304 research outputs found
Regulation of clpQ+Y+ gene expression in Escherichia coli. The Open Microbiology Journal 3: 29-39.
No full textWHY HAS THE PAPER ENTITLED "GREATWALL-PHOSPHORYLATED Α-ENDOSULFINE IS BOTH AN INHIBITOR AND A SUBSTRATE OF PP2A-B55 HETEROTRIMERS" BY WILLIAMS, M.C. ET AL. THAT WAS PUBLISHED IN ELIFE [WILLIAMS, B.C., FILTER, J.J., BLAKE-HODEK, K.A., FUDA, N.J., SHALLOWAY, D. AND GOLDBERG, M.L. (2014) ELIFE, DOI: 10.7554/ELIFE.01695 ] NOT BEEN RETRACTED?
No full textThe paper entitled "Greatwall-phosphorylated α-Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers" authored by Williams, B.C. et al. [Williams, B.C., Filter, J.J., Blake-Hodek, K.A., Fuda, N.J., Shalloway, D. and Goldberg, M.L. and Published in the Journal eLife [eLife (2014) e01695, doi: 10.7554/elife.01695] was the subject of an investigative critique [Tung, H.Y.L. (2020) J. Invest. Cri. Pub. Sci. Articles, Vol. 1, pp193-200, DOI: 10.5281/zenodo.5115188]. It was previously reported that the paper by Williams, et al. was riddled with Dishonest Scientific Reported, Data Falsification and possibly Data Fabrication. After, contacting the Editor in Chief of eLife, Drs Michael B. Eisen, the author of this report was referred to the Managing Editor of eLife, Dr Wei Mun Chan who is not an expert in Enzymology by any stretch of imagination. The Managing Editor of eLife apparently obtained some response from Williams, et al. which was not only unsatisfactory scientifically but aggravated the seriousness of this case as it was revealed that Williams et al. obtained conclusions of their paper based on some experiments in which they were counting ~3 cpm of radioactivity above background. When the author of this report pointed the fantastical results that Williams et al. claimed they were able to obtain, the author of this Report received no sign of life from the Managing editor and the Editor in Chief of eLife. This Report provides further evidence that Williams, B.C. et al. committed Dishonest Scientific Reporting, Data Falsification and Data Fabrication in their paper
The Incumbent's Reputation and the Effects of Negative Campaign Advertisement
No full text本研究旨在探討現任者的聲譽高／低以及?性／感性訴求型態，對於負面競選廣告的效果究竟有何影響。作者以實驗設計的方式，分別從廣告發起者是現任者或是挑戰者的?同面向?入，進???個實驗，研究結果發現：當負面廣告的發起人是現任者時，聲譽高的現任者比較?適合使用負面攻擊，因?如此一?，對於自己造成的傷害較大，其?使用感性訴求，則可以使傷害減少，而聲譽低的現任者，?發起負面攻擊，則??是使用?性或是感性訴求，並沒有顯著差?的效果；當負面廣告的發起人是挑戰者時，?其攻擊聲譽高的現任者，會對自己造成較大的傷害，然而，?攻擊聲譽低的，則會產生同情效應，使選民?加支持被攻擊者，因上述?種情況都產生於己??的結果，故挑戰者?適合使用負面競選廣告，?是執意使用，則以使用?性訴求?佳。Negative campaign ads have become an indispensable technique in modern day elections. Particularly for one-to-one elections, it is very common to see various ads attacking the other party, broadcast throughout the media. Although much research has been undertaken examining the effects of negative ads, the results are inconclusive and there are still many important issues worthy of further exploration. This paper investigates the effects of these ads on the incumbent's reputation. It also looks at which types of ads are important but were previously neglected by previous empirical research into negative campaign advertising. Based on the expectancy disconfirmation model and the theory of persuasive knowledge, we infer the hypotheses and conduct two experiments to explore the effects of these variables under different contexts: the ad sponsor being the incumbent or the challenger. Results indicate that when the sponsor is the incumbent, it is not beneficial for the incumbent to use attacking ads, as this leads to an increase in self imposed damage to reputation and a decrease in voters' voting intention to a greater degree than for those with lower reputation. Using emotional appeals would decrease the amount of damage done. As for low reputation incumbents, appealing types of advertisement do not make a significant difference to voter responses. When the ad sponsor was the challenger, attacking the high-reputation incumbent generated boomerang effect, causing greater damage to the sponsor, whilst attacking the low-reputation one would generate the victimsyndrome effect, improving voters' target evaluation, attitude, and voting intention toward the target. Thus it is not suitable for the challenger to use negative campaign ads. If he still decides to go with negative ads, rational appeals are more beneficial for him. Besides deceasing potential for self-inflicted damage, rational appeals would either make voters feel more unfavorable towards the targeted candidate or would maintain voters' political participation intent, depending on the incumbent's reputation. The implications of these and other findings are discussed
WHAT IS THE PURPOSE OF SUBMITTING A PREPRINT ARTICLE TO BIORXIV AND CHEMRXIV: ARE BIORXIV AND CHEMRXIV ACTING AS MOB PEER REVIEW CENSORSHIP BOARD?
