305,342 research outputs found
Sarcoidosis and maligancy: the chicken and the egg?
No full textPURPOSE OF REVIEW: There is a complex interaction between sarcoidosis and malignancy. Since tumors can elicit a granulomatous reaction, the presence of granulomas alone is insufficient to diagnose sarcoidosis in a patient with cancer. In addition, check point inhibitors can also lead to a granulomatous reaction which can be misdiagnosed as sarcoidosis. These issues need to be considered when exploring the relationship between sarcoidosis and malignancy. Despite these limitations, a growing amount of evidence supports the potential interaction of sarcoidosis and malignancy. RECENT FINDINGS: Several large epidemiologic studies of patients from Europe, the USA, and Japan reveal an increased relative risk for cancer in sarcoidosis patients. The highest relative risks are seen in patients with lymphoma and breast cancer. New criteria have been developed to standardize the diagnosis of sarcoidosis, which should further clarify the association. SUMMARY: The diagnosis of sarcoidosis may precede or occur after malignancy. In a sarcoidosis patient with an atypical lesion, such as a breast mass, a biopsy should be considered
Factors affecting sound exposure from firing an SA80 high-velocity rifle
No full textThe effect of distance on the peak sound pressure level and sound exposure level from an SA80 rifle has been investigated. Sound pressure waveforms were measured in two directions from the gun: downrange, from 50 m to 300 m, and to the left-hand side, from 0.3 m to 32 m. Some additional measurements were made to the right of the gun. Measurements made downrange showed three distinct features of the waveform; the shock wave from the supersonic bullet, the reflection from the ground, and the muzzle blast. The time elapsed between the shock wave and the muzzle blast increased with increasing distance: 94 ms for a distance of 50 m, and 507 ms for a distance of 300 m. The highest peak sound level downrange from a single round was between 151 dB(C) and 148 dB(C) at distances from 50 m to 300 m, and varied little if at all with distance. To the left of the gun, the peak sound pressure level of 161 dB(C) at 0.3 m reduced to 128 dB(C) at 32 m. The peak sound pressure level was estimated to be 137 dB(C) at a distance of approximately 20 m to the left-hand side. Hearing protection must therefore be worn by anyone closer than 20 m to a person firing. The peak sound pressure level was estimated to be 135 dB(C) at a distance of approximately 25 m and therefore hearing protection is recommended at distances of up to 25 m. The sound exposure level of 98 dB(A) at 20 m indicated that an observer at this distance could hear about 1440 rounds without hearing protection before the noise exposure reached the upper exposure action value specified in the Control of Noise at Work Regulations 2005. Peak sound pressure levels were on average 2.4 dB higher at the left ear compared with the right ear
Mining e-mail content for author identification forensics
No full textWe describe an investigation into e-mail content mining for author identification, or authorship attribution, for the purpose of forensic investigation. We focus our discussion on the ability to discriminate between authors for the case of both aggregated e-mail topics as well as across different email topics. An extended set of e-mail document features including structural characteristics and linguistic patterns were derived and, together with a Support Vector Machine learning algorithm, were used for mining the e-mail content. Experiments using a number of e-mail documents generated by different authors on a set of topics gave promising results for both aggregated and multi-topic author categorisation
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
Host blood proteins as bridging ligand in bacterial aggregation as well as anchor point for adhesion in the molecular pathogenesis of Staphylococcus aureus infections
No full textFibronectin (Fn) and fibrinogen (Fg) are major host proteins present in the extracellular matrix, blood, and coatings on indwelling medical devices. The ability of Staphylococcus aureus to cause infections in humans depends on favorable interactions with these host ligands. Closely related bacterial adhesins, fibronectin-binding proteins A and B (FnBPA, FnBPB) were evaluated for two key steps in pathogenesis: clumping and adhesion. Experiments utilized optical spectrophotometry, flow cytometry, and atomic force microscopy to probe FnBPA/B alone or in combination in seven different strains of S. aureus and Lactococcus lactis, a Gram-positive surrogate that naturally lacks adhesins to mammalian ligands. In the absence of soluble ligands, both FnBPA and FnBPB were capable of interacting with adjacent FnBPs from neighboring bacteria to mediate clumping. In the presence of soluble host ligands, clumping was enhanced particularly under shear stress and with Fn present in the media. FnBPB exhibited greater ability to clump compared to FnBPA. The strength of adhesion was similar for immobilized Fn to FnBPA and FnBPB. These findings suggest that these two distinct but closely related bacterial adhesins, have different functional capabilities to interact with host ligands in different settings (e.g., soluble vs. immobilized). Survival and persistence of S. aureus in a human host may depend on complementary roles of FnBPA and FnBPB as they interact with different conformations of Fn or Fg (compact in solution vs. extended on a surface) present in different physiological spaces.</p
Temperature enhancements and vertical winds in the lower thermosphere associated with auroral heating during the DELTA campaign
No full textA coordinated observation of the atmospheric response to auroral energy input in the polar lower thermosphere was conducted during the Dynamics and Energetics of the Lower Thermosphere in Aurora (DELTA) campaign. N2 rotational temperature was measured with a rocket-borne instrument launched from the Andøya Rocket Range, neutral winds were measured from auroral emissions at 557.7 nm with a Fabry-Perot Interferometer (FPI) at Skibotn and the KEOPS, and ionospheric parameters were measured with the European Incoherent Scatter (EISCAT) UHF radar at Tromsø. Altitude profiles of the passive energy deposition rate and the particle heating rate were estimated using data taken with the EISCAT radar. The local temperature enhancement derived from the difference between the observed N2 rotational temperature and the MSISE-90 model neutral temperature were 70–140 K at 110–140 km altitude. The temperature increase rate derived from the estimated heating rates, however, cannot account for the temperature enhancement below 120 km, even considering the contribution of the neutral density to the estimated heating rate. The observed upward winds up to 40 m s−1 seem to respond nearly instantaneously to changes in the heating rates. Although the wind speeds cannot be explained by the estimated heating rate and the thermal expansion hypothesis, the present study suggests that the generation mechanism of the large vertical winds must be responsible for the fast response of the vertical wind to the heating event
Author, publisher and bookseller : a tripartite synergy in Nigerian book industry
No full textThis work is about the roles of Author, Publisher and Bookseller in Book development in
Nigeria. The paper started by delving into the history of Book Publishing in Nigeria after
which it proceeded by defining who an author, a publisher, and a bookseller is and
expatiated on the indispensable roles of these key actors in Nigerian Book Industry and in
the emerging Information Society. Furthermore, the various constraints to book
development were identified while the paper advised on how the Book Industry can be
further promoted in Nigeria. However, the paper concluded and made recommendations
on how the Book sector can help in enhancing scholarship in the country
- …
