196,054 research outputs found
Correction: LH prevents cisplatin-induced apoptosis in oocytes and preserves female fertility in mouse (Cell Death & Differentiation, (2017), 24, 1, (72-82), 10.1038/cdd.2016.97)
No full textFollowing publication of their article, the authors reported that the name of the fifth author had been formatted incorrectly in PubMed. Instead of "Rella FD" it should be "Di Rella F"
The Crucial Role of Surgical Treatment in BIA-ALCL Prognosis in Early- and Advanced-Stage Patients
No full textBackground: Studies on breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) are trying to optimize medical and surgical treatments for early and advanced stages of this disease. The aim of this article is to share the experience gathered on the authors' prospectively collected 46 well-documented cases.Methods: Italian physicians are obliged to report BIA-ALCL cases to the Italian Ministry of Health. Because of this cooperation with health care professionals, the competent authority has coordinated and centralized the collection of information for each patient in 46 cases of BIA-ALCL. Statistical analyses with cumulative incidence and corresponding 95 percent confidence interval are provided for each year, dividing the number of new cases that occurred in a defined year and the population at risk of experiencing BIA-ALCL during the same year.Results: The mean time to the onset of symptoms is reduced to 6.4 +/- 3.77 years (range, 1 to 22 years). Increased knowledge has also shortened the average time to diagnosis, at 7.2 +/- 3.71 years (range, 2 to 22 years). A late seroma appears in 91 percent of cases. The patient who died underwent limited surgery. The Italian incidence has been estimated as 2.8 per 100,000 patients receiving implants (95 percent CI, 0.88 to 4.84) in 2015; 2.1 (95 percent CI, 0.43 to 3.86) in 2016; 3.2 (95 percent CI, 1.11 to 5.31) in 2017; and 3.5 (95 percent CI, 1.36 to 5.78) in 2018.Conclusion: Although the number of cases has risen slightly, BIA-ALCL is still a rare disease with a stable incidence, easily recognized and with a favorable prognosis also in advanced stages if complete surgical excision is performed
Testosterone Serum Levels Are Related to Sperm DNA Fragmentation Index Reduction after FSH Administration in Males with Idiopathic Infertility
No full textPurpose: Although a robust physiological rationale supports follicle stimulating hormone (FSH) use in male idiopathic infertility, useful biomarkers to evaluate its efficacy are not available. Thus, the primary aim of the study was to evaluate if testosterone serum levels are related to sperm DNA fragmentation (sDF) index change after FSH administration. The secondary aim was to confirm sDF index validity as a biomarker of FSH administration effectiveness in male idiopathic infertility. Methods: A retrospective, post-hoc re-analysis was performed on prospectively collected raw data of clinical trials in which idiopathic infertile men were treated with FSH and both testosterone serum levels and sDF were reported. Results: Three trials were included, accounting for 251 patients. The comprehensive analysis confirmed FSH’s beneficial effect on spermatogenesis detected in each trial. Indeed, an overall significant sDF decrease (p < 0.001) of 20.2% of baseline value was detected. Although sDF resulted to be unrelated to testosterone serum levels at baseline, a significant correlation was highlighted after three months of FSH treatment (p = 0.002). Moreover, testosterone serum levels and patients’ age significantly correlated with sDF (p = 0.006). Dividing the cohort into responders/not responders to FSH treatment according to sDF change, the FSH effectiveness in terms of sDF improvement was related to testosterone and male age (p = 0.003). Conclusion: Exogenous FSH administration in male idiopathic infertility is efficient in reducing sDF basal levels by about 20%. In terms of sDF reduction, 59.2% of the patients treated were FSH-responders. After three months of FSH administration, a significant inverse correlation between sDF and testosterone was detected, suggesting an association between the FSH-administration-related sDF improvement and testosterone serum levels increase. These observations lead to the hypothesis that FSH may promote communications or interactions between Sertoli cells and Leydig cells
How to foster Sustainable Continuous Improvement: A cause-effect relations map of Lean soft practices
No full textLean Management (LM) represents a complex socio-technical system where both technical and social practices should be consistently implemented and integrated in order to foster a Continuous Improvement (CI) culture. Despite initial gains in operational performances due to the implementation of the most common and well-established Lean techniques, the great majority of the companies approaching Lean Manufacturing fail in achieving sustainable outcomes in the long term, and most of them eventually come back to their traditional way of doing business. Recognized the pivotal role of soft practices, the purpose of this study is to investigate the role played by the human factor in fostering the establishment of a Sustainable Continuous Improvement (SCI) environment. Starting from surveying the literature, a comprehensive framework including all the relevant soft practices related to LM has been developed. Then, authors proposed, for the first time, Decision-Making Trail and Evaluation Laboratory (DEMATEL) analysis applied to soft practices of SCI, that provides an innovative understanding of the relevant soft practices which foster SCI by showing cause-effect association among them. The proposed methodology reveals precious insights for scholars and practitioners who intend to approach and apply SCI. The impact relations map shows that some soft practices are initiators and some others enablers of the SCI and allows to identify the most relevant Critical Success Factors (CSF) and interrelationships amongst them. Results show that the key for a SCI is represented by a full engagement of the workforce, which must be triggered and supported by Top Management with the use of some leverages such as an effective communication, training and use of Kaizen events
APOPTOSIS RATE IN CUMULUS CELLS AS POSSIBLE MOLECULAR BIOMARKER FOR OOCYTE COMPETENCE.
