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The Use of National Health Insurance Report to Explore The Relationship between Diagnosis and Order
No full text資料庫中同欄位(column)的資料(data)往往會隱含不同的屬性，而這些不同的屬性對應到其他特定欄位的資料也會隱藏一些非直接、不同意義上的關聯。越龐大的資料庫，各資料間隱含的資訊(information)越多且越複雜，想辦法從這些亂數中找出規則(rule)，這些規則可能就是屬性之間的關係，進而能從規則中找出例外或獨特性。使用系統化的流程和方法，只要使用者能夠先定義好要資料探勘的目標，即使並非該領域的專家也能分析出有意義和有趣的結果。本論文的目標是在健保申報資料庫上，建立一個圖形化自動系統，利用資料探勘的概念，能夠從不同的病例中判斷各個醫令是歸屬該病例的那個診斷中。如此就能建立一個以醫令為基礎，評估各個診斷在不同病例的費用比率之介面。系統除了能夠分辨診斷在醫令中的重要性以及診斷在病例中的重要性外，並建立了診斷醫令比較資料庫，能將所有醫令和所有診斷的關聯度做完整的呈現和查詢，提供一個住院醫令決策支援系統讓相關醫療工作者使用。Each item among the same data column of database is often different from each other in the agent of hidden relation with other specific data column. The bigger database, the more data have implicit information and complex. To explore a way to find out the rules from these nonrandom relationship. These rules decide the relationship between attributes, and it can be need to find out the exceptions or define the uniqueness. By systematic approach and the usage of defined analysis methods, the user can first set the goal of data mining, then non-experts can analyze the database with meaningful and interesting result.The purpose of this paper is to use the National Health Insurance claim report database to build an automatic graphical system to elucidate the relationship between diagnosis and case management orders. We are able to establish an interface which can evaluate the contribution of case expense among their various diagnoses.This system can also identify the relative importance of each diagnosis in different order usage of any particular case. In addition, we have established an order and diagnosis relationship database which included all the possible correlation between diagnoses and orders. Which is so comprehensive and user friendly. It can provide an inpatient management decision support system for relevant health care workers.口試委員會審定書 i文摘要 ii文摘要 iii一章 緒論 1.1 研究動機與目的 1.2 論文架構 2二章 相關文獻 3.1 住院醫令系統 3.2 資料探勘 4.3 相關度量測 5.4 國際疾病分類 8.5 分群演算法 9三章 研究方法 12.1 研究流程 17.2 醫令天數 18.3 醫令分群 19.4 醫令和診斷的相關度量測 20.5 病例醫療費用分析演算法 23四章 結果與討論 26.1 醫令分群結果 26.2 診斷醫令比較系統 28.3 病例醫療費用分析系統 30.4 討論 33五章 結論 35.1 結論 35.2 未來的工作 35考文獻 3
Investigation of Focused Ultrasound Combined with Microbubbles to Enhance the Accumulation and Efficacy of Anticancer Nanodrug in Mouse Tumors
No full text藥物傳遞的主要目標是希望增加藥物在腫瘤組織中的濃度，以達到控制腫瘤成長的效果；且降低藥物在身體其他部位的濃度，減少在正常組織中的副作用，達到所謂的標靶治療。高能量強度聚焦型超音波已用於臨床治療，近年來，許多研究更發現超音波搭配超音波顯影劑所產生的穴蝕效應對區域性的藥物傳遞有益。
本研究使用大腸癌CT-26小鼠皮下腫瘤模式，注射超音波顯影劑(SonoVue○R)，搭配1 MHz、1% duty cycle、10ms脈衝長度、1 Hz的脈衝重複頻率、聲壓1.2 MPa、超音波施打總時間120秒的低強度聚焦型超音波，以誘發穴蝕效應，與使用市售奈米抗癌藥物Doxil○R (Ben Venue, Laboratories, Inc., USA)。實驗結果發現，相較僅注射10 mg/kg Doxil○R，搭配穴蝕效應之實驗組顯著提升了在治療後24小時，doxorubicin於腫瘤組織內的累積量，且藥物搭配穴蝕效應實驗組在實驗後第24小時達其極值；持續給予治療，穴蝕效應對腫瘤組織的影響將會變高，可有效抑制大腫瘤(體積>100 mm3)的成長(p<.05)。同時，注射較低劑量5 mg/kg的Doxil○R，在穴蝕效應的加強下，相較無穴蝕效應實驗組，已可有效抑制小腫瘤(體積<30 mm3)的成長(p<.05)。實驗同時探討治療方式(額外施加超音波與否)對腫瘤成長的影響。The main goal of drug delivery is to enhance the drug accumulation in tumor tissue in order to control the tumor growth, and to decrease drug concentration in other sites of the body to avoid side effect on normal tissues. Such treatment is so-called “targeted therapy.” High intensity focused ultrasound (HIFU) has been used for clinical therapy for years. Recently, it was found that the cavitation effect due to ultrasound sonication and ultrasound contrast agent was beneficial to local drug delivery.
