highly Efficient siRNA Carriers with Low Toxicity
Full text linkPolymer carriers like PEI which proved their efficiency in DNA delivery were found to be far less effective for the applications with siRNA. In the current study, we generated a number of nontoxic derivates of branched PEI through modification of amines by ethyl acrylate, acetylation of primary amines, or introduction of negatively charged propionic acid or succinic acid groups to the polymer structure. The resulting products showed high efficiency in siRNA-mediated knockdown of target gene. In particular, succinylation of branched PEI resulted in up to 10-fold lower polymer toxicity in comparison to unmodified PEI. Formulations of siRNA with succinylated PEI were able to induce remarkable knockdown (80% relative to untreated cells) of target luciferase gene at the lowest tested siRNA concentration of 50 nM in Neuro2ALuc cells. The polyplex stability assay revealed that the efficiency of formulations which are stable in physiological saline is independent of the affinity of siRNA to the polymer chain. The improved properties of modified PEI as siRNA carrier are largely a consequence of the lower polymer toxicity. In order to achieve significant knockdown of target gene, the PEI-based polymer has to be applied at higher concentrations, required most probably for sufficient accumulation and proton sponge effects in endosomes. Unmodified PEI is highly toxic at such polymer concentrations. In contrast, the far less toxic modified analogues can be applied in concentrations required for the knockdown of target genes without side effects
Yuan yang pei : èr
No full textRomance fiction, this is a 19th century edition published by commercial publisherWork in 4 volumes. Double leaves, oriental style, in case. Case digitised with 鴛鴦配 : 一 = Yuan yang pei : yī著錄: 西諦書目, 內閣文庫漢籍分類目錄, 日本東京所見小說書目 Zhu lu: Xi di shu mu, Naikaku Bunko Kanseki bunrui mokuroku, Riben Dongjing suo jian xiao shuo shu m
Yuan yang pei : yī
No full textRomance fiction, this is a 19th century edition published by commercial publisherWork in 4 volumes. Double leaves, oriental style, in case. Case digitised with 鴛鴦配 : 一 = Yuan yang pei : yī著錄: 西諦書目, 內閣文庫漢籍分類目錄, 日本東京所見小說書目 Zhu lu: Xi di shu mu, Naikaku Bunko Kanseki bunrui mokuroku, Riben Dongjing suo jian xiao shuo shu m
Yuan yang pei : sì
No full textRomance fiction, this is a 19th century edition published by commercial publisherWork in 4 volumes. Double leaves, oriental style, in case. Case digitised with 鴛鴦配 : 一 = Yuan yang pei : yī著錄: 西諦書目, 內閣文庫漢籍分類目錄, 日本東京所見小說書目 Zhu lu: Xi di shu mu, Naikaku Bunko Kanseki bunrui mokuroku, Riben Dongjing suo jian xiao shuo shu m
The expression of clock protein, PER1, within the suprachiasmatic nucleus in temporal lobe epilepsy (TLE) rats.
No full textsj-doc-1-npx-10.1177_1934578X221076653 - Supplemental material for Total Synthesis and Anti-Inflammatory Activity of Velutone F
No full textSupplemental material, sj-doc-1-npx-10.1177_1934578X221076653 for Total Synthesis and Anti-Inflammatory Activity of Velutone F by Ying Li, Min Wu, Hongbo Dong, Pei Yu, Lan Lu, Weihong Du and Shenghua Cao in Natural Product Communications</p
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