12 research outputs found
Sikap pengurusan di kalangan pengurus tempatan di Sekitar Kuala Lumpur dan Shah Alam / Lin Lay Nien
No full textKajian ini adalah mengenai sikap pengurusan di kalangan pengurus tempatan di sekitar Kuala Lumpur dan Shah Alam. Kajian ini juga cuba melihat sikap pengurusan tempatan dalam konteks teori-teori pengurusan Barat . Golongan pengurus memainkan peranan yang penting dalam peranvangan dan pejalanan sesebuah organisasi. Sikap pengurusan menentukan corak pengurusan yang dipraktiskan. Maka, kajian mengenai sikap pengurusan adalah penting kerana ia akan memberi kesan terhadap golongan pekerja. Bab I menerangkan tentang tujuan kajian, metodologi kajian serta masalah- masalah yang dihadapi semasa kajian dijalankan . Bab II memberikan satu gambaran kasar mengenai syarikat-syarikat yang terlibat dalam kajian ini. Data-data syarikat yang telah ditinjau adalah seperti struktur syarikat, barang keluaran, industri keluaran, jualan, jumlah milik aset, bilangan pekerja
dan metod pengeluaran. Bab III memberi satu gambaran menfenai profail pengurus yang terlibat dalam kajian ini. Profail pengurus ditinjau dari segi-segi seperti pangkat, jantina, umur, pendidikan, latihan , pengalaman kerja dan cara- cara memperluaskan pengetahuan. Bab IV memberi satu gambaran mengenai perkembangan teori-teori pengurusan seperti Teori Pengurusan Klasik, Teori Pengurusan Perlakuan dan Teori Pengurusan Moden. Bab V membincangkan mengenai gaya pengurusan yang meliputi perkara- perkara seperti andaian- andaian seorang pengurus terhadap pekerja, peranan pengurusan, motivasi , kesedaran pekerja terhadap objektif syarikat, proses membuat keputusan dan kepimpinan. Bab VI pula menerangkan tentang kesimpulan keseluruhan perbincangan bab- bab yang awal
[[alternative]]A Study on Junior High School Science and Technology Teachers’ Attitudes Toward and Understanding Of the Implementation of the Grade 1~9 Curriculum
No full text[[abstract]]The main purpose of this research was to understand junior high school science and technology teachers’ attitudes toward and understanding of the implementation of the Grade 1~9 Curriculum.
In terms of the questionnaire, we composed the “Survey Questionnaire on Junior High School Science&Technology Teachers’ Attitudes Toward and Understanding of the Grade 1~9 Curriculum” as our survey tool. Our formal survey questionnaire respondents were 800 Science&Technology teachers from 141 sampled schools in Taiwan’s north, central, south, east, and off-island regions. The data we obtained was run through the following statistical analysis tests: frequency distribution, independent-sample t-test, one-way independent-sample ANOVA, and Scheffe’s post-hoc comparison. We conducted these statistical tests with a significance level of α=0.05.
Based on the results of our findings, we reached the following conclusions:
1) Teachers’ Knowledge:
a) Science&Technology teachers’ comprehensive understanding of the content of the Grade 1~9 Curriculum lay between “understanding for the most part” and “complete understanding.”
b) Science&Technology teachers’ comprehensive understanding of the content of the Science&Technology course lay between “understanding for the most part” and “complete understanding.”
c) 1) “Accumulated time spent taking part in the Grade 1~9 Curriculum upgrade seminars,” 2) “Accumulated time spent taking part in Science&Technology course upgrade seminars,” 3) “Served as a curriculum committee member,” 4) “Served as an Science&Technology group convener,” etc., factors, influenced Science&Technology teachers’ comprehensive understanding of the Grade 1~9 Curriculum guideline’s content and the Science&Technology course guideline’s content.
2) Teachers’ Attitudes:
a) Science&Technology teachers’ total attitude toward the Grade 1~9 Curriculum implementation was extremely positive.
b) Science&Technology teachers’ total attitude toward the content of the Grade 1~9 Curriculum was extremely positive.
c) “Gender,” “educational level,” etc., factors, affected Science&Technology teachers’ total attitude toward the content of the Grade 1~9 Curriculum.
d) Science&Technology teachers’ attitudes toward this course’s content were positive.
e) “Presently serving as an Science&Technology group convener,” etc., factors affected Science&Technology teachers’ attitudes toward this course’s guideline.
f) There were differences in Science&Technology teachers’ attitudes about whether the Grade 1~9 Curriculum affected teachers’ professional development.
g) There were differences in Science&Technology teachers’ attitudes about whether the Grade 1~9 Curriculum affected the effectiveness of student learning.
h) 72.8% of Science&Technology teachers did not believe that implementing the Grade 1~9 Curriculum could reduce student academic pressure.
i) Over half of Science&Technology teachers—52.9%—did not believe that the Basic Achievement Test would benefit the cultivation of the Ten Basic Abilities .
j) Most of the Science&Technology teachers were willing to accommodate the educational reforms brought by the implementation of the Grade 1~9 Curriculum; the force dragging against the Curriculum is already becoming smaller and smaller.
k) Junior high school Science&Technology teachers didn’t feel very positive about all the effort made by school administrative personnel and other teachers to accommodate the Grade 1~9 Curriculum.
Based on our research conclusions, this research proposes the following suggestions, which should have reference value for the implementation of the Grade 1~9 Curriculum:
1) Observe students’ academic pressure and look for ways to relieve this pressure.
2) Reorient the role and function of the Basic Achievement Test.
3) Assist and supervise each junior high school put on the Grade 1~9 Curriculum development activities.
4) Set up a rewards system for educational personal upgrading their education; encourage teachers to move on to a higher level in their education.
5) Encourage teachers to act as school curriculum development committee members or Science&Technology group conveners.
Functional roles of ImpL and ImpK, the two core components of a type VI secretion system, in Agrobacterium tumefaciens
No full text蛋白質分泌系統是用來運輸分子進出細胞的管道。革蘭氏陰性細菌演化出至少六套分泌系統，在感知到特定之訊息時用來將分泌分子運輸跨過細胞膜至細胞外或運送到寄主細胞中。 Intracellular Multiplication F family (IcmF) 蛋白家族係構成第六型分泌系統的核心組成分子，為分泌第六型分泌系統分泌蛋白質hemolysin coregulated protein (Hcp) 所必需的。 雖 IcmF 蛋白質具有一段可與三磷酸核甘酸(NTP)結合的Walker A motif 的保守區域，但IcmF 在第六型分泌系統(T6SS)的功能仍完全未知。 本研究中，我們研究農桿菌中屬於IcmF蛋白家族的ImpL蛋白質，其生化功能及其在基質轉移機制及/或組成第六型分泌機構上所扮演的角色。 我們証明ImpL為一內膜蛋白質並與另個含有肽聚糖結合模體的內膜蛋白質ImpK(IcmH家族蛋白)形成複合體。 利用定點突變分析Walker A及新發現的Walker B NTP水解模體其對分泌Hcp的影響，我們提出第一個遺傳學證據去支持ImpL蛋白質可能扮演一個與NTP結合及NTPase的角色，以提供能量進而促使此分泌系統的組合及/或將相關蛋白質分泌至胞外。 更進一步的ATP的結合及水解活性的生化分析證明ImpL蛋白質確為ATPase且其Walker A及Walker B則分別貢獻其ATP結合及ATP水解的活性。 進一步蛋白質交互作用的分析發現Hcp會和ImpK直接結合但與ImpL則無交互作用，而在農桿菌中形成ImpL-ImpK-Hcp的複合體。 更進一步活體內及活體外之交互作用分析發現ImpL Walker A及Walker B 模體功能缺失的ImpL突變蛋白質仍會與ImpK 形成ImpL-ImpK複合體，但其對ImpL-ImpK-Hcp複合體的形成卻明顯受到抑制。 換句話說，ImpL的ATPase活性在有效趨動Hcp與ImpK-ImpL複合體的交互作用則是必需的。 利用Walker B突變蛋白質其具ATP結合但為ATP水解缺失之特性，發現ATP的結合足夠誘導ImpL蛋白質構型改變，但卻不足以趨動Hcp與ImpK-ImpL複合體的形成及造成Hcp無法分泌至細胞外。 此結果表示ImpL水解ATP所獲得的能量可以觸發ImpL-ImpK-Hcp複合體的形成，同時亦提供能量促使Hcp分泌至細胞外。 綜合所述，我們提出一動態模型說明了ImpL的ATPase活性為提供Hcp通過外膜所需能量之因子。 另外，位於內膜的ImpL-ImpK複合體架起了連結內、外膜，並穿過肽聚糖細胞壁且能讓基質穿越的通道。 而ATP的結合，可能改變ImpL的構型因而觸發ImpL寡聚合現象。 ImpL ATP的水解則提供並趨動ImpK與Hcp在質膜空間的交互作用形成ImpL-ImpK-Hcp複合體，同時供給能量促使Hcp穿過外膜並分泌至細胞外。Protein secretion systems play central roles in the export or import of macromolecules in both prokaryotic and eukaryotic cells. In particular, Gram-negative bacteria have evolved a variety of protein secretion systems named as type I to VI (T1SS to T6SS) for transport of substrates across their cell membranes into extracellular milieu or directly into host cells in response to environmental cues. The intracellular multiplication F (IcmF) family protein is a conserved T6SS core component that is essential for the secretion of the T6SS hallmark secreted protein, Hemolysin coregulated protein (Hcp), into extracellular milieu. Despite the conservation of its Walker A nucleotide-binding motif, the biochemical function of IcmF in T6SS remains obscure. In this dissertation, I characterized the biochemical properties and functions of two T6SS core components: the IcmF-family protein ImpL and its interacting protein ImpK, an IcmH-family protein, in the plant pathogenic bacterium Agrobacterium tumefaciens. I demonstrated that ImpL is a polytopic inner membrane protein that forms a complex with ImpK, which is a bitopic inner membrane protein containing a peptidoglycan binding motif. By generating the amino acid substitution mutations in the conserved nucleotide binding Walker A and hydrolysis Walker B motifs in ImpL that lead to the loss of Hcp secretion, we provided strong genetic evidence that ImpL may function as an NTPase to mediate Hcp secretion. Further biochemical analysis of purified ImpL and the Walker A and B variants demonstrated that ImpL exhibits ATP binding and hydrolysis activity contributed by the Walker A and Walker B motifs respectively. The Walker B mutant that uncouples ATP binding and hydrolysis activity of ImpL remains same degree of ATP-regulated protease susceptibility but loses its ability in recruiting Hcp to interact with periplasmic domain of ImpK into the ImpL-ImpK-Hcp inner membrane protein complex in vivo and in vitro. These data suggested that ATP binding induces conformational change of ImpL and ATP hydrolysis is responsible to drive the formation of ImpL-ImpK-Hcp complex and Hcp secretion. Taken all together, we proposed a model depicting the roles of ImpL and ImpK for Hcp secretion across outer membrane. The inner membrane localization of ImpL-ImpK complex might bridge the cytoplasmic and outer membrane components through a peptidoglycan layer to build a transmembrane protein channel. Upon ATP binding, ImpL undergoes a conformational change that may stimulate ATP hydrolysis to drive the dynamic interaction between Hcp and periplasmic domain of ImpK to push Hcp secretion from periplasm to extracellular milieu.中文摘要 i
ABSTRACT iii
TABLE OF CONTENTS v
LIST OF TABLES vii
LIST OF FIGURES viii
LIST OF APPENDICES ix
CHAPTER 1: Introduction 1
Protein secretion systems in Gram-negative bacteria 2
Type VI secretion system (T6SS) 5
Discovery of T6SS in Agrobacterium tumefaciens 9
NTPases of protein secretion systems 10
CHAPTER 2: An IcmF Family Protein ImpLM, Is an Integral Inner Membrane Protein Interacting with ImpKL, and Its Walker A Motif is Required for Type VI Secretion System-Mediated Hcp Secretion in Agrobacterium tumefaciens 21
ABSTRACT 22
INTRODUCTION 23
MATERIALS AND METHODS 27
RESULTS 35
DISCUSSION 43
CHAPTER 3: The Type VI Secretion ATPase ImpL Energizes ImpL-ImpK-Hcp Complex Assembly and Hcp Secretion 61
ABSTRACT 62
INTRODUCTION 63
MATERIALS AND METHODS 66
RESULTS 73
DISCUSSION 81
CHAPTER 4: Conclusions and Future Prospects 98
REFERENCES 103
APPENDICES 11
[[alternative]]A Study on the Junior High School Integrative Activity Teachers’ Knowledge and Attitudes toward the Grade 1-9 Coherent Curriculum
No full text[[abstract]]The main purpose of the research was to understand junior high school Integrative Activity teachers’ cognition and attitudes toward the Grade 1~9 Coherent Curriculum.
