9,357 research outputs found
Father Andrew Mullen 1790-1818: a study in early nineteenth century spirituality
Full text linkThis thesis is laid out in three parts: Part I. The life and death of Andrew Mullen. The life is based, to a large extent, on a long letter to his mother, Catherine Mullen, dated 7 January 1810. The letter gives a definite insight into his spirituality based on his membership of the Archconfraternity of the Blessed Sacrament. There is a hint that he had a premonition of an early death. Part II. The burial of Andrew Mullen and the immediate cult to him This is based on documentary evidence. Part III. Most of this part is a catalogue of testimonies taken from 1993 onwards. Then there is the conclusion on the popular devotion to Andrew Mullen stressing the theological aspect of the subject. In the course of writing the thesis it was decided to separate the documentary evidence from the oral tradition. This was advantageous in developing the thesis, and the documents provided a secure basis for the oral tradition. Two pieces of information were found in March 1997. They are death notices: 2 January 1819, The Leinster Journal and 7 January 1819, The Car low Morning Post. There is a slight discrepancy between the two on the date of his death. Also this discrepancy shows a slight difference from the date of the tombstone
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
Letter from Andrew Steelman to James B. Finley
Full text linkSteelman writes concerning his incarcerated son James. He would like Finley to deal strictly with him. Author is great grandson of Andrew T. Steelman. He has recently gone home to New Jersey to deal with the estate of his great grandfather. Folks do not want James to return home when released. Abstract Number - 1086https://digitalcommons.owu.edu/finley-letters/2070/thumbnail.jp
Development Strategies and Regional Income Disparities in China
Full text linkSince the economic reforms began in 1978, China has achieved remarkable economic results. Real GDP per capita grew at an average annual rate of 8.1% in the period of 1978-2001. Maintaining such a high growth rate over such a long period of time with a population of more than one billion truly is a miracle in world economy history (Lin et. al. 1994 and 1999).China, Regional income disparities, Income Distribution
Approaches for solving some scheduling and routing problems
No full textWe study approaches for finding good solutions, and lower bounds, for three difficult combinatorial optimisation problems.The supply ship travelling salesman problem is a simplification of a situation faced by a naval logistics coordinator who must direct a support vessel tasked with resupplying ships in a fleet. It is a generalisation of the travelling salesman problem in which the nodes are in motion, each following some predetermined route. We apply dynamic programming state-space relaxation
techniques, producing lower bounds for the problem that are 73% to 84% of the best solution, on average. We also apply heuristics to find good solutions to this NP-hard problem, showing that restricted dynamic programming approaches outperform simple 2-opt and 3-opt local search procedures
for instances with 20 nodes.We introduce the supply ship scheduling problem, another roblem inspired by a support vessel environment. We wish to minimise the number of mobile machines required to process a set of jobs; each job is in a different stationary location and features a fixed start time. Jobs may be simultaneously processed by multiple machines, obtaining a speed-up in processing time. We represent the problem as a directed graph and use the minimum flow in a transformed network to determine the minimum number of machines. We present a neighbourhood structure based on the maximum cut, applying it
within descent and tabu search procedures. We construct a restricted dynamic programming based approach, but this is outperformed by the tabu search algorithm.The task allocation problem, arising in distributed computing, is to assign a set of tasks to a set of processors so that the overall cost is minimised. Costs are incurred from processor usage, interprocessor communication and task execution. We construct, and try to improve, semidefinite programming relaxations to find lower bounds for variants of this NP-hard problem. We develop a branch-and-bound approach to find optimal solutions, but this is only effective for small instances
Review of The Health of Nations: Infectious Disease, Environmental Change, and Their Effects on National Security and Development, by Andrew T. Price-Smith
Full text link[Excerpt] Andrew T. Price-Smith, author of The Health of Nations: Infectious Disease, Environmental Change, and Their Effects on National Security and Development, provides a well documented and reasoned analysis of the need for world leaders, including the United States, to place the threat of infectious disease on the front burner of consideration when shaping both national and international policy. Professor Price-Smith has provided both empirical data and historical analysis to support the impassioned plea for this natural threat to be taken seriously. The book is geared toward the academic community and policy analysts; however, other professionals not involved in these arenas yet interested in this under-explored consideration will find the book easy to read and follow
T Cell responses to whole SARS Coronavirus in humans
Full text linkEffective vaccines should confer long-term protection against future outbreaks of severe acute respiratory syndrome (SARS) caused by a novel zoonotic coronavirus (SARS-CoV) with unknown animal reservoirs. We conducted a cohort study examining multiple parameters of immune responses to SARS-CoV infection, aiming to identify the immune correlates of protection. We used a matrix of overlapping peptides spanning whole SARS-CoV proteome to determine T cell responses from 128 SARS convalescent samples by ex vivo IFN-γ ELISPOT assays. Approximately 50% of convalescent SARS patients were positive for T cell responses, and 90% possessed strongly neutralizing Abs. Fifty-five novel T cell epitopes were identified, with spike protein dominating total T cell responses. CD8+ T cell responses were more frequent and of a greater magnitude than CD4+ T cell responses (p < 0.001).
Polychromatic cytometry analysis indicated that the virus-specific T cells from the severe group tended to be a central memory phenotype (CD27+/CD45RO+) with a significantly higher frequency of polyfunctional CD4+ T cells producing IFN-γ, TNF-α, and IL-2, and CD8+ T cells producing IFN-γ, TNF-α, and CD107a (degranulation), as compared with the mild-moderate group. Strong T cell responses correlated significantly (p < 0.05) with higher neutralizing Ab. The serum cytokine profile during acute infection indicated a significant elevation of innate immune responses. Increased Th2 cytokines were observed in patients with fatal infection. Our study provides a roadmap for the immunogenicity of SARS-CoV and types of immune responses that may be responsible for the virus clearance, and should serve as a benchmark for SARS-CoV vaccine design and evaluation
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