1,720,952 research outputs found
Use of high-throughput DNA data for discovery of unknown genes in Zebrafish
No full textThe amounts of genetic data that are produced is steadily increasing. New methods to sequence genetic data are invented and existing methods are refined, resulting in the generation of more and larger datasets. To extract useful data from these growing datasets, the algorithms processing them have to support the new and larger datasets. In this thesis, four zebrafish NanoCAGE datasets have been processed using new algorithms to map the genetic expression to known genes, discover unknown gene candidates and extract the occurrence of five Transcription Factor Binding Sites (TFBSs). Also, the infected and control datasets have been compared to find infection induced genes. An unknown gene candidate has been found that appears to be highly expressed. The number of reads of that gene candidate is in the same order of the number of reads of the most expressed gene and in 3 out of 4 datasets it has more reads. A large number of other gene candidates have been found, of which more than 100 have more than 1000 matched reads. Furthermore, the TATA box TFBS occurs frequently upstream of highly transcribed locations on the genome. In the adult datasets, more than 40% of the locations on the genome with more than 100000 reads have a TATA box at the expected distance from the start of the reads and in the embryo datasets that percentage is more than 25%. In conclusion, the NanoCAGE method and the resulting datasets show to be valuable in the research of genetic expression and genetic regulation mechanisms.Computer EngineeringComputer EngineeringElectrical Engineering, Mathematics and Computer Scienc
Ontwerpproces van een grafische gebruikersinterface voor home automation
No full textIn deze thesis vindt u het ondezoek naar de beste implementatie van een op afstand te benaderen grafische gebruikersinterface, die hardware kan aansturen. Om de juiste keuze te kunnen maken, moet er onderzoek gedaan worden naar de verschillende mogelijke implementaties. Dit onderzoek is gedaan op basis van een literatuurstudie. Op basis van dit onderzoek is er een afweging gemaakt aan de hand van criteria. Hieruit is gekomen dat de beste implementatie een embedded systeem is waarop embedded Linux draait. Op dit besturingsysteem worden Apache, MySQL en PHP geïnstalleerd om te zorgen voor de benadering op afstand. Vervolgens dient een in C# geschreven programma voor de communicatie met de hardware, dit programma communiceert ook met PHP. In de toekomst kan dit onderzoek gebruikt worden om een afweging te maken voor een andere grafische gebruikersinterfaces. Eisen De interface dient voor het volgende: \u95 schakelen van eindpunten en groepen \u95 instellen van tijdschema’s die, eventueel op basis van sensor informatie, eindpunten of groepen in of uitschakelen \u95 het engergieverbruik per eindpunt of groep weer geven \u95 meerdere eindpunten in een groep plaatsen Implementaties Bij het onderzoek is er gekeken naar een hardwarematige oplossing, hieruit bleek dat hardware onvoldoende scoort op de mogelijkheid om te updaten, ook is een hardware oplossing niet goed online te benaderen. Een hardwarematige oplossing scoort wel erg goed op veiligheid. Ook is gekeken naar een oplossing met C#, deze scoort onvoldoende op de mogelijkheid om het via het internet te benaderen, wel wordt er goed gescoord op de ondersteuning. Daarnaast is er gekeken naar Java. Java scoort onvoldoende op de mogelijkheid om het te embedden, wel scoort Java net als C# erg goed op de ondersteuning. Als laatste is er gekeken naar webbased oplossingen en dan expliciet naar .NET, Java Web Start en PHP. Deze scoorden allemaal erg goed op de mogelijkheid tot updaten. Echter scoorden ze slecht op de mogelijkheid om het te embedden. Combineren van implementaties Uiteindelijk is er gekeken naar de mogelijkheid om meerdere implementaties te combineren. Zodat de zwakke punten van de ene implementatie worden opgevangen door de andere. Er is gekozen om C#, die het beste scoorde, te combineren met een webbased taal. Omdat het relatief moeilijk was op .NET op een andere besturingssysteem dan windows te draaien is er gekozen voor PHP. Ook is er gekozen om het totale systeem op embedded Linux te draaien omdat dit betrouwbaar is en niet meer kost als de alternatieven. Nadat deze implementatie gekozen was, is deze implemenatie ook daadwerkelijk gebruikt om een interface te ontwerpen voor het iNow systeem. Er zijn een aantal functies geschreven die de communicatie tussen de webinterface en de in C# geschreven controller verzorgen. Dit blijkt goed te werken, al is de snelheid nog niet hoog genoeg voor dagelijks gebruik.Circuits and SystemsElectrical Engineering, Mathematics and Computer Scienc
Morphological behaviour of shoreface nourishments along the Dutch coast: Data analysis of historical shoreface nourishments for a better understanding and design
No full textTo counteract relative sea level rise, Rijkswaterstaat nourishes the Dutch coast with sand. This sand spreads out over the shoreface zone, beach and dunes. One of the nourishment types is the shoreface nourishment. In this thesis, data of historical shoreface nourishments along the Dutch coast is analysed to find the factors that influence this behaviour. This research showed that there are two main categories in the migration of shoreface nourishments. The first one migrates only in cross-shore direction and alongshore migration is negligible, this mainly occurs at beaches without influence of surrounding structures and the outer delta of the Wadden Sea. The second one migrates onshore and in alongshore direction, this category occurs mainly southward of the outer delta of the Wadden Sea. The migration can be predicted by the behaviour of the original bar system. The first one exists at coasts with primarily cross-shore bar behaviour and the second one at coasts with primarily alongshore or no bar behaviour. For future application of shoreface nourishments, it is recommended to analyse the original bar system and determine the location of execution on this analysis. If the location is determined, even the prediction for the migration can be determined based on the behaviour of the original bar system.Civil Engineering and GeosciencesHydraulic Engineerin
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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