2,112,287 research outputs found
LISA Data Challenge software
No full textThe LDC software provides a set of tools to generate and analyse the LISA Data Challenge datasets
Lisa and John- Look at Us!
No full textAn immersive installation of new works chosen by
Lisa and John themselves. This installation opens up the archive via collaboration with Lisa and John’s choices, guided by memory, sentiment, and humour, drawing again on the transcripts of the couple, discussing their picture choices.
‘Look at Us!’ presents as a two-screen presentation employing facilitatory ideologies of installation as an immersive and audience autonomous environment, and offers a choreographed projection of Lisa and John’s selections of photographs. The running time of 1h 45m extends the unedited transcripts of the audio files with overlapping segments around the occasional use of the same imagery and contradictory recall of the couple.
‘Look at Us’ proposes a physicality suggested in ‘Oh My days’ in it's corner design and notions of an expanded photographic event
Lisa and John
Full text linkAs a collaborative and open-ended exploration of a photographic archive, via a variety of multimedia art forms, Moore’s research interrogates assumptions concerning normally concealed processes underlying the production of realist works or documentary. In this respect, the research relocates the photographic images in the wider field of contemporary art, using the conventions of verbatim theatre and immersive environments to critique documentary production within the
images. Moore calls into question the certainties of representation by using methods articulated within photography in an expanded field (Soutter). This includes the development of a Brechtian device that places the photographer as a character within the work, and by making Lisa and John, the original subjects, active agents in the new project. 3D work also further disrupts the documentary paradigm through the inclusion of the ‘photographer at the scene’ within a museum like diorama. Collaboration in documentary practice is usually thought of in terms of working with subjects in the moment of creating the images. Instead, Moore’s project uses collaboration to disrupt and re-explore past work, and creates a future space for research, revision and reinterpretation of archives. Lisa and John has been exhibited and performed in Belfast Exposed, The Mac, Belfast, London Gallery West, and other venues
LISA Constants
No full textLISA Constants is a Python package that provides values sanctioned by the LISA Consortium for physical constants and mission parameters. LISA Constants is intended to be consistently used by other pieces of software related to the simulation of the instrument, of gravitational wave signals, and others
LISA Pathfinder: in search of perfect stillness
No full textopenInsieme delle azioni svolte dal satellite LISA Pathfinder per raggiungere l'orbita assegnata e mantenere le condizioni migliori possibili al fine di poter avere un sistema isolato dalle interferenze e, così, in grado di registrare il passaggio delle onde gravitazionali
Lisa Law in front of Prophecy Rock
No full textLisa Law in front of Prophecy Rock. Lisa Law headed the Santa Fe Big Mountain Defense Support Group for 12 years, dedicated to repealing the Relocation Act. Also, Law, with many supporters, was involved in raising money for the Big Mountain Weaving Project
LISA Orbits
No full textLISA Orbits is a Python package which generates orbit files compatible with LISA Instrument, LISA GW Response, the LDC Software, and LISANode. Among others, an orbit file contains the spacecraft state vectors, the light travel times and the proper pseudoranges.
User manual and documentation are available here
Lisa Ann Cunningham's Graduate Recital
No full textOriginal Format: ReelComposers in the first graduate recital: Purcell; Schumann; Mozart; Mahler; Hahn; Massenet; Bizet; Coquard; Delibes; Gayla Rose; Jean Berger; BelliniComposers in the second graduate recital: Mozart; Wolf; Duparc; Delibes; OwensFirst Recital: Mezzo-SopranoSecond Recital: Mezzo-Sopran
Dexmedetomidine for LISA procedure in preterm infants: a pilot study
No full textreservedPresupposti. La LISA (Less Invasive Surfactant Administration) è la tecnica di somministrazione di surfattante attualmente raccomandata dalle Linee Guida Europee per la gestione della RDS nei neonati pretermine in respiro spontaneo supportati con CPAP. Tale tecnica comprende l’esecuzione di una laringoscopia, che è una procedura dolorosa, comportando quindi la necessità di un’adeguata analgosedazione. Il farmaco ideale in tale contesto dovrebbe avere un rapido onset e una breve durata d’azione, oltre a non impattare sul drive respiratorio ed essere sicuro nel breve e lungo termine. Finora sono stati studiati diversi farmaci per l’analgosedazione durante LISA, ma nessuno di essi è risultato ottimale a causa dell’aumentato rischio di depressione respiratoria osservato nei pazienti sedati. La dexmedetomidina, un agonista adrenergico α2-selettivo dall’effetto analgesico e sedativo con impatto minimo o assente sul drive respiratorio, potrebbe rappresentare un’opzione adatta alla premedicazione per LISA.
Obiettivi. Lo scopo di questo studio è indagare l’efficacia della dexmedetomidina in termini di analgesia e sedazione durante la procedura LISA e la sua sicurezza nei neonati pretermine.
Materiali e metodi. È stato condotto uno studio osservazionale longitudinale prospettico su neonati pretermine di età gestazionale compresa tra 26+0 e 36+6 settimane con RDS e necessità di terapia con surfattante, ricoverati presso una TIN di terzo livello. I pazienti sono stati inoltre suddivisi in due gruppi in base all’età gestazionale (< o ≥ 32 SG). La dexmedetomidina è stata somministrata in bolo lento alla dose di 1 μg/kg prima della LISA. Gli outcome primari sono stati l’efficacia della dexmedetomidina nel fornire adeguate analgesia e sedazione, misurate rispettivamente tramite gli score NIPS e N-PASS, e la sicurezza di tale farmaco in termini di effetti sul drive respiratorio (comparsa di apnea/desaturazione e necessità di intubazione) e di effetti collaterali cardiovascolari (bradicardia e ipotensione).
