1,721,058 research outputs found
FAVOR Essential Database (aGDS Format)
No full textFunctional Annotation of Variants - Online Resource (FAVOR, https://favor.genohub.org) is a comprehensive whole-genome variant annotation database and a variant browser, providing hundreds of functional annotation scores from a variety of aspects of variant biological function. This FAVOR Essential Database (aGDS Format) is comprised of a collection of essential annotation scores for all possible SNVs (8,812,917,339) and observed indels (79,997,898) in Build GRCh38/hg38, including variant info, chromosome, position, reference allele, alternative allele, aPC-Conservation, aPC-Epigenetics, aPC-Epigenetics-Active, aPC-Epigenetics-Repressed, aPC-Epigenetics-Transcription, aPC-Local-Nucleotide-Diversity, aPC-Mappability, aPC-Mutation-Density, aPC-Protein-Function, aPC-Proximity-To-TSSTES, aPC-Transcription-Factor, CAGE promoter, CAGE, MetaSVM, rsID, FATHMM-XF, Gencode Comprehensive Category, Gencode Comprehensive Info, Gencode Comprehensive Exonic Category, Gencode Comprehensive Exonic Info, GeneHancer, LINSIGHT, CADD, rDHS. These annotation scores are stored in annotated Genomic Data Structure (aGDS) file format (without genotype data) to support fast query and retrieval at variant-level. The aGDS file can then facilitate a wide range of functionally-informed downstream analyses
Going Beyond Counting First Authors in Author Co-citation Analysis
Full text linkThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Full text link“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Full text linkWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Full text linkWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Investigating the Role of Reactive Oxygen Species on Antibiotic Tolerance in Pseudomonas aeruginosa
Full text linkPseudomonas aeruginosa is the primary infectious agent in the lungs of people with cystic fibrosis. Chronic P. aeruginosa infections exacerbate the existing disease, while treating the bacteria with antibiotics is difficult due to its intrinsic adaptations. For example, P. aeruginosa has been found to display tolerance to antibiotic treatment in addition to its well-defined resistance mechanisms. The objective of this study was to investigate how reactive oxygen species mediate P. aeruginosa’s tolerance to antibiotics, as previous studies have illustrated that while reactive oxygen species are traditionally understood to be antibacterial agents, they may in fact improve tolerance. To assess how tolerance is impacted by these treatments, a series of tobramycin killing assays were performed where reactive oxygen species concentration was artificially increased to observe changes in tolerance. Additionally, various genes responsible for reactive oxygen species detoxification were deleted to further understand their roles in this process.
This study found promising trends that below a certain threshold, reactive oxygen species serve as a pathway for tolerance upon treatment with tobramycin. However, at excessive concentrations, oxidative stress has a detrimental effect to Pseudomonas aeruginosa’s survival. It was observed that deletions of the reactive oxygen species-neutralizing genes, ΔkatB and ΔsodM, increase survival at lower concentrations of paraquat, a prototypical reactive oxygen species generator. Meanwhile, deletion of part of the stringent response mechanism, ΔrelA, causes decreased survival across paraquat additions. Collectively, these results highlight the role of reactive oxygen species as a mechanism of antibiotic tolerance at manageable concentrations for Pseudomonas aeruginosa before increased concentrations sensitize the bacteria to tobramycin, and encourage further study on other reactive oxygen species-neutralization genes.Bachelor of Science in Public Healt
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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