No full textAccording to their websites of bioRxiv and chemRxiv do not perform peer reviews of preprint articles that are submitted to them and that they only screen submitted preprint articles for . The experience of this author is that bioRxiv and chemRxiv not only perform extensive reviews of submitted preprint articles, they also act a Mob Peer Review Censorship Board. The qualifications of the Mob Peer Reviewers of bioRxiv and chemRxiv are questionable. It is impossible to contact the persons who run bioRxiv and chemRxiv. It is quite disturbing and disgusting that the flow of scientific information in the "freest country of the world" is controlled by two outfits that acts as Mob Peer Review Censorship Board. The actions of bioRxiv and chemRxiv which operate with tax paper's largesse are selective, opaque, arbitrary and a violations of Fundamental Right of the United States citizens to write and publish
Distinct contributions of metabolic dysfunction and genetic risk factors in the pathogenesis of non-alcoholic fatty liver disease
Full text linkFunding Information: This study was supported by Academy of Finland Grant 309263 (H.Y.-J.) and Grant 138006 (J.P.), EU H2020 project ?Elucidating Pathways of Steatohepatitis? EPoS Grant 634413 (H.Y.-J.), H2020-JTI-IMI2 EU project 777377-2 Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) (H.Y.-J.), Government Funding (H.Y.-J.), Novo Nordisk Foundation (H.Y.-J., P.K.L., M.A.-K.), Ralph Gr?sbeck Scholarship of the Minerva Foundation (P.K.L.), Novo Nordisk Foundation (P.K.L.), Juho Vainio Foundation (J.P.), Finnish Medical Foundation (V.M.), British Heart Foundation Senior Research Fellowship in Basic Science (FS/15/56/31645) (L.H.) and Kuopio University Hospital Project grant (J.P., EVO/VTR grants 2005-2019). Funding Information: This study was supported by Academy of Finland Grant 309263 (H.Y.-J.) and Grant 138006 (J.P.), EU H2020 project ‘Elucidating Pathways of Steatohepatitis’ EPoS Grant 634413 (H.Y.-J.), H2020-JTI-IMI2 EU project 777377-2 Liver Investigation: Testing Marker Utility in Steatohepatitis (LITMUS) (H.Y.-J.), Government Funding (H.Y.-J.), Novo Nordisk Foundation (H.Y.-J., P.K.L., M.A.-K.), Ralph Gräsbeck Scholarship of the Minerva Foundation (P.K.L.), Novo Nordisk Foundation (P.K.L.), Juho Vainio Foundation (J.P.), Finnish Medical Foundation (V.M.), British Heart Foundation Senior Research Fellowship in Basic Science (FS/15/56/31645) (L.H.) and Kuopio University Hospital Project grant (J.P., EVO/VTR grants 2005-2019). Publisher Copyright: © 2021 The Author(s)Background & Aims: There is substantial inter-individual variability in the risk of non-alcoholic fatty liver disease (NAFLD). Part of which is explained by insulin resistance (IR) (‘MetComp’) and part by common modifiers of genetic risk (‘GenComp’). We examined how IR on the one hand and genetic risk on the other contribute to the pathogenesis of NAFLD. Methods: We studied 846 individuals: 492 were obese patients with liver histology and 354 were individuals who underwent intrahepatic triglyceride measurement by proton magnetic resonance spectroscopy. A genetic risk score was calculated using the number of risk alleles in PNPLA3, TM6SF2, MBOAT7, HSD17B13 and MARC1. Substrate concentrations were assessed by serum NMR metabolomics. In subsets of participants, non-esterified fatty acids (NEFAs) and their flux were assessed by D5-glycerol and hyperinsulinemic-euglycemic clamp (n = 41), and hepatic de novo lipogenesis (DNL) was measured by D2O (n = 61). Results: We found that substrate surplus (increased concentrations of 28 serum metabolites including glucose, glycolytic intermediates, and amino acids; increased NEFAs and their flux; increased