926 research outputs found
Health economics of breast cancer
No full textBreast cancer is a major cause of morbidity and mortality. Resources are spent in order to prevent, diagnose, and treat breast cancer. Since health care resources are limited, these resources must be allocated in an optimal way in order to maximise health. Currently, there are several different interventions available for breast cancer, and new interventions are under development. As new technologies are developed, it is important to evaluate if these new technologies produce improvements in health at an acceptable cost compared to the older technologies. The purpose of this thesis was to contribute to the development in health economics of breast cancer. The specific aspects addressed were the cost of illness of breast cancer, the cost and quality of life in different states of breast cancer, and economic evaluations of breast cancer interventions.The cost of illness of breast cancer in Sweden was estimated using a prevalence based top-down approach. The total cost of breast cancer in 2002 in Sweden was estimated to approximately 3 billion SEK. Direct costs accounted for about 30% of the total cost, with indirect costs accounting for the remaining 70%. For direct costs, the main cost item was hospitalisation, followed by outpatient visits. For indirect costs, productivity losses due to mortality was the main cost driver. Resource use, cost and health related quality of life in different states of breast cancer were estimated based on a naturalistic observational study. Breast cancer was found to be associated with both substantial direct and indirect costs. The total cost was found to be higher for patients in their first year after primary breast cancer, for patients in their first year after a recurrence, and for patients with metastatic disease compared to patients in their second and following years after a primary breast cancer or recurrence. For patients aged less than 65, indirect costs accounted for a majority of the total cost. The study also found breast cancer to be associated with a reduction of the health related quality of life. This reduction was most pronounced for patients with metastatic disease. For all the different disease states, this reduction seems to be driven by pain and discomfort as well as anxiety and depression. Two computer simulation models were developed to project costs and benefits for treatments of breast cancer in the metastatic setting and the adjuvant setting respectively. Health economic data collected in the naturalistic observational study were used in the models. The cost-effectiveness of trastuzumab and chemotherapy compared to chemotherapy alone was estimated for Swedish women with metastatic breast cancer. In the adjuvant setting, the cost effectiveness of one year of adjuvant trastuzumab after adjuvant chemotherapy compared to adjuvant chemotherapy alone was estimated. In both the metastatic and the adjuvant setting, the addition of trastuzumab was found to be cost-effective.This thesis presents new information about the economic burden of breast cancer, as well as new data on the cost and quality of life for patients in different states of breast cancer. These data represent an important input for economic evaluations of breast cancer interventions, and will improve future economic evaluations of breast cancer. The economic evaluations presented in this thesis can be used for informed decisions about resource allocation for patients with breast cancer within the healthcare system.List of scientific papersI. Lidgren M, Wilking N, Jonsson B. (2007). Cost of breast cancer in Sweden in 2002. Eur J Health Econ. 8(1):5-15. https://pubmed.ncbi.nlm.nih.gov/17216424II. Lidgren M, Wilking N, Jonsson B, Rehnberg C. (2007). Resource use and costs associated with different states of breast cancer. Int J Technol Assess Health Care. 23(2):223-31. https://pubmed.ncbi.nlm.nih.gov/17493308III. Lidgren M, Wilking N, Jonsson B, Rehnberg C. (2007). Health related quality of life in different states of breast cancer. Qual Life Res. Apr 28. https://pubmed.ncbi.nlm.nih.gov/17468943IV. Lidgren M, Wilking N, Jonsson B, Rehnberg C. (2007). Cost-effectiveness of HER2 testing and trastuzumab therapy for metastatic breast cancer. [Submitted]V. Lidgren M, Jonsson B, Rehnberg C, Wilking N, Bergh, J. (2007). Cost-effectiveness of HER2 testing and 1 year adjuvant trastuzumab therapy for early breast cancer. [Submitted]</p
Mauersegler weiter Wege. Mathias Enard: Kompass
No full textAnalysis of the peculiar scientific narrative in the novel of the Prix-Goncourt winning author Mathias Enard
Les commissions électorales en Afrique de l'Ouest
No full text[author: Mathias Hounkpe ; Ismaila Madior Fall]Electronic ed.: Abuja ; Bonn : FES, 201
Paul Bourget, écrivain engagé
No full textPaul Bourget, A committed writer, Yehoshua Mathias.