Questionnaire survey and focus groups interviews were used. In the literature reviews section which constituted a theory background for this research, it discussed the 1-9 curriculum and the essence of Integrative Activity learning, and the teachers’ knowledge and attitude toward the reform program. In terms of the questionnaire, we composed the “Survey Questionnaire on Junior High School Integrative Activity Teachers’ Cognition and Attitudes Toward the Grade 1~9 Coherent Curriculum” as our survey tool. Our formal survey questionnaire respondents were 800 Integrative Activity teachers from 141 junior high schools across Taiwan selected from the northern, central, southern, eastern, and off-island regions. 446questionnaires were returned（i.e.,55.8% return rate）.The data was analyzed used SPSS 8.0 for Windows to perform description statistics, independent-sample t-test, one-way independent-sample ANOVA, and Scheffe’s post-hoc comparison.
Based on the findings, the research obtained the following conclusions:
1)Aspect of cognition:
The purpose of the research on aspect of cognition was to
understand the junior high school Integrative Activity
Teachers’ Cognition toward the following two sections：（1）The content of the Grade 1-9 Coherent Curriculum Framework（2）The content of the Integrative Activity course.
a)The junior high school Integrative Activity teachers’
cognition toward the Grade 1~9 Coherent Curriculum appeared
on“understanding for the most part.” and “complete
understanding.”
b)Integrative Activity teachers’ cognition toward the
content of the Integrative Activity course lay between
“understanding for the most part” and “complete
understanding.”
c)The cognition of individual teachers to the content of 1-9
Curriculum had a large variety due to the locations of the
schools, the school year of field-testing，ages，the
highest record of formal schooling, years of teaching，
their job duties, if the subject is a member in the
Curriculum Development Committee, if the subject serves as
the chair of the Committee, and the total credits of
training courses for the 1-9 Coherent Curriculum.
d)The cognition of individual teachers toward the content of
the Integrative Activity course were varied due to the
locations of the schools, the school year of field-testing，
ages，the highest record of formal schooling, years of
teaching，their job duties ,if the subject is a member in
the Curriculum Development Committee, if the subject serves
as the chair of the Committee, the course of teaching and
the total credits of training courses for the 1-9 Coherent
Curriculum.
2)Aspect of Attitudes:
The purpose of the research on aspect of attitudes was to
understand the junior high school Integrative Activity
Teachers’ Attitudes toward the following three sections：
（1）Curriculum reform（2）The belief of teachers（3）The
circumstance of the education system.
a)The junior high school Integrative Activity teachers hold
more positive attitude toward the 1-9 Coherent Curriculum
Reform.
b)The junior high school Integrative Activity teachers’
cognition toward the Grade 1~9 Coherent Curriculum draw
the conclusion between “disagreement and agreement”.
c)Teachers have different responses to the contents of the 1-
9 Curriculum due to the number of classes and the course
of teaching.
d)The junior high school Integrative Activity teachers are
generally positive regarding the content of Integrative
Activity learning.
e)The attitude of the junior high school Integrative
Activity teachers toward the Integrative Activity course
have great variety due to the locations of the schools,
heir job duties , if the subject is a member in the
Curriculum Development Committee, if the subject serves
as the chair of the Committee, the course of teaching and
the total credits of training courses for the 1-9
Coherent Curriculum.
f)The junior high school Integrative Activity teachers hold
extremely positive belief towardthe Grade 1~9 Coherent
Curriculum
g)he belief of the junior high school Integrative Activity
teachers toward the Grade 1-9 Coherent Curriculum was
varied based on the school year of field-testing, ages,
years of teaching, their job duties , the course of
teaching and the total credits of training courses for
the 1-9 Coherent Curriculum.
h)The junior high school Integrative Activity teachers’
cognition toward the climate of the education system
draw the conclusion between “disagreement andagreement”.
i)The locations of the schools, the school year of field-
testing, if the subject serves as the chair of the
Committee and the total credits of training courses for
the 1-9 Coherent Curriculum,” etc. The factors such as
affected Integrative Activity teachers’ attitudes
toward the circumstance of the education system.
Based on the research conclusions, several suggestions for in-service seminars in the future are made in the last sections.
Greening textile industry in Vietnam
No full text The textile and garment industry has made a remarkable contribution to the economic development of Vietnam and employs currently a large labor force of 2.5 million people.However, the textile industry is also seen as a most polluting and unsustainable industry due to the use of excessive amounts of materials and the release of large amounts of pollutants into the environment. In order to improve the environmental sustainability and effectiveness of the textile industry in Vietnam this study has looked into preventive measure, reuse/recycling options and improved end-of-pipe technologies, separately and in combination. The end-of-pipe treatment is the last step in the greening production model. Textile wastewater is very difficult to treat, especially regarding the high color intensity. Removal of color from textile wastewater was studied by varying the pH, the application of a biological treatment step, the application of coagulation/flocculation and of Advanced Oxidation Processes (O3, O3/H2O2, Fenton’s reagent). The coagulation process was very effective in color removal of insoluble dyestuffs (98%), but this process is not so suitable for wastewater containing only soluble dyestuffs (12-55%). Of the Advanced Oxidation Processes, the Fenton’s reagent process was the most effective method for color removal (81-98%)for the four types of wastewater tested. The decolorization with the ozone process at low pH (pH 5)showed that direct oxidation by molecular ozone is much more selective in color removal than the oxidation by hydroxyl radicals. The presence of colloidal particles caused a 12-fold increase for ozone needed to obtain the same color removal efficiency as for a wastewater without colloidal particles.Each of the investigated processes could only remove one or a few types of pollutants from the wastewater, with the consequence that effluents could not meet all the discharge regulations. The combination of an activated sludge process, and a coagulation and ozone process yielded the best color (45 Pt-Co) and COD (30 mg O2/L) removal at the lowest costs (0.3 €/m3), compared with all other tested combinations. Separate collection of wastewater streams in a factory can also strongly contribute to the efficiency and sustainability of wastewater treatment. In the wet processes of the textile industry 75% of the total water consumption is for rinsing purposes. Wastewater from most rinsing steps contains low amounts of pollutants and can be reused in other process stages or can be discharged without treatment. An industrial ecology zone model, integrating preventive cleaner production approaches, a waste exchange network for reuse and recycling, and new end-of-pipe technologies, has been developed and assessed in two case studies: the Thanh Cong Company and the Nhon Trach 2 Industrial Zone. The greening production model developed for the Thanh Cong Company, a large-scale textile company in Hochiminh city, included the combination of cleaner production, external waste exchange and end-of-pipe technology. The dyestuffs, auxiliary chemicals, water and energy consumption can be reduced significantly when the proposed cleaner production, the external waste exchange options and the improved end-of-pipe technologies are implemented. Total benefits in savings per day can be more than 1,000 US$. The industrial ecology zone model was designed in three steps. Firstly the greening production model developed for the Thanh Cong Company was applied to all textile enterprises in the industrial ecology zone that was considered. Secondly an outside waste exchange network was designed. The outside network includes reuse of waste plastics, waste paper and waste oil at recycling companies in the neighborhood. The last step is to treat solid waste and polluted air and to treat and reuse wastewater for irrigation (cotton cultivation), for use in sanitary systems and to water plants in the industrial zone. The case studies of the greening production model and of the industrial ecology zone model demonstrated that a successful industrial ecology practice not only depends on the interaction between enterprises inside but also on the interaction with the actor networks outside the industrial system:the economic networks, the social networks and the policy networks. These networks can contribute in different ways to the implementation of the models. In the case study of a large textile company the economic network is very important in the implementation of the greening production model and in the case study of an industrial ecology zone the policy network play the most important role in the implementation of the industrial ecology model. </p
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Proteomics as a tool for the characterisation of nosocomial pathogens
No full textThe aim of the present investigation was to develop and assess the potential of various proteomic approaches for the characterisation of two major nosocomial pathogens, S. aureus and C. difficile and to further investigate the intraspecies diversity of C. difficile using a genotypic approach. The surface-associated proteins of S. aureus and intracellular stable ribosomal proteins of C. difficile were analysed by MALDI-TOF-MS and the resulting spectra interrogated using two databases viz. MMU (Waters®) and SARAMIS™ (AnagnosTec) respectively. A total of 134 clinical S. aureus isolates were tested using the MMU database and the MicrobeLynx™ software. All were successfully identified with minor contamination errors that corroborated with 16S rRNA sequencing. By contrast, C. difficile isolates were only partially identified (to the genus level) using the MMU database and protocol. Changes in the matrix solution and use of the new database (SARAMIS™) resulted in the correct identification of all C. difficile isolates and, detailed ultra-structural studies indicated that intracellular proteins were the new diagnostic biomarkers
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No full textSailg lain Alto ®tmi>B
TWENTY-FIFTH YEAR.
EIGHT PAGES.
!*AU* ALTO. CAL. THURSDAY. MAY 17. 1017
EIGHT PAGES.
NO. .05.
RANGES
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WANT VOLUNTEERS
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to station. Very reasonable.
Apply
Dudfield Lumber Co.
