540 research outputs found
Investigations of the suppressor of cytokine signalling 5
No full text© 2016 Dr. Edmond Michael LinossiThe SOCS family of proteins provide crucial negative regulation of cytokine and growth factor signalling. They achieve this through multiple mechanisms, including ubiquitination and degradation of target substrates by the proteasome, direct inhibition of enzyme activity and steric competition for key binding sites in signalling proteins. Whilst the biology and mechanisms of action have been well defined for a number of SOCS family members, a clear physiological function has not been described for SOCS5. This is due in part to discrepancies in the literature, where exogenous expression of SOCS5 in mice suggests a role in CD4+ T cells that is not supported by analysis of SOCS5- deficient mice. It has also been implicated as a negative regulator of EGFR signalling and its expression is inversely correlated with receptor levels in aggressive hepatocellular carcinoma patients. SOCS5 shares a high degree of sequence homology with Socs36E of Drosophila, which is known to regulate EGFR and JAK signalling in vivo.
In this work, I aimed to identify SOCS5 interacting proteins to better understand its role. I have characterised two specific targets in JAK1 and ShcA and extended the search for interacting proteins using mass spectrometry to broadly define the SOCS5 interactome in HEK293T cells. These studies revealed an extensive network of interactions, likely mediated by the poorly defined N-terminal region of SOCS5, which was heavily modified by phosphorylation. Most interestingly, in the PyMT mouse model of breast cancer, which is driven by many of the identified SOCS5 interacting proteins, SOCS5- deficient mice exhibited accelerated disease onset and tumour growth. These data show for the first time that SOCS5 plays an important protective role in the mammary gland. This was supported by analyses of SOCS5 in human breast cancer that shows patients with low SOCS5 expression exhibit a worse clinical outcome and more aggressive disease
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Edmond White
No full textHandwritten notes about author Edmond (sic) White
Edmond Rostand ou la communion perdue
No full textFor Edmond Rostand, dramatic writing is a medium ensuring communion between the author and the spectator, a bond questioned by Plato. This article studies how Edmond Rostand’s poetic plays illustrate the quest for the public’s understanding of the poet and how the characters thrive for their lost social recognition. His works shed light on the poet at work, each of the characters being an accomplished or budding versifier to reveal that poetry is legitimate work, which requires skills. Edmond Rostand’s poetic style deconstructs literary and social norms that have led to his contemporaries’ loss of authenticity. Misunderstood by theater goers and critics, disappointment led the playwright to improvisation and to pantomime, in which gestures could not alter the fragile and fleeting idea, making poetry easier to comprehend and bridging the gap between the author and his audience, establishing the poet as a worthy citizen again.For Edmond Rostand, dramatic writing is a medium ensuring communion between the author and the spectator, a bond questioned by Plato. This article studies how Edmond Rostand’s poetic plays illustrate the quest for the public’s understanding of the poet and how the characters thrive for their lost social recognition. His works shed light on the poet at work, each of the characters being an accomplished or budding versifier to reveal that poetry is legitimate work, which requires skills. Edmond Rostand’s poetic style deconstructs literary and social norms that have led to his contemporaries’ loss of authenticity. Misunderstood by theater goers and critics, disappointment led the playwright to improvisation and to pantomime, in which gestures could not alter the fragile and fleeting idea, making poetry easier to comprehend and bridging the gap between the author and his audience, establishing the poet as a worthy citizen again.For Edmond Rostand, dramatic writing is a medium ensuring communion between the author and the spectator, a bond questioned by Plato. This article studies how Edmond Rostand’s poetic plays illustrate the quest for the public’s understanding of the poet and how the characters thrive for their lost social recognition. His works shed light on the poet at work, each of the characters being an accomplished or budding versifier to reveal that poetry is legitimate work, which requires skills. Edmond Rostand’s poetic style deconstructs literary and social norms that have led to his contemporaries’ loss of authenticity. Misunderstood by theater goers and critics, disappointment led the playwright to improvisation and to pantomime, in which gestures could not alter the fragile and fleeting idea, making poetry easier to comprehend and bridging the gap between the author and his audience, establishing the poet as a worthy citizen again
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Understanding 1968: the case of Brest
No full textThis article examines the dominance of Paris in how May '68 has been portrayed over the years. It will be argued, through a case-study of the revolt in the Breton city of Brest, that the Paris-centred approach is one that belies the true nationwide aspect of May/June 1968. As one of a range of characteristics, the concentration on the Latin Quarter has helped mould what Kristin Ross has described as the 'official history' of 1968. An examination of how the events were played out within different regional contexts would go a long way towards helping overcome the shortcomings of the increasingly narrow portrayal that has come to dominate the stereotypical image of 1968
Edmond Rostand ou la communion perdue
