1,720,968 research outputs found
BK virus immunity in patients undergoing hematopoietic stem cell transplant.
No full textHematopoietic stem cell transplant (HSCT) is an important modality of treatment for hematological diseases and cancers. Latent BK virus (BKV) infection is found in more than 90% of the world’s population. A challenging complication associated with BKV reactivation in HSCT patients is hemorrhagic cystitis (HC). There is currently little data about the reconstitution of BKV-specific immunity after HSCT and its relationship to HC. Peripheral blood mononuclear cells (PBMCs) were stimulated with BKV antigens large T and VP1 and the number of BKV-specific T cells were analysed by flow cytometry. Higher levels of CD4+IL-17+ (p<0.01) and CD8+IL-17+ (p=0.05) BKV-specific cells were observed in post engraftment HSCT patients that developed HC compared to those that did not. Furthermore, peak levels of these BKV-specific T cells were observed just before or after the onset of HC and this coincided with high levels of BKV detected in the urine. These preliminary results suggest that BK associated HC is an immunopathology caused by IL-17 secreting BK-specific T cells. Our study will need to be confirmed in a larger cohort of patients.Bachelor of Science in Biological Science
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Investigations into T cell mediated tumour immunity in the colon
No full textEThOS - Electronic Theses Online ServiceGBUnited Kingdo
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Analysis of helicobacter pylori antimicrobial susceptibility and virulence genes.
No full textHelicobacter pylori, which causes gastric ulcers and cancers, contains the polymorphic virulence genes cagA and vacA. Differences in the cagA EPIYA motifs and polymorphisms of vacA signal (s), middle (m) and intermediate (i) regions were thought to be important in determining disease severity. This study aims to determine cagA and vacA polymorphisms of H. pylori isolated from Singapore’s multi-ethnic population. Furthermore, a 12-year trend of antibiotic resistance from the isolates was studied. A total of 86 H. pylori isolates were obtained from patients with dyspeptic symptoms. Antibiotic resistance was determined by Etest; DNA was extracted from the isolates and allelic variation of virulence genes were determined by PCR and sequencing. High metronidazole resistance and increasing clarithromycin and levofloxacin resistance were observed through the 12 years. Chinese patients predominantly carried vacA s1/m2/i1 strains as compared to non-Chinese who mainly carried s1/m1/i1 (p<0.001). Furthermore, the Chinese isolates mainly possessed CagA with EPIYA-ABD motif, whereas non-Chinese isolates predominantly carried the EPIYA-ABC motif (p<0.001). With increased antibiotic resistance, enforcement of alternative treatments is essential. Marked polymorphic differences of cagA and vacA genotypes were observed between ethnic groups. Though vacA was not correlated with disease, cagA EPIYA genotypic differences may identify high-risk patients.Bachelor of Science in Biological Science
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
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