2,807 research outputs found
Novel Dialogue 5.1 We Have This-ness, Y’all! Ocean Vuong and Amy E. Elkins (EH)
No full textSeason 5 of Novel Dialogue opens with an impassioned refresher course in literary theory brought to you by Ocean Vuong, poet and author of the bestselling novel On Earth We’re Briefly Gorgeous (2019). Ocean talks with critic Amy E. Elkins and host Emily Hyde about browsing bookstore shelves and building his personal reading list of “life-giving weirdos.” They discuss genre and gender, antiquing and thrifting, fish sauce and photography, all the while integrating the insights of queer theory and the full range of literary history. What does looking at the world as a junkyard have to do with making art? What does it feel like to run smack dab into a memory? How can we be mindful of the fact that words (like “this”) are tiny objects with infinite possibilities? If autofiction annoys you, listen for how the form reinvents the self against dominant class and gender structures. And if your boots have ever touched down in Hot Springs, Arkansas, stay tuned for our signature question and don’t miss this episode
Creighton University Magazine Summer 2010
No full textDEVELOPING ENTREPRENEURS
It is a safe bet that 10 or 20 years from now the sun will rise on an America filled with millions of inventions that do not currently exist. The questions are: What will those inventions be? Will they make the world a better place? And who will bring them to market? Creighton’s entrepreneurship programs are helping provide some answers. Page 8.
AT SECOND GLANCE: THE KARL MARX YOU NEVER KNEW
What is it in Marx that is, and has remained, so powerful in the more than a century since his death in 1883? To answer this question, we will have to begin thinking about Marx in different ways, writes Creighton’s Amy Wendling, Ph.D., assistant professor of philosophy, a Marx scholar and author of the new book Karl Marx on Technology and Alienation. Page 12.
FACULTY AFTER HOURS
In and out of the classroom, a Creighton University education is about the development of the whole person. Learn about some of the life-affirming pursuits of Creighton faculty members outside of academe — from the whimsical to the more serious. Page 16.
EVENING OF HONORS: ALUMNI AWARDS CEREMONY / EVENING OF HONORS
Five Creighton alumni, who have distinguished themselves in their professional and personal lives, were recognized on April 8 during an Evening of Honors Alumni Awards Ceremony on campus. Page 20.
AYERS ON PACE TO CROSS FINISH LINE AFTER 38 YEARS / FRANK AYERS RETIRES
Frank Ayers, DDS’69, is more than an administrator and faculty member in the School of Dentistry — he is an institution. Ayers is retiring June 30, after 38 years of service to Creighton University. Page 22.32
045 - Amy Elizabeth Boncella
No full textMutations in a number of stress granule-associated proteins have been linked to various neurodegenerative diseases. Several of these mutations are found in aggregation-prone intrinsically disordered domains (IDRs) of these proteins. My studies have focused on two IDR-containing yeast stress granule proteins, Pab1 and Pbp1. I have introduced mutations designed to enhance aggregation of these proteins and observed effects on stress granule dynamics. Results suggest that these mutations affect IDR localization in the context of overexpression, but do not affect stress granule dynamics in an endogenous system. This has led to questions about how the proteostasis machinery affects stress granule dynamics
Correction: Gheyoh Ndzi, E.; Holmes, A. Paternal Leave Entitlement and Workplace Culture: A Key Challenge to Paternal Mental Health. Int. J. Environ. Res. Public Health 2023, 20, 5454
No full textAmy Holmes was not included as an author in the original publication [...
Regulation of lin-4 miRNA expression, organismal growth and development by a conserved RNA binding protein in C. elegans
No full textAbstractTranscription and multiple processing steps are required to produce specific 22 nucleotide microRNAs (miRNAs) that can regulate the expression of target genes. In C. elegans, mature lin-4 miRNA accumulates at the end of the first larval stage to repress its direct targets lin-14 and lin-28, allowing the progression of several somatic cell types to later larval fates. In this study, we characterized the expression of endogenous lin-4 and found that temporally regulated independent transcripts, but not constitutive lin-4 containing RNAs derived from an overlapping gene, are processed to mature lin-4 miRNA. Through an RNAi screen, we identified a conserved RNA binding protein gene rbm-28 (R05H10.2), homologous to the human RBM28 and yeast Nop4p proteins, that is important for lin-4 expression in C. elegans. We also demonstrate that rbm-28 genetically interacts with the lin-4 developmental timing pathway and uncover a previously unrecognized role for lin-14 and lin-28 in coordinating organismal growth
The Period protein homolog LIN-42 negatively regulates microRNA biogenesis in C. elegans
No full textAbstractMicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate gene expression in many multicellular organisms. They are encoded in the genome and transcribed into primary (pri-) miRNAs before two processing steps that ultimately produce the mature miRNA. In order to generate the appropriate amount of a particular miRNA in the correct location at the correct time, proper regulation of miRNA biogenesis is essential. Here we identify the Period protein homolog LIN-42 as a new regulator of miRNA biogenesis in Caenorhabditis elegans. We mapped a spontaneous suppressor of the normally lethal let-7(n2853) allele to the lin-42 gene. Mutations in this allele (ap201) or a second lin-42 allele (n1089) caused increased mature let-7 miRNA levels at most time points when mature let-7 miRNA is normally expressed. Levels of pri-let-7 and a let-7 transcriptional reporter were also increased in lin-42(n1089) worms. These results indicate that LIN-42 normally represses pri-let-7 transcription and thus the accumulation of let-7 miRNA. This inhibition is not specific to let-7, as pri- and mature levels of lin-4 and miR-35 were also increased in lin-42 mutants. Furthermore, small RNA-seq analysis showed widespread increases in the levels of mature miRNAs in lin-42 mutants. Thus, we propose that the period protein homolog LIN-42 is a global regulator of miRNA biogenesis
