4,332 research outputs found
The Rhetoric of Landscape in Gregory of Nyssa’s Homilies on the Song of Songs
No full textThis is the author accepted manuscript. The final version is available from Brill via the ISBN in this recordAnalytical and Supporting Studies. Proceedings of the 13th International Colloquium on Gregory of Nyssa (Rome, 17-20 September 2014)Series:
Vigiliae Christianae, Supplements, Volume: 150In this paper I want to take you on a walk through a garden. It is, to be sure, an imaginary garden; nevertheless, it bears a significance which extends beyond itself. Some of this significance concerns words and texts: for as we shall see, the garden is, amongst other things, a ‘garden of rhetoric’. The garden in question appears in the Gregory of Nyssa’s Homilies on the Song of Songs.[...
Lin-Kernighan Heuristic Adaptations for the Generalized Traveling Salesman Problem
No full textThe Lin-Kernighan heuristic is known to be one of the most successful heuristics for the Traveling Salesman Problem (TSP). It has also proven its efficiency in application to some other problems. In this paper, we discuss possible adaptations of TSP heuristics for the generalized traveling salesman problem (GTSP) and focus on the case of the Lin-Kernighan algorithm. At first, we provide an easy-to-understand description of the original Lin-Kernighan heuristic. Then we propose several adaptations, both trivial and complicated. Finally, we conduct a fair competition between all the variations of the Lin-Kernighan adaptation and some other GTSP heuristics. It appears that our adaptation of the Lin-Kernighan algorithm for the GTSP reproduces the success of the original heuristic. Different variations of our adaptation outperform all other heuristics in a wide range of trade-offs between solution quality and running time, making Lin-Kernighan the state-of-the-art GTSP local searc
Gregory of Nyssa: The Letters - Introduction, Translation and Commentary
No full textThis book gathers 37 letters of St Gregory of Nyssa (c. 335-394), translated into English, some for the first time, and equipped with up-to-date scholarly notes.It begins with a biography focusing on Gregory's family background and young adulthood. A study of Gregory the letter writer follows, with a dateline of the letters. Three sub-collections of letters follow: 1. 'Prelude' comprising testimonia from Basil and Gregory Nazianzen, 2. 'The Pasquali Collection', the 30 letters established by G. Pasquali, 3. 'Supplementary', one letter always known as Gregory's, five letters reassigned to Gregory by scholars, and a new one proposed by the author for reassignment. A specially commissioned icon, an original map, and two architectural sketches are included. This book will both stimulate veteran scholars in the Cappadocian Fathers and early Christianity, and serve English speaking lovers of the Fathers who do not have ready access to the sources in other languages
Identifying direct miRNA-mRNA causal regulatory relationships in heterogeneous data
No full textAbstract not availableJunpeng Zhang, Thuc Duy Le, Lin Liu, Bing Liu, Jianfeng He, Gregory J. Goodall, Jiuyong L
Author Co-Citation Analysis (ACA): a powerful tool for representing implicit knowledge of scholar knowledge workers
No full textIn the last decade, knowledge has emerged as one of the most important and valuable organizational assets. Gradually this importance caused to emergence of new discipline entitled ―knowledge management‖. However one of the major challenges of knowledge management is conversion implicit or tacit knowledge to explicit knowledge. Thus Making knowledge visible so that it can be better accessed, discussed, valued or generally managed is a long-standing objective in knowledge management. Accordingly in this paper author co- citation analysis (ACA) will be proposed as an efficient technique of knowledge visualization in academia (Scholar knowledge workers)
The ‘insider/outsider’ dilemma of ethnography: Working with young children and their families in cross-cultural contexts
No full textIn this article we unravel the difficulty of being researchers in the homes and classrooms of children and
their families whose origins are, for one of us, very different and, for the other, very similar to our own.
We first situate our work within theories of early socialization and literacy teaching which underpin our
understanding of how young children in cross-cultural contexts learn. We then turn to the question of
working with the families and teachers of these children which poses dilemmas not explained by the theories
presented. We illustrate these through a series of vignettes typifying both the ‘Outsider’ and the ‘Insider’ role.