In the France of the early twentieth century, Paul Bourget's figure is that of a successful novelist who became gradually a «committed author». A monarchist, deeply conservative, passionate defender of religion and the family as the vital bases of the social order, he thus became the bard of the bourgeois ethic faced with the destabilization of modernity.Mathias Yehoshua. Paul Bourget, écrivain engagé. In: Vingtième Siècle, revue d'histoire, n°45, janvier-mars 1995. pp. 14-29
„Nature must be felt“ – Alexander von Humboldt, pioneer of an ecological worldview and protagonist of „transversal reason“
No full textDer Text erinnert zum 250sten Geburtsjahr an Alexander von Humboldt, ein Vordenker für eine ökologische Sicht der Welt und ein früher Protagonist „transversaler Vernunft“. Er ist als Ideengeber für die „neuen Naturtherapien“, für die Integrative Therapie und für eine ökologische Sicht in der Psychotherapie eine unverzichtbare Quelle. Einige aus dieser Perspektive wichtige Aspekte seines Denkens und Werkes werden aufgezeigt. Er ist ein Referenzautor für transversales und integratives Konzeptualisieren in unserer Zeit.The text commemorates the 250th year of birth of Alexander von Humboldt, a thought leader for an ecological view of the world and an early protagonist of „transversal reason“. He is an indispensable source of ideas for the „new nature therapies“, for integrative therapy and for an ecological viewpoint in psychotherapy. Some important aspects of his thinking and work are shown from this perspective. He is a reference author for transversal and integrative conceptualization in our time.https://www.fpi-publikation.de/gruene-texte/17-2019-petzold-h-g-mathias-wiedemann-u-natur-muss-gefuehlt-werden-alexander-v-humboldt/peerReviewedpublishedVersio
„Natur muss gefühlt werden“ – Alexander von Humboldt, Vordenker einer ökologischen Weltsicht und Protagonist „transversaler Vernunft“
No full textDer Text erinnert zum 250sten Geburtsjahr an Alexander von Humboldt, ein Vordenker für eine ökologische Sicht der Welt und ein früher Protagonist „transversaler Vernunft“. Er ist als Ideengeber für die „neuen Naturtherapien“, für die Integrative Therapie und für eine ökologische Sicht in der Psychotherapie eine unverzichtbare Quelle. Einige aus dieser Perspektive wichtige Aspekte seines Denkens und Werkes werden aufgezeigt. Er ist ein Referenzautor für transversales und integratives Konzeptualisieren in unserer Zeit.The text commemorates the 250th year of birth of Alexander von Humboldt, a thought leader for an ecological view of the world and an early protagonist of „transversal reason“. He is an indispensable source of ideas for the „new nature therapies“, for integrative therapy and for an ecological viewpoint in psychotherapy. Some important aspects of his thinking and work are shown from this perspective. He is a reference author for transversal and integrative conceptualization in our time.https://www.fpi-publikation.de/polyloge/25-2019-petzold-h-g-mathias-wiedemann-u-natur-muss-gefuehlt-werden-alexander-v-humboldt/peerReviewedpublishedVersio
The reality of fiction: the ECO by Mathias Goeritz
No full textAbstract
This article covers the full biography of a building, the Experimental Museum El Eco, designed by Germanborn and Mexican émigré artist and architect Mathias Goeritz. It provides an approach intersecting the biography of the author, the history of the building, and prominent individuals of the two cultural traditions, German and Mexican, who participated in the creation of a very special and unique building: El Eco. On the one hand, the ethics of Expressionism, the interest in non-European art, the cult of primitivism and the aesthetic system of the pair of concepts abstraction-empathy, all stemming from German culture. On the other, the pantheistic religiosity of landscape, zoomorphism and anthropomorphism, the interest in masks, and the aesthetics of monumental scale, stemming from pre-Cortesian Mexican culture. Taking the stance of intertwining Mathias Goeritz parcours with those of individuals and issues from his German past and his Mexican future – highlighting the figures of Wilhelm Worringer, Paul Westheim, Luis Barragán, Edmundo O'Gorman, and Ida Rodríguez Prampolini – this article proposes a return trip from fiction to reality, following in the footsteps of the author and comparing them with the pathway of the very building El Eco
Oswald Mathias Ungers and Sol LeWitt: Variations
No full textOne of the fundamentals of Oswald Mathias Ungers work is the definition of a new unity between art and architecture. What this investigation is focused on is the identification of the intersection point between art and architecture, considering the project for the Entrance to the Kaiserthermen in Trier (20032007) as case study, revealing the system of theoretical, methodological and compositional correspondences. Plastic art is Ungers' main interlocutor: one of the author's most important references is Sol LeWitt (1928-2007), an artist he admired and collected. Setting the work of Oswald Mathias Unger and Sol LeWitt side by side, offers the opportunity to underline the shared interpretation that the two authors have of the world of forms postulated by Henri Focillon (1881-1943) in Life of Forms, according to which form, autonomous with respect to time and place, has its own universe, governed by its own laws, space and matter. According to these premises, we propose to read Trier's building through the instruments of art, following the hypothesis that in this project art embodies a creative and positive component in the definition of architecture, a cultural stimulus that guides the author in the design process
