72 research outputs found
Palermo nominata e innominata. Considerazioni onomastiche su Borgo Vecchio di Giosuè Calaciura
No full textIn 2017, Giosuè Calaciura presented to the public the novel Borgo Vecchio. He
infused it with an almost Greek sense, of Greek tragedy, a collective chorus where each character
steps forward to narrate their own drama, their own contradiction. The Palermitan
author demonstrates the ability to tell a ‘true’ story without journalistic referentiality. Borgo
Vecchio is not just a neighborhood in Palermo; in this work, it aims to be representative
of all neighborhoods with similar characteristics. This contribution aims to investigate the
onomastic system of the work, oscillating between deliberate reticence and equally deliberate
naming. After analyzing the modalities of toponymic representation, an analysis of the anthroponomic
system of the work will be carried out, attempting to identify in the absence or
presence of names various keys to varied readings for the overall interpretation of the novel
Discovery of presumably introduced spiders, Oedignatha scrobiculata Thorell, 1881 (Araneae, Liocranidae) and Boagrius qiong Lin & Li, 2022 (Araneae, Palpimanidae) on Chichi-jima Island, the Ogasawara Islands, Japan
No full textThe spider fauna of the Ogasawara Islands, oceanic islands located 1,000 km south of mainland Japan was comprehensively examined by the National Museum of Nature and Science in 2011, which revealed that approximately 70% of the spider fauna was composed of non-native species. Following the preceding study, however, only descriptions of several new species have been added and no major updates have been made for the overall spider fauna of the Islands.The faunistic survey of spiders conducted on Chichi-jima Island, the largest island in the Ogasawara Islands in 2023 revealed the presence of two ground-dwelling spider species, Oedignatha scrobiculata Thorell, 1881 (Araneae, Liocranidae) and Boagrius qiong Lin & Li, 2022 (Araneae, Palpimanidae) on the Island. This represents the first record of the two species from Japan, the first record of palpimaid spiders from Japan and the initial documentation of liocranid spiders in the Ogasawara Islands
Integrin αvβ5 inhibition protects against ischemia-reperfusion-induced lung injury in an autophagy-dependent manner
No full textIntegrin αvβ5 mediates pulmonary endothelial barrier function and acute lung injury (LI), but its roles in cell apoptosis and autophagy are unclear. Thus, the aims of this study were to investigate the significance of αvβ5 in ischemia-reperfusion (I/R)-induced apoptosis and LI and to explore the relationship between αvβ5 and autophagy. Human pulmonary microvascular endothelial cells (HPMVECs) were pretreated with an αvβ5-blocking antibody (ALULA) and challenged with oxygen-glucose deprivation/oxygen-glucose restoration, which mimics I/R; then, cellular autophagy and apoptosis were detected, and cell permeability was assessed. In vivo, mice were pretreated with the autophagy inhibitor chloroquine (CLQ), followed by treatment with ALULA. The mice then underwent operative lung I/R. LI was assessed by performing a pathological examination, calculating the wet/dry lung weight ratio and detecting the bronchial alveolar lavage fluid (BALF) protein concentration. αvβ5 inhibition promoted HPMVEC autophagy under I/R in vitro, alleviated cell permeability, decreased the apoptosis ratio, and activated caspase-3 expression. These outcomes were significantly diminished when autophagy was inhibited with a small-interfering RNA construct targeting autophagy-related gene 7 (si ATG7). Moreover, ALULA pretreatment alleviated I/R-induced LI (I/R-LI), which manifested as a decreased wet/dry lung weight ratio, an altered BALF protein concentration, and lung edema. Preinhibiting autophagy with CLQ, however, eliminated the protective effects of ALULA on I/R-LI. Therefore, inhibiting αvβ5 effectively ameliorated I/R-induced endothelial cell apoptosis and I/R-LI. This process was dependent on improved autophagy and its inhibitory effects on activated caspase-3.</jats:p
Mechanical Behaviour and Microstructure of Reactive-Air-Brazed Metal/Ceramic Joints
No full textThe microstructure evolution dependent deformation and damage mechanisms of reactive air brazed metal/ceramic joints were studied under long term isothermal/thermal cycling conditions. The mechanical behavior and microstructural properties of joints produced using three Ag-base brazes, i.e. a Cu-containing braze (Ag4Cu, as a state of the art SOFC metal braze), an Al-containing (Ag0.5Al, as a newly developed advanced braze) and a pure Ag braze were compared. Ambient temperature delamination, high temperature shear and thermal cycling tests were applied to characterize the thermomechanical properties of the joints. The interfaces prove to be the weakest link of the joints in ambient temperature delamination testing. The long-term operability of the joints was found to be limited by aging induced degradation of