20,062 research outputs found
Four and a half LIM protein 1C (FHL1C)
No full textFour-and-a-half LIM domain protein 1 isoform A (FHL1A) is predominantly expressed in skeletal and cardiac muscle. Mutations in the FHL1 gene are causative for several types of hereditary myopathies including X-linked myopathy with postural muscle atrophy (XMPMA). We here studied myoblasts from XMPMA patients. We found that functional FHL1A protein is completely absent in patient myoblasts. In parallel, expression of FHL1C is either unaffected or increased. Furthermore, a decreased proliferation rate of XMPMA myoblasts compared to controls was observed but an increased number of XMPMA myoblasts was found in the G(0)/G(1) phase. Furthermore, low expression of K(v1.5), a voltage-gated potassium channel known to alter myoblast proliferation during the G(1) phase and to control repolarization of action potential, was detected. In order to substantiate a possible relation between K(v1.5) and FHL1C, a pull-down assay was performed. A physical and direct interaction of both proteins was observed in vitro. In addition, confocal microscopy revealed substantial colocalization of FHL1C and K(v1.5) within atrial cells, supporting a possible interaction between both proteins in vivo. Two-electrode voltage clamp experiments demonstrated that coexpression of K(v1.5) with FHL1C in Xenopus laevis oocytes markedly reduced K(+) currents when compared to oocytes expressing K(v1.5) only. We here present the first evidence on a biological relevance of FHL1C
Quantitative Measurement of Sweat as a Diagnostic
No full textThis research was supported by the Undergraduate Research Opportunities Program (UROP).Therneau, Joel; Campbell, Stephen; Lim, Jun Young. (2014). Quantitative Measurement of Sweat as a Diagnostic. Retrieved from the University Digital Conservancy, https://hdl.handle.net/11299/166534
Study on design of stress wave micro sensor for high speed transportation safety system
No full text학위논문(석사) - 한국과학기술원 : 기계공학전공, 2010.2, [ viii, 80 p. ]운송기구가 발달함에 따라 승객의 안전을 보장하고 만일에 대비하기 위해 많은 안전시스템이 개발되고 있다. 안전시스템은 승객의 생명과 직결되어 있으므로 매우 중요하다. 승객을 보호하기 위한 안전시스템은 크게 충돌을 감지하는 장치와 감지된 충돌신호에 따라 승객을 보호하는 장치로 구성된다. 충돌을 감지하는 장치는 가속도센서 등과 같은 충격센서로 구성되어 있으며, 충돌 후 충격센서에서 감지된 신호는 승객보호장치로 전달된다. 이후 안전벨트나 에어백과 같은 승객보호장치는 승객이 받는 충격을 감소시킴으로써 승객을 보호한다. 하지만 고속운송기구의 경우 사고가 발생하고 매우 짧은 시간 내에 승객이 상해를 입는 반면, 안전시스템의 충격감지속도는 이에 미치지 못해 승객의 안전을 보장하지 못하는 문제가 발생한다. 따라서 고속운송기구의 안전시스템의 안정성을 확보하기 위해서는 충격센서의 충격감지시간을 단축시킬 필요가 있다.