No full textFor Edmond Rostand, dramatic writing is a medium ensuring communion between the author and the spectator, a bond questioned by Plato. This article studies how Edmond Rostand’s poetic plays illustrate the quest for the public’s understanding of the poet and how the characters thrive for their lost social recognition. His works shed light on the poet at work, each of the characters being an accomplished or budding versifier to reveal that poetry is legitimate work, which requires skills. Edmond Rostand’s poetic style deconstructs literary and social norms that have led to his contemporaries’ loss of authenticity. Misunderstood by theater goers and critics, disappointment led the playwright to improvisation and to pantomime, in which gestures could not alter the fragile and fleeting idea, making poetry easier to comprehend and bridging the gap between the author and his audience, establishing the poet as a worthy citizen again
Edmond Couchot teorico delle immagini digitali
No full textAuthor of some of the first interactive artworks (La plume and Je sème à tout vent), Edmond Couchot was more prolific as a theoretician than as an artist. This paper seeks to reflect on his writings of the 1980s and early 1990s, when digital technologies were not pervasive yet. Defining a digital image as the product of a mathematical language, Couchot reflects on the born of a “new visual order” and its cultural consequences in the creation, perception and circulation of images
Ambulatory blood pressure measurements: reproducibility and predictive capability for serious adverse health outcomes
No full textBackground: Hypertension is present in approximately 25% of all adults in the US aged 20 to 74 years according to the National Health and Nutrition Examination Survey (NHANES 1999-2002). Ambulatory Blood Pressure (ABP) monitoring data contains far more information than is captured by a single office measurement and this additional information may be useful for diagnosis and treatment decisions. Objectives: There are three primary aims. The first aim is to evaluate the association between mean ABP values and various measures of ABP variability. The second aim is to assess the reproducibility of ABP measures of variability in a sample of patients treated in a specialty hypertension and nephrology practice. The third aim is to evaluate the association between ABP measures of BP variability and all cause mortality. Methods: The study sample consisted of subjects with ABP data collected at a specialty hypertension and nephrology practice as part of routine clinical assessments. The practice focuses primarily on the treatment of hypertension in adults and the clinical population is highly enriched with hypertensive subjects. The data cover all ABP sessions from 1984 to 2004 which met the data completeness criteria. There were 2015 subjects with a total of 2292 ABP monitor sessions that met these inclusion/exclusion criteria. Of these, 200 subjects had more than one ABP session. Aim one was evaluated by Pearson correlation coefficients. Aim two was evaluated by intracluster correlation coefficients using GEE methods and by the Bland-Altman method for assessment of reproducibility. Aim three was evaluated by Cox proportional hazards analyses. Results: For aim one, standard deviations (SD) as a measure of BP variability were highly correlated with their respective mean values, whereas coefficients of variations (CV) did not. Day-night differences, a measure of diurnal variation, were correlated with mean systolic (SBP), diastolic (DBP) and pulse (PP) pressure. For aim two, SD and CV showed good reproducibility over time. The same was true for day-night measures of diurnal variation. However, dipping status, defined as a greater than 10% drop in ABP from daytime to nighttime was not reproducible over time. For aim three, SD and CV for SBP, DBP and mean arterial pressure (MAP) was associated with an increased risk of all cause mortality. The same was true for mid-BP and PP. Increased SD and CV for heart rate (HR) were generally associated with a reduced risk of all cause mortality. Results were similar for an endpoint of combined cause specific mortality due to cardiovascular, cerebrovascular or renal disease. Conclusions: ABP measures of variability generally showed good reproducibility with the exception of dipping status, defined as day-night drop of 10% or more. Further study is warranted on the use of this common 10% cutoff value utilized to define dippers in the literature. Associations between ABP measures of variability and their respective mean values were consistent with the published literature, as was the association between these measures of variability and all cause mortality.Ph.D.Includes bibliographical referencesIncludes vitaby Edmond S. Malk
Résonance. La condition d'intelligibilité de l'image
No full textThis study explores the temporal aspects of the visual image, mainly the time of its visual perception, its past, and that of its technical conception, its future. Through an analogy with Pierce' s theory of the temporal orientation of signs and the transposition of Benveniste' s theory of linguistic time, the author shows that temporal simultaneity (resonance), essential to the communication of the visual image to the viewer, is achieved by using as analogue for Benveniste' s linguistic present the moment of the visual image's engenderment.Couchot Edmond. Résonance. La condition d'intelligibilité de l'image. In: Littérature, n°87, 1992. La moire de l'image. pp. 65-76
The Euro in the International Arena
No full textThis article explains the author point of view about two questions :
- « Does the euro’s exchange rate with the dollar really matter ? »
- « What has been the impact of the euro on foreign investment in Europe ? »
Beyond their purely technical aspects, both questions relate to the whole set of doubts on the international consequences of the euro’s growing role. The author doesn’t think that the euro’s introduction in the international monetary arena present a serious threat to stability. The three arguments of those who expect an increase exchange rate instability, i. e. the « openness argument », the « portfolio argument » and the «hegemonic argument », are weak.
JEL classifications : E42, F31Alphandéry Edmond. The Euro in the International Arena . In: Revue d'économie financière (English ed.), n°62, 2001. Banking and Financial Europe after the Euro. pp. 63-70
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