3,063 research outputs found
Macrocephenchelys nigriventris Lin, Shao & Smith
No full text* Macrocephenchelys nigriventris Lin, Shao & Smith, this volume Macrocephenchelys nigriventris Lin, Shao & Smith, 2018: this volume. (type locality: Nan-fang-ao, Yilan, northeastern Taiwan). Remarks. Newly described in this volume by Lin et al. (2018). This species is commonly collected from off northeastern and southwestern Taiwan, by bottom trawl.Published as part of Ho, Hsuan-Ching, Smith, David G., Tighe, Kenneth A., Hibino, Yusuke & Mccosker, John E., 2018, Checklist of eels of Taiwan (orders Anguilliformes and Saccopharyngiformes): An update, pp. 5-17 in Zootaxa 4454 (1) on page 12, DOI: 10.11646/zootaxa.4454.1.3, http://zenodo.org/record/144668
Pylorobranchus hoi McCosker, Loh & Lin 2012
No full text* Pylorobranchus hoi McCosker, Loh & Lin, 2012 ¼R÷№ª Pylorobranchus hoi McCosker, Loh & Lin in McCosker et al., 2012: 1192, figs. 1–4 (type locality: Changbin, 23 ° 18 'N, 121 ° 29 'E, Taitung County, Taiwan, 300 m). McCosker, 2014: 337. Remarks. A deepwater species known only from the type series collected by hook and line off southeastern Taiwan.Published as part of Ho, Hsuan-Ching, Smith, David G., Mccosker, John E., Hibino, Yusuke, Loh, Kar-Hoe, Tighe, Kenneth A. & Shao, Kwang-Tsao, 2015, Annotated checklist of eels (orders Anguilliformes and Saccopharyngiformes) from Taiwan, pp. 140-189 in Zootaxa 4060 (1) on page 175, DOI: 10.11646/zootaxa.4060.1.16, http://zenodo.org/record/24365
The stem cell E3-ligase Lin-41 promotes liver cancer progression through inhibition of microRNA-mediated gene silencing
No full textLin-41 is a stem cell-specific E3 ligase and a known target of the tumour suppressor microRNA (miRNA) let-7. Lin-41 was recently reported to mediate ubiquitylation and degradation of the miRNA pathway protein Ago2. We demonstrate that Lin-41 is over-expressed in hepatocellular carcinoma (HCC). Lin-41 over-expression correlates with high a-fetoprotein level, high tumour grade and high tumour stage and predicts early tumour recurrence. Lin-41 is a strong predictor of poor long-term survival for patients with HCC. Lin-41 knock-down by RNA interference in HCC cell lines Huh7 and Hep3B suppressed proliferation in vitro and reduced in vivo tumour growth in NOD/SCID mice. On the other hand, over-expression of Lin-41 in the HCC cell line SK-Hep1 enhanced tumourigenicity. Over-expression and knock-down of Lin-41 led to inverse changes in the levels of Ago1 and Ago2 proteins. Over-expression of Ago1 and Ago2 reduced in vivo tumour growth. Lin-41 over-expression suppressed let-7 activity in HCC cell lines and expression of Lin-41 enhanced the expression of let-7-regulated oncogenes c-Myc, Lin-28B, HMGA2 and type 1 insulin-like growth factor receptor (IGF1R). Expression of Lin-28B and c-Myc enhanced the expression of Lin-41. Chromatin immunoprecipitation and reporter assays revealed direct association of c-Myc with the Lin-41 promoter, resulting in transcriptional transactivation. Our results indicate that Lin-41 plays an important role in the growth of HCC by regulating RISC complex proteins Ago1 and Ago2 to inhibit miRNA-mediated gene silencing and promote the expression of oncogenic proteins. Lin-41 is also a strong prognostic factor for patients with HCC. Copyright (C) 2012 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd
An antinociceptive role for substance P in acid-induced chronic muscle pain
No full text[[sponsorship]]生物醫學科學研究所[[note]]已出版;[SCI];有審查制度;具代表性[[note]]http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=Drexel&SrcApp=hagerty_opac&KeyRecord=0027-8424&DestApp=JCR&RQ=IF_CAT_BOXPLOT[[note]]http://gateway.isiknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=RID&SrcApp=RID&DestLinkType=FullRecord&DestApp=ALL_WOS&KeyUT=00029895020000
Design and Implementation of a Sigma-Delta Modulated Fractional-N Frequency Synthesizer