Palo Alto
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.year 3 12 per cent gold i.nnds of an
| i**u*- author I led bv tin «n of con
!get-as approved April 2*. IS-17
Application may be made at the
j banks, at Ibe pv-iofflce or al the
Time* office
Itotid* [-ayabie io bearer, with in
; teres: r*oapoo* attached, will be la*u«-d
, in denominations of J&O. I10&. |&00.
'and II.ih.0
; llond* r«*gl*ier-*d as to prtnrlpa) and
j tdtereai in ihe name of the buyer will
t- Issued in denominations of {100.
fSM. It.OOt), $10,000. fSO.DOO aod 1100.
{000
The bonds will be dated June li.
11*17, and will bear lnt.-r*-«t at-thi- rate
'of .1 1 2 per cent per arrYiutn from that
.date, payable seml-anmiailv on fx-i,-m
ber }b and June ir. The bond* will
(Continue** on page tl)
SEVEN MEN ALREADY VOLUN
. TEER SERVICES—1? MORE
ARE NEEDED
County n.-rk il a Pflater i* aak
lug fot volunteers for one day lo con
duct the reflet ration „f men subjet-l
to draft Two ti.ei. ar.- needed for
each precinct and these volunteer*
will be swom In a* federal official*
for this work The (.*dt-ral govern
m-nt tasks th-it »,r sor-.le* of both the
m.-n and th.- use of the polling plar»s
(Continue,) on page *• >
AKK IS AHOl T
TIMOTHY WH'hlNS LOTS
THK 1 •KIVKIttlTV ltl-.A1.TV
COMPAN I
Palo Alto **..i. 1 t.ior'no
In Memorial Cburcb this evening
Mia* KHeen Everett, a graduate of
Stanford Culv.vslt) and a resident
of Orange. Cal . «lll become the
bride or Krneet tl Folsoni 10 of
the tnlverstty of Nevada Th* Rev.
1> Char In* Gardner will perform the
ceremony
IClnboret* piepaiaitons hnva
I n made tor ihe wedding. **.ilrh
I* eapeeled to Ik* Otic nl the preltlest
of the ■•-.' The liiiiK'h l* lo be
decorate**] in pink
Miss KiiTsbeth Maynard will he
the maid of honor, while Frank Folsom. a brother of the bridegroom,
will )>** host man The Ml—.-* .Ml.
snd Ruth Rowan will b* flower girl*,
whtlit the sorority -Inters of the
bride, the member-, ol Mphs Oml-
■ ron I'l. will be garland bemers
Ini nk Klilrn nn.l Wilbur Thoburn
nre the uabar*.
Haniid Rvereti. brother of lb*
bride wilt li'ii.l tils sk*|er to Ihe altar when- her mother Mr* F I.
Bvertat will Rlie her away The
double tin-: leremony I* lo be n*ed
After Ibr weddtni- reremon* sn.
Informal ret-optlon " 111 be held .iti
il." \lplia i*niI-run house and the!
••li,-la- a1|| Iht**TI leave Nil Ca-iii.'l '
■Alien- ih-** u.|)l spend • t*-**■ hone*
mi.-.ii The. nre t nke iheir
hum*1 In ('arson <*i'i Me. where
Ml Col (ain ha* Ui-.li..-. Inloi eat *
Mn I'uUoiIi -ll' : '..mllii-tit nt :
Staiifoid diliin* het lei graduate
rtn*. For [WO i-*iii« -br *m *et*re-
tj.*. ,.f tf,.* Stanford \ w c A
Donates Ambulance For
Stanford Wen on
French Front
MH*. s \|. m"Vi,ih\i, t.ltl*** \i\.
illlM \*. MRMOItl II. Til HKH
l»Kt*KAMlSll KATHKIt
Mr. H M Spuldloi; ol Menlo
Park lo-ta) donated to the third
Slanlotd anibulanre unit - ompletely1
•*t,illpp«tj sinl.ulan**.* a hlch the
■ Stanford men will drive al tho
| French front The ambulanre |* n
i memorial fot in-- father, Chart**
j t'aiiiOi'l.i who (lied ul.o.it three
tiwirs ago in |.o* Angi 1<- nnd It
: a ll» lieai hi* name
■\ Ullum t;ib'-on «ho I* leading
tl..- third nnli ia now making ar
1'angementa for ih.- purehase of the
*rti t.n la tu-.- u* l.l- h ail) <o-f al.oul
|l.Cno This Is the sa**ond ambu-
. lan*e wblefa has b*-.-n donated by
j M.-nlo park people Th- first one
of Menlo
1'a
li seem* that even war can't
make the student* of Klanford and
California forget their rivalry. IB
(set the war has been th* '-ause of
unite rivalry, snd a.vordlng to word
from New York clly Ihe Cardinal
has slipped anothel rlctorj over on
the Pine and I)Old
The '.n» wbl.h l* now on between tin- tw" universities Is to
carry ihe nt nt American flag to lh*
Frenrh l.fttllefrout
Aithiii Kimber of I'alo Alto, a
Slanfoid man. left recently for Sew
York t<**si ink a large American (lag
whte-g he stinomiied would be carried to i ,ii.. a* t he fir*! official
\nii-rlnn Mag to hear tbe hum of
hull..t* In Franc* Tbia ..nnmtn.e-
m-.nl it*mhi*d (lie ear* of certain
Iterkrle* men «ho nre nlso going
ki Fran-'' lo etriie amhulnne-es. and
they di'li-Miiined (o rob him of tb*
hone.t
Kimber i.-lu* lh* eacltlng story of
how (he Herkelev contingent nearly
i Continued "■* paga 4)
SENIOR FARCE IS
1/
Florence Maaon and Mary Flower*. Arc Women Stars in
A Full House"
Feed and Fuel
W. O. HOR4BIN
2JJ HAMILTON AVCl*.
PHO** PAIaO ALTO —
J AX 17
PHONE
15
AM,III'. TAXI tKRV.C*
25c Service
Special Kates for Trips
Town Taxi
I'iniVE
25
aKiiviit:
25c
STANFORD SHQE SHOP
Vou can Mvr money snd tunc lay
letting us save your aolcs-
VY( ■*> lha-
OOODVILAR WILT SVSTliM
l.ailoam niOidi f P.....
Duk J«lin.ston .Bay Murray. B.
B Rohmson .ind Blondy
Paul Arc Mnlr St.irs
Mi nil star caul outdid llaelf u.*t
night in the produntlon "' A Full
House ' and a* a re.uM 'he 1917
saniot fan • *> ui ion* live in the
memories of Stan ford student* aa
one or the beat comedies that has
ever **ten the Inside or the Stanford
assembly hall
There were two reason* why the
tdr audience went home pleased:
flrai the piny Itseir wan full of clever 11 .on. .-lied situation*, secondly,
the** km.unions sere ably handled
by ever* one of the characters Thera
w-nsn i ', weak apol on Frank
Mathieti * . a*I who showed his usual
good judgment ln the Hr.-Htm of
parts
Perhaps the moat dlhVult part of
tin* evening waa thai played by Mlaa
Flowers, .is Susie the mild Mis*
[Continued nn paga 4)
MARQUEE
THEATER
llltAt. V,NT..-AT.ON
home oi thiamii.i:. METgOan* woki.i) i i;atuki;s
TKIANQLI-: PRODRAM-William S. Hart In
"The Desert Man"
In Cilia lm,- i lT-Un|t.e play Mr. Hull M.umr*. a new ami -.tr.m^.-r
,1mm, irr—(li«t ot a man ihruugll fulth. (»-i --.-,,. „i„ , ami i tiur
a*ie Min- out—irlH.H aaj hi* In**., t.l.tur*..
"HIS I>AI1M>K /iMf■—TKIAM.I l KOMRI>V.
AIM l,T*l I.V
M.I.I 7:18— Marine* 2:HO
('HII.IIKKN Re
MAT! KJlAl — Mtlti;i. TIMU FltlUi in -THK HAItilKAIiK.
Mi-rrim i-i.*!.
MOTOR TRUCKS
Fl KMT. Kl MOllNfl
l.ong aud ai.ort Hauls.