본 논문에서는 응력파 측정식의 새로운 마이크로 충격센서를 유한요소해석을 통해 제안한다. 응력파는 충격흡수부재 내에서 매우 빠른 속도로 전파하는 성질을 가지고 있기 때문에, 응력파 측정식 센서를 고속운송기구의 안전시스템에 적용하면 충격감지시간을 획기적으로 단축시킬 수 있다. 고속운송기구의 안전시스템을 분석하기 위해 한 예로써 가장 널리 사용중인 자동차 에어백 시스템을 다룬다. ULSAB-AVC full car model의 충돌해석을 통해 응력파 센서의 필요성을 평가하였다. 충돌해석에서 가속도 값과 응력파 값의 비교를 통해 응력파 센서의 필요성을 확인하였다. 마이크로 응력파 센서는 응력파의 투과와 반사원리를 응용하여 설계되었다. 센서는 니켈과 SU-8 감광제로 구성되며 응력파가 전파되는 충격흡수부재에 부착되어 전파되는 응력파의 세기를 감지함으로써 작동하도록 설계되었다. 센서의 민감도를 증가시키기 위해 유한요소해석을 수행하여 센서의 구체적인 치수를 결정하였다. 또한 니켈도금공정을 적용한 센서의 가상공정도를 두 가지 방법으로 제안하였다. 마지막으로 점용접 모자형 사각관의 충돌해석을 통해 그 위에 부착된 센서의 구현성을 보다 현실적인 경우에 대해 평가하였다. 그 결과, 마이크로 응력파 센서는 목표 응력파 세기에서 정상 작동할 수 있음을 확인하였다.한국과학기술원 : 기계공학전공
Enhanced vertical photo-sensitivity in mu c-Si : H/a-Si : H superlattices
No full textThe microcrystalline silicon/amorphous silicon (mu c-Si:H/a-Si:H) superlattice showed an enhanced vertical,photo- sensitivity (photo-conductivity/dark-conductivity), whereas it reserved a lateral photo-sensitivity nearly unchanged. The film was fabricated by alternating the mixing of SiH4 and HZ in a photo-chemical vapor deposition system. The fact that a high vertical photo-sensitivity and an obvious crystalline volume fraction can be obtained at the same time distinguishes the mu c-Si:H/a-Si:H superlattice from the bulk mu c-Si:H. The change of the vertical dark-conductivity with the sublayer thickness was explained by the change of the a-Si:PI sublayer's electrical conduction property. We think that the thin a-Si:H sublayers play an important role of perturbing a columnar structure of the mu c-Si:H. (C) 2000 Elsevier Science B.V. All rights reserved
원통형 마이크로 프로브 제조를 위한 전기 화학적 가공 공정
No full textDisclosed is an electrochemical machining process for fabrication of cylindrical microprobes, which is effected by the tool acting as the cathode against the workpiece acting as the anode, taking advantage of a chemical reaction occurring between the workpiece and the tool, both being beneath the surface of an electrolyte, under such a controlled electric field that the workpiece can be machined to have a uniform diameter throughout its entire length. The electrochemical machining can be carried out with greater precision because a precise machining process because the volume to be additionally processed owing to the surface tension generated when the workpiece is dipped into the electrolyte is taken into consideration
전류 밀도 제어 기술을 사용한 전기 화학적 공정
No full textAn electrochemical process using current density controlling techniques is disclosed. In the electrochemical process of this invention, a carbon cathode rod activated with a negative voltage and an electrode activated with a positive voltage are sunk into an electrolyte contained in a container, and so the electrode is electrochemically etched while properly controlling both the metal ion dissolving rate and the metal ion diffusing rate of the electrode by controlling the amount of applied current to maintain the two rates at a desired balance. This process thus creates a diffusion effect thickening the tip of the cylindrical electrode, and compensates for a conventional geometric effect sharpening the tip of the electrode. Therefore, this process produces a precise product having a uniform diameter along its length. In the electrochemical process of this invention, the electrode is ultrasonically washed on its surface with both acetone and distilled water before the process so as to remove impurities from the surface of the electrode. In addition, the electrolyte is a potassium hydroxide solution having a molar density of 402dc#6 M
전기 화학 방전 가공 장치와 가공 방법
No full textAn electrochemical discharge machining method may include electrolytically machining a tool fed by a three-dimensional tool feeder which can accurately feed a tool in three dimensions. The electrolytic machining may be performed in a current controlled mode, during which a concentration and a height of an electrolyte may be regulated. Further, the method may include performing electrochemical discharge machining of the workpiece using the machined tool in a voltage controlled mode
Learn a Language: Find a Language Buddy at Goldsmiths
No full textLearn a Language is about facilitating language learning and connections at Goldsmiths. It is open to all students and staff and aims at pairing up individuals speaking different languages through an exchange board on learn.gold and at language mixer events.
This project was started in ICCE by Dr Carla Figueira in 2013 and was later scaled to the whole of College in 2017, with the support of Dr Sarah Maitland (English) and Jun Lim (Student Union), thanks to the financial support of the Annual Fund and several services at Goldsmiths.
On the learn.gold exchange board anyone can post a message offering / seeking particular languages. Participants reply to each other’s messages to find a buddy, organise regular meetings and share information on news, resources and experiences. To support independent learning resources are available in the Library.
Learn a Language supports the development of foreign language skills and raises awareness of its benefits, while providing a means to connect and socialise Goldsmiths’ super-diverse linguistic and cultural community
Low Degradation and High Annealing Effects of Amorphous Silicon Multilayer Processed through Alternate Hydrogen Dilution
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