1,646 research outputs found
Dimer-dimer stacking interactions are important for nucleic acid binding by the archaeal chromatin protein Alba
No full textArchaea use a variety of small basic proteins to package their DNA. One of the most widespread and highly conserved is the Alba (Sso10b) protein. Alba interacts with both DNA and RNA in vitro, and we show in the present study that it binds more tightly to dsDNA (double-stranded DNA) than to either ssDNA (single-stranded DNA) or RNA. The Alba protein is dimeric in solution, and forms distinct ordered complexes with DNA that have been visualized by electron microscopy studies; these studies suggest that, on binding dsDNA, the protein forms extended helical protein fibres. An end-to-end association of consecutive Alba dimers is suggested by the presence of a dimer-dimer interface in crystal structures of Alba from several species, and by the strong conservation of the interface residues, centred on Are and Phe(60). In the present study we map perturbation of the polypeptide backbone of Alba upon binding to DNA and RNA by NMR, and demonstrate the central role of Phe(60) in forming the dimer dimer interface. Site-directed spin labelling and pulsed ESR are used to confirm that an end-to-end, dimer dimer interaction forms in the presence of dsDNA.Peer reviewe
Presentació de llibre: El "gran tenedor" en la normativa de vivienda, editora Chantal Moll de Alba Lacuve [vídeo]
No full textPodeu trobar el llibre en el següent enllaç al Cercabib: https://cercabib.ub.edu/permalink/34CSUC_UB/13d0big/alma991013540678406708Podeu consultar la versió en castellà a: https://hdl.handle.net/2445/222584.La doctora Chantal Moll de Alba Lacuve, directora de l'obra, és professora de Dret Civil a la Universitat de Barcelona. Directora de la Càtedra de Dret Registral de la UB, directora CMA Consulta Jurídica de la Fundació Bosch i Gimpera, corresponsal a Espanya de la "International Construction Law Review" i vocal de la Secció de Dret Civil de l'Il.lustre Col.legi d'Advocats de Barcelona.
Aquest llibre tracta de la figura del gran tenidor a la complexa i canviant normativa d'habitatge. En una primera part, s'analitza el concepte de gran tenidor, que resulta tan difícil de concretar per la diversitat de definicions a la legislació estatal i autonòmica. En una segona part, s'aborden les conseqüències jurídiques d'ostentar aquesta condició als contractes d'arrendament, com són el deure d'informació i la contenció de rendes a zones de mercat residencial tensionat.
Finalment, a la tercera part, s'estudien els requisits processals que afecten els grans tenidors en els procediments de desnonament. El llibre fa especial referència als pronunciaments del Tribunal Constitucional i a les importants novetats legislatives que afecten els grans tenidors, que s'han produït des d'octubre de 2024, com són l'eliminació de determinats requisits processals a nivell estatal o la creació del complex règim jurídic del gran tenidor a la normativa d'habitatge
First person – Alba Delrio-Lorenzo
No full textFirst Person is a series of interviews with the first authors of a selection of papers published in Journal of Cell Science, helping early-career researchers promote themselves alongside their papers. Alba Delrio-Lorenzo is first author on ‘Sarcoplasmic reticulum Ca2+ decreases with age and correlates with the decline in muscle function in Drosophila’, published in JCS. Alba is a PhD student in the lab of Javier García-Sancho and María Teresa Alonso at the Instituto de Biología y Genética Molecular (IBGM), University of Valladolid, Spain, investigating the molecular mechanisms implicated in aging, particularly muscle aging.Peer reviewe
Característiques del contracte de compravenda en el Llibre sisè del Codi civil de Catalunya (Especial referència a la seva finalitat transmissora i a la no necessitat de regular la promesa de venda)
No full textEl projecte de llei del Llibre sisè del Codi Civil de Catalunya, relatiu a les
obligacions i els contractes, dóna una regulació del contracte de compravenda
que, segons es desprèn de l’Exposició de Motius, pretén ser moderna, integral,
unitària, respectuosa amb la tradició però també influenciada pels moviments
d’unificació del dret europeu dels contractes
Característiques del contracte de compravenda en el Llibre sisè del Codi civil de Catalunya (Especial referència a la seva finalitat transmissora i a la no necessitat de regular la promesa de venda)
No full textEl projecte de llei del Llibre sisè del Codi Civil de Catalunya, relatiu a les
obligacions i els contractes, dóna una regulació del contracte de compravenda
que, segons es desprèn de l’Exposició de Motius, pretén ser moderna, integral,
unitària, respectuosa amb la tradició però també influenciada pels moviments
d’unificació del dret europeu dels contractes
L'atribució de l'ús de l'habitatge en processos de familia. L'aplicació del Llibre II del Codi civil de Catalunya pels Tribunals
No full textTreballs Finals de Màster en Dret. Facultat de Dret, Universitat de Barcelona, Curs: 2013-2014, Tutor: Chantal Moll de Alba LacuveEn aquest treball destaco les deficiències de tècnica legislativa detectades perquè
l’absència de regulació o una regulació incompleta o defectuosa generen decisions
judicials contradictòries; per exemple, el diferent tractament que mereix al legislador l’atribució de l’ús en supòsits de crisi matrimonial i en els d’extinció de parella de fet,
les limitacions que impliquen les solucions processals que dóna el llibre segon per
demanar la pròrroga de l’atribució o la possessió de l’habitatge després de l’extinció del
dret d’ús, o la regulació separada de l’exclusió de l’atribució i de l’extinció del dret d’ús
que, per les causes i conseqüències, necessita de lege ferenda d’un tractament
simplificat i —en allò clarament coincident― unitari d’ambdues figures..