Regulation by let-7 and lin-4 miRNAs Results in Target mRNA Degradation
No full textSummaryMicroRNAs (miRNAs) are ∼22 nucleotide RNAs that negatively regulate the expression of protein-coding genes. In a present model of miRNA function in animals, miRNAs that form imperfect duplexes with their targets inhibit protein expression without affecting mRNA levels. Here, we report that in C. elegans, regulation by the let-7 miRNA results in degradation of its lin-41 target mRNA, despite the fact that its 3′UTR regulatory sequences can only partially base-pair with the miRNA. Furthermore, lin-14 and lin-28 are targets of the lin-4 miRNA, and we show that the mRNA levels for these protein-coding genes significantly decrease in response to lin-4 expression. This study reveals that mRNAs containing partial miRNA complementary sites can be targeted for degradation in vivo, raising the possibility that regulation at the level of mRNA stability may be more common than previously appreciated for the miRNA pathway
Atlas of canine and feline peripheral blood smears /
No full text"An illustrated guide to the morphology of blood cells, Atlas of Canine and Feline Peripheral Blood Smears covers patient assessment for common hematologic disorders and diseases in dogs and cats. Over 1,000 full-color photomicrographs depict abnormalities within each blood cell line, with multiple pictures of each morphologic abnormality and variations in their appearance. Written by pathology experts Amy Valenciano, Rick Cowell, Theresa Rizzi, and Ronald Tyler, this concise reference will enhance your skills as you interpret blood smears and recognize hematological cellular response to inflammation, infection, and toxicity."--Provided by publisher.Includes bibliographical references and index.Online resource; title from e-book title screen (ScienceDirect platform, viewed August 18, 2016)."An illustrated guide to the morphology of blood cells, Atlas of Canine and Feline Peripheral Blood Smears covers patient assessment for common hematologic disorders and diseases in dogs and cats. Over 1,000 full-color photomicrographs depict abnormalities within each blood cell line, with multiple pictures of each morphologic abnormality and variations in their appearance. Written by pathology experts Amy Valenciano, Rick Cowell, Theresa Rizzi, and Ronald Tyler, this concise reference will enhance your skills as you interpret blood smears and recognize hematological cellular response to inflammation, infection, and toxicity."--Provided by publisher.General assessment -- Red blood cells -- White blood cells -- Platelets -- Hematopoietic neoplasia -- Extracellular organisms.Produced by the publisher.Held by CAPER-BC, Langara College.Elsevie
Articulating the Value of Our Daily Work: An Initial Discussion of the Assessment Challenges of Engineering Librarians
No full textEngineering librarians need to assess the effectiveness of our library instruction and outreach for many reasons, including communicating library value to institutional stakeholders and making impactful contributions to the scholarly literature. However, as practitioners, most librarians have not been formally educated in research design, data collection, and data analysis. To increase our skills and knowledge and to better align with various publication expectations and guidelines (e.g., ELD Author Guidelines), this panel will lead a discussion on library assessment needs with regard to research design, data collection, data analysis, and dissemination and discovery. The goal of the panel is to facilitate a conversation regarding librarian assessment challenges and needs to design a future ASEE workshop.
Panelists: Amy Buhler, Margaret Phillips, Amy Van Epps
This presentation was delivered as part of a modified panel session at the 2019 ASEE Annual Conference in Tampa, Florida
Axel Honneth and Amy Allen: "Historical progress" and the legacy of the Dialectic of Enlightenment
No full textThe article aims to present a contention between Axel Honneth and Amy Allen regarding the idea of historical progress and its role for a Critical Theory of Society. In particular, the following points are discussed: a) the Honneth's understanding of the Dialectic of Enlightenment, regarding to his critique of progress, and the social theory that the author develops in response; b) Allen's criticism of Honneth's perspective, from which she proposes an alternative understanding of Adorno's contribution to the concept – extracting from the Frankfurt philosopher clues to a project of decolonization of Critical Theory. To this end, the text analyzes centrally the works The End of Progress, by Allen, and The Critique of Power and Freedom's Right, by Honneth.O artigo propõe apresentar a divergência entre Axel Honneth e Amy Allen quanto à ideia de progresso histórico e seu papel para uma teoria crítica da sociedade. Particularmente, são discutidas: a) a leitura de Honneth da Dialética do esclarecimento no que se refere à sua crítica do progresso, e a teoria social que o autor formula em resposta; b) a crítica de Allen à perspectiva de Honneth, a partir da qual a autora propõe um entendimento alternativo sobre a contribuição de Adorno ao debate – enxergando no filósofo de Frankfurt pistas para um projeto de descolonização da Teoria Crítica. Para tal, foram estudadas centralmente as obras O fim do progresso, de Allen, e A crítica do poder e O direito da liberdade, de Honneth
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