138,264 research outputs found
Guidebook for Pre-conference North Island Field Trip A1 ‘Ashes to Issues’, 28-30 November, 2008
No full textWelcome to New Zealand or Aotearoa – „Land of the long lingering day [twilight]‟ – and to our three-day pre-conference North Island field trip „Ashes and Issues‟. We trust your stay in New Zealand is both informative and friendly and there is something for everyone on the trip. The itinerary in brief and a map of the North Island showing the main scientific stops are shown above. At the time of guidebook preparation, we have a group of 23, including four students, on the tour with participants from Japan, Taiwan, USA, UK, Australia and New Zealand. The tour leaders are Prof David Lowe (Univ. of Waikato, Hamilton) and Dr Haydon Jones (Scion Research, Rotorua). Assistant leader is Prof Paul McDaniel (Univ. of Idaho, Moscow), on leave at the Univ. of Waikato July-December, 2008. We offer a warm welcome to you all. Because we have considerable distances to travel (especially Day 3), as well as a range of stops planned, we will need to leave the hotel at 8.00 am each day
Lowe, Angela
No full textMs. Lowe attended West Amory High School, but graduated from Amory High School in 1975
Ruby Lowe
No full textHandwritten in pencil on verso: Ruby Lowe - daughter of the Fells Point artist; S-206-E-EBC-1. Signed: Elinor B. Cahn, 1979
Barbaracurus zambonellii Kovařík & Lowe & Šťáhlavský 2018, comb. n.
No full textBarbaracurus zambonellii (Borelli, 1902) comb. n. (Figures 7, 28, 36, 58–61, 79–80, 88–89, 219–244, 248– 251, 261–262, 265, Table 1) Babycurus zambonellii Borelli, 1902: 1–4; Hirst, 1907: 209; Kraepelin, 1913: 181; Caporiacco, 1947: 232; Probst, 1973: 329; Lamoral & Reynders, 1975: 498; Kovařík, 1998: 104 (in part); Fet & Lowe, 2000: 80 (in part); Lowe, 2000: 185–191 (in part); Kovařík, 2000: 260–261 (in part); Kovařík, 2003: 137 (? in part); Chiarle et al., 2012: 21. TYPE LOCALITY AND HOLOTYPE DEPOSITORY. Eritrea, Chenafena; MZUT. MATERIAL EXAMINED. Eritrea, Chenafena (14.786N 39.018E), 1♀ (holotype), MZUT; Filfil, Salamuna river, 15°36'34.6"N 38°57'22.8"E, 817 m a.s.l., 3.-4.XI.2015, (Figs. 224–225, Locality No. 15 EH), 3♂ 3♀1♀ im.3juvs. (No. 876, Figs. 28, 36, 219–223, 226–244, 258–251, 258–259), leg. F. Kovařík, FKCP. DIAGNOSIS. Total length of adult males 32–35 mm, adult females 46–52 mm. Coloration yellowish brown to grey with darker markings, chelicerae yellow without or with traces of reticulation. Pedipalp chela manus much wider in male than female, chela length/width ratio 3.42 in males and 4.29 in female; proximal margins of pedipalp fingers of female straight (Figs. 61, 231), of male undulate so as to leave a gap with fingers closed (Figs. 59, 233); dentate margin of movable finger armed with 7 rows of granules, and a short apical row of 3–4 denticles (Fig. 7); most proximal granule row with one external accessory granule. Pectines with 17–19 teeth in both sexes. Hemispermatophore basal lobe a weak, oblique carina (Figs. 28, 36). Metasoma narrow, metasoma V length/width ratio is 2.40–2.46 in males and 2.56–2.58 in females (Figs. 76–77); metasoma I with 10 carinae, II–IV with 8 carinae. Telson setose, bearing numerous long macrosetae and short, pointed subaculear tubercle; vesicle smooth, elongate, ellipsoidal, slightly bulbous, telson length/depth ratio 2.27–2.37 in both sexes; aculeus slender, curved, shorter than vesicle. NOTE. In his original description, Borelli (1902: 3) assumed that the holotype was a male, and this was accepted by most subsequent authors. Only Lowe (2000: 190–191) questioned this assumption, observing that the holotype exhibited some characters more consistent with females of other species of Babycurus sensu lato, and noted that “Study of additional material is needed to clarify variation and sexual dimorphism in B. zambonellii ”. Recently, the first author (F.K.) was able to finally settle this question by collecting additional material representing both sexes of B. zambonellii. The new specimens clearly demonstrated that the holotype is indeed female, not male. B. zambonellii is an Eritrean endemic and the female which Sissom (1994) cited from Yemen represents a new species which we describe here as B. yemenensis sp. n. COMMENTS ON LOCALITY AND LIFE STRATEGY. The first author (F.K.) visited the locality 15EH (Figs. 224–225), a montane, forested habitat along a riverbed of an occasional river, on 3–4 November 2015. At this locality, the author recorded a maximum daytime temperature of 30.3 ºC, and minimum nighttime temperatures of 19.6 ºC. The recorded humidity was between 46% and 92%. In addition to B. zambonellii the first author also recorded Hottentotta minax (L. Koch, 1875) at this locality.Published as part of Kovařík, František, Lowe, Graeme & Šťáhlavský, František, 2018, Review of the genus Babycurus Karsch, 1886 (Arachnida, Scorpiones, Buthidae), with descriptions of Barbaracurus gen. n. and two new species from Oman and Yemen, pp. 1-41 in Euscorpius 267 on pages 33-36, DOI: 10.5281/zenodo.654415
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Study of the cell biological role of Lowe Syndrome protein OCRL1
No full textOculocerebrorenal syndrome of Lowe (OCRL) is caused by mutations in a
phosphatidylinositol 5-phosphatase, OCRL1, and is believed to lead to an
elevation of its preferred substrate, PI(4,5)P2. To date, much of the work on
OCRL1 has centred on its role at Golgi and endosomal membranes.