The Author/Translator Interactional Process. A Case Study
No full textSee Naples and Kill (1988) is a lively and colourful novel by the con-temporary English writer, Gregory Dowling, translated into Italian in 2015.
Following the tradition of translation studies (Venuti 2000, Bass-nett 2002, Cronin 2006), this paper analyses the rewriting process of literary translation, considering in particular the fruitful but sometimes tense and even conflictual relationship between writer and translator.
The translation of the novel See Naples and Kill was an ongoing rewriting process entailing a constant dialogue between the writer and the translator. Therefore, the study aims at answering two main ques-tions: what happens if the rewriting process of translation is constant-ly questioned by the author? What happens if the author has a good mastery of the target language and s/he is her/himself a translator?
By exploring the relationship between translation and re-creation, the research focuses on the differences and similarities between the primary creation (source text) and the secondary creation (target text), and aims to verify in which way the dialogic encounter of two different personalities and cultures does not make them merge but, by retaining their own uniqueness, leads eventually to their mutually en-riching each other. A comparative analysis of the source text and the different drafts of the translated version accompanied by the author’s comments will shed light on the tense author-translator relationship in the specific case under investigation and how both actors handle this tension in order to create a new work resulting from the (dis)agreement of the two parties
Expression, regulation and function of lectin-like transcript 1 (LLT1)
No full textReceptor-ligand pairs of C-type lectin-like proteins have been shown to orchestrate and modulate immune responses within particular immune cell subsets or in distinct body locations. The function of CD161 and Lectin-Like Transcript 1 (LLT1) has not been extensively studied, partially due to the lack of validated anti-LLT1 antibodies. Here, I characterised two novel anti-LLT1 monoclonal antibodies (2H7 and 7G7). Using them for flow cytometric and immunohistological staining, I characterised the expression of LLT1 in different healthy human tissues and found that LLT1 levels were particularly high in immune-privileged sites. Germinal centres (GC) are microanatomical structures that are critical for the development of high-affinity antibodies and B cell memory. They are organised into two zones, light and dark, with coordinated roles controlled by local signalling. LLT1 protein is known to be expressed on B cells, but its functional role in the GC reaction has not been explored. I found high expression of LLT1 on GC-associated B cells, early plasmablasts and GC- derived lymphomas. LLT1 expression was readily induced via BCR, CD40 and CpG stimulation on B cells. Ubiquitous expression of CD161 on Follicular Dendritic Cells (FDCs) was revealed, as well as on a subset of T follicular cells. Triggering of LLT1 supported B cell activation, CD83 upregulation and Chemokine (C-X-C Motif) Receptor 4 (CXCR4) downregulation, which is consistent with a role in drivingtransition from a dark to a light zone phenotype. Overall, these data suggest that LLT1-CD161 interactions play a novel and important role in B cell maturation within the GC in humans. A deep understanding of the GC reaction and the process of B cell selection could provide invaluable knowledge into effective vaccine design, generation of auto-antibodies and malignant transformation
Presentación de libro: El "gran tenedor" en la normativa de vivienda, editora Chantal Moll de Alba Lacuve [vídeo]
No full textPodeu trobar el llibre en el següent enllaç al Cercabib: https://cercabib.ub.edu/permalink/34CSUC_UB/13d0big/alma991013540678406708.Podeu consultar la versió en català a: https://hdl.handle.net/2445/222583[spa] La doctora Chantal Moll de Alba Lacuve, directora de la obra, es profesora de Derecho Civil en la Universidad de Barcelona. Directora de la Cátedra de Derecho Registral de la UB, directora CMA Consulta Jurídica de la Fundación Bosch i Gimpera, corresponsal en España de la "International Construction Law Review" y vocal de la Sección de Derecho Civil del Ilustre Colegio de Abogados de Barcelona. Este libro trata de la figura del gran tenedor en la compleja y cambiante normativa de vivienda. En una primera parte, se analiza el concepto de gran tenedor, que resulta tan difícil de concretar por la diversidad de