The stories highlight paradigmatic moments of complexity, clashes or collusion which we unpick in terms of
their generalizability for others working in the field. Finally, we extend theories of dialogue in our search for
a methodology for collaborative work in future cross-cultural ethnographic studies
Differential roles of the microRNA let-7 in C. elegans tissue development
No full textThe organs and tissues of the human body comprise of an astonishing variety of cells as different in morphology and function as muscle cells and neurons. Amazingly, despite their different protein contents, they largely contain the identical genomic information. In order to understand the processes that enable this differentiation, we need to determine the underlying regulatory mechanisms. A very recent discovery in this context was the posttranscriptional regulation of gene expression by microRNAs (miRNAs). miRNAs are small RNA molecules that mediate translational repression and degradation of mRNA transcripts through partial complementarity to their 3’ untranslated region (UTR) . Among the first miRNAs to be identified, let-7 stands out for its high conservation in sequence and developmental functions in development throughout the animal kingdom. During my PhD, I studied the role of let-7 in Caenorhabditis elegans in the context of two distinct processes of tissue development, namely differentiation of the epidermis (called hypodermis), and morphogenesis of the vulva. The functions of the let-7 miRNA in formation of the adult cuticle have been extensively studied and are well understood. let-7 controls differentiation of specific, mitotically active epidermal cells by inducing cell cycle exit, fusion, and switch to an adult specific transcriptional program upon repression of targets such as lin-41, daf-12, hbl-1 and let-60/ras. I set out to identify novel interactors of let-7 in a genome-wide RNAi screen for suppression of the lethal let-7 bursting phenotype. Candidates were then verified using fluorescence-based reporter systems for onset of hypodermis differentiation and intensity of repression of a known target. Thereby, I was able to validate a whole set of novel members of the let-7 network, comprising genes downstream in the pathway as well as potential regulators of let-7 activity. Notably, both groups of repressors contain factors required for cell cycle progression and mitosis, which indicates an active crosstalk between let-7 and the cell-cycle machinery. In a second project, I explored the molecular basis for the prominent let-7 vulval bursting phenotype. Despite the absence of overproliferation or any other obvious phenotype in vulval morphogenesis, I was able to show that let-7 activity is required in the vulva, and that its major function in this context is repression of a single target, namely lin-41. Disruption of let-7 binding to lin-41 through modification of the let-7 complementary sites by CRISPR/Cas9 mediated genome editing suffices to trigger the bursting phenotype, proving that repression of a single target is the key function of the miRNA in this context. In summary, my work shows that while both differentiation of hypodermis as well as vulval integrity are mediated through repression of lin-41, the downstream effect of this regulation seem to differ, suggesting that let-7 can be wired to control distinct processes depending on the cellular context. With respect to the latest findings both in C. elegans as well as in mammals, it will be interesting to determine if this depends on differential molecular functions of LIN-41 in the two tissues
FIGURE 3 in Begonia benitotanii (section Petermannia, Begoniaceae) a new species endemic to the Philippine island of Bucas Grande
No full textFIGURE 3. Begonia benitotanii Rubite, Tandang & C.W.Lin. A, B. Habit and habitats; C. Stipule; D. Inflorescence; E. Staminate flower; F. Pistillate flower, face and side views; G. Immature capsules; H. Cross section of an immature capsule. All from R. Rubite 1003.Published as part of Rubite, Rosario Rivera, Brillantes, Rochelle Yongque, Tandang, Danilo N., Moran, Cecilia B., Rule, Mark Gregory Q. & Lin, Chei-Wei, 2021, Begonia benitotanii (section Petermannia, Begoniaceae) a new species endemic to the Philippine island of Bucas Grande, pp. 257-264 in Phytotaxa 513 (3) on page 261, DOI: 10.11646/phytotaxa.513.3.5, http://zenodo.org/record/531258
FIGURE 3 in Begonia benitotanii (section Petermannia, Begoniaceae) a new species endemic to the Philippine island of Bucas Grande
No full textFIGURE 3. Begonia benitotanii Rubite, Tandang & C.W.Lin. A, B. Habit and habitats; C. Stipule; D. Inflorescence; E. Staminate flower; F. Pistillate flower, face and side views; G. Immature capsules; H. Cross section of an immature capsule. All from R. Rubite 1003.Published as part of Rubite, Rosario Rivera, Brillantes, Rochelle Yongque, Tandang, Danilo N., Moran, Cecilia B., Rule, Mark Gregory Q. & Lin, Chei-Wei, 2021, Begonia benitotanii (section Petermannia, Begoniaceae) a new species endemic to the Philippine island of Bucas Grande, pp. 257-264 in Phytotaxa 513 (3) on page 261, DOI: 10.11646/phytotaxa.513.3.5, http://zenodo.org/record/531258
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