No full textSeveral lines of evidence showed that apoptosis rate of cumulus cells in oocytes derived by assisted
reproductive technologies could be used as an indicator of fertilizing gamete quality. Aim of the study
was to investigate the effects of three different ovarian stimulation protocols on the biological and clinical
outcome in hyporesponder patients. Collected data showed a higher significant rate of DNA fragmentation
index (DFI) in U group (patients treated with Highly Purified human Menopausal Gonadotrophin) than in
P group (treated with recombinant human Follicle Stimulating Hormone (r-hFSH) combined with
recombinant human Luteinizing Hormone (r-hLH)). Both groups R (treated with r-hFSH alone) and P
showed a significant increase in collected and fertilized oocytes number, embryo quality number. This
study showed that combined r-hFSH/r-hLH therapy could represent the best pharmacological strategy for
controlled ovarian stimulation and suggests to use DFI as a biomarker of ovarian function in
hyporesponder patients
Dr. Duane M. Jackson, Morehouse College, July 2011
No full textThis video is a conversation with Dr. Duane M. Jackson. Dr. Jackson talks about his paper, "Recall and the Serial Position Effect: The Role of Primacy and Recency on Accounting Students' Performance." Jackie Daniel, AUC Woodruff Library, is the interviewer
Exploring the human chorionic gonadotropin induced steroid secretion profile of mouse Leydig tumor cell line 1 by a 20 steroid LC-MS/MS panel
No full textThe canonical androgen synthesis in Leydig cells involves Delta 5 and Delta 4 steroids. Besides, the backdoor pathway, eompassing 5 alpha and 5 alpha,3 alpha steroids, is gaining interest in fetal and adult pathophysiology. Moreover, the role of androgen epimers and progesterone metabolites is still unknown. We developed a liquid chromatographytandem mass spectrometry (LC-MS/MS) method for measuring 20 steroids and used it to investigate the steroid secretion induced by human chorionic gonadotropin (hCG) in the mouse Leydig tumor cell line 1 (mLTC1). Steroids were extracted from 500 mu L supernatants from unstimulated or 100 pM hCG-exposed mLTC1 cells, separated on a Luna C8 100 x 3 mm, 3 mu m column, with 100 mu M NH4F and methanol as mobile phases, and analyzed by positive electrospray ionization and multiple reaction monitoring. Sensitivity ranged within 0.012-38.0 nmol/L. Intra-assay and inter-assay imprecision were < 9.1% and 10.0%, respectively. Trueness, recovery and matrix factor were within 93.4-122.0, 55.6-104.1 and 76.4-106.3%, respectively. Levels of 16OH-progesterone, 11-deoxycortisol, androstenedione, 11-deoxycorticosterone, testosterone, 17OH-progesterone, androstenedione, epitestosterone, dihydrotestosterone, progesterone, androsterone and 17OH-allopregnanolone were effectively measured. Traces of 17OH-dihydroprogesterone, androstanediol and dihydroprogesterone were found, whereas androstenediol, 17OH-pregnenolone, dehydroepiandrosterone, pregnenolone and allopregnanolone showed no peak. hCG induced an increase of 80.2-102.5 folds in 16OH-progesterone, androstenedione and testosterone, 16.6 in dihydrotestosterone, 12.2-27.5 in epitestosterone, progesterone and metabolites, 8.1 in 17OH-allopregnanolone and <= 3.3 in 5 alpha and 5 alpha,3 alpha steroids
"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States" By M. Carey.
No full text"Reflections on the subject of Emigration from Europe with a view to Settlement in the United States: containing bried sketches of the moral and political character of those states.
By M. Carey, member of the American philosophical, and of the American Antiquarian Society, and author of The Olive Branch, Cindiciae Hibernicae, essays on banking, on political economy, and on internal improvement.
To which are now added the English editor's comments on the subject; together with Important Advice to Emigrants, and Cautions Against Impositions Practiced in the Outports
ATP1A3 mutant patient with alternating hemiplegia of childhood and brain spectroscopic abnormalities.
No full textAlternating hemiplegia of childhood (AHC) is a rare and severe disorder characterized by episodes of hemiplegia and dystonia alternating in laterality, possibly associated with seizures, abnormal ocular movements, headache and hypotonia. AHC is caused by dominant mutations in the ATP1A3 gene [4, encoding a neuron specific Na+-K+-ATPase pump, which has a crucial role in excitability of neurons and muscles.We present an unreported AHC patient with ATP1A3 gene mutation, who received an unusually long clinical follow-up (44 years) and underwent brain 1H magnetic resonance spectroscopy (MRS) to understand the etiology of neurological deterioration with age
Neuromuscular transmission abnormalities in myotonic dystrophy type 1: A neurophysiological study
No full textObjectives: Weakness and fatigue are frequent symptoms in myotonic dystrophy type 1 (DM1), mainly as a result of muscle impairment. However, neuromuscular junction (NMJ) abnormalities could play an additional role in determining these manifestations. We aimed to document the possible NMJ involvement in DM1.Patients and methods: In order to substantiate this hypothesis we performed low rate repetitive nerve stimulation (RNS) and single fiber electromyography (SFEMG), in 14 DM1 subjects.Results: RNS resulted abnormal in four patients while SFEMG revealed a pathological jitter in ten. A significative correlation was found between jitter values and decrementing response (p < 0.000311; r= 0.822).Conclusion: These results suggest a possible involvement of NMJ in DM1. (C) 2016 Elsevier B.V. All rights reserved
- …
