1,721,377 research outputs found
Hereditary Diseases of Orthopedic Interest
No full textMusculoskeletal problems in patients with hereditary disorders are common,
although their clinical severity can vary significantly, and their transmission
can be autosomal dominant, autosomal recessive, or X-linked; similarly, their
estimated prevalence is variable. Depending on the disorder, some musculoskeletal problems are present at birth,
while some others become evident later in life; the neuromotor development can be normal or delayed, and some disorders are associated with mental retardation.
Specific orthopedic problems are typical for each type of disorder; important and common manifestations of orthopedic interest are spine deformity and instability, chest deformity, upper and lower extremity deformity, joint
contractures, and tumor; moreover, a variable and heterogeneous panel of
extra-skeletal signs can complete the clinical picture of each disorder.
Musculoskeletal problems can significantly impact the quality of life of affected individuals, and timely surgical treatment is usually needed. However, the timing and outcome of surgical procedures vary according to the type of musculoskeletal problem and its severity. Life expectancy in patients with
hereditary disorders can be normal or reduced.
This chapter describes the clinical manifestations and treatment principles for
hereditary disorders of interest to the orthopedis
Programmed cell death in the yeast Saccharomyces cerevisiae
No full textThe yeast Saccharomyces cerevisiae is one of the most studied model systems for molecular and cellular biology. In 1996, it became the first eukaryotic organism to have a completely sequenced genome (Dujon, 1996; Goffeau et al., 1996), which led to a number of valuable and widely accessed databases. Among its features is the short generation time (usually 90–120 minutes) and the ability to grow at various temperatures in relatively inexpensive media. Moreover, many of its genes are well characterized, thanks in part to its amenability to modifications such as gene disruption, gene marking, mutations, or gene-dosage modifications. Because of these advantageous features, it has become the model organism of choice for many investigators in fields ranging from basic biology to biomedical research
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
I confini della cittadinanza
No full textQuesto libro è il prodotto di una serie di lezioni tenute tra il 2008 e il 2009 nel corso Donne Politica Istituzioni, insegnamento attivato presso l'Università di Padova con il co-finanziamento del Ministero delle Pari Opportunità, all'interno di un progetto che ha visto coinvolte per circa sei anni più di quaranta atenei e più di 20.000 corsisti. I temi trattati spaziano dalla rappresentanza politica alla vita quotidiana, dalla comunicazione ai diritti di cittadinanza, dalla teoria alla pratica delle pari opportunità. Riunire in un libro questi saggi inediti - che non sono solo la mera trascrizione delle lezioni, bensì una rielaborazione critica della materia analizzata - permette di testimoniare un lavoro svolto con passione e con grande serietà, documenta le ragioni del successo di questi corsi e si configura come un'utile base interpretativa della relatà politica e sociale in cui le donne di oggi si trovano a vivere
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