Prompt and *pecla* *tt*n(lon
glvan io t.aggage order*
ritoNB *>o
Palo Alto Transfer anl
Storage Company
ill cii'i i.r
PHONE 13
FORTUNE TAXI
Day and Night Service
Special prices on parties and trips
108 Circle Palo Alt
Friend, 1875-10
No full textPublished by the Rev. Samuel Chenery Damon from 1845 to 1885, The Friend focused on temperance and Christian mission to seamen. It began as a monthly newspaper that included news from both American and English newspapers, and gradually expanded to adding announcements of upcoming events, reprints of sermons, poetry, local news, editorials, ship arrivals and departures and a listing of marriages and deaths. From 1885 through 1887, it was co-edited by the Revs. Cruzan and Oggel. The editorship then passed to Rev. Sereno Bishop, who held the post until the publication of the paper fell under the auspices of the Board of the Hawaiian Evangelical Association in April of 1902 where it remained until June 1954. Since then, it has continued in a different format under the Hawaii Conference-United Church of Christ up to the present day, making it the oldest existing newspaper in the Pacific. Note that there are some irregularities in the numbering of individual issues, so that two issues may have the same volume and number, but different dates will distinguish them.T h e Pacif"ic. E~tablished ,..,,_.,.~.....,__~~.~y 18, 1-0 ~1- _/ {@lb Stries, fol. S2. CONTE~TS Fo1• Octobet• l,JS7;j. PAGE What Causes the Mildness of our Climate?............ 81 An Englishwoman on Hawaii ........................ 81-82 F.ditor·~ \u27l\u27ahle....................................... 83 Letter from Japan................................... 83 !Capiolaui, a Poem .........•...•...••..•••.....•..... 84-85 Ttie two great Poems of lnuia........................ 86 86 Murder of Commodore Goodenough................... Y . M. C. A......................................... 88 current when it reaches the North Paci fie comes nearer the ~urface than it does in the Southern Ocean, even in higher latitudes, and this, modifying still further the reflux surface flow towards the Equator, would appear to account for the well-known moderation of the 8andwich Islands climate, though they lie within the tropic of Cancer. ln rending this paper of Dr. Carpenter. and noting the amount of information deI rived from the cruises of the U. S. S. Tus: cm·ora and H. B. M. S. Challenger, we could not but deplore the fact that more of OCTOBER 1, 181:\u27; • • our national vessels in times of peace were What Causes the Mildness of Our Climate 1 not employed in scientific cruises. How much better for officers and men to be ·emD1;. Carpenter read an interesting paper ployed in the cause of science, than in merebefore the Royal Geographical Society in ly making passages from port to port, or London June 28th, which is reported in the lying idle for .months in foreign ports. August number of the Geographical MagaU We take much pleasure in copying zine. This paper was based upon the ob~ervations taken by the Cliallengm· and from the London Leisiwe .liour a beautiful Tusca1;m·a. Among the conclusions drawn poem, suggested by a remarkable incident in from these· observations, Dr. Carpenter ad- Hawaiian history and the life of the chiefess vanc~s the theory, that the mildness of our Kapiolani. This incident is one which is climate on the Sandwich Islands is owing not well caiculated to give inspiration to the so much to "currents" in the atmosphere as poet. Some years ago we published a simito "currents " in the ocean. He argues that lar poem upon the same theme, written by the glacial current from the south pole is an English clergyman, the Rev. Robert vastly operative in the North Pacific! Grant, B.C.L., fellow of Win chester College, We copy as follows from Dr: Carpenter\u27s &c. See FRIEND for August, 1866. Lord Byron, (cousin of tlie poet) when he visited report: the islands, becoming acquainted with the The observations taken alona the northern line appear to point out that in the North facts, thus comments upon the same event Pacific there is the general want of that sub- as " one of the greatest acts of moral coursurface stratum of above 40 ° F., which in age which bas perhaps ever been performed; ~he North Atlantic under the same or yet and the actor was a woman and, we are higher parallels has a thickuess of at least 500 fathoms. The true cause of this pecu- pleased to call her, a savage." See history liarity is that the North Pacific derives its of the " Blonde." deep stratum of glacial water, which nearly fills its basin, from the Polar area of the opBETHEL F LAG.-W e would acknowledge po:-;ite hemisphere, th€\u27 inlet at Behring\u27s the donation of a new Bethel flag from the .Straits being too narrow and too shallow to "sail loft" of J. M. Oat & Co. Many :admit a flow of water of any appreciable imthanks. portance. This northward flow of water THE FRll~ND, !from the Equator must have as its complement a movement of the superficial stratum from the northermost limit of this flow towards the Southern Pole. The glacial AN ENGLISHWOMAN ON HAWAII. Some months ago we copied some extracts from Miss Bird\u27s book, but on giving the volume a second reading, we meet scores of paragraphs and passages which we should be glad to republish in our columns. 1t is a book of genius; it is a prose-poem. Some of her descriptions of mountain and valley scenery are exquisitely beautiful and truthful. She revels m the beauties of wild nature. English naval officers (as we happen to know) sitting around their mess-table and touching their champagne glasses, may smile at what they style lV~iss Bird\u27s descriptions as good specimens of "gush " in literature, but until they explore our mountc1ins and valleys on horseback, and after a hard day\u27s ride of forty miles over the rough and rugged lava roads of Hawaii, can sit down in a· native hut by the dim light of an old lamp, and write such letters as this volume contains, we think these critics may modestly withhold their supercilious comments. Miss Bird came to the islands nn invalid, and totally ignorant of what they contained. She came, too, with perhaps a tinge of prejudice, and at first thought of spending only a month, making merely a rapid trip to the crater of Kilauea; but how changed her plans, when with the eye of a poet, a naturalist and a scientist, she began her explorations. For months she roamed over the islands, and this volume of letters to her sister in England, are the "jottings " which she noted from day to day. They partake. of the sweet perfume of the fields and the woods, the valleys and the mo untains. We regret that our book-sellers are so tardy in, placing the volume upon their counters. A few copies- were received by the last s~eamer, and are for sale at Thrum\u27s, and we learn that Whitney expects some by th~ ne~t arrival from San Francisco. When we first U- In our last issue several typographical glanced over this book, we w~r~ so much errors appeared in the Jetter of the Rev. Dr. p1eased with its contents that we ordered Boyd, which we sincerely regret. from London , by mail \ thrPe copies to be 0 8.2 \u27J\u27 II •~ It" R I JiJ N D , 0 C 1, 0 B -\u271~ It , l 8 7 5 . forwarded to friends m the United States, loneliest, saddest, dreariest expanse I ever and the remain1t1g copy now lies before us. saw. The ait was clear and the sun bright, yet Our limits only allow us to copy a few i:iothing softened into beauty this formless paragraphs relating to her second trip to desert of volcanic sand, stones, and lava, on Hawaii and her ascent of Mauna Kea. But which tufts of grass and a harsh scrub war few foreign ladies can pride themselves upon with wind and drought for a loveless existence. Yet, such is the effect of atmosphere, st eep that Mauna Loa, utterlv destitute of vegetahaving asce nd ed th is rugged a nd mountain: tion, and with his sides scored and stained I delight in Hawaii more than ever, with by the black lava-flows of ages, looked like its unconveniential life, great upland sweeps, a sapphire streaked with lapis lazuli. Nearly unexplored forests, riotous breezes, and gen- blinded by scuds of sand, we rode for hours ·· era 1 atmosp here off ree d om, amness, an d ex- through the volcanic wilderness·, always the pansion. As I find that a lady can travel same rigid niamane, (Sophora Chrysoalone with perfect safety, I have many pro- phylla ?) the same withered grass, and the jects in view, but whatever I ,000 to 6,000 feet, there is not a single ;native dwelling on it, or even a trail acr-0ss it, it is totally destitute of water, and sustains only .a miserable scrub of rna.mane, stunted oliias, pu1ceawe, olielos, a few .compositre, and some of the hardiest ferns. The transient residents of this sheep station, and those of another on Hualalai, thirty miles off, are the only human inhabitants of a region as large as Kent.- W il<,l goats, wild geese .(}3ernicla sandvicensis), anc;l the Melithreptes ,Pacifica, constitute its chief population. These geese are web-foote~, though water does not exist. They build their nests in the grass, and lay two or three white eggs. Our track from Waimea lay for the first few miles over light soil, destitute of any vegetation, across dry glaring rocky beds of streams, and round the bases of numerous tufa cones, from 200 to 1,500 feet"in height, with steep smooth ~ides, composed of a very red ash. We crossed a flank of Mauna Kea at a height of 6,000 feet, and a short deseent brought us out upon this vast table \u27land, which lies betwP.en the bulbous domes of M auna Ken, Mauna Loa , and Hualalni, the deep snow on the crest of the highest peak in the Pacific, 13,953 feet above the sea. This summit 1s a group of six red tufa cones, with very little apparent difference in their altitude, and with deep valleys filled with red ash between them. The terminal cone on which we were has no cavity, but most of those forming the group, as well as the thirty which I counted around and below us, are truncated cones with craters within, and with outer slopes, whose estimated angle is about 30 On these slopes the snow lay heavily. In coming up we had had a superb view of Mauna Loa, but before ,ve reached the top, the clouds had congregated, and lay in glistening masses all round the mountain about half-way up, shutting out the smiling earth, and leaving us alone with the view of the sublime desolation of the volcano. We only remained an hour on the top, and came down by a very circuitous route, which took us round numerous cones, and over miles of clinkers varying in size from a ton to a few ounces, and past a lake the edges of which were frozen, and which in itself is a curiousity, as no other part of the mountain "hold:s water." Not far off is a cave, a lava-bubble, in which the natives used to live when they came up here to quarry a very hard adjacent phonolite for their axes and other tools. While the others poked about, 1 was glad to make it a refu ge from the piercing wind. Hundreds of unfinished axes lie round the cave entrance, * Mauna* Kea, and * the forests * * * and there is quite a large mound of unfinwhich skirt ished chips. his base are the resort of thousands of wild This is a very interesting spot to Hawaiian cattle, and there are many men nearly as antiquaries. They argue, from the amount wild, who live half savage lives in the woods, of the chippings, that this mass of phonolite gaining their living by lassoing and shooting was quarried for ages by countlPss generathese anim.al.s fo,r ,thei;r s,kins. Wild black tions of nien, and that the mountain top swine also abolJlnd. must have been upheaved, and the island The mist as us,u:;tl disappeared at night, inhabited, in a very remote past. The stones leaving a ~ky wo:nderful with stars, which have not been worked since Captain Cook\u27R burned blue and pale against the furnace day; yet there is not a weather-stain upon glare on the top of Mauna Loa, to which we them, and the air is so dry and rarified that are comparatively near. I woke at three meat will keep fresh for three months. 