186,416 research outputs found
Personnel du collège de Loche
No full textPersonnel du collège de Loche. In: Bulletin administratif de l'instruction publique. Tome 2 n°22, octobre 1851. p. 412
Personnel du collège de Loche
No full textPersonnel du collège de Loche. In: Bulletin administratif de l'instruction publique. Tome 2 n°22, octobre 1851. p. 412
The effect of puberty on insulin resistance in obese children.
No full textJ Endocrinol Invest. 2009 May;32(5):401-5.
The effect of puberty on insulin resistance in obese children.
Pilia S, Casini MR, Foschini ML, Minerba L, Musiu MC, Marras V, Civolani P, Loche
S.
Pediatric Endocrinology Unit, Microcitemico Hospital, ASL Cagliari, Cagliari,
Italy.
OBJECTIVE: Insulin resistance (IR) increases during puberty in normal children.
IR is the first adverse metabolic event of obesity, and the marker of the
metabolic syndrome. We aimed to study the effect of puberty on IR in obese and
normal-weight children.
DESIGN: Cross-sectional evaluation of fasting glucose, insulin concentrations,
and homeostasis model assessment of IR (HOMA-IR) in obese and control children
throughout puberty.
PATIENTS AND METHODS: We recruited 424 obese children (207 pre-pubertal and 217
pubertal divided in Tanner stages 2-3, 4, and 5) and estimated IR using the
HOMA-IR index. Data were compared to those obtained in 123 healthy normal-weight
children (40 pre-pubertal and 83 pubertal divided in Tanner stages 2-3, 4, and
5).
RESULTS: In the obese children mean HOMA-IR increased progressively across Tanner
stages, and was significantly higher in all groups (pre-pubertal and Tanner
stages 2-3, 4, and 5) of obese than in control children. HOMA-IR was
significantly correlated with BMI.
CONCLUSIONS: HOMA-IR in obese children increases at puberty more than in
normal-weight children and does not return to pre-pubertal values at the end of
puberty.
PMID: 19794287 [PubMed - indexed for MEDLINE
Determinación de la cantidad de Polifenoles y su Actividad Antioxidante en el Zapallo Loche (Cucurbita moschata Duchesne) fresco, sancochado y frito procedente del departamento de Lambayeque.
No full textObjetivo: Determinar el contenido de polifenoles y su actividad antioxidante del zapallo loche (Cucurbita moschata Duchesne) fresco, sancochado y frito. Materiales y métodos: Estudio de tipo experimental in vitro. Los zapallos loches fueron obtenidos delGran Mercado Mayorista de Lima, ubicado en el distrito de Santa Anita, procedentes del departamento de Lambayeque. La muestra fue el extracto etanólico de zapallo fresco, sancochado y frito. Para la determinación de fenoles totales se utilizó el método espectrofotométrico desarrollado por Folin-Ciocalteu, en el cual los resultados se expresan como equivalente de ácido gálico. Por otro lado, para la determinación de la capacidad antioxidante se utilizó el método desarrollado por Brand-Williams basado en la reducción del radical 2,2-difenil-1-picrilhidrazilo (DPPH). Resultados: El contenido de polifenoles en el zapallo loche fresco (103.869 mg ácido gálico/ 100g muestra) fue mayor que en el zapallo loche sancochado (48.000 mg ácido gálico/ 100g muestra), seguido del zapallo loche frito (43.804 mg ácido gálico/ 100g muestra). La capacidad antioxidante del zapallo loche sancochado destacó ya que inhibió en un 95% a los radicales libres, comparado con zapallo loche frito (86%) y zapallo loche fresco (80%). Conclusión: El zapallo loche fresco presenta mayor cantidad de polifenoles.El zapallo loche sancochado tiene una mayor capacidad antioxidante para inhibir los efectos de los radicales libres. Palabras Claves: Zapallo loche, actividad antioxidante, polifenoles, fenoles totales, DPPH.Tesi
An INSIG2 polymorphism affects glucose homeostasis in Sardinian obese children and adolescents
No full textAllelic variants of a single nucleotide polymorphism (SNP), rs7566605, located approximately 10 kb upstream of the INSIG2 gene have been found in association with body weight and with other clinical features related to obesity in some populations but not in others. Our objective was to test the association of this SNP in obese children and adolescents from the genetically isolated population of Sardinia. We tested the association of rs7566605 with body mass index (BMI) and with serum glucose and insulin concentrations and a surrogate measure of insulin resistance (HOMA-IR) in a cohort of 747 Sardinian obese children and adolescents. A case control analysis was performed using 548 ethnically-matched healthy controls. Allelic frequencies of the SNP were similar between patients and controls. Mean glucose and insulin concentration and mean HOMA-IR values were significantly higher in patients carrying the CC genotype than in the CG and GG carriers. In the patients with impaired fasting glucose (IFG) and/or impaired glucose tolerance (IGT), allele C was significantly more frequent than in controls. Although INSIG2 polymorphisms do not consistently associate with BMI, the observation of an association with glucose concentration would support a role for this gene in the metabolic complications of obesity
Allelic variants of INSIG2 gene are associated with glucose concentrations and HOMA-IR but not with BMI in Sardinian obese children and adolescents
No full textGiant Axial Dielectric Response in Water-Filled Nanotubes and Effective Electrostatic Ion–Ion Interactions from a Tensorial Dielectric Model
No full textSimulation and analysis files
for simulating water filled carbon nanotubes as presented in
P. Loche, C. Ayaz, A. Schlaich, Y. Uematsu, and R. R. Netz, ‘Giant Axial Dielectric Response in Water-Filled Nanotubes and Effective Electrostatic Ion–Ion Interactions from a Tensorial Dielectric Model’, J. Phys. Chem. B, vol. 123, no. 50, pp. 10850–10857.
The scripts for creating the geometries are located inside a public repository (https://gitlabph.physik.fu-berlin.de/ploche/gmx_builder).
Some Analysis scripts require the analysis toolkit MAICosS
Breakdown of Linear Dielectric Theory for the Interaction between Hydrated Ions and Graphene
No full textSimulation setup, run and analysis files
for simulating the free energy of a chloride ion at a graphene interface using thermodynamic integrations as presented in
P. Loche, C. Ayaz, A. Schlaich, D. J. Bonthuis, and R. R. Netz, ‘Breakdown of Linear Dielectric Theory for the Interaction between Hydrated Ions and Graphene’, J. Phys. Chem. Lett., vol. 9, no. 22, pp. 6463–6468.
Some Analysis scripts require the analysis toolkit MAICosS. The folders vdw, coul_- and coul_+
contain the input files for the Lennard-Jones
the negative and positive Coulomb part of thermodynamic integration simulations
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