DNL) characterized the ‘MetComp’. In contrast, the ‘GenComp’ was not accompanied by any substrate excess but was characterized by an increased hepatic mitochondrial redox state, as determined by serum β-hydroxybutyrate/acetoacetate ratio, and inhibition of hepatic pathways dependent on tricarboxylic acid cycle activity, such as DNL. Serum β-hydroxybutyrate/acetoacetate ratio correlated strongly with all histological features of NAFLD. IR and hepatic mitochondrial redox state conferred additive increases in histological features of NAFLD. Conclusions: These data show that the mechanisms underlying ‘Metabolic’ and ‘Genetic’ components of NAFLD are fundamentally different. These findings may have implications with respect to the diagnosis and treatment of NAFLD. Lay summary: The pathogenesis of non-alcoholic fatty liver disease can be explained in part by a metabolic component, including obesity, and in part by a genetic component. Herein, we demonstrate that the mechanisms underlying these components are fundamentally different: the metabolic component is characterized by hepatic oversupply of substrates, such as sugars, lipids and amino acids. In contrast, the genetic component is characterized by impaired hepatic mitochondrial function, making the liver less able to metabolize these substrates.Peer reviewe
Characterization of the Escherichia coli ClpY (HslU) Substrate Recognition Site in ClpYQ (HslUV) Protease by the Yeast Two-Hybrid System
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White Slavery Writing Contemplates China: Jean Turner Zimmermann’s The Social Menace of the Orient
No full text齊墨曼的《東方社會威脅》是極少數專門討論中國白奴問題的著述，顯示美國進步主義年代的除惡運動自詡道德，積極參與了當時美國擴張主義的論述，藉由批評經濟霸權支持文化帝國主義。本文細讀這本宣傳小冊，分析書中如何將白奴買賣描繪成跨國女性回收市場，並將異族的嫖妓行為類比為強暴，透露出作者交雜的白人優越意識與亞洲威脅恐慌。白奴的海外輸出與作者的跨國救援更模糊了內政與外事之分。作者最終藉由種族、階級與性別的交錯關係，護衛了美國中產階級白人女性的社會與政治權利，並在除惡運動中找到自己的利基。但是齊墨曼與中國白奴問題的邊緣化卻也透露出除惡運動對救援對象的取捨，謹防回歸的中國白奴威脅主流種族文化。This paper looks at Jean Turner Zimmermann’s The Social Menace of the Orient: White or Yellow (1921), one of the very few white slavery tracts focusing on white prostitution in China, as an example of how the anti-vice activists of the Progressive Era injected a moralistic discourse into American expansionism, advocating cultural imperialism while deploring the operations of economic imperialism. Zimmermann elaborates the white slavery tropes of big business into transnational female-recycling corporations dealing in fatal diseases and compares forced prostitution to war-time rape, thus revealing the fears of Asiatic threats lurking beneath white supremacy. The intercontinental career of the white slaves and Zimmermann’s mission, however, blur the demarcation between the domestic and the foreign. The intersection of race, class and gender in her writing enables the author to assert the social and political rights of white middleclass women and find her niche in the Social Purity Movement; yet the marginalization of Zimmermann and her branch of the anti-vice campaign implies that the American prostitutes in China, should they be rescued, could become a menace to the American mainstream
On the Alexandrov problem of distance preserving mapping
No full textAbstractIn this paper the author has studied the Alexandrov problem of area preserving mappings in linear 2-normed spaces and has provided some remarks for the generalization of earlier results of H.Y. Chu, C.G. Park and W.G. Park.In addition the author has introduced the concept of linear (2,p)-normed spaces and for such spaces he has solved the Alexandrov problem
Intelligente daglichtsystemen: De toepassingsmogelijkheden van 'smart materials'
No full textBuilding TechnologyArchitectur
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