1,077 research outputs found
MAGNETIC-PROPERTIES OF (ND(0.9)R(0.1))(5)FE-17 WITH R=SM, GD, AND Y
No full textPhysics, AppliedSCI(E)
Total small RNA type annotations of the three libraries (CC, CY, CX).
No full text<p>Total small RNA type annotations of the three libraries (CC, CY, CX).</p
Total small RNA reads length distributions of the three libraries (CC, CY, and CX).
No full text<p>Total small RNA reads length distributions of the three libraries (CC, CY, and CX).</p
Josephson current via an isolated Majorana zero mode
No full textWe study the equilibrium dc Josephson current in a junction between an s-wave and a topological superconductor. Cooper pairs from the s-wave superconducting lead can transfer to the topological side either via an unpaired Majorana zero mode localized near the junction or via the above-gap continuum states. We find that the Majorana contribution to the supercurrent can be switched on when time-reversal symmetry in the conventional lead is broken, e.g., by an externally applied magnetic field inducing a Zeeman splitting. Moreover, if the magnetic field has a component in the direction of the effective spin-orbit field, there will be a Majorana-induced anomalous supercurrent at zero phase difference. These behaviors may serve as a signature characteristic of Majorana zero modes and are accessible to devices with only superconducting contacts.QRD/Wimmer GroupBUS/Quantum Delf
Oregon serious crime survey
No full textauthor, survey administration and data processing: Stan WoodwellCaption titleThis archived document is maintained by the State Library of Oregon as part of the Oregon Documents Depository Program. It is for informational purposes and may not be suitable for legal purposesBureau of Justice Statistics, United States Department of Justice 80-BJ-CX-K009 82-BJ-CX-0002 82-BJ-CX-0014Mode of access: Internet from the Oregon Government Publications CollectionText in Englis
Casein Kinase 2 Inhibitor, CX-4945, as a Potential Targeted Anticancer Agent in Gastric Cancer
No full textBACKGROUND/AIM: Casein kinase 2 (CK2) is involved in multiple cellular processes. Furthermore, its overexpression in several human cancers has been associated with tumor progression. In this study, we evaluated the efficacy of the CK2 inhibitor, CX-4945, in gastric cancer cell lines and explored the potential predictive biomarkers for CX-4945 sensitivity.
MATERIALS AND METHODS: The sensitivity to CX-4945 was screened in 49 gastric cancer cell lines by the MTT assay. The mRNA and protein expression of CK2 subunits (α and α') were determined using qRT-PCR and western blot. Furthermore, the activity of CK2α was measured by ELISA. Gene expression and mutations were analyzed via whole-exome and RNA sequencing.
RESULTS: The sensitivity to CX-4945 was determined by the inhibition rate (%) at the effective dose (10 μM) which ranged from -1% to 89% in 49 gastric cancer cell lines. CK2α', but not CK2α, mRNA expression was correlated with CX-4945 sensitivity.
CONCLUSION: In this study, CX-4945 showed modest antitumor efficacy in gastric cancer cell lines. CK2 might represent a potential therapeutic target for gastric cancer.restrictio
Compositional changes of <i>Cx. quinquefasciatus</i> and <i>Cx. tritaeniorhynchus</i> in total mosquitoes collected in Mangshi and Ruili, 2010.
No full text<p>Compositional changes of <i>Cx. quinquefasciatus</i> and <i>Cx. tritaeniorhynchus</i> in total mosquitoes collected in Mangshi and Ruili, 2010.</p
CX-5461 is a DNA G-quadruplex stabilizer with selective lethality in BRCA1/2 deficient tumours.
No full textG-quadruplex DNAs form four-stranded helical structures and are proposed to play key roles in different cellular processes. Targeting G-quadruplex DNAs for cancer treatment is a very promising prospect. Here, we show that CX-5461 is a G-quadruplex stabilizer, with specific toxicity against BRCA deficiencies in cancer cells and polyclonal patient-derived xenograft models, including tumours resistant to PARP inhibition. Exposure to CX-5461, and its related drug CX-3543, blocks replication forks and induces ssDNA gaps or breaks. The BRCA and NHEJ pathways are required for the repair of CX-5461 and CX-3543-induced DNA damage and failure to do so leads to lethality. These data strengthen the concept of G4 targeting as a therapeutic approach, specifically for targeting HR and NHEJ deficient cancers and other tumours deficient for DNA damage repair. CX-5461 is now in advanced phase I clinical trial for patients with BRCA1/2 deficient tumours (Canadian trial, NCT02719977, opened May 2016)
The Application of CX and UX Design in the Marketing Field in Finland
No full textThis Bachelor’s thesis was conducted based on the author’s observation on the potential of UX and CX applications in the marketing field in Finland. The author noticed that Finland’s marketing could be changed to become better with innovation and creation instead of using repetitive methods. The thesis aims to identify essential points to clarify that Finland is a potential market for both UX/CX design and marketing development, especially from the aspect of firms and organizations.
