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Potential biomarker discovery revealing the mechanism of reversal in the DMN-induced rat reversible liver fibrosis
No full text此篇論文的研究目的在於探討可逆性肝臟纖維化和不可逆性肝臟纖維化在大鼠血清中蛋白質的變化，藉此剖析初期肝臟纖維化在可逆性與不可逆性之分水嶺時，調控肝臟纖維化選擇日後發展路徑的可能機制。本篇論文中，利用致癌劑 dimethylnitrosamine (DMN) 誘導大鼠產生肝臟纖維化，在纖維化不同程度以及休息不同週數的個別時期，經過肝臟切片、免疫染色確定纖維化程度，並定義肝臟纖維化可逆與不可逆的時間點。抽取肝臟纖維化不同時期的大鼠血清進行蛋白質體分析；藉由二維電泳 (Two Dimensional Electrophoresis)、膠體內水解(In gel digestion)、質譜分析，並利用PDQUEST 分析軟體，鑑定出有差異的蛋白質，其中包括血紅素結合蛋白 (haptoglobin)，脂蛋白E (Apolipoprotein E)及補體蛋白C3 (Complement C3)等蛋白質。依據鑑定出表現量有差異的蛋白質，透過生物資訊軟體MetacoreTM, 分析在統計上有顯著意義的網絡 (Network)，發現Alternative complement pathway是參與調控肝臟纖維化，選擇可逆與不可逆性路徑的可能機制。補體蛋白C3被視為是調控肝細胞增殖的重要因子，但目前文獻並沒有提到補體蛋白C3與肝臟纖維化可逆性的關係。本研究的重要結果在於，由MetacoreTM分析的網絡中發現，基質金屬蛋白酵素2,9及基質金屬蛋白酵素抑制物1,2，參與由補體蛋白C3所調控的網絡，而基質金屬蛋白酵素及基質金屬蛋白酵素抑制物是影響肝臟纖維化重要的酵素。因此，研究結果顯示，補體蛋白C3可能扮演調控可逆性與不可逆性肝臟纖維化的重要角色。The aim of study is to compare protein expression profile between reversible and irreversible liver fibrosis in DMN-induced rat model and find out the pivotal pathway regulating the development of liver fibrosis. In this study, DMN (Dimethylnitrosamine), carcinogen, was used to induce liver fibrosis in rat. The degree of liver fibrosis was determined by histological analysis of liver sections. Immunohistochemistry stain of liver sections was performed in different liver fibrosis stages for timing definition of reversible and irreversible liver fibrosis in the DMN-induced rat model. Collecting the rat serum in different stages of fibrosis followed by proteomic analysis, which included 2DE (two-dimensional electrophoresis)、In-gel digestion and matrix-assisted laser desorption/ionization mass spectrometry. The differentially expressed protein spots were analyzed by computer-assisted image analysis (PDQEST) software (p<0.05). Identified proteins included Hp (haptoglobin), ApoE (apolipoprotein E) and complement C3. Based on the identified proteins, MetacoreTM was applied to organize network relevant to the identified proteins. The bioinformatics tool-based analyzed result shows Alternative complement pathway might be associated with the reversible regulation of liver fibrosis. Complement C3 is regard as a pivotal factor regulating the proliferation of hepatocyte. The result indicated complement C3 might be an of importance factor regulating the development of liver fibrosis, up to now, no studies elucidate the role of complement C3 in the reversibility of liver fibrosis. We also found MMPs and TIMPs involved in complement C3 regulated pathway. The functional role of MMPs and TIMPs in liver fibrosis was studied in a number of previous researches, but detail still not completely understood. Taken together, complement C3 might serve as a notable mediator involved in reversibility of liver fibrosis
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
Author Under Sail The Imagination of Jack London, 1893-1902
No full textIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Intro -- Title Page -- Copyright Page -- Dedication -- Contents -- Acknowledgments -- Introduction -- 1. Spirit Truth -- 2. From Absorption to Theatricality and Back Again -- 3. "I Will Build a New Present" -- 4. Sons as Authors -- 5. Fathers as Publishers -- 6. The Daughter as Author -- 7. Lovers as Authors -- 8. At Sea with the Family -- 9. Yellow News, Yellow Stories -- 10. The Return Home -- Notes -- Bibliography -- Index -- About Jay WilliamsIn Author Under Sail, Jay Williams offers the first complete literary biography of Jack London as a professional writer engaged in the labor of writing. It examines the authorial imagination in London's work, the use of imagination in both his fiction and nonfiction, and the ways he defined imagination in the creative process in his business dealings with his publishers, editors, and agents. In this first volume of a two-volume biography, Williams traverses the years 1893 to 1902, from London's "Story of a Typhoon" to The People of the Abyss. The Jack London who emerges in the pages of Author Under Sail is a writer whose partnership with publishers, most notably his productive alliance with George Brett of Macmillan, was one of the most formative in American literary history. London pioneered many author models during the heyday of realism and naturalism, blurring the boundaries of these popular genres by focusing on absorption and theatricality and the representation of the seen and unseen. London created an impassioned, sincere, and extremely personal realism unlike that of other American writers of the time. Author Under Sail is a literary tour de force that reveals the full range of London as writer, creative citizen, and entrepreneur at the same time it sheds light on the maverick side of machine-age literature.Description based on publisher supplied metadata and other sources.Electronic reproduction. Ann Arbor, Michigan : ProQuest Ebook Central, YYYY. Available via World Wide Web. Access may be limited to ProQuest Ebook Central affiliated libraries
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