Risultati. Sono stati arruolati 47 neonati, di cui 30 di età compresa tra 26+0 e 31+6 SG e 17 di età tra 32+0 e 36+6 SG. La mediana (IQR) di età gestazionale e peso alla nascita è stata rispettivamente 29+6 (28+5, 33+1) SG e 1421 (1069, 2074) g. L’analgesia è stata adeguata, con il 76% dei pazienti con NIPS ≤ 4 durante la laringoscopia e percentuali maggiori, attorno al 90%, negli altri momenti della procedura. La sedazione, invece, è stata tardiva e prolungata, con solo 10 neonati (23%) al livello di sedazione desiderato (N-PASS tra -2 e -5) all’inizio della LISA, stato che si è protratto per almeno 60 minuti dopo la procedura. Sono stati rilevati cinque casi (11%) di apnea/desaturazione e sei pazienti (13%) hanno richiesto intubazione entro le 72 ore dalla procedura. Nessun paziente ha presentato bradicardia, mentre si è verificata ipotensione in tre neonati (6%).
Conclusioni. La dexmedetomidina ha garantito un’analgesia adeguata e permesso un’agevole esecuzione della procedura, senza causare al contempo effetti avversi gravi. Non ha, tuttavia, permesso di raggiungere il livello desiderato di sedazione al momento della LISA, dimostrando un effetto sedativo tardivo e prolungato nel tempo. La premedicazione con dexmedetomidina non sembra, quindi, ideale per la procedura LISA, che richiede un farmaco con un più rapido onset e una più breve durata d’azione.Background. Less invasive surfactant administration (LISA) is the surfactant administration method currently recommended by the European Guidelines for the management of respiratory distress syndrome (RDS) in preterm neonates spontaneously breathing on CPAP. This technique involves a laryngoscopy, a painful procedure that requires appropriate analgesia and sedation. The ideal drug for this purpose should have a rapid onset and a short duration of action, should not affect respiratory drive, and should be safe in both the short and long term. Several drugs have been tested for analgesia and sedation during LISA, but none have proven ideal due to an increased risk of respiratory depression. Dexmedetomidine, a selective α2-adrenergic agonist with analgesic and sedative effects and minimal or no impact on respiratory drive, seems a promising option for LISA premedication.
Objectives. This study aimed to evaluate the efficacy of dexmedetomidine for analgesia and sedation during the LISA procedure, as well as its safety in preterm neonates.
Methods. This prospective observational study enrolled preterm neonates with a gestational age between 26+0 and 36+6 weeks diagnosed with RDS and requiring surfactant therapy, admitted to a level III NICU. Patients were further divided into two groups based on gestational age (<32 or ≥32 weeks). Dexmedetomidine was administered as a slow bolus at a dose of 1 μg/kg before LISA. Primary outcomes were the efficacy of dexmedetomidine in providing adequate analgesia and sedation – evaluated using the Neonatal Infant Pain Scale (NIPS) and the Neonatal Pain, Agitation, and Sedation Scale (N-PASS), respectively – and its safety, determined by the lack of side effects, both respiratory (apnea/desaturation and need of intubation) and cardiovascular (bradycardia and hypotension) ones.
Results. A total of 47 neonates were enrolled, 30 aged between 26+0 and 31+6 weeks GA and 17 between 32 and 36+6 weeks GA. The median (IQR) gestational age and birth weight were 29+6 (28+5, 33+1) weeks and 1421 (1069, 2074) g, respectively. Analgesia was adequate, with 76% patients achieving a NIPS score ≤4 during laryngoscopy and around 90% at other time points during the procedure. However, sedation was delayed and prolonged, with only 10 neonates (23%) reaching the desired sedation level (N-PASS between -2 and -5) at the beginning of LISA, which persisted for at least 60 minutes after the procedure. Apnea/desaturation occurred in five cases (11%), and six patients (13%) required intubation within 72 hours. No episodes of bradycardia were observed, while hypotension occurred in three neonates (6%).
Conclusion. Dexmedetomidine provides adequate analgesia and good technical conditions without causing severe adverse effects. However, the desired level of sedation was not consistently achieved, due to a delayed and prolonged sedative effect. Therefore, dexmedetomidine may not be the optimal choice for LISA premedication, as this procedure requires a drug with a faster onset and shorter duration of action
COMPUTATIONAL ANALYSIS OF GRAVITATIONAL BALANCE REQUIREMENTS FOR LISA MISSION
No full textembargoed_20260412Regarding the Laser Interferometer Space Antenna (LISA) mission, modeling and simulation of satellite mass distributions in order to evaluate the resultant gravitational acceleration on Test Mass (Gravitational Balance). Developing an algorithm to evaluate gravitational attraction noise caused by thermic dilations of the structures alongside the optical axes.Regarding the Laser Interferometer Space Antenna (LISA) mission, modeling and simulation of satellite mass distributions in order to evaluate the resultant gravitational acceleration on Test Mass (Gravitational Balance). Developing an algorithm to evaluate gravitational attraction noise caused by thermic dilations of the structures alongside the optical axes
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