1 from the hopeless cold, and before five went found a mass of crystals of the greenish ,out with Mr. Green to explore the· adjacent volcanic glass, called olivine, imbedded in a lava. The atmosphere was perfectly pure, piece of phonolite which looked as blue and and suffused with rose-color, not a cloud- fresh as if only quarried yesterday. fleece hung round the mountain tops, hoarWe traveled for miles through ashes and frost whitened the ground, the pure white srorire, and then descended into a dense smoke of the volcano rose into the reddening afternoon fog; but Mr. S. is a practiced sky, and the air was elixir. It has been said mountaineer, and never faltered for a moand written that there are no steam-cracks ment, and our horses xpade such good speed or similar traces of volcanic action on Mauna that late in the afternoon we were able to Kea, but in several fissures I noticed ferns warm ourselves by a gallop, which brought growing belonging to an altitude 4,000 feet us in here ravenous for supper before dark, lower, and on putting my arm down, found a having ridden for thirteen hours. I hope 1 heat which compelled me to withdraw it, have made it cJear that the top of this dead and as the sun rose these cracks steamed in volcano, whether cones or ravines, is deep all directions. There are caves full of ferns, soft ashes and sand. lava bubbles in reality, crust over crust, each To-morrow morning I intend to ride the from twelve to eighteen inches thick, rolls of thirty miles to Waimea with two native lava cooled in coils, and hideous a-a streams women, and the next day to go off on my on which it is impossible to walk two yards adventurous expedition to Hilo, for which I without the risk of breaking one\u27s limbs or have bought for $45 a big, strong, heavy \u27cutting one\u27s boots to pieces. horse, which I have named Kahele. He has * * * .J!: * * the poking head and unmistakable gait of a After riding steadily for six hours, our bullock horse, but is said to be "a good horses, snorting and panting, and plunging traveler." up to their knees in fine volcanic ash, and halting, trembling and exhausted, every few A disposition to do good, and go forward feet, carried us up the great tufa cone which in duty, at any sacrifice, in the face of any crowns the summit of this vast fire-flushed, obstacle, is the best evidence of grace in the .fire-created mountain , and we dismounted in heart. °. 1• \u27fBE FRIEND, OC\u27fOBEll, EDITOR\u27S TABLE. THE HAWAIIAN GurnE Boox FOR TRAVELERS, con- taining a brief description of the Hawaiiau Islands, their Harbors, Agricultural Rebources, Plantations, Scenery, Volcanoes, Climate, Population, and Commerce. First edition. Published by H. M. Whitney, Honolulu, H. I., 1875. We take special interest in calling attention to this book of 144 pages. It is " multum in parvo.\u27\u27 We only wonder somethrng of the kind nas :not previously been issued, and only shows that we move rather slowly at the Sandwich Islands. The author of this little book is really a " live \u27\u27 man so far as types are concerned, and it seems strange that he h~ not previously started on this line of publication. Better late than never, as the old adage runs, and now, having a guide book, we recommend all persons desirous of gleaning information respecting o\u27ur islands to invest in the purchase of this book, and they may rely upon the information which it contains. The price is only sixty cents. Any of our readers in America or England who will send us seventy-five cents in postage stamps, we will send them by mail a copy of this little book. Correspondent in Japan. KoBE, JAPAN, Aug. 4th, 1875. R ev. S. C. Damon :-I suppose you will be glad to hear of the recent movement at Sanda, twenty miles northwest of Kobe. On the 27th ult. a church was organiied there. While so much is being done to circulate the Bible, it is cheering to know how the Gospel wa::; first introduced at this station. Some ten or fifteen years ago a Bible or two in Chinese was left there, by whom we kaow noT. The Daim_io, being a liberal man, did not binder those who understood that language from reading it. The number who read or heard it grew large, and became much interested in it. Hence when Mr. Davis, two years ago, began to preach there, they gladly received his message. And it is said most of the church members of Kobe were originally from Sanda; and now a church of seven males and nine females has just been organized there. The house in which the church was organized has an interesting history. It is a one-story building, probably 100 feet by 50, covered with tile, and is said to have been built three hundred years ago, (fifty years before the pilgrims arrived in New England) and to have been occupied, until the recent revolution, by the Daimios, viz., governors of that district. The last one now lives in Kobe, aud his mother is a member of the church here. It was recently sold to a compa ny in Sanda , who let out part of it for a dispensa ry a nd hospita l, a nd two la rge a nd 1875. two small rooms to the Bible venders; _a nd now to the church. Miss Dudley has spent four or five months with them, and several other female members of the mission, a week at a time, reading the Scriptures to and with them, and trying to show them their meaning. The year past my son has preached to them once a fortnight, and occasionally spent several days there instructing them. And when they wished t9 be organized into a church, Mr. Davis, being pressed with labors in Kobe, urged that my son should take the lead. It is said the work there has reached females more than at any other station in Japan. It is also remarkable that r.nost of the converts there and at Kobe are · of the soldier class. They are pretty generally educated, and being now disbanded and their pension much reduced, they seem to be more ready than most to hear and embrace the Gospel. Imamura, who was with my son at the islands, is of that class, and seems now to be a true Christian. And those who understand Japanese ~ay he preaches well. His mother, who at first much opposed to his professfog Christianity, is apparently quite reconciled, and seems to be a serious inquirer; and I beHeve his wife is, also. Although I know almost nothing of Japanese, still it is sweet to hear the natives sing in familiar tunes, but in their own tongue, such hymns as " Rock of Ages," "Jesus Loves Me," "The Old, Old Story," "In the Sweet By-and-by,\u27\u27 and others of that class. In prayers, both public and private, there is one very striking and to me agreeable feature. When through the ordinary petitions of the leader, they repeat in conce1·t the Lord\u27s Prayer, which of course takes in the whole world. · As ever yours, in Christ, P. J. GULICK. A MoNUMENT TO BAXTER.-Only think of it,-Dean Stanley and other dignitaries of the Church of England uniting with Nonconformists in erectmg a monument or statue to the memory of Richard Baxter. We copy as follows frem the Pctcijic: Distinguished gentlemen antl dignitaries in Church and State graced the occasion with their presence. It is cheering to observe how much the memory of such godly men as Bunyan and Baxter is honored \u27in the times in which we live. A London paper says: " The statue is in gray Sicilian marble. The height of the figure is 10 feet; and it will be placed on a granite pedestal 12 feet high. The sculptor · has made use not only of the well-known portrait at Kidc,.lerminster, but also of others in the British Museum; and he has produced what is probably a faithful, and is certainly a striking and impreRsive, semblance of that great and earnest spirit who, in spite of bodily weakness, ever living as he did upon the very brink of the grave, achieved an amount of work which few men in robust health have equaled an
Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)
No full textEAS Familial Hypercholesterolaemia Studies Collaboration (FHSC): Antonio J Vallejo-Vaz, Christophe A T Stevens, Alexander R M Lyons, Kanika I Dharmayat, Tomas Freiberger, G Kees Hovingh, Pedro Mata, Frederick J Raal, Raul D Santos, Handrean Soran, Gerald F Watts, Marianne Abifadel, Carlos A Aguilar-Salinas, Khalid F Alhabib, Mutaz Alkhnifsawi, Wael Almahmeed, Fahad Alnouri, Rodrigo Alonso, Khalid Al-Rasadi, Ahmad Al-Sarraf, Nasreen Al-Sayed, Francisco Araujo, Tester F Ashavaid, Maciej Banach, Sophie Béliard, Marianne Benn, Christoph J Binder, Martin P Bogsrud, Mafalda Bourbon, Krzysztof Chlebus, Pablo Corral, Kairat Davletov, Olivier S Descamps, Ronen Durst, Marat Ezhov, Dan Gaita, Jacques Genest, Urh Groselj, Mariko Harada-Shiba, Kirsten B Holven, Meral Kayikcioglu, Weerapan Khovidhunkit, Katarina Lalic, Gustavs Latkovskis, Ulrich Laufs, Evangelos Liberopoulos, Marcos M Lima-Martinez, Jie Lin, Vincent Maher, A David Marais, Winfried März, Erkin Mirrakhimov, André R Miserez, Olena Mitchenko, Hapizah Nawawi, Børge G Nordestgaard, Andrie G Panayiotou, György Paragh, Zaneta Petrulioniene, Belma Pojskic, Arman Postadzhiyan, Katarina Raslova, Ashraf Reda, Željko Reiner, Fouzia Sadiq, Wilson Ehidiamen Sadoh, Heribert Schunkert, Aleksandr B Shek, Mario Stoll, Erik Stroes, Ta-Chen Su, Tavintharan Subramaniam, Andrey V Susekov, Myra Tilney, Brian Tomlinson, Thanh Huong Truong, Alexandros D Tselepis, Anne Tybjærg-Hansen, Alejandra Vázquez Cárdenas, Margus Viigimaa, Luya Wang, Shizuya Yamashita, John J P Kastelein, Eric Bruckert, Branislav Vohnout, Laura Schreier, Jing Pang, Christoph Ebenbichler, Hans Dieplinger, Reinhold Innerhofer, Yvonne Winhofer-Stöckl, Susanne Greber-Platzer, Konstantin Krychtiuk, Walter Speidl, Hermann Toplak, Kurt