124,617 research outputs found
Data for 19F MAS-NMR Membrane Partition Experiments
No full textSupporting information for 2023 Angewandte Chimie paper:
Wang, Z., Felstead, H. R., Troup, R. I., Linclau, B., & Williamson, P. (2023). Lipophilicity modulations by fluorination correlate with membrane partitioning. Angewandte Chemie International Edition, [e202301077]. https://doi.org/10.1002/anie.202301077</span
Data for 'Synthesis and conformational properties of 3,4-difluoro-L-prolines'
No full textData supporting the paper:
Hofman, G-J., Ottoy, E., Light, M., Kieffer, B., Martins, J. C., Kuprov, I., ... Linclau, B. (2019). Synthesis and conformational properties of 3,4-difluoro-L-prolines. Journal of Organic Chemistry. DOI: 10.1021/acs.joc.8b02920
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Data for 'A synthesis of 2,3,4-trideoxy-2,3,4-trifluoroglucose'
No full textData supports the publication:
Quiquempoix, L. G., Wang, Z., Graton, J., Latchem, P. G., Light, M., Le Questel, J-Y., & Linclau, B. (2019). A synthesis of 2,3,4-trideoxy-2,3,4-trifluoroglucose. Journal of Organic Chemistry. DOI: 10.1021/acs.joc.9b00310</span
A novel stereoselective one-pot conversion of alcohols into alkyl halides mediated by N,N '-diisopropylcarbodiimide
No full textAlcohols can be converted in high yields to the corresponding alkyl halides in a one-pot procedure via the corresponding O-alkylisourea; very short reaction times are possible when microwave irradiation is used
Going Beyond Counting First Authors in Author Co-citation Analysis
No full textThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Dispelling the Myths Behind First-author Citation Counts
No full textWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Short synthesis of enantiopure C-2-Symmetric 1,2 : 4,5-diepoxypentane and "Pseudo"-C-2-symmetric 3-azido-1,2 : 4,5-diepoxypentane from arabitol
No full textOn the basis of our previously described selective protection of arabitol as its 1,2:4,5-bis-pentylidene acetal 5, we report a straightforward synthesis of the novel "pseudo"-C-2-symmetric 3-azido-1,2:4,5-diepoxypentane building block 4 in 6 steps from arabitol. Using a similar synthetic route, an improved synthesis of the C-2-symmetrical 1,2:4,5-bis-epoxypentane building block I is described, also in 6 steps from arabitol. Both enantiomers of 1 and 4 are accessible, and all reactions involved are easily amenable for large-scale synthesis
A novel, versatile D?BCD steroid construction strategy, illustrated by the enantioselective total synthesis of estrone
No full textA general steroid synthesis is presented that relies on prior formation of three stereogenic centers (C8, C13, and C14) on a D ring template, followed by C- and B-ring cyclizations. The assembly of the key D ring template, achieved by a 3-component conjugate addition/alkylation process, allows introduction of structural variety as required. The method is illustrated by the total synthesis of estrone via a C-ring closing metathesis and a B-ring Heck cyclization
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