definiciones en la legislación estatal y autonómica. En una segunda parte, se abordan las consecuencias jurídicas de ostentar esta condición en los contratos de arrendamiento, como son el deber de información y la contención de rentas en zonas de mercado residencial tensionado. Por último, en la tercera parte, se estudian los requisitos procesales que afectan a los grandes tenedores en los procedimientos de desahucio. El libro hace especial referencia a los pronunciamientos del Tribunal Constitucional ya las importantes novedades legislativas que afectan a los grandes tenedores, que se han producido desde octubre de 2024, como son la eliminación de determinados requisitos procesales a nivel estatal o la creación del complejo régimen jurídico del gran tenedor en la normativa de vivienda
A ALBA e a luta pela hegemonia no continente americano: uma topologia do discurso bolivariano
No full textDissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Filosofia e Ciências Humanas. Programa de Pós-graduação em Sociologia PolíticaO objetivo da dissertação é analisar o movimento bolivariano, liderado pela Venezuela, enquanto projeto de construção de uma nova hegemonia na América Latina e o Caribe. Tal projeto se constrói discursivamente em oposição à histórica hegemonia pan-americana liderada pelos Estados Unidos (EUA). Para isso é estudada a ALBA (Aliança Bolivariana para os Povos de nossa América) como organização internacional que facilita a alineação de países e sociedades latino-americanos em relação ao movimento bolivariano, gerando novas modalidades de construção de sentido, assim como novas vias e regras de relacionamento internacional. A pesquisa analisa os discursos de mandatários nas reuniões de Cúpula da ALBA, e, apelando à teoria do discurso de Ernesto Laclau, identifica nesse conjunto os três passos previstos pelo autor na configuração de um desafio hegemônico: (1) o estabelecimento de um antagonismo face ao imperialismo dos EUA que é identificado como o poder hegemônico institucionalizado, e a dicotomização do espaço social americano através da construção de uma fronteira entre esse poder e o resto da comunidade (América Latina e o Caribe); (2) a articulação contingente entre diversas demandas sociais, características da América Latina e do Caribe, cuja insatisfação é atribuída ao imperialismo dos EUA; e (3) a formação de um campo popular, através da expressão positiva dessas demandas numa nova identidade, no caso a identidade bolivariana. A pesquisa conclui que o movimento bolivariano consegue gerar elementos para permitir uma nova lógica de construção de sentido, configurando assim estruturalmente um campo de luta pela hegemonia. Porém, também são destacados vários problemas nessa tarefa, especialmente ligados à identificação de diversas unidades com o bolivarianismo.The dissertation research the Bolivarian Movement, headed by Venezuela, as a new hegemonic project, still under construction, at Latin America and the Caribbean. This hegemonic project is discursively constructed in opposition to the historic Pan American hegemony, led by the U.S. In this way, the Bolivarian Alliance for the Peoples of Our America (ALBA) is approached as an international organization that seeks to align the Latin American countries and societies behind the Bolivarian Movment. The ALBA generates new ways of sense-making, as well as new norms of international relations. The research analyzes the speeches at the ALBA's presidential summits, using the Ernesto Laclau's Discourse Theory, and identifying the three steps proposed by this author to the hegemonic construction: Firstly, the establishment of an antagonism against U.S. imperialism and the dicotomization of the hemispheric social space, through the definition of a boundary between the powerful country and the rest of continental community (Latina America and the Caribe). Secondly, the contingent articulation of a variety of social demands, which dissatisfaction are ascribed to the U.S. imperialism. Thirdly, the formation of a new popular field, through the positive expression on a new identity of this unified set of demands, in this case the Bolivarian identity. The dissertation concludes that the Bolivarian movement manages a new logic of sense-making, and therefore places the hegemonic struggle in a new structural field. However, it also identified some problems on this task, particularly in the difficulty to construct a Bolivarian identity shared by various social unities (countries, societies and social sectors)
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