1,720,981 research outputs found
Harmonizing brain magnetic resonance imaging methods for vascular contributions to neurodegeneration
No full textAlzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring111191-20
Imaging markers of small vessel disease and brain frailty, and outcomes in acute stroke
No full text10.1212/WNL.0000000000008881NEUROLOGY945E439-E45
The Amyloid-β Pathway in Alzheimer’s Disease
Full text linkBreakthroughs in molecular medicine have positioned the amyloid-β (Aβ) pathway at the center of Alzheimer's disease (AD) pathophysiology. While the detailed molecular mechanisms of the pathway and the spatial-temporal dynamics leading to synaptic failure, neurodegeneration, and clinical onset are still under intense investigation, the established biochemical alterations of the Aβ cycle remain the core biological hallmark of AD and are promising targets for the development of disease-modifying therapies. Here, we systematically review and update the vast state-of-the-art literature of Aβ science with evidence from basic research studies to human genetic and multi-modal biomarker investigations, which supports a crucial role of Aβ pathway dyshomeostasis in AD pathophysiological dynamics. We discuss the evidence highlighting a differentiated interaction of distinct Aβ species with other AD-related biological mechanisms, such as tau-mediated, neuroimmune and inflammatory changes, as well as a neurochemical imbalance. Through the lens of the latest development of multimodal in vivo biomarkers of AD, this cross-disciplinary review examines the compelling hypothesis- and data-driven rationale for Aβ-targeting therapeutic strategies in development for the early treatment of AD
VASCULAR AND INFLAMMATORY BLOOD BIOMARKERS OF COGNITIVE IMPAIRMENT AND DEMENTIA
No full textPh.DDOCTOR OF PHILOSOPHY (SOM
Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation
No full text10.1021/acsomega.9b04439ACS OMEGA52313528-1354
The role of inflammasomes in vascular cognitive impairment
No full text10.1186/s13024-021-00506-8MOLECULAR NEURODEGENERATION17
SINgapore GERiatric intervention study to reduce physical frailty and cognitive decline (SINGER)–pilot: A feasibility study
No full text10.1002/trc2.12141Alzheimer's and Dementia: Translational Research and Clinical Interventions71e12141
Pathophysiology of blood brain barrier dysfunction during chronic cerebral hypoperfusion in vascular cognitive impairment
No full text10.7150/thno.68304THERANOSTICS1241639-165
INTERMITTENT FASTING MODULATES EPIGENETIC PATTERNS IN ANIMAL MODELS OF VASCULAR DEMENTIA
No full textPh.DDOCTOR OF PHILOSOPHY (NUSGS
Prediction of poor clinical outcome in vascular cognitive impairment: TRACE-VCI study
No full text10.1002/dad2.12077Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring121e12077
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