Correction to: Editorial: symmetries and asymmetries in physics
No full textThe article Editorial: symmetries and asymmetries in physics, written by Radin Dardashti, Mathias Frisch, Giovanni Valente, was originally published electronically on the publisher’s internet portal on 3 July 2020 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 16 June 2021 to © The Author(s) 2021 and the article is forthwith distributed under a Creative Commons Attribution
Mathias Niendorf. Das Grossfuertentum Litauen : Studien zur Nationsbildung in der Fruehen Neuzeit (1569-1795) : recenzija
No full textRecenzijoje yra analizuojamas Mathiaso Niendorfo darbas, kuriame svarbiausias dėmesys yra skiriamas politinės tautos temai. Tokia tema yra dar mažai tyrinėta, bet pastaruoju metu jai skiriamas vis didesnis dėmesys. Recenzijoje yra nurodoma, kad M. Niendorfo darbas LDK istoriografijai svarbus naujų probleminių temų įvedimu. Savo darbe M. Niendorfas pristato LDK istorijos raidą po Liublino unijos iki 1795 m. Po to pradeda detaliai analizuoti problemą. Pažymima, kad naujumu labai išsiskiria ketvirtas M. Niendorfo darbo skyrius. Jis skirtas aptarti, kokį vaidmenį turėjo religingumas to laikotarpio tautos formavimuisi. Šioje temoje autorius didelį dėmesį skiria šventųjų kultams, laikydamas juos politinės tautos integraciniu faktoriumi. Taip pat pabrėžia, kad kultai yra vienas svarbesnių veiksnių formuojantis politinei bendruomenei. Atkreipiamas dėmesys, kad M. Niendorfas sugeba tradicines istoriografijos temas išnaudoti savo analizuojamos temos naudai, nors kai kada tai galima laikyti tik hipotezėmis. Pastebima, kad kituose knygos skyriuose yra iškeliami tautų ir valdovų kilmės mitai, teisinė sąranga, o nuvertinama pagrindiniu tautiškumo požymiu laikyta kalba. Pastebima, jog autorius suformuluoja dar vieną naują tezę. Jis teigia, kad ne vien bajorų luomo atstovai yra politinės tautos sudėtinė dalis, tačiau nereiškia, jog šis teiginys yra pagrįstas. Pažymima, kad didelis knygos privalumas yra tas, kad autorius iš istoriografijos sugeba ,,išspausti“ maksimumą. Pažymima, kad darbas yra vertingas tuo, kad tyrimų tema yra nauja, įdomi, skatinanti tautiškumo tyrimus. Reikšminiai žodžiai: Abiejų Tautų Respublika (ATR; Rzeczpospolita Obojga Narodów; Žečpospolita; Sandrauga; Polish-Lithuanian Commonwealth); Akultūracija; Istoriografija; Lietuvos Didžioji Kunigaikštystė (LDK; Grand Duchy of Lithuania; GDL); M.Niendorf; Mathias Niendorf; Nacija; Niendorf, Mathias; Politinė tauta; Polonizacija; Reformacija; Religingumas; Tautos formavimasis; Tautos struktūra; Šventųjų kultai; Acculturation; Cult of the Saints; Formation of the nation; Historiography; M.Niendorf; Mathias Niendorf; Nation; Niendorf, Mathias; Polish–Lithuanian Commonwealth; Political nation; Polonisation; Reformation; Structure of nationThe review analyses a work by Mathias Niendorf, which focuses on the topic of a political nation. This subject has been little examined yet, but it has recently received an increasing attention. The review points out that the work by Mathias Niendorf is significant to historiography of the Grand Duchy of Lithuania, since it introduces new problematic topics. In his work, Mathias Niendorf presents the development of the history of the Grand Duchy of Lithuania after the Union of Lublin until 1795. Afterwards, he begins a detailed analysis of the problem. It should be stressed that chapter 4 of the work by Mathias Niendorf is clearly distinguished by its novelty. It discusses the role of religiosity in the formation of the nation in that period. In this topic, the author gives close attention to cults of saints, considering them an integration factor for a political nation. He also highlights that cults represent one of the major factors in the formation of a political community. It should be noted that Mathias Niendorf manages to use traditional subjects of historiography to the benefit of the analysis of his topic, although sometimes this can be considered to be hypotheses only. It should be emphasised that other chapters of the book praise myths of the descent of nations and rulers, and the legal structure, but underestimate the language that was held to be the main feature of nationality. The author formulates one more new thesis. He states that representatives of not only the caste of noblemen were a constituent part of the political nation; however, it does not mean that this statement is valid. It is worthwhile stressing that the author’s ability to “squeeze” the maximum out of historiography is a big advantage of the book. It should be highlighted that the research topic, which is new, interesting and encourages studies on nationality, makes the work valuable
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