However, there is also evidence of plasma membrane activity for OCRL1,
where its PI(4,5)P2 substrate is known to be highly abundant. PI(4,5)P2
regulates a wide array of downstream cellular functions such as cytoskeletal
dynamics, membrane trafficking and signalling. The tight regulation of
PI(4,5)P2 levels and localisation, like other phosphoinositides, provides a
framework upon which many of these cellular processes work. In this thesis,
effects of OCRL1 loss have been tested through siRNA depletion of OCRL1,
focussing where possible on multiple PI(4,5)P2-dependent mechanisms, and
also focussing on cells forming polarised epithelia. Firstly, we have visualised
the localisation of PI(4,5)P2 in living HeLa cells lacking OCRL1 through
immunostaining for Annexin A2, which showed a marked translocation to the
plasma membrane. This change in distribution of Annexin A2 suggested that
OCRL1 depletion may have an effect on intracellular calcium dynamics as
well as PI(4,5)P2 localisation. We also used a GFP-chimera of the well
characterised PI(4,5)P2-binding pleckstrin homology domain of PLCδ1. This
showed no difference in localisation upon OCRL1 depletion. As OCRL1 is
highly enriched at the TGN, we fused the pleckstrin homology domain of
PLCδ1 to a mutated pleckstrin homology domain of OSBP known to bind ARF1 at the TGN, to act as a coincidence detector for PI(4,5)P2 at the TGN.
This construct also showed no reproducible effect of OCRL1 depletion.
Secondly we tested the effect of loss of OCRL1 on cytosolic calcium levels.
Using two phospholipase C (PLC) agonists, and a SERCA pump inhibitor, we
found no consistent differences in calcium handling upon depletion of OCRL1.
Thirdly, we have assessed the potential specialised role that OCRL1 has in
polarised epithelial cells, which might relate to the clinical picture in Lowe
Syndrome. We found that OCRL1 targets the tight junctions of immortalised
lines and primary cells. Through co-immunoprecipitation, we found OCRL1 in
complexes with the tight junction scaffold protein ZO-1. Most significantly, we
found that depletion of OCRL1 in human polarised epithelial cell lines
interfered with epithelial differentiation, reducing cell number and altering
morphology, to produce large flat cells. We attribute this phenotype, stronger
than any other so far described experimentally, to a defect in tight junction
maturation
Butterfly 2 A B and C
No full textQuilt pattern from the Linda Lowe Quilt Patterns Collection titled Butterfly 2 A B and C.https://scholarworks.moreheadstate.edu/lowe_quilt_patterns/1133/thumbnail.jp
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Susan Lowe, Fells Point artist
No full textHandwritten in pencil on verso: Susan Lowe, Fells Pt artist freely confides that she supplements her income by performing as a stripper; S-207-E-EBC-2. Signed: Elinor B. Cahn, 1979
No.176, Mary Lowe, interview by Winnifred Margetts
No full textTranscript (71 pages) of interview by Winn Margetts with Mary G. Lowe, Professor Emeritus in childhood education at the University of Utah, on April 28, 1986. This interview is no. 176 in the Everett L. Cooley Oral History Project, and tape nos. 451 and 452Lowe (b. 1917), professor emeritus of family and consumer studies at the University of Utah, recalls her early life and education, her career at the University, the administrative discrimination faced by women on the faculty, and her international studies. Interviewer: Winnifred Margett
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