No full text在今日的射頻前級電路中，本地震盪器是一個不可或缺的要件，而設計一個兼具快速的鎖定速度、低相低雜訊和高頻率解析度的頻率合成器也成為一個挑戰。本論文探討MASH的三角積分調變器對於頻率合成器輸出相位雜訊的影響，另外由積體電路實現一個整合性的除小數頻率合成器，並使用MASH 1-1-1 三角積分調變器作為除頻數之調變，一方面藉由打亂除頻器的模數得到較好雜訊抑制，另一方面將雜訊推至較高頻的頻率，而能被鎖相迴路所澸除。此頻率合成器使用0.18μm Mixed-signal 1P6M CMOS製程，可操作於4GHz，模擬的相位雜訊在1MHz處為-115dBc/Hz，並在600MHz的跳頻間距下可達到小於30μm的鎖定時間。Nowadays, local oscillator is an essential component of the RF front-end. And the design for a frequency synthesizer with agile settling speed, low phase noise and high frequency resolution has become a challenge. The thesis discusses the influence of the MASH Sigma-Delta Modulator (SDM) to the synthesizer output phase noise. The integrated fractional-N frequency synthesizer is implemented with MASH 1-1-1 SDM. On one hand, better fractional and reference spurious suppression is achieved by randomizing the modulus of frequency dividers; on the other hand, the spurious noise is push to higher frequency and will be further filtered out by the PLL. The frequency synthesizer is operated over 4GHz. The simulated phase noise is -115dBc/Hz at 1MHz offset, and the settling time is less than 30μs at 600MHz frequency jumping.ABSTRACT…………………………………………………………………v
LIST OF FIGURE……………………………………………………… xi
LIST OF TABLES……………………………………………………… xv
CHAPTER 1 INTRODUCTION………………………………………………1
1.1 Motivatio………………………………………………………… 1
1.2 Various Types of Frequency Synthesizer Architectures…2
1.2.1 Digital Synthesizer………………………………………… 2
1.2.2 Direct Synthesizer……………………………………………3
1.2.3 PLL-Based Synthesizer……………………………………… 3
1.2.4 Fractional-N Synthesizer……………………………………5
1.3 Fractional-N Synthesis in Various CommunicationSystems8
1.4 Thesis Organization…………………………………………… 9
CHAPTER 2 THE BASICS OF FREQUENCY SYNTHESIZER………………11
2.1 General Considerations……………………………………… 11
2.1.1 Phase Noise……………………………………………………12
2.1.2 Spurs……………………………………………………………13
2.2 Phase Locked Loop(PLL) Fundamentals………………………14
2.2.1 Voltage Controlled Oscillator(VCO)…………………… 15
2.2.2 Phase Frequency Detector(PFD)……………………………16
2.2.3 Charge Pump(CP)………………………………………………19
2.2.4 Loop Filter……………………………………………………21
2.3 Phase Noise Performance Analysis………………………… 23
2.3.1 Noise at Input……………………………………………… 23
2.3.2 Noise of VCO………………………………………………… 25
2.4 Charge-Pump PLL Design……………………………………… 26
2.4.1 Second-Order PLL…………………………………………… 26
2.4.2 Third-Order PLL………………………………………………29
2.4.3 Fourth-Order PLL…………………………………………… 32
CHAPTER 3 SYBTHESIZER ARCHITECTURE BEHAVIORAL SIMULATION 35
3.1 Design Specification………………………………………… 35
3.2 Synthesizer Architecture…………………………………… 36
3.3 Behavioral Simulation…………………………………………36
3.3.1 Integer-N PLL Model…………………………………………38
3.3.2 Dual-Controlled Integer-N PLL Model……………………40
3.3.3 Fractional-N PLL Model…………………………………… 42
CHAPTER 4 DESIGN OF FREQUENCY SYNTHESIZER……………………47
4.1 PLL Building Blocks……………………………………………47
4.1.1 Phase Frequency Detector(PFD)……………………………47
4.1.2 Charge Pump(CP)………………………………………………49
4.1.3 Loop Filter(LF)………………………………………………50
4.1.4 Voltage Controlled Oscillator(VCO)…………………… 53
4.1.5 Multi-Modulus Divider(MMD)……………………………… 55
4.2 Sigma-Delta Modulator…………………………………………57
4.2.1 Modulator Topology………………………………………… 58
4.2.2 Implementation of Pipelined MASH 1-1-1 Modulator… 60
CHAPTER 5 SIMULATION AND MEASUREMENT RESULTS……………… 65
5.1 Mixed Signal Design Flow…………………………………… 65
5.2 Simulation Tools……………………………………………… 67
5.3 Simulation Results…………………………………………… 67
5.3.1 Simulation Results of PFD and Charge Pump……………68
5.3.2 Simulation Results of VCO…………………………………71
5.3.3 Simulation Results of MMD…………………………………73
5.3.4 Simulation Results of MASH 1-1-1 SDM………………… 74
5.3.5 Closed-Loop Simulation ……………………………………76
Reference………………………………………………………………8
Pressure estimation of piezoelectric rings embedded orthogonally in cynlindrical shells
Full text linkThesis (M.S.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1998.Includes bibliographical references (leaves 93-94).by Ching-Yu Lin.M.S
Supplemental material for Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity
No full textSupplemental Material for Immunomodulatory properties of medicinal mushrooms: differential effects of water and ethanol extracts on NK cell-mediated cytotoxicity by Chia-Chen Lu, Ya-Jing Hsu, Chih-Jung Chang, Chuan-Sheng Lin, Jan Martel, David M Ojcius, Yun-Fei Ko, Hsin-Chih Lai and John D Young in Innate Immunity</p
Design drawing / Francis D.K. Ching with Steve Juroszek.
