149,777 research outputs found
Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
No full textThe crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a dominant-negative CLIM molecule (DN-CLIM) that contains the LIM interaction domain (LID) during early developmental stages of zebrafish embryos results in an impairment of eye and midbrain-hindbrain boundary (MHB) development and disturbances in the formation of the anterior midline. On a cellular level we show that the outgrowth of peripheral but not central axons from Rohon Beard (RB) and trigeminal sensory neurons is inhibited by DN-CLIM overexpression. We demonstrate a further critical role of CLIM cofactors for axonal outgrowth of motor neurons. Additionally, DN-CLIM overexpression causes an increase of Isl-protein expression levels in specific neuronal cell types, likely due to a protection of the DN-CLIM/LIM-HD complex from proteasomal degradation. Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels
Lim (Or Lim You), Mr H P, [No Service Number]
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/399461Surname: LIM (OR LIM YOU). Given Name(s) or Initials: MR H P. Military Service Number or Last Known Location: [No Registration Number]. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 47767.217246
Item: [2016.0049.31754] "Lim (Or Lim You), Mr H P, [No Service Number]
Optimal estimates for the electric field in two dimensions
No full textAbstractWe establish both upper and lower bounds on the electric field in the case where two circular conductivity inclusions are very close but not touching. We also obtain such bounds when a circular inclusion is very close to the boundary of a circular domain which contains the inclusion. The novelty of these estimates, which improve and make complete our earlier results in [H. Ammari, H. Kang, M. Lim, Gradient estimates for solutions to the conductivity problem, Math. Ann. 332 (2005) 277–286], is that they give an optimal information about the blow-up of the electric field as the conductivities of the inclusions degenerate
Data used for Lim et al. (2024)
No full text<p>Data used in Lim et al. (2024)</p>
<p> </p>
<p>Lim, H., Cho, C. S., & Son, M. (2024). The 2022 Goesan earthquake of the moment magnitude 3.8 along the buried fault in the central Korean Peninsula. Journal of Seismology. https://doi.org/10.1007/s10950-024-10201-y</p>
Epanerchodus gangwonus Mikhaljova & Lim 2002
No full textEpanerchodus gangwonus Mikhaljova & Lim, 2002 Epanerchodus gangwonus Mikhaljova & Lim, 2002: 19 –21, 20: figs 1–8. Remarks. Originally described from Gangwon-do, South Korea (Mikhaljova & Lim, 2001), this species has since never been rediscovered. Distribution. South Korea.Published as part of M, E L E N A V., Va, I K H A L J O & Lim, Kil-Young, 2006, The millipede genus Epanerchodus Attems, 1901 in the Korean Peninsula, with a description of a new species (Diplopoda, Polydesmida, Polydesmidae), pp. 45-53 in Zootaxa 1350 on page 48, DOI: 10.5281/zenodo.17451
Four and a half LIM protein 1C (FHL1C)
No full textFour-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied myoblasts from XMPMA patients. We found that functional FHL1A protein is completely absent in patient myoblasts. In parallel, expression of FHL1C is either unaffected or increased. Furthermore, a decreased proliferation rate of XMPMA myoblasts compared to controls was observed but an increased number of XMPMA myoblasts was found in the G(0)/G(1) phase. Furthermore, low expression of K(v1.5), a voltage-gated potassium channel known to alter myoblast proliferation during the G(1) phase and to control repolarization of action potential, was detected. In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. A physical and direct interaction of both proteins was observed in vitro. In addition, confocal microscopy revealed substantial colocalization of FHL1C and K(v1.5) within atrial cells, supporting a possible interaction between both proteins in vivo. Two-electrode voltage clamp experiments demonstrated that coexpression of K(v1.5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C
Parakysis grandis Ng and Lim 1995
No full textParakysis grandis Ng and Lim, 1995 Parakysis grandis Ng and Lim, 1995: 260 (type locality: Riau, near Pangkalankasai, Sumatra). Parakysis verrucosa: Kottelat et al., 1993: 76, pl. 37 (in part). Material examined. BATANG HARI DRAINAGE: ZRC 39178 (1), paratype, 29.3 mm SL. ZRC 38632 (3), CMK 11192 (3), 21.8±24.5 mm SL. ZRC 42419 (1), 23.6 mm SL. ZRC 42494 (1), 25.0 mm SL. INDRAGIRI DRAINAGE: ZRC 39111 (1), holotype, 27.8 mm SL. CMK 9032 (5), 16.2±21.8 mm SL. Remarks. See Ng and Lim (1995) for a discussion of the species.Published as part of Ng, H. H. Tan H. H., 2000, The cat ® shes (Teleostei: Siluriformes) of central Sumatra, pp. 267-303 in Journal of Natural History 34 on page 29
Do insectivorous bird communities decline on land-bridge forest islands in Peninsular Malaysia?
No full textTo assess the impact of habitat fragmentation on tropical avian communities, we sampled lowland forest birds on six land-bridge islands and two mainland forest sites in Lake Kenyir, Peninsular Malaysia using timed point counts, hypothesizing that insectivorous birds are the worst affected guild. We used an information-theoretic approach to evaluate the effects of area, isolation, primary dietary guild (omnivore, frugivore and insectivore) and their interactions in predicting species richness, abundance and diversity. Our analysis showed that a model that considered the effects of area, dietary guild and their interaction best explained observed patterns of species richness. But amodel considering both area and dietary guild best explained the variation in abundance. Notably, insectivorous birds were singled out as the dietary guild most sensitive to fragmentation, followed by frugivorous and omnivorous birds and hence provide support for our hypothesis. Assemblages of insectivorous birds were clearly depauperate on anthropogenic forest islands in Lake Kenyir and are consistent with forest fragmentation studies in the Neotropics. Given their specialized foraging ecology and diversity, conservation of intact communities of insectivorous bird guilds in Malaysia will be critical for maintaining predator–prey interactions in lowland tropical forests.Ding Li Yong, Lan Qie, Navjot S. Sodhi, Lian Pin Koh, Kelvin S.-H. Peh, Tien Ming Lee, Haw Chuan Lim and Susan L.-H. Li
- …
