196,023 research outputs found
Partial Endograft Removal Preserves the Aortic Walls During Delayed Open Conversions of Endovascular Aortic Repair
No full textBackground: Open conversion of endovascular aortic repair (EVAR) is the first-choice treatment in case of endograft failure or high-flow endoleak. However, the traditional technique based on the total removal of the endograft can produce injuries of the aortic walls, with severe consequences on the anastomoses quality. Our aim is to show the advantages of the partial endograft removal on the aortic integrity by reporting a case series including 25 delayed open conversion performed with this technique. Methods: A retrospective study was conducted over the cases of delayed open conversions performed in the last 30 months. Demographics, past medical history, endograft type, causes for conversions, and early and mid-term outcomes were recorded and analyzed in relation with the technique employed (partial vs total endograft removal). Results: Between September 2016 and March 2019, 25 consecutive cases of EVAR failure were converted to open treatment. In all cases, the endografts were resected leaving in place part of the iliac branches, and, whenever possible, also the proximal stent of the main body. Primary technical success was achieved in 100% of cases. Disease-free survival over 18-month median follow-up was 100%. All patients underwent abdominal aortic duplex scan controls as scheduled, with no early or late postoperative complication. No anastomotic aneurysms or any surgery-related complications were observed. Conclusions: Partial endograft removal is a safe and effective technique that could be used to protect the aortic integrity in delayed open conversions of EVAR
Effects of cooked molasses licking block supplementation pre- and post-partum on feed intake, suckling lamb performance, milk yield and milk quality in dairy sheep. Part 1
No full textThis study tested the nutritional benefit of a supplement offered freely to dairy sheep over a period from 60 days before lambing to 60 days after lambing, at stall and grazing. Thirty Sarda dairy sheep on Day 90 of gestation, homogeneous for age, parity number, bodyweight (BW) and body condition score (BCS), were allocated to one of two groups: control (Ctr) or treated (Cry). Over 120 days, both groups received ryegrass hay and concentrate indoors. After weaning, the ewes also had access to pasture for 6 h/day. Throughout the experimental period, the Cry group had ad libitum access to a cooked molasses licking block. No significant differences were observed between the groups in forage, concentrate and total DM intake. During the experiment, the reduction in BCS in early lactation tended to be slower in the Cry than in Ctr group (Ptrend < 0.09), whereas no significant effects were seen on BW. Lamb performance tended to be improved by Cry in terms of liveweight of litter size per sheep (9.65 vs 8.22 kg for Cry and Ctr, respectively; P < 0.07), whereas no significant effects were observed on milk yield and composition, except for a trend for increased fat content in the Cry versus Ctr group (6.15% vs 5.95%, respectively; P < 0.08). Cry ewes had higher blood cholesterol concentrations than did Ctr ewes (1.96 vs 1.63 mmol/L; P < 0.01). Because there were no differences between feed intake at stall and the estimated total DM intake at stall and during grazing between the two groups, the better performance of the Cry group could be explained by an increase of feed use efficiency at the digestive and/or metabolic level. © CSIRO 2014
Emergency endovascular treatment of complicated type B acute aortic dissections: proximal repair without distal covering.
No full textBackground: Endovascular treatment is now the first choice for complicated type B dissections requiring surgery,
but some authors claim that merely sealing the entry tear with Thoracic Endovascular Aortic Repair is not enough,
advocating use of distal aortic stenting and ballooning. Objectives: This study aims to analyze 12 consecutive
complicated type B acute aortic dissections to prove the safety and effectiveness of staged endovascular repair
without distal ballooning or stenting. Methods: From January 2016 to September 2018, 15 cases of complicated
type B dissections in need of emergency treatment (in less than 24 hours) were referred to our Unit. Endovascular
repair was performed to cover the entry tear and the proximal tract of the false lumen, leaving its distal segment
untouched. All patients were followed up with serial computed tomography angiography to assess the evolution of
the false lumen. Results: Technical success was achieved in all cases. No peri-operative or post-operative deaths from
any cause were reported over a mean follow-up of 28 months (range 12-45). False lumen thrombosis and regression
> 5mm were observed in 11 cases. One patient underwent endovascular reintervention after 10 months because of
expansion of the false lumen. No procedure-related complication was recorded. Conclusions: Staged endovascular
repair is, in most cases, a feasible and safe technique for treatment of acute aortic dissections in emergency settings,
with low morbidity/mortality rates and low risk of reintervention. Randomized clinical trials will be needed to establish
an outcome-based comparison with new techniques such as PETTICOAT and STABILISE
Effects of abomasal infusion of branched-chain amino acids or branched-chain keto-acids on liver function, inflammation, and oxidative stress in multiparous fresh cows
No full textReduced liver function, increased oxidative stress, and inflammation in early lactation negatively affect lactation performance and health of fresh cows. Previous findings from our group demonstrated that branched-chain AA (BCAA) infusion improved lactation performance and branched-chain keto-acids (BCKA) infusion decreased liver triglyceride (TG) in fresh cows. The objectives of this study were to determine the effect of BCAA and BCKA on blood and liver biomarkers of liver function, oxidative stress, and inflammation as well as expression of genes regulating inflammation and antioxidant metabolism in the liver. Thirty multiparous Holstein cows were used in a randomized block design receiving continuous abomasal infusion for 21 d after parturition. Treatments (10 cows each) were control (CON), cows abomasally infused with 0.9% saline; cows abomasally infused with BCAA (67 g valine, 50 g leucine, and 34 g isoleucine; BCA); and cows abomasally infused with BCKA (77 g keto-valine, 57 g keto-leucine, and 39 g keto-isoleucine; BCK). All cows were randomly assigned to treatments after parturition and received the same diet throughout the experimental period. Blood was collected at 3, 7, 14, and 21 d postpartum for liver function, oxidative stress, and inflammation biomarker profiling. Liver was also harvested on 7, 14, and 21 d postpartum for quantification of glutathione, protein carbonylation, and expression of genes. ANOVA was conducted for all data using PROC GLIMMIX in SAS. No treatment differences were observed for liver function biomarkers (bilirubin, gamma-glutamyl transferase, and aspartate aminotransferase). Cows receiving BCAA had lower blood NO2− and NO3− concentrations compared with CON. A tendency for lower advanced oxidized protein products was also observed in BCA cows compared with CON. Additionally, on d 7, BCA cows had lower protein carbonylation in the liver compared with CON. In contrast, BCK cows had higher plasma thiol and albumin, as well as liver reduced and total glutathione compared with CON cows. Compared with CON, BCK cows had higher expression glutathione reductase in the liver. Overall, these results suggest favorable alterations in oxidative stress and inflammation status in fresh cows receiving BCAA or BCKA infusion during the first 3 wk of lactation, which likely contributed to previously-observed changes in lactation performance and liver TG concentrations. Future work is required to evaluate the interrelated metabolism of BCAA and BCKA to better understand their effects on oxidative and immune metabolism
The Bolton Treo Endograft: A Single-Center Preliminary Experience
No full textEndovascular repair is currently the most frequently used treatment of abdominal aortic aneurysms, but its feasibility and success highly depend on the characteristics and the correct choice of the endograft to be used. Bolton Treo is one of the most popular endografts of newer generation which have been launched in the past few years, and this study aims to analyze the preliminary outcomes (8 months in average) of a single-center experience with this device
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