131 research outputs found
A Bayesian Response-Adaptive Randomization Design for Clinical Trials with Survival Endpoints
No full textNEW SPECIMENS OF ANCHIORNIS HUXLEYI (THEROPODA: PARAVES) FROM THE LATE JURASSIC OF NORTHEASTERN CHINA
No full textFour new specimens of Anchiornis huxleyi (PKUP V1068, BMNHC PH804, BMNHC PH822, and BMNHC PH823) were recently recovered from the Late Jurassic fossil beds of the Tiaojishan Formation in northeastern China. These new specimens are almost completely preserved with cranial and postcranial skeletons. Morphological features of Anchiornis huxleyi have implications for paravian character evolution and provide insights into the relationships of major paravian lineages. Anchiornis huxleyi shares derived features with avialans, such as a straight nasal process of the premaxilla and the absence of an external mandibular fenestra in lateral view. However, Anchiornis huxleyi lacks several derived deinonychosaurian features, including a laterally exposed splenial and a specialized raptorial pedal digit II. Morphological comparisons strongly suggest Anchiornis is more closely related to avialans than to deinonychosaurians or troodontids. Anchiornis huxleyi exhibits many conservative paravian features, and closely resembles Archaeopteryx and other Jurassic paravians from Jianchang County, such as Xiaotingia and Eosinopteryx. The other Jianchang paravian, Aurornis xui, is likely a junior synonym of Anchiornis huxleyi.Division of Paleontology at the American Museum of Natural History, Columbia University; Jurassic FoundationSCI(E)ARTICLE4114-6
Association between response kinetics and outcomes in relapsed/refractory multiple myeloma: analysis from TOURMALINE-MM1
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Supporting information for: "Diastereomeric Fullerene Composite Engineering for Enhanced Perovskite Solar Cells"
No full textAchieving high performance and long-term stability in perovskite solar cells (PSCs) typically requires the use of surface passivation layers to suppress the interfacial defects. However, these additional passivation agents often introduce chemical and structural instabilities, limiting the device lifetime. Here, we present a molecular engineering strategy utilizing a chiral series of C60-Furan-Sugar (CFS) fullerene derivatives blended with [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) to modify the electron transport layer (ETL). The incorporation of CFSs significantly enhances the electron mobility and dielectric constant of the ETL, while their intrinsic passivation functionality effectively passivates perovskite surface defects. As a result, PSCs employing PCBM:CFS-RS blends achieve a power conversion efficiency (PCE) of 25.81% without the use of additional passivation layers and retain 95% of their initial performance after 1000 h of aging. Notably, CFS-RS is a chiral molecule bearing a side chain with R/S configurational isomers, which facilitates interfacial compatibility and contributes to the enhanced device performance. This work demonstrates that tuning the orientation of polar substituents in fullerene side chains can effectively influence the optoelectronic properties of the blended films, thereby simultaneously enhancing both efficiency and stability in PSCs.The supporting information for: Wu, Jianchang; Zhang, Jiyun; Wang, Luyao; Jakšić, Jovana; Barabash, Anastasia; Veljković, Dušan; Bornschlegl, Andreas J.; Jovanov, Vladislav; Lahn, Leopold; Kasian, Olga; Pérez-Ojeda, M. Eugenia; Götz, Klaus; Unruh, Tobias; Li, Chaohui; Peng, Zijian; Wang, Yunuo; Hauch, Jens A.; Deng, Lin-Long; Maslak, Veselin; Mitrović, Aleksandra; Li, Gang; Brabec, Christoph J.. (2025). Diastereomeric Fullerene Composite Engineering for Enhanced Perovskite Solar Cells. in Journal of the American Chemical Society., 147, 35, 32045-32053. [https://pubs.acs.org/doi/10.1021/jacs.5c10340]Published article: [https://cherry.chem.bg.ac.rs/handle/123456789/7281
Practical Recommendations for Regional Consistency Evaluation in Multi-Regional Clinical Trials with Different Endpoints
No full textAn adaptive seamless 2-in-1 design with biomarker-driven subgroup enrichment
No full textAdaptive seamless phase 2/3 subgroup enrichment design plays a pivotal role in streamlining efficient drug development within a competitive landscape, while also enhancing patient access to promising treatments. This design approach identifies biomarker subgroups with the highest potential to benefit from investigational regimens. The seamless integration of Phase 2 and Phase 3 ensures a timely confirmation of clinical benefits. One significant challenge in adaptive enrichment decisions is determining the optimal timing and maturity of the primary endpoint. In this paper, we propose an adaptive seamless 2-in-1 biomarker-driven subgroup enrichment design that addresses this challenge by allowing subgroup selection using an early intermediate endpoint that predicts clinical benefits (i.e. a surrogate endpoint). The proposed design initiates with a Phase 2 stage involving all participants and can potentially expand into a Phase 3 study focused on the subgroup demonstrating the most favorable clinical outcomes. We will show that, under certain correlation assumptions, the overall type I error may not be inflated at the end of the study. In scenarios where the assumptions may not hold, we present a general framework to control the multiplicity. The flexibility and efficacy of the proposed design are highlighted through an extensive simulation study and illustrated in a case study in multiple myeloma.</p
Evaluation of Consistency Requirements in Multi-Regional Clinical Trials with Different Endpoints
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Topics in Applied Statistics2012 Symposium of the International Chinese Statistical Association /
No full textXVII, 344 p. 75 illus., 60 illus. in color.onlin
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