Widhalm, Thomas Stulnig, Kurt Huber, Florian Höllerl, Gersina Rega-Kaun, Lucas Kleemann, Martin Mäser, Sabine Scholl-Bürgi, Christoph Säly, Florian J Mayer, Gaelle Sablon, Eric Tarantino, Charlotte Nzeyimana, Lamija Pojskic, Ibrahim Sisic, Azra D Nalbantic, Cinthia E Jannes, Alexandre C Pereira, Jose E Krieger, Ivo Petrov, Assen Goudev, Fedya Nikolov, Snejana Tisheva, Yoto Yotov, Ivajlo Tzvetkov, Alexis Baass, Jean Bergeron, Sophie Bernard, Diane Brisson, Liam R Brunham, Lubomira Cermakova, Patrick Couture, Gordon A Francis, Daniel Gaudet, Robert A Hegele, Etienne Khoury, G B John Mancini, Brian W McCrindle, Martine Paquette, Isabelle Ruel, Ada Cuevas, Sylvia Asenjo, Xumin Wang, Kang Meng, Xiantao Song, Qiang Yong, Tao Jiang, Ziyou Liu, Yanyu Duan, Jing Hong, Pucong Ye, Yan Chen, Jianguang Qi, Zesen Liu, Yuntao Li, Chaoyi Zhang, Jie Peng, Ya Yang, Wei Yu, Qian Wang, Hui Yuan, Shitong Cheng, Long Jiang, Mei Chong, Jian Jiao, Yue Wu, Wenhui Wen, Liyuan Xu, Ruiying Zhang, Yichen Qu, Jianxun He, Xuesong Fan, Zhenjia Wang, Elaine Chow, Ivan Pećin, Dražen Perica, Phivos Symeonides, Michal Vrablik, Richard Ceska, Vladimir Soska, Lukas Tichy, Vera Adamkova, Jana Franekova, Renata Cifkova, Pavel Kraml, Katerina Vonaskova, Jana Cepova, Magdalena Dusejovska, Lenka Pavlickova, Vladimir Blaha, Hana Rosolova, Barbora Nussbaumerova, Roman Cibulka, Helena Vaverkova, Lubica Cibickova, Zdenka Krejsova, Katerina Rehouskova, Pavel Malina, Milena Budikova, Vaclava Palanova, Lucie Solcova, Alena Lubasova, Helena Podzimkova, Juraj Bujdak, Jiri Vesely, Marta Jordanova, Tomas Salek, Robin Urbanek, Stanislav Zemek, Jan Lacko, Hana Halamkova, Sona Machacova, Sarka Mala, Eva Cubova, Katerina Valoskova, Lukas Burda, Ahmed Bendary, Ihab Daoud, Sameh Emil, Atef Elbahry, Samir Rafla, Osama Sanad, Ghada Kazamel, Mohamed Ashraf, Mohamed Sobhy, Amro El-Hadidy, Mohamed A Shafy, Saif Kamal, Mohamed Bendary, Grete Talviste, Denis Angoulvant, Franck Boccara, Bertrand Cariou, Valérie Carreau, Alain Carrie, Sybil Charrieres, Yves Cottin, Mathilde Di-Fillipo, Pierre H Ducluzeau, Sonia Dulong, Vincent Durlach, Michel Farnier, Emile Ferrari, Dorota Ferrieres, Jean Ferrieres, Antonio Gallo, Regis Hankard, Jocelyne Inamo, Julie Lemale, Philippe Moulin, François Paillard, Noel Peretti, Agnès Perrin, Alain Pradignac, Jean P Rabes, Vincent Rigalleau, Ariane Sultan, François Schiele, Patrick Tounian, René Valero, Bruno Verges, Cécile Yelnik, Olivier Ziegler, Ira A Haack, Nina Schmidt, Alexander Dressel, Isabel Klein, Jutta Christmann, Antonia Sonntag, Christine Stumpp, Diana Boger, Dana Biedermann, Monica M N Usme, F Ulrich Beil, Gerald Klose, Christel König, Ioanna Gouni-Berthold, Britta Otte, Gereon Böll, Anja Kirschbaum, Jürgen Merke, Johannes Scholl, Thomas Segiet, Marco Gebauer, Florentina Predica, Manfred Mayer, Frank Leistikow, Sabine Füllgraf-Horst, Cornelius Müller, Melanie Schüler, Judith Wiener, Konrad Hein, Peter Baumgartner, Stefan Kopf, Reinhold Busch, Michael Schömig, Stephan Matthias, Nicole Allendorf-Ostwald, Bruno Fink, Dieter Böhm, Alexander Jäkel, Ann-Cathrin Koschker, Rüdiger Schweizer, Anja Vogt, Klaus Parhofer, Wolfgang König, Wibke Reinhard, Andrea Bäßler, Alexander Stadelmann, Volker Schrader, Julius Katzmann, Adrienne Tarr, Elisabeth Steinhagen-Thiessen, Ursula Kassner, Gerret Paulsen, Jürgen Homberger, Claudia Zemmrich, Wolfgang Seeger, Kathrin Biolik, Dorothee Deiss, Corinna Richter, Elina Pantchechnikova, Elena Dorn, Ulrike Schatz, Ulrich Julius, Antje Spens, Tobias Wiesner, Michael Scholl, Christos V Rizos, Nikolaos Sakkas, Moses Elisaf, Ioannis Skoumas, Konstantinos Tziomalos, Loukianos Rallidis, Vasileios Kotsis, Michalis Doumas, Vasileios Athyros, Emmanouil Skalidis, Genovefa Kolovou, Anastasia Garoufi, Eleni Bilianou, Iosif Koutagiar, Dimitrios Agapakis, Estela Kiouri, Christina Antza, Niki Katsiki, Evangelos Zacharis, Achilleas Attilakos, George Sfikas, Charalambos Koumaras, Panagiotis Anagnostis, Georgia Anastasiou, George Liamis, Amalia-Despoina Koutsogianni, Zsolt Karányi, Mariann Harangi, László Bajnok, Mária Audikovszky, László Márk, Béla Benczúr, István Reiber, Gergely Nagy, András Nagy, Lakshmi L Reddy, Swarup A V Shah, Chandrashekhar K Ponde, Jamshed J Dalal, Jitendra P S Sawhney, Ishwar C Verma, Mays Altaey, Khalid Al-Jumaily, Dilshad Rasul, Ali F Abdalsahib, Amer A Jabbar, Mohanad Al-Ageedi, Ruth Agar, Hofit Cohen, Avishay Ellis, Dov Gavishv, Dror Harats, Yaacov Henkin, Hila Knobler, Leah Leavit, Eran Leitersdorf, Ardon Rubinstein, Daniel Schurr, Shoshi Shpitzen, Auryan Szalat, Manuela Casula, Veronica Zampoleri, Marta Gazzotti, Elena Olmastroni, Riccardo Sarzani, Claudio Ferri, Elena Repetti, Carlo Sabbà, Antonio Carlo Bossi, Claudio Borghi, Sandro Muntoni, Francesco Cipollone, Francesco Purrello, Arturo Pujia, Angelina Passaro, Rossella Marcucci, Valerio Pecchioli, Livia Pisciotta, Giuseppe Mandraffino, Fabio Pellegatta, Giuliana Mombelli, Adriana Branchi, Anna Maria Fiorenza, Cristina Pederiva, Josè Pablo Werba, Gianfranco Parati, Francesca Carubbi, Lorenzo Iughetti, Arcangelo Iannuzzi, Gabriella Iannuzzo, Paolo Calabrò, Maurizio Averna, Giacomo Biasucci, Sabina Zambon, Anna Rita Roscini, Chiara Trenti, Marcello Arca, Massimo Federici, Maria Del Ben, Andrea Bartuli, Andrea Giaccari, Antonio Pipolo, Nadia Citroni, Ornella Guardamagna, Katia Bonomo, Andrea Benso, Gianni Biolo, Lorenzo Maroni, Alessandro Lupi, Luca Bonanni, Maria Grazia Zenti, Kota Matsuki, Mika Hori, Masatsune Ogura, Daisaku Masuda, Takuya Kobayashi, Kumiko Nagahama, Mohammed Al-Jarallah, Mirjana Radovic, Olga Lunegova, Erkayim Bektasheva, Elyor Khodzhiboboev, Andrejs Erglis, Dainus Gilis, Georgijs Nesterovics, Vita Saripo, Ruta Meiere, Arta Upena-RozeMicena, Elizabete Terauda, Selim Jambart, Petra E Khoury, Sandy Elbitar, Carine Ayoub, Youmna Ghaleb, Urte Aliosaitiene, Sandra Kutkiene, Noor A M Kasim, Noor S M Nor, Anis S Ramli, Suraya A Razak, Alyaa Al-Khateeb, Siti H S A Kadir, Suhaila A Muid, Thuhairah A Rahman, Sazzli S Kasim, Ahmad B M Radzi, Khairul S Ibrahim, Salmi Razali, Zaliha Ismail, Rohana A Ghani, Muhammad I A Hafidz, Ang L Chua, Marshima M Rosli, Muthukkaruppan Annamalai, Lay K Teh, Rafezah Razali, Yung A Chua, Azhari Rosman, Abdul R Sanusi, Nor A A Murad, A Rahman A Jamal, Sukma A Nazli, Aimi Z Razman, Norhidayah Rosman, Radzi Rahmat, Nur S Hamzan, C Azzopardi, Roopa Mehta, Alexandro J Martagon, Gabriela A G Ramirez, Neftali E A Villa, Arsenio V Vazquez, Daniel Elias-Lopez, Gustavo G Retana, Betsabel Rodriguez, Jose J C Macías, Alejandro R Zazueta, Rocio M Alvarado, Julieta D M Portano, Humberto A Lopez, Leobardo Sauque-Reyna, Laura G G Herrera, Luis E S Mendia, Humberto Garcia Aguilar, Elizabeth R Cooremans, Berenice P Aparicio, Victoria M Zubieta, Perla A C Gonzalez, Aldo Ferreira-Hermosillo, Nacu C Portilla, Guadalupe J Dominguez, Alinna Y R Garcia, Hector E A Cazares, Jesus R Gonzalez, Carla V M Valencia, Francisco G Padilla, Ramon M Prado, Manuel O De Los Rios Ibarra, Ruy D A Villicaña, Karina J A Rivera, Ricardo A Carrera, Jose A Alvarez, Jose C A Martinez, Manuel de Los Reyes Barrera Bustillo, Gonzalo C Vargas, Roberto C Chacon, Mario H F Andrade, Ashanty F Ortega, Hector G Alcala, Laura E G de Leon, Berenice G Guzman, Jose J G Garcia, Juan C G Cuellar, Jose R G Cruz, Anell Hernandez Garcia, Jesus R H Almada, Ursulo J Herrera, Fabiola L Sobrevilla, Eduardo M Rodriguez, Cristina M Sibaja, Alma B M Rodriguez, Jose C M Oyervides, Daniel I P Vazquez, Eduardo A R Rodriguez, Ma L R Osorio, Juan R Saucedo, Margarita T Tamayo, Luis A V Talavera, Luis E V Arroyo, Eloy A Z Carrillo, Alphonsus Isara, Darlington E Obaseki, Khalid Al-Waili, Fahad Al-Zadjali, Ibrahim Al-Zakwani, Mohammed Al-Kindi, Suad Al-Mukhaini, Hamida Al-Barwani, Asim Rana, Lahore S U Shah, Ewa Starostecka, Agnieszka Konopka, Joanna Lewek, Marcin Bartłomiejczyk, Mariusz Gąsior, Krzysztof Dyrbuś, Jacek Jóźwiak, Marcin Gruchała, Marcin Pajkowski, Marzena Romanowska-Kocejko, Marta Żarczyńska-Buchowiecka, Magdalena Chmara, Bartosz Wasąg, Aleksandra Parczewska, Natasza Gilis-Malinowska, Justyna Borowiec-Wolna, Aneta Stróżyk, Marlena Woś, Aleksandra Michalska-Grzonkowska, Ana M Medeiros, Ana C Alves, Francisco Silva, Goreti Lobarinhas, Isabel Palma, Jose P de Moura, Miguel T Rico, Quitéria Rato, Patrícia Pais, Susana Correia, Oana Moldovan, Maria J Virtuoso, Jose M Salgado, Ines Colaço, Andreea Dumitrescu, Calin Lengher, Svetlana Mosteoru, Alexey Meshkov, Alexandra Ershova, Tatiana Rozkova, Victoria Korneva, Kuznetsova T Yu, Vitaliy Zafiraki, Mikhail Voevoda, Victor Gurevich, Dmitry Duplyakov, Yulia Ragino, Maya Safarova, Igor Shaposhnik, Fahmi Alkaf, Alia Khudari, Nawal Rwaili, Faisal Al-Allaf, Mohammad Alghamdi, Mohammed A Batais, Turky H Almigbal, Abdulhalim Kinsara, Ashraf H A AlQudaimi, Zuhier Awan, Omer A Elamin, Hani Altaradi, Natasa Rajkovic, Ljiljana Popovic, Sandra Singh, Ljubica Stosic, Iva Rasulic, Nebojsa M Lalic, Carolyn Lam, Tan J Le, Eric L T Siang, Sanjaya Dissanayake, Justin T I-Shing, Tai E Shyong, Terrance C S Jin, Karin Balinth, Ingrid Buganova, Lubomira Fabryova, Michaela Kadurova, Alexander Klabnik, Miriam Kozárová, Jana Sirotiakova, Tadej Battelino, Jernej Kovac, Matej Mlinaric, Ursa Sustar, Katarina T Podkrajsek, Zlatko Fras, Borut Jug, Matija Cevc, Gillian J Pilcher, D J Blom, K H Wolmarans, B C Brice, Ovidio Muñiz-Grijalvo, Jose L Díaz-Díaz, Leopoldo P de Isla, Francisco Fuentes, Lina Badimon, François Martin, Angela Lux, Nien-Tzu Chang, Poranee Ganokroj, Mehmet Akbulut, Gökhan Alici, Fahri Bayram, Levent H Can, Ahmet Celik, Ceyhun Ceyhan, Fatma Y Coskun, Mesut Demir, Sabri Demircan, Volkan Dogan, Emre Durakoglugil, Ibrahim E Dural, Omer Gedikli, Aysa Hacioglu, Muge Ildizli, Salih Kilic, Bahadir Kirilmaz, Merih Kutlu, Aytekin Oguz, Oner Ozdogan, Ersel Onrat, Savas Ozer, Tevfik Sabuncu, Tayfun Sahin, Fatih Sivri, Alper Sonmez, Ahmet Temizhan, Selim Topcu, Abdullah Tuncez, Mirac Vural, Mustafa Yenercag, Dilek Yesilbursa, Zerrin Yigit, Aytul B Yildirim, Aylin Yildirir, Mehmet B Yilmaz, Bassam Atallah, Mahmoud Traina, Hani Sabbour, Dana A Hay, Neama Luqman, Abubaker Elfatih, Arshad Abdulrasheed, See Kwok, Nicolas D Oca, Ximena Reyes, Rano B Alieva, Ravshanbek D Kurbanov, Shavkat U Hoshimov, Ulugbek I Nizamov, Adolat V Ziyaeva, Guzal J Abdullaeva, Doan L Do, Mai N T Nguyen, Ngoc T Kim, Thanh T Le, Hong A Le, Lale Tokgozoglu, Alberico L Catapano, Kausik K RayEAS Familial Hypercholesterolaemia Studies Collaboration (FHSC): Mafalda Bourbon (INSA)Background: The European Atherosclerosis Society Familial Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for the global surveillance of familial hypercholesterolaemia through harmonisation and pooling of multinational data. In this study, we aimed to characterise the adult population with heterozygous familial hypercholesterolaemia and described how it is detected and managed globally.