The thesis contains three main parts, theoretical framework, research method, and data analysis. The theoretical framework aims to provide basic knowledge of UX and CX design and their relation to marketing. Additionally, the study of Finland’s market is done by analysing aspects digitalization and technological development, B2B and B2C performance, the number of SMEs and large corporations in the market, and the digital marketing situation. All the listed components are analysed in detail to provide high-quality overview of the chosen market which supports the conclusion of the potential of Finland.
The second part of the thesis is the research method. The thesis only has qualitative research and interviews as the main method to assist the idea of the topic. The questionnaire of 10 questions was made and sent to the interviewee for preparation to ensure that the interviewed person had knowledge relating to the topic. The criteria for the candidates are working or having worked experience in Finland, familiar with the thesis topic having an academic understanding of the topic and having a job title related to UX/CX design and marketing. Each interview lasted from 30-40 minutes giving each question 3 more minutes to answer ensuring the deep in length of the answer.
The data analysis part requires the author to collect and combine all answers from all candidates to give the conclusion to each and finalize the output of the thesis which must answer the research question and all 5 investigated questions. The analysis was done by going through each question and combining the relation between each to conduct well-researched contention for each part. There are 4 small points in the data analysis: UX and CX application in Finland, marketing performance in Finland, components for a good UX and CX design, and tools and strategies for UX and CX in Finland. The solution for the Finland’s market is optimistic, the country itself is suitable for both UX/CX and marketing development and application despite some barriers related to general behaviour and trending.
Finally, the thesis conclusion provides certain knowledge to readers about the potential of UX and CX in marketing in Finland both pros and cons. The thesis indicates clearly what could have been done and what should be done to improve the development of both UX/CX and marketing in the Finnish market
Enhancing team collaboration in the Customer Experience department: Improving collaboration between the teams of the CX department for a more consistent implementation of the customer needs
No full textFlyco is a large airline company who has built its strategy emphasising on operational excellence. Yet, since competitors can now achieve similar results, they have expanded their strategy to offering excellent customer experience too, resulting in the foundation of the Customer Experience (CX) department. Nevertheless, Flyco notices their NPS is not rising above 50. One of the reasons is the silo-driven lay-out a typical corporate as Flyco has, where teams lack knowledge sharing. A way to bridge these silos is by using cross-functional collaboration, where multiple distinct functions come together to tackle complex problems with a multidisciplinary perspective. This results in the research question: “How can Flyco improve the consistent implementation of customer needs throughout the customer journey through more effective collaboration between the different teams of the CX department?” During the research, multiple perspectives are taken into consideration. At first, the connection between collaboration and customer needs is defined to learn why the stated claim is currently a problem. Thereafter, the current way of collaboration between the different teams is reflected on by means of seven in-depth interviews with employees. Simultaneously, a literature review gives insights into what way effective cross-functional collaboration should be framed and which elements are essential. However, since multiple elements have a considerable effect on cross-functional collaboration, a decision needs to be made for a focal point to realise effective change at one, or a few of these elements. A quantitative analysis, filled in by the CX department, gives insight into where the department believes they could improve. The focus is put where most progress can be made for the CX department. This results in a focus on effective knowledge sharing between the different teams through more effective and open communication to lead the focus within the department towards the group.Plenty literature has been written in knowledge management including multiple tools and methods. Nevertheless, earlier attempts in implementing a new knowledge management method have failed due to unacceptance of implementation by the employees. Therefore the behaviour of the employees needs to change. Consequently, literature in behaviour change is reviewed, resulting in four behaviour change techniques most appropriate for this problem. Five concepts are established through combining cocreation insights on the behaviour change techniques with knowledge management tools and methods. These concepts in unison form a system for a profound knowledge management, which ideally are all developed and applied. However, for the purpose of this thesis, the concept ‘Community of Practice (CoP)’ is chosen for further development.The concept focuses on knowledge sharing through a group, sharing a domain/passion, a practice, and a community, coming together to discuss a question or statement stated by one of the teams of the CX department. People can apply when they are interested to learn more or have gained expertise in this area. The group of employees form a community group where they run through five steps to get an agreement on the topic. The results will be shared with the department for knowledge sharing.Strategic Product Desig
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