79,709 research outputs found
Multiple functions of LIM domain-binding CLIM/NLI/Ldb cofactors during zebrafish development
No full textThe crucial involvement of CLIM/NLI/Ldb cofactors for the exertion of the biological activity of LIM homeodomain transcription factors (LIM-HD) has been demonstrated. In this paper we show that CLIM cofactors are widely expressed during zebrafish development with high protein levels in specific neuronal cell types where LIM-HD proteins of the Isl class are synthesized. The overexpression of a dominant-negative CLIM molecule (DN-CLIM) that contains the LIM interaction domain (LID) during early developmental stages of zebrafish embryos results in an impairment of eye and midbrain-hindbrain boundary (MHB) development and disturbances in the formation of the anterior midline. On a cellular level we show that the outgrowth of peripheral but not central axons from Rohon Beard (RB) and trigeminal sensory neurons is inhibited by DN-CLIM overexpression. We demonstrate a further critical role of CLIM cofactors for axonal outgrowth of motor neurons. Additionally, DN-CLIM overexpression causes an increase of Isl-protein expression levels in specific neuronal cell types, likely due to a protection of the DN-CLIM/LIM-HD complex from proteasomal degradation. Our results demonstrate multiple roles of the CLIM cofactor family for the development of entire organs, axonal outgrowth of specific neurons and protein expression levels
Lim (Or Lim You), Mr H P, [No Service Number]
No full textThis record was harvested from a previous catalogue system and will be withdrawn in 2025. Information in this record may be superseded or incomplete. Visit this record in UMA's new catalogue at: https://archives.library.unimelb.edu.au/nodes/view/399461Surname: LIM (OR LIM YOU). Given Name(s) or Initials: MR H P. Military Service Number or Last Known Location: [No Registration Number]. Missing, Wounded and Prisoner of War Enquiry Card Index Number: 47767.217246
Item: [2016.0049.31754] "Lim (Or Lim You), Mr H P, [No Service Number]
Do insectivorous bird communities decline on land-bridge forest islands in Peninsular Malaysia?
No full textTo assess the impact of habitat fragmentation on tropical avian communities, we sampled lowland forest birds on six land-bridge islands and two mainland forest sites in Lake Kenyir, Peninsular Malaysia using timed point counts, hypothesizing that insectivorous birds are the worst affected guild. We used an information-theoretic approach to evaluate the effects of area, isolation, primary dietary guild (omnivore, frugivore and insectivore) and their interactions in predicting species richness, abundance and diversity. Our analysis showed that a model that considered the effects of area, dietary guild and their interaction best explained observed patterns of species richness. But amodel considering both area and dietary guild best explained the variation in abundance. Notably, insectivorous birds were singled out as the dietary guild most sensitive to fragmentation, followed by frugivorous and omnivorous birds and hence provide support for our hypothesis. Assemblages of insectivorous birds were clearly depauperate on anthropogenic forest islands in Lake Kenyir and are consistent with forest fragmentation studies in the Neotropics. Given their specialized foraging ecology and diversity, conservation of intact communities of insectivorous bird guilds in Malaysia will be critical for maintaining predator–prey interactions in lowland tropical forests.Ding Li Yong, Lan Qie, Navjot S. Sodhi, Lian Pin Koh, Kelvin S.-H. Peh, Tien Ming Lee, Haw Chuan Lim and Susan L.-H. Li
Data used for Lim et al. (2024)
No full text<p>Data used in Lim et al. (2024)</p>
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<p>Lim, H., Cho, C. S., & Son, M. (2024). The 2022 Goesan earthquake of the moment magnitude 3.8 along the buried fault in the central Korean Peninsula. Journal of Seismology. https://doi.org/10.1007/s10950-024-10201-y</p>
Effects of ion exchange and calcinations on the structure and photocatalytic activity of hydrothermally prepared titanate nanotubes
