177,617 research outputs found
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Gemeinsam aus unterschiedlichen Perspektiven – Phasenverbindende Fortbildungen im Workshopprogramm BiConnected
No full textSchicht S, Schüssler R, Obermeier A-C. Gemeinsam aus unterschiedlichen Perspektiven – Phasenverbindende Fortbildungen im Workshopprogramm BiConnected . In: Maurer C, Rincke K, Holzäpfel L, Lipowsky F, eds. Wie viel Wissenschaft braucht die Lehrerfortbildung - Arbeitsbündnisse im analogen und virtuellen Raum. Regensburg; 2021: 108-111
Force-Dependent Unbinding Rate of Molecular Motors from Stationary Optical Trap Data
Get PDFMolecular
motors walk along filaments until they detach stochastically with
a force-dependent unbinding rate. Here, we show how this unbinding
rate can be obtained from the analysis of experimental data of molecular
motors moving in stationary optical traps. Two complementary methods
are presented, based on the analysis of the distribution for the unbinding
forces and of the motor’s force traces. In the first method,
analytically derived force distributions for slip bonds, slip-ideal
bonds, and catch bonds are used to fit the cumulative distributions
of the unbinding forces. The second method is based on the statistical
analysis of the observed force traces. We validate both methods with
stochastic simulations and apply them to experimental data for kinesin-1
"Closing the R&D Gap, Evaluating the Sources of R&D Spending"
Get PDFBoth spending and tax policies have been implemented in the United States with the goal of stimulating private sector research and development (R&D). Karier questions whether current R&D policy, especially the research and experimentation tax credit, can contribute to closing the gap between nondefense expenditures on R&D in the United States and such expenditures in other countries, such as Japan and Germany. He also explores possible changes to our current R&D policy to make it more effective.
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