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Supplemental Material - Evaluation of the Psychometric Properties of a Newly Developed Chinese Screening Tool for Speech Disorders in Patients With Parkinson’s Disease
No full textSupplemental Material for Evaluation of the Psychometric Properties of a Newly Developed Chinese Screening Tool for Speech Disorders in Patients With Parkinson’s Disease by Chi-Lin Chen, Ching-Huang Lin, Chen-San Su, Hsiang-Chun Cheng, Li-Mei Chen, Rong-Ju Cherng in Evaluation & the Health Professions</p
Dynamic Modularity and Regulation in Protein Interaction Networks
No full text蛋白質交互作用網路可用來呈現細胞內分子間活動的基礎架構並且提供了解疾病可能機制的契機。信使核醣核酸的表現量以及微型核醣核酸的調控會影響蛋白質的量，進而影響蛋白質交互作用網路中的每筆交互作用。因此，我們結合蛋白質交互作用網路、信使核醣核酸的表現量以及微型核醣核酸的調控發展出一套整合型的分析方法，並利用這套方法去探討蛋白質交互作用網路中的動態模組性以及微型核醣核酸調控的特定蛋白質交互作用網路。
在分析動態模組性方面，藉由整合擴張型心肌病變病人的信使核醣核酸表現量與蛋白質交互作用的資料，我們發現在正常及疾病的樣本間有大量的交互作用發生重新連結的現象，這可能揭露了隱含於靜態交互作用網路中的動態資訊。我們更發現了兩個與心臟衰竭相關的功能性網路模組，而這兩個模組在正常及疾病樣本間的動態特性更進一步地提供了一個潛在的擴張型心肌病變的分子機制。
在微型核醣核酸方面，藉由整合微型核醣核酸的調控目標基因以及蛋白質交互作用網路，我們發展了一套方法來發掘出微型核醣核酸調控的交互作用網路以及預測它們在特定情況下的功能。另外，運用這個方法在胃癌的研究中也發現了幾個與癌症的發展有關的微型核醣核酸調控網路。進一步的分析更發現這些微型核醣核酸具有抑制胃癌腫瘤的可能性。其中，miR-148a更可以透過其調控目標去減少癌細胞的侵略、遷移以及附著的能力來降低癌細胞的增生及轉移。
在此我們提出了一個新方法去探索不同情況下蛋白質網路中的動態模組性及微型核醣核酸調控機制，也成功找到了和心臟衰竭高度相關的網路模組及具抑制胃癌腫瘤潛力的微型核醣核酸。最後，這些找到的網路模組及微型核醣核酸調控的蛋白質網路可能可以作為新的藥物標靶和提供治療心臟衰竭及胃癌的新方向。Protein interaction networks can represent the backbone of molecular activity within cells and thus provide opportunities for understanding the mechanism of diseases. Through their influence on protein abundance, mRNA expression and microRNA regulation can affect the interaction dynamics within protein networks. Therefore, we developed an integrative analysis of protein interaction network by incorporating mRNA expression and microRNA regulation to reveal the dynamic modularity and microRNA-regulated networks in protein interaction networks.
For the dynamic modularity analysis, we integrated mRNA expression profiles of a cohort of dilated cardiomyopathy patients with protein-protein interactions and found a large amount of interaction rewiring between normal and disease samples. It might suggest that the condition-specific dynamic information hid among otherwise common static interactions. We identified two heart-failure related functional modules that significantly emerged from the protein interaction networks. Additionally, the dynamic change of these modules between normal and disease states further suggested a potential molecular model of dilated cardiomyopathy.
For microRNA regulations, we integrated the information of microRNA expression, target mRNA expression, and target protein-protein interaction and developed an approach to reveal microRNA-regulated protein interaction networks and to determine their functional roles in specific biological conditions. Applying this approach to investigate gastric tumor samples revealed several microRNA-regulated networks which were enriched in functions related to cancer progression. Further analyses showed that these microRNAs could be potential tumor suppressors of gastric cancer. Among them, miR-148a decreased tumor proliferation and metastasis by reducing the invasiveness, migratory and adhesive activities of tumor cells through its targets.
In conclusion, we proposed a novel framework to discover the dynamic modularity and microRNA regulation embedded in the protein interaction networks in different biological states. It successfully revealed network modules closely related to heart failure and potential tumor suppressor microRNAs involved in gastric cancer. The revealed molecular modules and microRNA-regulated networks might be able to be used as potential drug targets and provide new directions for heart failure and gastric cancer therapy
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
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