No full textTitanate nanotubes (TiNTs) were prepared by alkaline hydrothermal processing. The TiNTs are thermodynamically unstable and easily transformed to the titania phase by heat or acid treatment. These phase transformations are affected by the preparation conditions. In this study, we investigated the effects of using the washing process to modify the sodium content of the TiNTs. After an alkaline hydrothermal process was used to prepare the TiNTs, the resulting suspensions were washed with weak acid solution and distilled water until the pH value of the wash solution reached approximately 1 or 7, and the products were identified as H-TiNTs or Na-TiNTs, respectively. The characteristics and photocatalytic activities of the H-TiNTs and Na-TiNTs were compared for various calcination temperatures. The H-TiNTs were transformed completely to anatase-type TiO 2 by dehydration during calcination, while the crystallinity of the Na-TiNTs increased with calcination temperature. However, the photocatalytic H 2 production rates on calcined H-TiNTs were much higher than on Na-TiNTs, which could be attributed to the crystalline anatase phase. Copyright © 2012 WILEY-VCH Verlag GmbH &amp; Co. KGaA, Weinheim.1
Four and a half LIM protein 1C (FHL1C)
No full textFour-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied myoblasts from XMPMA patients. We found that functional FHL1A protein is completely absent in patient myoblasts. In parallel, expression of FHL1C is either unaffected or increased. Furthermore, a decreased proliferation rate of XMPMA myoblasts compared to controls was observed but an increased number of XMPMA myoblasts was found in the G(0)/G(1) phase. Furthermore, low expression of K(v1.5), a voltage-gated potassium channel known to alter myoblast proliferation during the G(1) phase and to control repolarization of action potential, was detected. In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. A physical and direct interaction of both proteins was observed in vitro. In addition, confocal microscopy revealed substantial colocalization of FHL1C and K(v1.5) within atrial cells, supporting a possible interaction between both proteins in vivo. Two-electrode voltage clamp experiments demonstrated that coexpression of K(v1.5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C
Pseudohaliotrema falcata Lim 2010, n. sp.
No full textPseudohaliotrema falcata n. sp. (gures 2c, 4–6) Description Comparatively large worms, with broad body proper, 1172 (1008–1300) Ö 285 (268–294); narrow cephalic region; three pairs of head organs; four eye-spots consisting of scattered pigment (in xed specimens); comparatively shorter peduncle, 112 (84–143) Ö 125 (117–134), demarcating body from haptor. Intestinal caeca con uent just anterior to peduncle. Haptor broader than long, 92 (84–109) Ö 128 (117–143); dorsal anchors with well-developed roots, inner length 43 (42–44), outer length 34 (32–36), inner root 22 (20–24), outer roots 9 (8–10), point 6 (4–10); ventral anchors robust with expanded outer roots, inner length 32 (30–34), outer length 31 (30–34), inner root 14 (14–16), outer root 8 (6–10), point 5 (4–6); dorsal connecting bar stout, broad, V-shaped, 9 (8–10) Ö 34 (32–36); ventral connecting bar V-shaped, 4 (3–5) Ö 36 (35–38); 14 marginal hooks of larval type, length 11 (10–12). Testis round to ovoid, lateral to ovary; vas deferens leaves left margin of testis antero-ventrally, passing anteriorly intercaecally, to level of male organ, distending forming seminal vesicle; descending, narrowing as ejaculatory duct, turning anteriorly, entering male organ. Male organ consisting of two sclerotized parts: large curved sclerotized piece with scythe-like ending (ap 1 in gure 1f) with broad rather obscure opening (indicated by arrow in gure 1f) through which ejaculatory duct and duct from prostatic reservoir enter; second sclerotized piece with club-like ending (ap 2 in gure 1f) and large proximal opening. Spermatophor e size roughly estimated to be 220 (200–250) Ö 180 (150–200) but shape diYcult to ascertain due to distortion, stored in chamber with ventral opening, antero-ventral to male organ. Prostatic glands postero-lateral (on both sides) of pharyngeal region; left and right prostatic ducts unite to form common duct, draining into large prostatic reservoir. Ovary elongate; oviduct leaves anterior part of ovary; oötype receiving ducts from Mehlis' gland and seminal receptacle; uterus ascends mid-ventrally; uterine pore opens ventrally, near male organ. Dextro-lateral vaginal pouch housing eversible spermatophore transfer tube; vaginal duct linking to seminal receptacle. Vitelline system co-extensive with intestinal caeca; lateral elds unite posterior to intestinal caeca. Type-host. Siganus guttatus (Bloch). Type-locality. OV Singapore. No. of specimens measured. Twenty.Published as part of Lim, L. H. S., 2010, Three new species of Pseudohaliotrema Yamaguti, 1953 (Monogenea: Ancyrocephalidae) from Siganus species (Siganidae) and the description of a mechanism for cross-insemination, pp. 1639-1660 in Journal of Natural History 36 (14) on page 1650, DOI: 10.1080/00222930110067935, http://zenodo.org/record/474760
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