1,720,956 research outputs found
Assessment of alopecia prevention and effect of hair growth using heabal plants
No full text학위논문 (석사)-- 서울대학교 대학원 : 약학과, 2012. 2. 송준명.최근 탈모인구가 증가하면서 탈모에 대한 치료욕구 또한 높아지고 있다. 본 연구 에서는 Western blot과 HCS(High Content Screening) 법을 이용하여 모유두세포와 각질형성세포 내에서의 표적신호 전달 단백질의 발현 변화를 봄으로써 탈모방지 효능이 기대되는 15종의 천연물 추출물의 탈모방지 및 발모효능을 확인하였고 또한 동일한 방법을 이용하여 천연물 추출물과 세계적으로 잘 알려진 탈모치료용 의약품인 Minoxidil 제제와의 효능 비교를 하였다. 실험을 위해 선정된 표적신호 전달 단백질은 총 5 종으로, IGF-1(insulin like growth factor-1), TGF-β2(transforming growth factor-b2), VEGF(Vascular endothelial growth factor), DKK-1(Dickkopf-1) 및 Wnt5a이다. 모발 성장 주기에서 이러한 모낭주기 관련 표적 신호 전달 단백질들은 퇴화기에서 성장기 단계로의 진행을 촉진시키고 성장기에서 휴지기 단계로의 진행을 억제시킴으로써, 탈모를 방지하고 발모를 유도한다. 따라서 탈모방지 및 발모유도제로써의 기능을 가지고 있다면 모근부의 세포를 활성화시키는 IGF-1, 혈관확장에 관여하여 모발 성장을 유도하는 VEGF, 및 성장기를 장기화하고 모유두 세포 사멸을 억제하는 역할을 하는 Wnt5a의 발현률은 증가하게 되고, 케라티노사이트의 세포사멸을 유도하는 DKK-1과 모발 세포 사멸을 유도하는 TGF-β2의 발현률은 감소하게 된다. 실험 결과 EEX0_Vis_EA추출물을 처리시 모유두 세포에서 TGF-β2이 감소하고 Wnt5a, IGF-1이 증가하는 경향을 보였고 각질 형성 세포에서는 TGF-beta2, DKK-1이 감소하고 VEGF, Wnt5a가 증가하는 경향을 보였으며 EEX2_Vis_EA추출물을 처리시 모유두 세포에서 TGF-β2, DKK-1이 감소하고 IGF-1이 증가하는 경향을 보였고 각질 형성세포에서는 TGF-β2가 감소하고 VEGF, Wnt5a가 증가하는 경향을 보였다. 그리고 EEX1_Vis_EA_7.5추출물을 처리한 결과 모유두 세포에서는 TGF-β2, DKK-1이 감소하고 IGF-1이 증가하는 경향을 보였고 각질 형성 세포에서는 TGF-β2, DKK-1이 감소하고 VEGF가 증가하는 경향을 보였다. 그리하여 총 15종의 추출물 중 3종이 탈모 방지 및 발모의 효능이 있을 것으로 기대된다. 이들 추출물을 minoxidil과 동일한 농도에서 비교한 결과, minoxidil보다는 활성이 약한 것으로 나타났다.Recently urge of care is increasing as increasing number of alopecia patient. In this thesis, we used Western blot and HCS for researching alopecia prevent and hair growth efficiency of herbal plants from change of target signal delivery protein in HaCaT and HFDPC. Also, we compared efficiency of drugs to minoxidil. We selected 5 target signal delivery proteins, IGF-1(insulin like growth factor-1), TGF-β2(transforming growth factor-b2), VEGF(Vascular endothelial growth factor), DKK-1(Dickkopf-1) and Wnt5a. These target signal delivery proteins promote period of growth from peroid of atrophy so that prevent the alopecia and induce the hair growth in hair growth period. If drugs have function of alopecia prevention and hair growth effect, revelations of IGF-1, VEGF, Wnt5a are increased, but DKK-1, TGF-β2 are decreased. We decision that appropriate to efficiancy more than 3 target signal delivery proteins in HFDPC and HACaT from experiment. According to these result, there are 3 efficiant drugs that EEX0_Vis_EA which decreasing TGF-β2 and increasing Wnt5a, IGF-1 in HFDPC and decreasing TGF-β2, DKK-1 and increasing VEGF, Wnt5a in HaCaT, EEX0_Vis_EA which decreasing TGF-β2, DKK-1 and increasing IGF-1 in HFDPC and decreasing TGF-β2, DKK-1 and increasing VEGF, Wnt5a in HaCaT, EEX1_Vis_EA_7.5 which decreasing TGF-β2, DKK-1 and increasing IGF-1 in HFDPC and decreasing TGF-β2, DKK-1 and increasing VEGF in HaCaT. But these drugs were not have more than minosidils efficiency.Maste
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Understanding Virtual Meeting Engagement in the Professional Environment : Conceptualization, Development, Validation, and Application of Virtual Meeting Engagement
No full textThesis (Ph.D.)--Michigan State University. Information and Media - Doctor of Philosophy, 2025With the growing need for remote work and collaboration, virtual meetings\u2014synchronous interactions facilitated by technology-mediated communication\u2014have become increasingly common across various professional settings, including workplaces and classrooms. Scholars and practitioners alike recognize that effective virtual meeting practices and tools are essential for mitigating negative outcomes (e.g., Zoom fatigue) while fostering positive experiences such as meeting engagement. Understanding virtual meeting engagement is also critical from an equity perspective, particularly in examining how technology use and communication behaviors intersect with personal characteristics such as health conditions and status characteristics (e.g., gender, race, job level) to shape individual engagement. Chapter 1 introduces the significance of virtual meeting engagement and its relationships with other factors and behaviors in virtual meeting environments. Chapter 2 explores professionals\u2019 lived experiences with virtual meetings and their perceptions of engagement through qualitative interviews with individuals who regularly participate in virtual meetings for professional purposes. Building on these insights, Chapter 3 conceptualizes, develops, and validates a Virtual Meeting Engagement (VME) scale. Informed by the qualitative findings and the validated scale, Chapter 4 investigates the relationship between social interaction anxiety and virtual meeting fatigue and engagement. This chapter draws on the Hyperpersonal Model and impression management theory to examine how virtual meeting technologies may help alleviate anxiety-related barriers to engagement. Chapter 5 focuses on how individual status characteristics (e.g., gender, racial identities, job levels) influence virtual meeting fatigue and engagement, further exploring whether specific virtual meeting features (e.g., camera control, avatars, filters) can mitigate these effects by supporting impression management and reducing fatigue. Building upon the literature about virtual work, social presence, and social facilitation, Chapter 6 examines the role of social presence in shaping virtual meeting engagement, analyzing how meeting features and modalities are associated with social presence and engagement. This dissertation project integrates perspectives from media psychology, computer-mediated communication, and organizational communication, offering theoretical contributions to the understanding of engagement, fatigue, impression management, mental health, and social presence in virtual meeting contexts. Chapter 7 discusses the theoretical, methodological, and practical contributions, as well as the future research directions. Ultimately, this project advances understanding of how affordances of virtual meeting technologies, mental health conditions, and status characteristics influence virtual meeting engagement\u2014mediated by fatigue and social presence. It contributes to the broader effort to foster effective computer-mediated group communication, supporting employee well-being, enhancing collaboration, and promoting a sustainable virtual workplace culture and technologies.Description based on online resource. Title from PDF t.p. (Michigan State University Fedora Repository, viewed ).Includes bibliographical references
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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