183 research outputs found
Organic Dots Based on AIEgens for Two‐Photon Fluorescence Bioimaging
No full textTwo-photon fluorescence imaging technique is a powerful bioanalytical approach in terms of high photostability, low photodamage, high spatiotemporal resolution. Recently, fluorescent organic dots comprised of organic emissive cores and a polymeric matrix are emerging as promising contrast reagents for two-photon fluorescence imaging, owing to their numerous merits of high and tunable fluorescence, good biocompatibility, strong photobleaching resistance, and multiple surface functionality. The emissive core is crucial for organic dots to get high brightness but many conventional chromophores often encounter a severe problem of fluorescence quenching when they form aggregates. To solve this problem, fluorogens featuring aggregation-induced emission (AIE) can fluoresce strongly in aggregates, and thus become ideal candidates for fluorescent organic dots. In addition, two-photon absorption property of the dots can be readily improved by just increase loading contents of AIE fluorogen (AIEgen). Hence, organic dots based on AIEgens have exhibited excellent performances in two-photon fluorescence in vitro cellular imaging, and in vivo vascular architecture visualization of mouse skin, muscle, brain and skull bone. In view of the rapid advances in this important research field, here, we highlight representative fluorescent organic dots with an emissive core of AIEgen aggregate, and discuss their great potential in bioimaging applications.</p
Bioinspired superwetting surfaces for biosensing
No full textInspired by nature, scientists and researchers have studied the wetting behaviors on various creatures and mimicked their structures to fabricate diverse functional superwetting materials. As one kind of emerging application, the bioinspired superwettable surfaces used for biosensing have been aroused wide interests. In this review, we summarized the recent developments of bioinspired superwettable surfaces in the field of biosensing. In the first part, superwettable creatures in nature, namely, superhydrophobic self-cleaning lotus leaf, high-adhesion superhydrophobic rose petal, amphiphobic springtail, patterned wetting desert beetles, slippery pitcher plant, were introduced. In sequence, we successively described the special wetting models of superhydrophobicity, superamphiphobicity, responsive wettability, patterned wettability, and slipperiness. Then, biosensing applications based on the respective patterned wettable, superhydrophobic, responsive wettable, and slippery substrates that were combined with the common detection approaches (colorimetry, fluorescence, surface-enhanced Raman scattering (SERS), electrochemistry) were shown in detailed. At last, an insight of remaining challenges and future development for bioinspired superwetting materials applied in biosensing was provided.link_to_subscribed_fulltex
Organic AIE Dots: Organic Dots Based on AIEgens for Two‐Photon Fluorescence Bioimaging (Small 47/2016)
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A highly sensitive DNA-AIEgen-based “turn-on” fluorescence chemosensor for amplification analysis of Hg2+ ions in real samples and living cells
No full textThe Economic Consequences of IPO Spinning
No full textUsing a sample of fifty-six companies going public in 1996--2000 in which top executives received allocations of other hot initial public offerings (IPOs) from the bookrunner, a practice known as spinning, we examine the consequences of spinning. The fifty-six IPOs had first-day returns that were, on average, 23% higher than similar IPOs. The profits collected by these executives were only a small fraction of the incremental amount of money left on the table by their companies when they went public. These companies were dramatically less likely to switch investment bankers in a follow-on offer: only 6% of issuers whose executives were spun switched underwriters, whereas 31% of other issuers switched. These findings suggest that the spinning of executives accomplished its goal of affecting corporate decisions. The Author 2010. Published by Oxford University Press on behalf of The Society for Financial Studies. All rights reserved. For Permissions, please e-mail: [email protected]., Oxford University Press.
A New Disubstituted Polyacetylene Bearing Pyridine Moieties: Convenient Synthesis and Sensitive Chemosensor toward Sulfide Anion with High Selectivity
No full textSandwich Assays Based on SPR, SERS, GMR, QCM, Microcantilever, SAW, and RRS Techniques for Protein Detection
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