Methods: Using FHSC global registry data, we did a cross-sectional assessment of adults (aged 18 years or older) with a clinical or genetic diagnosis of probable or definite heterozygous familial hypercholesterolaemia at the time they were entered into the registries. Data were assessed overall and by WHO regions, sex, and index versus non-index cases.
Findings: Of the 61 612 individuals in the registry, 42 167 adults (21 999 [53·6%] women) from 56 countries were included in the study. Of these, 31 798 (75·4%) were diagnosed with the Dutch Lipid Clinic Network criteria, and 35 490 (84·2%) were from the WHO region of Europe. Median age of participants at entry in the registry was 46·2 years (IQR 34·3-58·0); median age at diagnosis of familial hypercholesterolaemia was 44·4 years (32·5-56·5), with 40·2% of participants younger than 40 years when diagnosed. Prevalence of cardiovascular risk factors increased progressively with age and varied by WHO region. Prevalence of coronary disease was 17·4% (2·1% for stroke and 5·2% for peripheral artery disease), increasing with concentrations of untreated LDL cholesterol, and was about two times lower in women than in men. Among patients receiving lipid-lowering medications, 16 803 (81·1%) were receiving statins and 3691 (21·2%) were on combination therapy, with greater use of more potent lipid-lowering medication in men than in women. Median LDL cholesterol was 5·43 mmol/L (IQR 4·32-6·72) among patients not taking lipid-lowering medications and 4·23 mmol/L (3·20-5·66) among those taking them. Among patients taking lipid-lowering medications, 2·7% had LDL cholesterol lower than 1·8 mmol/L; the use of combination therapy, particularly with three drugs and with proprotein convertase subtilisin-kexin type 9 inhibitors, was associated with a higher proportion and greater odds of having LDL cholesterol lower than 1·8 mmol/L. Compared with index cases, patients who were non-index cases were younger, with lower LDL cholesterol and lower prevalence of cardiovascular risk factors and cardiovascular diseases (all p<0·001).
Interpretation: Familial hypercholesterolaemia is diagnosed late. Guideline-recommended LDL cholesterol concentrations are infrequently achieved with single-drug therapy. Cardiovascular risk factors and presence of coronary disease were lower among non-index cases, who were diagnosed earlier. Earlier detection and greater use of combination therapies are required to reduce the global burden of familial hypercholesterolaemia.Pfizer, Amgen, Merck Sharp & Dohme, Sanofi-Aventis, Daiichi Sankyo, and Regeneron.info:eu-repo/semantics/publishedVersio
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No full textTHE DAILY PALO ALTO Tl..1 &8
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Dltll.L AT
HOPKINK
it* ■nd iinii s.'-ft
Slmklns. Publiiher,
Mr-mil t'tm* mttur fr*-nu*T i
ka? ;■*, -He* at Palo Alt*, Cslt-
•**• Mt -H C«**«*-**-**ai o* Mirth >
v I'olk of Pslo Alto'.
Apfava-M- In ***tm%dy W
ntere'n Fan."
WANTS
CLASSIFIED.
WAMEK.
BON VOYAOK.
The public schooja of Pslo Alto
opened this morning for registration
and were dismissed after s .hort
se*-aioo. Tbe rest of tbe dsy bas
been sj-ent by tbe boys snd girls In
purchealng new books snd pencils
for the year's work, and br the.
tsaehors Id srrsngtng their pr-***-rsms' £»/ ***** **** ********* Oscar
so as to begin regitIsr lessons tomorrow.
Most of the teachers sre well
known, snd together with tho new
superintendent, Mr. J. C. Temple-
Tbe rehearsal of" "l*sdy Windermere's Psa," which Is to be presented at Redwodd City next Saturday night by a cast msde up of
Burllngame amateurs wss subjected
to a change of location yesterday,
owing to" the invasion by a street Wanted—To buy S or -S-room cot-
raralral of the Kedwood City the- tage. Bute location, terms snd
ater. where It was scheduled to oc- price. H. P. Scbwlng, 361 WsVerley.
Wanted.—Cottage, with or without
*nh\e. by October. Lesie. T. B.
Sullivan, Motimaie View. -i**-tm*
CLASSIFIED.
laOHT.
J£m/B3m\*a^
t SCHOOL SUPPLIES f
Laat—A CI«T»laad wbaal »sa ta- X ^u, pjajjcitj,, EVERTTIiING FOK THE SCHOOL CHILDREN S
T.f'T ,.'*., '""i" "*. '"' M""t°"' I *maHt BCTTinUCK FATIW.X& {
Thoits building Tuesday. An Km-; ***
plre wheel wss left ln Its stesd, A
re-exchsnge would be sppreclsted.j
Dr. Oeorge Blskesly Little. 13-lt-c
HMTfcLLAJflGOt-li
IlnM-i*-'* boar-fling bam and stor-:
agr* boosr, 172 Hamilton avrase.
Furnlturs bought snd sold by W.
P. Pennebsker. lit Emerson street.
Phone Whits 4*7. lfi*tf
*
The only .branch tn Palo Alto of
j ths P. Thomas Parisian Dye Works.
Wilde's charming play* Is being put' Wanted---Woman for clesnlng I S, Tenth street, fPsn Frsnclsco, is nt
throngh s course of reeharsalt. v*hlch anA washing by the dsy. Apply *■*■** Cnlrerslty avenue, st tbe Three
are developing a histrionic talent Mrs. H. A. Alderton, Channing lane. J tJUle Tailors. L. J. Bloom manager,
thst on the night of August Jl«t at IS-lw-*-
-tod Cilr end oh Semtember 3d. ***->
Coder the Inspiration, Instruction, encouragement and general dl-
Motion of Frank Mathleu tho rom-
II .ids
I»-lw»
Wanted—Capable laundress oae ■
or two days each week. Apply H2T,
University sv«nue. 20-tf
j Phons Black 111
—v —.. -. -. --*—**"* i .. .... „. ,., -,„,„_,.i tttmm,!** ■« Wanted—Trustworthy salesgirl st
to., tber baala th. -ear with th, »»* '1 'he.„°^J"' \h;°';.'; local art store. Experl*.-. onn.c«-
■.mp.lt,- »d kindest rwra-a, „,«,.: Baa Praoel^o -1 altrartlam, not retereneen. Addre* Bo. I
c-ntlro -omioaoll*. Th. Tlm,. «•***« JJVAm." !!!.„™. f„ ™. „,"!,. ,„ „„ M. Time, offle*. **-JtHI
to, sentiment of the people of Palo """* * " —-* " - -*—*
Alto, particular!* th. parent*, la
llalliii; F.rm . Knrr,...
During tbe pa*t week tbe direct-<
fashionable anillencM and b. of ""* „"1'!Z"""""""' """tnZiJo" iOT* "' ""' °*"""* F"m A*wd"Uo» ;
financial Interest to the oraan fund "■ T"t"* *"*"**• .. . , , ataaa their Dual payment on tb*
at si Dominic's Cborcb. A* the Wanted—.Purnl*b*d aeten orjland. Tbo* tbe "ouilnt rarm" for
wishing every teacher well and hop
in* tbat the *chools may be (Mod
durln- tbe year with a spirit of ob*-'
dlence and anlbnslasm on tbe part j •rraaaad tor a rehearsal yestcrda
*t pupils, and a spirit of ■entlene*. ■"•""»" ■< tn" '*"*''" «' «««*"-**
aad llrmnwa oa lb* part of thai <*"*'■ |D «-**•** """ •"• ""*"-"'
teaching fort* jmlabt acqulro an acurate conception
It Is hoped by .-erybody Inter-1"' "■*> B™«ra|.hlc«l relation ol sucb
aataa* la the w.ltar, of Palo Alto w*,r(l" •• |;1«*|l.**n""-i *° !^*™_llv
lime Is ill ii win* near Mr. MM Men I* rt„ht rMD1 hou*o by September l«t.! city children h«* bocom. «n c*lnb-
Incresslu Ihe number nnd se-crlly for ,„rc« „r four months—160. Ad-|llshe* ->Un*' *• •,ro-**' «•
seat iprlnf with ceremonle. appro-"""*1"0* aollfylaa blm that tbla dra-
prlate lo the conclusion of a *oe-|m,Uc '*"" *"•"'* acca*" ,h* ">-"1'-
o**sful terra. !nn* theeter darloc the ,ie*ter p«rt
| of the day. Redwood City atreet*
j wa* therefore strowa wltb confetti
Tb, Palo Alio board ot trade I* l *°d vaaaat *hella la*tead of automo-
•aariouily cotuiderlna tie leaal ilepa jMl*** *** "ojcart* and tho robean.-
neetsury toward* Ihe fulrlllnwnt oil*'* ,00* •,1,c* *' ""* "0l,k,M l"jme
tbelr aim to annex Mayfleld to Palo ■ ■* U**'* p*rk-
Alio, and also lo aane- a pl-c..oli *""*** "'"•"** '-> <*** P*rt up to
land In San Mateo counly. In order!"1" prcwot lime aro Mr*. II. McDon-
tb.l tbe lar«*r Palo Alio may all h.i«"- *******. »**• Wortblnaton
whero II* «r*l triumph I* lo b, en- hy • Jipanese *lud*nt. Apply to P.
moroment. Inaoirurated by Mr.. *
Bertha M. Rice Ual March In behalt
Wanted—A few hour*' garden; of tho children of San Francisco.
or a poaltlon aa a school boy, seems to have touched * responsive
0. box 218, SUnford I*nlvorally, Cal.
H-Jt*
KVIK HKMT
chord lo tba he.ru of SanU Clarans.
Bar Ihe outing fsrra bss sprung Into
existence In a *lag1e teaaoa, and *o:
remarkable ts the popularity of the
raua. Ihst Its lulure is assured.
San Franclaco
CALL
I IIBOMCI.E
KXAMIMUt
IHLLEnS
Saa lone— MBRCI-BT
IIKKALD
TIMED
Lo* Angelee— TIMES
. CONGDON & CROME <
I Leading Stationers
I PALO ALTO 1
230 University Ave. Telephone White 383 f
tnootmmammmnmmmaommtmmommmmmnommiT
A Desirable Country Home
Four [4] acres Und, a new shingled house, six rooms,
floored attic, cement cellar, all modern improvements;
good barn; -within three miles ol Palo Alto; fine views,
best of soil and climate. An ideal place. Price 6,500.
Palo Alto Realty Co.
JOHN F. RYXBMX AMI B. P. HAM-, MjUMLger*.