No full textIncludes index.Book fair 2013.viii, 408 p. :Get the completely revised edition to mastering the visual language of architecture. In his distinctive graphic style, world-renowned author and architecture educator Francis D.K. Ching takes us on another exciting journey through the process of creation. In Design Drawing, Second Edition, he unmasks the basic cognitive processes that drive visual perception and expression, incorporating observation, memory, and rendering into a creative whole. This edition unites imaginative vision with fundamental architectural principles to cover the traditional basics of drawing, including line, shape, tone, and space. Guiding the reader step-by-step through the entire drawing process, Design Drawing also examines different types of drawing techniques such as multiview, paraline, and perspective drawings -- and how they can be applied to achieve stunning results. In addition, this edition: -Goes beyond basic drawing books'Ching not only covers the principles, media, and techniques of drawing, but also places these within the context of what and why designers draw.-Features more than 1,500 hand-rendered drawings'beautiful illustrations that reinforce the concepts and lessons of each chapter.-Includes a supplemental CD-ROM'viewers will gain a greater appreciation of the techniques presented in this book through the power of animation, video, and 3D models. Twelve new modules are included, as is a video of the author demonstrating freehand techniques in a step-by-step manner. For professional architects, designers, fine artists, illustrators, teachers and students alike, this all-in-one package is both an effective tool and an outstanding value, demonstrating concepts and techniques in a visually stimulating format that transends comparable works in the field
Nettenchelys proxima
No full text* Nettenchelys proxima Smith, Lin & Chen, 2015 ⁂ffiAEª Nettenchelys proxima Smith, Lin & Chen in Smith et al., 2015: 114. (type locality: Dong-gang, southwestern Taiwan). Remarks. A rare species only represented by the holotype and a tentatively identified specimen from the Philippines.Published as part of Ho, Hsuan-Ching, Smith, David G., Mccosker, John E., Hibino, Yusuke, Loh, Kar-Hoe, Tighe, Kenneth A. & Shao, Kwang-Tsao, 2015, Annotated checklist of eels (orders Anguilliformes and Saccopharyngiformes) from Taiwan, pp. 140-189 in Zootaxa 4060 (1) on page 165, DOI: 10.11646/zootaxa.4060.1.16, http://zenodo.org/record/24365
Reproductive Contributions of Foreign Wives in Taiwan: Similarities and Differences among Major Source Countries
Full text linkIn light of the entrenchment of sub-replacement fertility and the sharp increase in the stock of foreign wives in Taiwan in recent years, this research studies the reproductive contributions of Taiwan’s foreign wives from the top five source countries (China, Vietnam, Indonesia, Thailand, and the Philippines), based mainly on an application of a multinomial logit model to the micro data of the 2003 census of foreign wives. Our main findings are as follows. First, the overall fertility level of the foreign wives was probably somewhat higher than that of the native-born women and definitely lower than the replacement level. Second, among the five nationalities, those from China were much less reproductive than those from the other countries, mainly because the former were more prone to (1) having a rather old marriage age, (2) having a very large spousal age gap, (3) being separated or divorced, (4) having their current marriage being their second marriage, and (5) having a veteran as the husband. Third, among the four Southeast Asian nationalities, those from Indonesia and the Philippines were more reproductive than those from Thailand and Vietnam. This contrast was a muted reflection of the fertility difference in countries of origin. Fourth, for every nationality, marriage duration and marriage age were the most powerful explanatory factors and must be included in the model to avoid getting misleading estimated coefficients of other less powerful explanatory factors, whereas current age was a spurious factor that should not be used in the model. Fifth, in the context of marriage duration and marriage age, the explanatory factors with rather strong explanatory powers for at least one nationality included spousal age gap, marital status, remarriage status, co-residence with parent, and wife’s employment status. Sixth, the expected negative effect of wife’s educational attainment on lifetime fertility turned out to be either non-existent or modest. In particular, it had practically no effect on the probability of being childless. These findings implied that getting better educated foreign wives could increase the quality of their children with little or no reduction in the number of their children and in their probability of being childlessASEAN countries, China, international marriage, international migration, fertility, Taiwan
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