1,721,033 research outputs found
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Identification of a Novel Peptide Ligand for Targeted Drug Delivery against Hepatocellular Carcinoma
No full text肝癌在世界上的發生率排行為第五位，而導致癌症病患死亡排行為第四位。在美國，罹患肝癌的病人即使在接受傳統治療，五年存活率也僅有8.9%，使得肝癌為致死率第二高的癌症。在台灣，肝癌為造成癌症病患死亡的主因之一，每年約奪走6000~8000人的生命。目前有許多新興的治療策略持續的被發展來治療這個疾病。利用噬菌體顯現法(phage display)的方法，我們找到一種肝癌細胞的標的胜肽。在活體外，藉由ELISA與flow cytometry分析，此PC94噬菌體顯現的標的胜肽具有與肝癌細胞專一性結合的能力。在活體內，PC94噬菌體也可以和異體移植的肝癌細胞有專一性的結合，而不與正常組織結合；同時，PC94噬菌體專一性結合到異體移植的肝癌細胞的能力會被相對應的標的胜肽SP94競爭抑制。而免疫染色也證實此表現標的胜肽的PC94噬菌體只聚集在異體移植的肝癌細胞卻不聚集於正常組織。當標的胜肽SP94與微脂體包裹化學治療藥物連結後，可應用於引導抗癌藥物至異體移植的肝癌細胞，有效地殺死肝癌細胞。同時，PC94噬菌體表現之標的胜肽與其合成之標的胜肽SP94具有與肝癌病人檢體專一性結合的能力。因此，該標的胜肽亦可被應用於作為開發肝癌檢驗試劑，同時對於未來在臨床肝癌病患的治療方面也具有極大的潛力。Hepatocellular carcinoma (HCC) is the fifth most common cancer and ranks the forth leading cause of cancer death worldwide. The 5-year survival rate of individuals with liver cancer in the United States is only 8.9% despite aggressive conventional therapy, marking this malignancy as the second most lethal cancer. In Taiwan, liver cancers cause 6000~8000 deaths annually and rank the leading cause of cancer death. Novel treatment strategies derived from increased knowledge of molecular oncology are constantly being developed to cure this disease. In this study, we describe the identification of a novel peptide (SP94) which could bind specifically to HCC cells using in vitro phage display. In vitro, the phage clone PC94 was able to bind to HCC cell lines but not normal cells by ELISA and flow cytometry analysis. In vivo, PC94 has homing ability to tumor tissues but not normal visceral organs in human HCC xenografts model. In addition, the homing ability of PC94 could be competitively inhibited by synthetic peptide SP94. Immunohistochemical staining also confirmed that the localization of PC94 were found in the tumor tissues but not in SP94 competed tumor tissues nor in the normal organs. Furthermore, with conjugation of the targeting peptide SP94 and liposomes containing doxorubicin, the targeting drug delivery system enhanced the therapeutic efficacy against human HCC xenografts through decreased tumor vessels density and enhanced tumor apoptosis. Moreover, PC94 and biotin-labeled SP94 could recognize the unknown target protein expressed on the cell surface in surgical specimens from HCC patients. Our results indicate that this targeting peptide has a strong clinical potential as a drug delivery guider in the treatment of HCC.中文摘要 1
Abstract 2
Introduction 3
Materials and methods 9
Results 17
Discussion 23
Figures 28
Reference 4
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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