Palo Alt", HsnU Clara Cnnntr. California.
rOB KENT FUHS1RHK:>--A house
ot li rooms, suitable for a Isrg*
(smlly, club or bosr-llni- house. Seel
J. J. Morris. 7-J-Jm* |
To Rent.—Nice furnished rooms,
U] Kvcrctt. Good hoardiiiB limwt
nesr. io-jw**.
located In one count*-. Those whol**"*' ***■
Fr-Mt MrNesr. Miss
welcomed the Idea of anns-tln* Pslo! ******* Ut*; Wlllsrd Drown MUs
Alto to Ssn Msteo county will stand | '»"• *■*»*******■ M1"f a*******
sshsst st the new turn sff.lt. here Hyde-Smith Mto J«wtt# Houper.
Uhen.-Ilurlln„me Advance. W* »■-*• Clark- *,ta» ,>""1;; *
McDonsId 8t»enc*r, Hoyden Wlllinm-
Ison, Courtney Ford, Fred McNear,
HAV JOUR JAIL 18 . | Willsrd Drown snd Worthln-cton
CKOWDKD TO MH1T j Ames.
For Rent.—Furnished fiat-., 704 Bryant snd T6S Bryant. 13-lm*
for Rcm.~~ix room furtii-.lied cot-
t-igr in Menlo Park. Adrc-.t Mrs.
Msri[*r*-t McXalty IJ-im**
For Rent—Rooms, with or without bosrd. Sit Emsrson. 19-lm-c
No I'..,- 1. ,11 11. r< .
Pslo Alto N'stionsls had a
day off '-.■•TiI..y, Manager Cashsl
belnic unable to secure s s*srne for
the lint.'. Many of tho local players went to Mountain View to take
In tbe same between tbe team of
thst town end Ssn M.teo. The l.t-
,ter tesm won by a score of 4 to 1.
Those who weat from Pslo Alto
were Bert Qnlnn. It. IMeklnson, Arthur Shorman, Wm. Pelppers, It. Ot-
sen. II. Orosssel. J. Gibson. W. Jory
snd H. Rafferty.
Hay Ferer and Aammer Colds.
Victims of hsy lerer will experl-1
Sing a song of gladness,
When all is rest and ease,
With not a trace of sadness,
A chance which only one can seize
By using a Gas Range!
Prisos-cts .WU-..I of Petty Off. too- 1 i;i MIM \ *- MM I (Kit
Held Itt**'*lll*M* Thii Jililj-.s
Are Asmy.
San Jose, Auff. 26.—The H-in
Jose city 'sit, scc-ardlas to City Jus-
tire Darldson, has become a veritable bsstlle. Into which men .reused
of minor offenses sre thrown without w.rrsnis snd held without trial.
There sre three Justices of the *-«n-*o
In Ssn Joss.
OF THK CHAPARHAI.
First Ui-ut* of the Year Contain-.
Mini* lti('-.*r*-*hii- Feature*—
On Hate T-itiH-r-r--**-
The freshman number of the' 4>T Klplln«'street
Chspsrr.l will .ppesr tomorrow
mornlntt. lt will consist of fourteen
pARe. of dr.wln.N. prose skits, short
these, Jnstlcs * ****• and wrsgrnphs. Two full*
For Rent—Nicely furnished snn-
nv rooms, stnule or en suite. Apply - ^*>... 1
Ut Hawthara. a.™... eor-r ***■ "*"**' ■**** b*MOt *' U'*1"* Fo"* "
,.,„,,„ 2<-lw* Honey sad Tsr. as It stops difficult
""For RetJt-Larts psrlorTlS^i D'"**lh''-*- 'mmedlstely snd basis ths:
bed. housekeeping rooms; re«ttlsr t tnflsmsd sir passsses, snd seen If It
kitchen. Ill University svenue, should fsll to cure you It will give
_^ L8*1W* -1 ******* **Uot. Ths genuine is la s!
For Rent—Furni.hed front room, yellow pscksge. Esgls Drue Co.
suitable for one or two gontletnen., m ..i... mi.hi. i_ im | ■.
n-tf !
Palo Alto Gas Company
W7 Mil ill ST.
PHONE MAIN 62
For Rent—Three Urge bouse-
kt-e-ilhg rooms, furnished or unfurnished. 313 Kmerson strvet
2-t-St*
Brown Is out ons vwation. end im*]***** *-r»wlBgi. 'The Etemsl Que«-
Uce Wsllsos Is too III to attend t.*:*1011" *aA "Belectlons from a Sen-
eases. Since Isst Tuesdsy the cliy. *•*■-* rdl*-" *** *** **** ** D* "*
HU has been nillng up with drunks, ****** '*** **A *** ***** ** 8 M*
disturbers of the pei.ee and other! v« D**«nien. 'lO. will be sn Intor-
•rlolators of city ordinances. ! ******* ******** »• *■*■ Helmlek. OS.
Bather than take the eases he-\**** *** ******* ****** -.ketches.
fore Justice Davidson, whom tho! •*- s* ***** '°8* -»«trll"*t«* ■
municipal administration recently I front-page poem. "Tho Msgnol." and
Mdasrored to oast from the offlce i ******* ***** stunts, smong which
of city instlre. the chief of polios, i1* **** ■»«-*-*•"-« of * ****** ********
Davidson declares Is allowing men I"Foolish Conversations."
to He In prison without a trial. Their C. 8. Thompson. *65, under the
For Rent—Furnished suite of two
rooms; large clothes presses; use of
piano. HO Forest avenue. t4*3t
t-MH HAlM
object, hs says. Is to refuse any rec-j ***** °r
"Bravo Toro," gives an
ognlttou of the fsct that he haWi|-Mnutl,*« description of . Mexican
the office of city Justice. | *>"■• ***** **■ •*• Morgan, ex-6». U
The tdtnstlon Is Just ss bsd ss! the author of "Mixed Mall" and a
"before tho French revolution, when 1 number of short paragraphs,
they used to throw men Into the! T*>* editorials, the "Now Thsts,"
bsstlle by lettres de cschet." said;"* the first reverberations of
Justice Davidson Isat evening. "Men i Chappie's hammer for the present
have been allowed to Ho lo J.njw- •*-'*• ********* 'os- •• »*-llor'
ever clnce Judge Brown left tows
For Sale—A No. 1 shop-made
business wsgon, slso a rosd wagon
with two seats. c:,b Chaanlng sve*
nue. 1-tf
For Sale—Thimble »kein wagon and
I- :\t n e»». Inquire Cardiiinl *t.*l>1r,
Mayfield. i3*niv*
For Sate.—Fine Home Place. Lot
too x JOO. 68 fruit and nut tree-*. Ber*
rict and grape* in abundance: al*" 5
o-ik**. Pec owner, 55S Forcit avenue.
"13-101-*
because ' ths police department
would rather violets the Isw thsn
bring the cases before me."
Justice Davidson, whose salary
has been held up by the city sdmln-
Istrstlos. will make application next
week tor a writ of mandamus to
-compel the city treasurer to pay him
his -talsry for the months ot July
snd August.
A tall Uae of -fountain pens snd
Stanford Jewelry. A specialty of
wstch repairing; all work guarantee** J. Ksllson. Ill University
svenue.
... Rsymond. '08. manager, will hsve. ^^^
tho paper £pr salo st the bookstores 1 y*r*cy ******
and on the quad, at which latter
place subscrlptlona tor the yesr will
be taken.
For Ssle or Rent—Furnished; sn
artistic homo suitable for two or
three students. Address ttt Ws-
lHw-c
For Ssle—A splendid investment
—Twelve-room house divided Into
two lists: rants for Hi per month:
corner lot &0X126 feet: splendid lo-
cstlon. Will sell furnished for
IB.JftO. Apply S. W, Cbsrles, Slm-
l»-lw-e
ft*ta»*«t*r>>*t*->t'**»i'*t sv-wst-Ha.*.-**, vsvtavs**
I \\. II. Bille
i
Eandscapi*
Gardener
*
Phone Slus 131
Trees, Shrubs. Plants sad £
Seeds. Bxpsrleared men for *
all branches of work. Contract £
.lay work.
Residence, 1T0 Wsverloy
* rALO Aim>. CAL.
• a **.*>*. h-a n.m nta **x*xa*ata **m tva wm 9
Fete st Hnriin-csnie.
The street carnival, conducted by
the Woman's Club of Hurllngame onjklna building, Pslo Alto.
Saturday, waa successful beyond all "■*■
aatlrliaiiloa, of Ih. promol.r.. Tb,. "»• **•'*— *«»«•-• »»-»« ot I
-ocl«lr peo|.l. ol that portion ot Ul.|-0»°,■• ««aaal«l c*llar -.III. ta-aaca.
P.ala.01. all.od«l .a au. aad "■■**• ,1*'"« room «l.h «r.pl*-..
rl^ with ~-h other, la kwpla,"-'* • ********** 't-t*** <«* °* **-*•'
...ni. moils-. Mor. ihao a thoii.!°" ">** ""*"* ln *****■.*******
s.Dd dollar, bad b«a r-*ll.«l trom;»"»-' C *- *'1*M' *'3 ***!****
tb* carol.al b.twp«a r p. la. aad j I«-lw-<
U p. in. Th* a-aou. wa. a riot ot i For gal*—8lorr aad hall *-room
d>x»r*llr. color. In bunllna and hous.. chMP. Addr*** A. L. a..
dow.r.. red p-cdomln«tln- a* the j ,„„, g,,, JoM „**ue, Alam*4a.
rho.cn color. (-ontervalori*. on p.| **-lw*
"ihe hill'' aavc- of their choice.!
..................
ABSOLUTELY A BARGAIN
12,000
Best Ever Offered in Palo Alto
blooms and greenery. Pretty women in cbarmlng gowns with parasols strolled about. Money clinked
st all the booths, fasughlng children d.nced with the sunbeams
along the troe-ab.ded wsy. Everything was what the Woman's Club
had promised It should be. Stock
ws. sold out, re-tleulahed and sold
nut agiiln. At midnight nurllngame
went to bed. tired, bnt triumphant.
Por Sale-—Two iron beds, spring*
and mattresses: slso, lsdlee' bicycle.
Tl» Waverley street. I4-Jt-c
For Sale—-12.300—One acre or
lees; hard-flnlahed house, four room*
j beside* bath, pantry, reception hstl:
f upstairs unfinished. Wide porches.
: IMg basement. Itarn, cor, chickens.
* furniture, fruit trees. Terms. Address Walter N. Vcstays. Mountain
View, Csl. " »l*St*
*.!
W, A. Itarkins. rrotesor Of chemistry In the t'niverslty of Montana,
has arrived In Palo Alio to take examination* for his master's degree
at Stanford.
To Lsose—-Cottage, ' fnrnUhc-d,
four rooms snd hath, with or without stable. Address R. J. M.. Wl
Mmu.I SavUu*** Hank building. 101
Market street, San Franei-.<.**
University Avenue, 2-Story New Building—-
I Income $1 10.00 per month. Lot 50x200.
See us at once.
I J. J. Morris Real Estate Co.
y
120 University Avenue
Pa4X0 a-YLTO
• ***********a*******