In this study, we used s.c. colon carcinoma CT-26 mice tumor model and sonicated the tumors with focused ultrasound (frequency 1 MHz、1% duty cycle、pulse length 10ms、pulse repetition frequency 1Hz、pressure 1.2 MPa、total duration 120 seconds) after the injection of ultrasound contrast agent (SonoVue○R), and then inkected nanoparticles—commercial nanodrug Doxil○R (Ben Venue, Laboratories, Inc., USA). We have found that cavitation effect combined with 10 mg/kg Doxil○R can significantly increase doxorubicin accumulation in tumor tissue 24 hour after treatment as compared to injecting Doxil○R only. Keeping the treatment for a duration time (at least 4 weeks), the effect of cavitaiton on tumor tissue becomes more obvious and able to inhibit big tumor (volume>100 mm3) growth effectively(p<.05). In addition, 5 mg/kg Doxil○R injection with cavitation has significant impact (p<.05) on inhibiting the growth of small tumors (volume<30 mm3). This study also investigated treatment effects to mouse tumors with applying additional focused ultrasound
Going Beyond Counting First Authors in Author Co-citation Analysis
Get PDFThe present study examines one of the fundamental aspects of author co-citation analysis (ACA) - the way co-citation
counts are defined. Co-citation counting provides the data on which all subsequent statistical analyses and mappings
are based, and we compare ACA results based on two different types of co-citation counting - the traditional type that
only counts the first one among a cited work's authors on the one hand and a non-traditional type that takes into
account the first 5 authors of a cited work on the other hand. Results indicate that the picture produced through this non-traditional author co-citation counting contains more coherent author groups and is therefore considerably clearer. However, this picture represents fewer specialties in the research field being studied than that produced through the traditional first-author co-citation counting when the same number of top-ranked authors is selected and analyzed. Reasons for these effects are discussed
Variations on the Author
Get PDF“Variations on the Author” discusses two of Eduardo Coutinho’s recent films (Um Dia na Vida, from 2010, and Últimas Conversas, posthumously released in 2015) and their contribution to the general question of documentary authorship. The director’s filmography is characterized by a consistent yet self-effacing form of authorial self-inscription: Coutinho often features as an interviewer that rather than express opinions propels discourses; an interviewer that is good at listening. This mode of self-inscription characterizes him as an author who is not expressive but who is nonetheless markedly present on the screen. In Um Dia na Vida, however, Coutinho is completely absent form the image, while Últimas Conversas, on the contrary, includes a confessional prologue that moves the director from the margins to the center of his films. This article examines the ways in which these works stand out in the filmography of a director who offers new insights into the notion of cinematic authorship
Appropriate Similarity Measures for Author Cocitation Analysis
Get PDFWe provide a number of new insights into the methodological discussion about author cocitation analysis. We first argue that the use of the Pearson correlation for measuring the similarity between authors’ cocitation profiles is not very satisfactory. We then discuss what kind of similarity measures may be used as an alternative to the Pearson correlation. We consider three similarity measures in particular. One is the well-known cosine. The other two similarity measures have not been used before in the bibliometric literature. Finally, we show by means of an example that our findings have a high practical relevance.information science;Pearson correlation;cosine;similarity measure;author cocitation analysis
Dispelling the Myths Behind First-author Citation Counts
Get PDFWe conducted a full-scale evaluative citation analysis study of scholars in the XML research field to explore just how different from each other author rankings resulting from different citation counting methods actually are, and to demonstrate the capability of emerging data and tools on the Web in supporting more realistic citation counting methods. Our results contest some common arguments for the continued
use of first-author citation counts in the evaluation of scholars, such as high correlations between author rankings by first-author citation counts and other citation
counting methods, and high costs of using more realistic citation counting methods that are not well-supported by the ISI databases. It is argued that increasingly available digital full text research papers make it possible for citation analysis studies to go beyond what the ISI databases have directly supported and to employ more
sophisticated methods
koamabayili/VECTRON-author-checklist: VECTRON author checklist
No full textWe have done our best to complete the author checklist relating to the use of animals in the hut study. Note that the objective for the hut study was to evaluate the IRS treatment applications for residual efficacy against Anopheles mosquitoes, including the local An. coluzzii mosquito population. Cows were only used to attract mosquitoes into the huts and no tests were carried out directly on the cows. The author checklist is intended for use with studies where experiments are carried out on animals, which is why we have had such difficulty in completing this for the hut study, as many of the questions do not relate to how the cows were used
Author-wise bibliometric analysis based on entropy.
No full textAuthor-wise bibliometric analysis based on entropy.</p
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