5 research outputs found
Factors Influencing on Private Enterprises Doing Business in Yangon (Lin Htut Aung, 2025)
No full textThis study explores the perceptions of business owners in Yangon, Myanmar,
regarding key factors influencing private enterprises in Yangon. The objective is to
assess how regulatory environment, access to finance, infrastructure, human capital,
and political stability affect business growth. Using a structured survey administered to
200 entrepreneurs across various sectors. Descriptive analysis indicated strong human
capital and moderate satisfaction with financial access and infrastructure, while
governance issues remained a major barrier. Reliability testing confirmed the
consistency of the measurement tools. The findings indicate strong confidence in
human capital and infrastructure, but highlight concerns over regulatory clarity,
governance, and political instability. Access to finance was viewed as moderately
sufficient. The study recommends improving regulatory frameworks, enhancing
financial inclusion, and investing in workforce development through partnerships with
educational institutions. It also calls for further research using qualitative and regional
approaches to inform long-term policy reforms. These insights are vital for creating a
more supportive business environment and fostering sustainable private sector growth
in Myanmar
Assessment of ambient dust pollution status at selected point sources (residential and commercial) of Mingaladon area, Yangon region, Myanmar
No full text
Purpose
Dust (particulate matters) is very dangerous to our health as it is not visible with our naked eyes. Emissions of dust concentrations in the natural environment can occur mainly by road traffic, constructions and dust generating working environments. The purpose of this paper is to assess the ambient dust pollution status and to find out the association between PM concentrations and other determinant factors such as wind speed, ambient temperature, relative humidity and traffic congestion.
Design/methodology/approach
A cross-sectional study was conducted for two consecutive months (June and July, 2016) at a residential site (Defence Services Liver Hospital, Mingaladon) and a commercial site (Htouk-kyant Junction, Mingaladon) based on WHO Air Quality Reference Guideline Value (24-hour average). Hourly monitoring of PM2.5 and PM10 concentration and determinant factors such as traffic congestion, wind speed, ambient temperature and relative humidity for 24 hours a day was performed in both study sites. CW-HAT200 handheld particulate matters monitoring device was used to assess PM concentrations, temperature and humidity while traffic congestion was monitored by CCTV cameras.
Findings
The baseline PM2.5 and PM10 concentrations of Mingaladon area were (28.50±11.49)µg/m3 and (52.69±23.53)µg/m3, means 61.48 percent of PM2.5 concentration and 54.92 percent of PM10 concentration exceeded than the WHO reference value during the study period. PM concentration usually reached a peak during early morning (within 3:00 a.m.-5:00 a.m.) and at night (after 9:00 p.m.). PM2.5 concentration mainly depends on traffic congestion and temperature (adjusted R2=0.286), while PM10 concentration depends on traffic congestion and relative humidity (adjusted R2=0.292). Wind speed played a negative role in both PM2.5 and PM10 concentration with r=−0.228 and r=−0.266.
Originality/value
The air quality of the study area did not reach the satisfiable condition. The main cause of increased dust pollution in the whole study area was high traffic congestion (R2=0.63 and 0.60 for PM2.5 and PM10 concentration).
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Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial
No full textAssociation of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments : a WWARN individual patient data meta-analysis
No full textBackground: Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion. A molecular marker of the slow clearance phenotype has been identified: single genetic changes within the propeller region of the Kelch13 protein (pfk13; Pf3D7_1343700). Global searches have identified almost 200 different non-synonymous mutant pfk13 genotypes. Most mutations occur at low prevalence and have uncertain functional significance. To characterize the impact of different pfk13 mutations on parasite clearance, we conducted an individual patient data meta-analysis of the associations between parasite clearance half-life (PC1/2) and pfk13 genotype based on a large set of individual patient records from Asia and Africa. Methods: A systematic literature review following the PRISMA protocol was conducted to identify studies published between 2000 and 2017 which included frequent parasite counts and pfk13 genotyping. Four databases (Ovid Medline, PubMed, Ovid Embase, and Web of Science Core Collection) were searched. Eighteen studies (15 from Asia, 2 from Africa, and one multicenter study with sites on both continents) met inclusion criteria and were shared. Associations between the log transformed PC1/2 values and pfk13 genotype were assessed using multivariable regression models with random effects for study site. Results: Both the pfk13 genotypes and the PC1/2 were available from 3250 (95%) patients (n=3012 from Asia (93%), n=238 from Africa (7%)). Among Asian isolates, all pfk13 propeller region mutant alleles observed in five or more specific isolates were associated with a 1.5- to 2.7-fold longer geometric mean PC1/2 compared to the PC1/2 of wild type isolates (all p≤0.002). In addition, mutant allele E252Q located in the P. falciparum region of pfk13 was associated with 1.5-fold (95%CI 1.4-1.6) longer PC1/2. None of the isolates from four countries in Africa showed a significant difference between the PC1/2 of parasites with or without pfk13 propeller region mutations.Previously, the association of six pfk13 propeller mutant alleles with delayed parasite clearance had been confirmed. This analysis demonstrates that 15 additional pfk13 alleles are associated strongly with the slow-clearing phenotype in Southeast Asia. Conclusion: Pooled analysis associated 20 pfk13 propeller region mutant alleles with the slow clearance phenotype, including 15 mutations not confirmed previously
Genomic epidemiology of artemisinin resistant malaria
No full textAbstract: The current epidemic of artemisinin resistant Plasmodium falciparum in Southeast Asia is the result of a soft selective sweep involving at least 20 independent kelch13 mutations. In a large global survey, we find that kelchl3 mutations which cause resistance in Southeast Asia are present at low frequency in Africa. We show that African kelch13 mutations have originated locally, and that kelch13 shows a normal variation pattern relative to other genes in Africa, whereas in Southeast Asia there is a great excess of non-synonymous mutations, many of which cause radical amino-acid changes. Thus, kelch13 is not currently undergoing strong selection in Africa, despite a deep reservoir of variations that could potentially allow resistance to emerge rapidly. The practical implications are that public health surveillance for artemisinin resistance should not rely on kelchl3 data alone, and interventions to prevent resistance must account for local evolutionary conditions, shown by genomic epidemiology to differ greatly between geographical regions
