1,721,424 research outputs found
Painful herpetiform aphthous ulcers in the oral mucosa in a 15-year-old man
No full textOral manifestations of secondary syphilis showing as aphthous-like lesion, in the mucosa are observed, independently with oral sex habits. Detailed clinical history, expert physical examination and specific serological/microbiological assays are mandatory. A single intramuscular dose of 2.400.000 IU of penicillin benzathine is the recommended treatment of choice for primary and secondary syphilis. Such treatment can be repeated weekly for 2 or 3 weeks only in selected cases.Sin financiaciónNo data WoSNo data Scopus670 SPI – ICEE (2018), 4/96 General – Editoriales extranjerasUE
Vesicles on the Tongue of a 3-Months-Old Baby
No full textPrimary herpetic gingivostomatitis is the most common viral infection of the oral cavity in children. It is caused by Herpes Virus 1 and less often by Herpes Virus 2 infection. Sometimes the vesicular lesions are first observed by odonto stomatologists.Sin financiaciónNo data WoSNo data Scopus670 SPI – ICEE (2018), 4/96 General – Editoriales extranjerasUE
The management of the outbreak of acral skin manifestations in asymptomatic children during COVID-19 era
Get PDFnot availabl
SIRT1 activity is decreased in lesional psoriatic skin
Get PDFDear Editor,
Psoriasis is a chronic immune-mediated hyperproliferative
inflammatory skin disease of unknown etiology characterized
by the appearance of sore patches of thick, red skin
with silvery scales. It affects about up to 3 % of the world
population and it is equally prevalent in both genders,
although results from a recent study have shown that on
average, men have more severe forms of the disease.
Psoriasis treatment often requires a varied team of
clinicians with a range of expertise due to the fact that high
prevalence, chronicity, disfiguration, disability, and associated
comorbidity characterize the disease. The deep
understanding of the role of immune function in psoriasis
permits the management of this complex disease, which
dramatically affects patients far beyond the skin
Are Anti-TNF-α Agents Safe for Treating Psoriasis in Hepatitis C Virus Patients with Advanced Liver Disease? Case Reports and Review of the Literature
Get PDFTumor necrosis factor-alpha (TNF-α) inhibitors represent an effective treatment for severe psoriasis in hepatitis C virus (HCV) patients. The literature reports mainly on short-term treatment in patients with chronic hepatitis with minimum-to-moderate activity with an acceptable safety profile. We report the first 2 cases of hepatocellular carcinoma (HCC) arising in HCV psoriatic patients with advanced liver disease during long-term treatment with etanercept. Our first patient, known to have had HCV infection for 41 years, developed an HCC after 21 months of therapy with etanercept (50 mg/week). The second patient, HCV+ for 20 years, was treated for 58 months with the same therapy, and despite no signs of liver function impairment was diagnosed with HCC. Both of them presented with cirrhosis, which was diagnosed 9 and 5 years earlier, respectively. It remains to be clarified whether there is any connection between psoriasis treatment with anti-TNF-α agents and the development of HCC in HCV-infected patients. Further long-term, follow-up studies and registries of HCV patients with mild/moderate activity may contribute to clarify this issue
Efficacy and tolerability of short contact therapy with tretinoin, clindamycin and glycolic acid gel in acne: A randomised, controlled, assessor-blinded two-centre trial: The MASCOTTE study
No full textRetinoids and antibiotics topical treatments are commonly used as first line therapy in mild to moderate acne. However, irritant contact dermatitis is a common side effect of topical retinoids. A strategy to increase local tolerability is the “short contact therapy” (SCT) approach, consisting in the application of the product with the complete removal after 30 to 60 minutes using a non-aggressive cleanser. A gel containing tretinoin 0.02%, clindamycin 0.8%, and glycolic acid 4% in polyvinyl alcohol (MP-gel) has shown to be effective as monotherapy in mild to moderate acne with a tolerability profile similar to other topical retinoids. So far, no trials have been performed with this gel comparing the tolerability profile of SCT with standard application therapy (SAT). We conducted a 2-center randomized parallel groups, controlled, assessor-blinded study, comparing MP-gel applied as SCT in comparison with MP-gel used as SAT (The “MASCOTTE” trial). Forty-six subjects (nine men and 37 women, mean age 23 ± 4 years, range 18-31 years) with mild-to-moderate acne were enrolled, after their written informed consent in a randomized, parallel groups controlled, assessor-blinded 8-week trial. Twenty-three were assigned to MP-gel once daily (evening application) using the SCT approach (ie, complete removal of product after 1 hour using a gentle cleanser), and 23 were randomized to the SAT approach with the same gel. The primary endpoint was the evolution of the tolerability score (TS) assessed evaluating four items: erythema, dryness, stinging, and burning, using a 4-point score scale (from 0: no symptom to 3: severe symptom). Secondary endpoints were the evolution of global acne grading system (GAGS) score (range: from 0 to >39) and the investigator global assessment (IGA of acne severity) score (range from 0 to 4). TS was evaluated at 2, 4, and 8 weeks. GAGS and IGA scores were evaluated at baseline and at week eight. At week eight, an efficacy global score (EGS) (from 1: no efficacy to 4: very good efficacy) and a tolerability global score (TGS) (from 1: very low tolerability to 3: very good tolerability) evaluation were also done. All the evaluations were performed by an investigator unaware of treatment groups allocation (SCT or SAT). Thirty-eight subjects (83%) completed the 8-week treatment period. Eight subjects (two in the SCT group and six in the SAT group) dropped out prematurely due to low skin tolerability. In the SCT the TS at week two was 1.3 ± 1.7, in the SAT group TS was significantly higher (3.1 ± 1.7) (P =.028). TS was significantly lower in SCT group vs SAT also at weeks four and eight (P =.01; ANOVA test). The GAGS score at baseline was 19 ± 7 in the SCT group and 23 ± 4 in the SAT group (NS). At week 8 the GAGS score in SCT was significantly reduced to 8.5 ± 2.8 (−55%) (P =.001 vs baseline) and was also significantly lower in comparison with SAT group (8.5 vs 15; P =.0054). The IGA scores at baseline were 1.9 ± 0.6 in SCT and 2.4 ± 0.7 in SAT group. At week eight, in comparison with baseline values IGA score was reduced significantly by 48% in SCT and by 30% in SAT. EGS and TGS were significantly higher (better clinical efficacy and better tolerability) in SCT in comparison with SAT (3.6 ± 0.5 and 2.9 ± 0.3 vs 2.7 ± 0.6 and 1.5 ± 0.7; respectively). This tretinoin, clindamycin, glycolic acid gel, applied as SCT, has shown a better skin tolerability and at least a comparable clinical efficacy in comparison with the standard application modality in the treatment of mild-to-moderate acne. The SCT therefore could be an effective treatment strategy which could improve subjects' compliance and adherence
- …
