1,367 research outputs found
Exploring cell apoptosis and senescence to understand and treat cancer: an interview with Scott Lowe
No full textScott W. Lowe is currently principal investigator at the Memorial Sloan-Kettering Cancer Center. After beginning his studies in chemical engineering, he decided to take another path and became fascinated by biochemistry, genetics and molecular biology, which ultimately led to an interest in human disease, particularly cancer. During his PhD at the Massachusetts Institute of Technology (MIT), Scott had the opportunity to benefit from the exceptional mentorship of Earl Ruley, David Housman and Tyler Jacks, and contributed to elucidating how the p53 (TP53) tumor suppressor gene limits oncogenic transformation and modulates the cytotoxic response to conventional chemotherapy. This important work earned him a fellowship from the Cold Spring Harbor Laboratory, which helped to launch his independent career. Scott is now a leading scientist in the cancer field and his work has helped to shed light on mechanisms of cell apoptosis and senescence to better understand and treat cancer. In this interview, he talks about this incredible scientific journey
Improving the performance of the trolley supply chain with a focus on visibility.
No full textThe lack of visibility, significant investment and a presumption of fleet shrinkage falter the decision-making process of a Dutch airline. Five decision areas have been identified and for each decision area improvements strategies or alternatives have been designed. Selecting the best alternative per decision area is a multi-criteria decision making problem. Therefore, a more sophisticated method is required to support the decision-maker. For this problem the novel Best-Worst Multi-Criteria Decision Making Method (BWM) has been selected. The BWM has been successfully applied to select the best alternative per decision area. Next steps for the airline are the implementation of the chosen alternatives.SEPAMTransport & LogisticsTechnology, Policy and Managemen
Stop 2 Kainui silt loam and Naike clay, Gordonton Rd
No full textAt this stop are several remarkable features both stratigraphic and pedological, and a “two-storied” soil, the Kainui silt loam alongside (in just a few places) the Naike clay. Both soils are Ultisols. The sequence of tephra beds and buried soil horizons spanning about 1 million years was exposed in 2007 by road works
Buckfast Abbey Archaeological Projects 1982-2016 Photographic Archive
No full textThis photographic archive is intended to augment the two publications on the abbey's archaeology by S.W. Brown (Proceedings of the Devon Archaeological Society 46, 1988, 13-89; and Devon Archaeological Society Occasional Paper 21, 2018) and the series of more detailed interim archive reports appearing on the ADS website (unpublished grey literature, accessible via author Stewart Brown)
Environment-insensitive two-photon ratiometric probe for in cellulo quantitative measurement of hydrogen peroxide
No full textThe quantitative analysis of a biological analyte directly through fluorescence imaging is essential in biomedical sciences but remains as a challenge owing to the environment-sensitive nature of fluorescence intensity. We show that a fluorescent hydrogen peroxide probe based on an in cellulo super-bright benzothiazolyl-benzocoumarin dye of which emission properties are insensitive to environmental changes offers a reliable and practical means for the quantitative analysis of hydrogen peroxide in cells and tissues directly through ratiometric imaging both under one-photon and two-photon excitation conditions. Different cellular hydrogen peroxide concentrations were determined for several cell lines and also for tumour and normal tissues. © 2021 The Author(s)11Nscopu
Molecular simulation of porous silica and B-alumina, using a scalable method for electrostatic interactions
No full textApplied Science
Computer simulations of colloidal suspensions - using an improved lattice-Boltzmann scheme
No full textApplied Science
On the Vitruvius of Cesare Cesariano
No full textThe focus of the essay is the Vitruvius edition of Cesare Cesariano (Como 1521). In particular Alessandro Rovetta wrote the sections on the editorial venture, the author, the translation, the lexica and the others sources
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