33,298 research outputs found

    Scaptodrosophila zebromyia Peng, Lin & Chen, 2022, nom. nov.

    No full text
    Scaptodrosophila zebromyia nom. nov. Scaptodrosophila zebrina Liu & Chen, 2018, hom. of S. zebrina (Bezzi, 1928). Distribution. China (Yunnan).Published as part of Peng, Hongen, Lin, Yong & Chen, Hongwei, 2022, Morphological and molecular evidence of eight new species of the genus Scaptodrosophila Duda (Diptera, Drosophilidae) from China, pp. 169-194 in Zootaxa 5093 (2) on page 186, DOI: 10.11646/zootaxa.5093.2.3, http://zenodo.org/record/590508

    Martin Loughlin, Public Law and Political Theory

    No full text
    In this chapter, Ben Yong discusses Martin Loughlin’s Public Law and Political Theory. Drawing in part on conversation with the author, Yong explores the significance of a book that, despite interrogating the nature of public law as a discipline in a novel and methodologically important way, is often poorly understood

    Psychological and cultural insights into consumption of luxury western brands in India

    Full text link
    India has always had wealthy elites such as the maharajas, upper class and royalty that consume luxury products throughout its consumption history. The relatively recent economic rise of the middle class with an increase in disposable income is leading to consumption of luxury en mass. This qualitative study examines why consumers buy luxury, what they believe luxury is and how their perception of luxury impacts buying behaviour in the context of India. The present study explores luxury constructs drawn from the literature and provides some explanation for luxury consumption behaviour in India. The findings reveal that psychological and cultural factors in Indian society play a major part in shaping luxury consumption. While the findings suggest little support for homogenous luxury preference, Indian consumers share cultural characteristics of lavish consumption of luxury and display of wealth in social functions. Luxury reflects conspicuous consumption and status, and signals wealth for individuals, and conveys social identity and status in Indian society

    Supplementary material - Supplemental material for A Pair of Novel Sulfonyl-Containing <i>N</i>-Acetyldopamine Dimeric Enantiomers From <i>Aspongopus chinensis</i>

    No full text
    Supplemental material, Supplementary material, for A Pair of Novel Sulfonyl-Containing N-Acetyldopamine Dimeric Enantiomers From Aspongopus chinensis by Li Liao, Yong-Ming Yan, Te Xu, Hou-Lin Xia and Yong-Xian Cheng in Natural Product Communications</p

    Review of the Leafhopper Genus Macrosteles Fieber (Hemiptera: Cicadellidae: Deltocephalinae) from China

    No full text
    Yalin, Zhang, Lin, Lu, Kwon, Yong Jung (2013): Review of the Leafhopper Genus Macrosteles Fieber (Hemiptera: Cicadellidae: Deltocephalinae) from China. Zootaxa 3700 (3): 361-392, DOI: 10.11646/zootaxa.3700.3.

    How people react to the ‘also recommended’ section of online stores

    No full text
    Retailers can take advantage of recommendation networks to drive product demand, write Zhijie Lin, Khim-Yong Goh and Cheng-Suang Hen

    The microrna deregulation in Colorectal Cancer / Yong Fung Lin

    Full text link
    Colorectal cancer (CRC) is the carcinoma of the colon and rectum in the gastrointestinal system. CRC is the third most common cancer in men and the second in women worldwide. The limitations of the currently available biomarkers and technologies for CRC screening and surveillance have highlighted the necessity of finding novel biomarkers. Recently, microRNA (miRNA)-based studies have rendered remarkable contribution in the elucidation of mechanisms of carcinogenesis. miRNAs are short, non-coding RNA molecules that act as regulators of gene expression through messenger RNA (mRNA) degradation or translational inhibition. Blood miRNA expression profiles offer great potential as non-invasive biomarkers. In the present study, the aims were to characterise and correlate the tissue and blood miRNA expression patterns of primary CRC patients, and establish the functional roles of the identified miRNAs in the carcinogenesis of CRC. Firstly, the miRNA profiling study was divided into two phases: (I) marker discovery by miRNA microarray using paired cancer tissues (n = 30) and blood samples (CRC, n = 42; control, n = 18); (II) marker validation by reverse transcription-quantitative real-time polymerase chain reaction (RT-qPCR) using an independent set of paired cancer tissues (n = 30) and blood samples (CRC, n = 70; control, n = 32). Logistic regression and receiver operating characteristic curve analyses were applied to obtain diagnostic utility of the miRNAs. Seven miRNAs (miR-150, miR-193a-3p, miR-23a, miR-23b, miR-338-5p, miR-342-3p and miR-483-3p) were found to be differentially expressed in both tissue and blood samples. Significant positive correlations were observed in the tissue and blood levels of miR-193a-3p, miR- 23a and miR-338-5p. These miRNAs were demonstrated as a classifier for CRC detection, with a receiver operating characteristic curve area of 0.887 (80.0% sensitivity, 84.4% specificity and 83.3% accuracy). Next, these miRNAs were subjected to functional and miRNA:mRNA target validation studies via miRNA mimics and iv inhibitors transfections. SW480 and SW620 CRC cell lines were utilised. Cell viability, apoptosis, migration and invasion assays were conducted. Luciferase assays were performed for the validation of target mRNAs. The expression levels of target mRNAs and proteins in clinical CRC samples and cell lines were assessed using RT-qPCR and Western blot. miR-193a-3p was identified to be involved in CRC cell migration and invasion by targeting FOXO4. miR-23a was determined to possess apoptosis resistance function by targeting APAF1. However, the transfection of miR-338-5p did not reveal significant findings in the cell viability, apoptosis, migration and invasion analyses. In conclusion, miRNA deregulation in the blood is reflective of that in the CRC tissue. The triple miRNA classifier of miR-193a-3p, miR-23a and miR-338-5p may serve as potential blood biomarkers for CRC detection. The miRNA:mRNA target validation studies have highlighted the potential application of miR-193a-3p:FOXO4 and miR- 23a:APAF1 regulation axes in miRNA-based therapy and prognostication
    corecore