the braze/steel and/or the braze/ceramic interfaces. In high temperature shear testing, competing failure of the interfaces and the braze matrix was discovered. Aging in air strengthened both the interface and the braze matrix, thus enhancing the high temperature shear and creep resistance of the joints. Thermal cycling induced mechanical twinning of the initially single crystalline matrices of the Ag and the Ag4Cu braze, which in turn promotes recrystallization of the matrix. Both processes compensate thermal mismatch stresses arising from temperature change and thermal expansion coefficient mismatch. With the introduction of an initially polycrystalline matrix – in case of an advanced Ag0.5Al braze – both mechanisms were exploited to reach greatly increased resistance against rapid thermal cycling. Considering the progress achieved by the advanced Ag0.5Al braze in thermal stress compensation, it could be stated that reactive air brazes have great potential especially for rapid thermal cycling application. Nevertheless brazing properties and thermomechanical stability still need further improvement. Future R&D activities in reactive air brazing should focus on joint stability during combined long term thermal cycling operation under dual atmosphere conditions
Influence of the Thermomechanical Treatment History on a Laves-Phase Hardened Ferritic Steel
No full textMechanical behavior and microstructure of reactive air brazed metal ceramic joints
No full textThe microstructure evolution dependent deformation and damage mechanisms of reactive air brazed metal/ceramic joints were studied under long term isothermal/thermal cycling conditions. The mechanical behavior and microstructural properties of joints produced using three Ag-base brazes, i.e. a Cu-containing braze (Ag4Cu, as a state of the art SOFC metal braze), an Al-containing (Ag0.5Al, as a newly developed advanced braze) and a pure Ag braze were compared. Ambient temperature delamination, high temperature shear and thermal cycling tests were applied to characterize the thermomechanical properties of the joints. The interfaces prove to be the weakest link of the joints in ambient temperature delamination testing. The long-term operability of the joints was found to be limited by aging induced degradation of the braze/steel and/or the braze/ceramic interfaces. In high temperature shear testing, competing failure of the interfaces and the braze matrix was discovered. Aging in air strengthened both the interface and the braze matrix, thus enhancing the high temperature shear and creep resistance of the joints. Thermal cycling induced mechanical twinning of the initially single crystalline matrices of the Ag and the Ag4Cu braze, which in turn promotes recrystallization of the matrix. Both processes compensate thermal mismatch stresses arising from temperature change and thermal expansion coefficient mismatch. With the introduction of an initially polycrystalline matrix – in case of an advanced Ag0.5Al braze – both mechanisms were exploited to reach greatly increased resistance against rapid thermal cycling. Considering the progress achieved by the advanced Ag0.5Al braze in thermal stress compensation, it could be stated that reactive air brazes have great potential especially for rapid thermal cycling application. Nevertheless brazing properties and thermomechanical stability still need further improvement. Future R&D activities in reactive air brazing should focus on joint stability during combined long term thermal cycling operation under dual atmosphere conditions
Aspektsysteme
No full text„Die folgenden Papiere sind im Umfeld eines Hauptseminars "Aspekt und Tempus" entstanden, das im Wintersemester 1989/90 am Institut für Sprachwissenschaft der Universität zu Köln stattfand. In den folgenden Beiträgen werden nicht alle Aspekte des Aspekts gedeckt; im Vordergrund steht hauptsächlich die Frage der Interaktion von lexikalischer Semantik und Aspektmorphologie, so daß sich die Beschreibung der Aspektmorphologie auf aspektrelevante Fälle beschränkt und Nebenfunktionen (z.B. temporale), Konventionalisierungen, Neutralisierungen usw. weitgehend vernachlässigt werden. Kritik und Anregungen sind höchst willkommen.“ ---
Inhalt:
Aspekttheorie (Hans-Jürgen Sasse); Albanisch (Christina Leluda); Spanisch (Olga Chapado Chorro & Luisa Garcia Garcia); Japanisch (Antje Seidel & Helga Weyerts); Maa (Christa König); Modemes Chinesisch (Chor-Shing Li); Samoanisch (Mario Longino
Seasonal variation of levoglucosan in aerosols over the western North Pacific and its assessment as a biomass-burning tracer
No full textLevoglucosan is considered as a useful molecular tracer of biomass-burning aerosols in the atmosphere. To characterize the seasonal variation of its concentrations over the Pacific Ocean and to assess its usefulness as a tracer after long-range transport, we investigated long-term variations of levoglucosan over Chichi-jima in the western North Pacific, from 2001 to 2004. Organic carbon (OC), elemental carbon (EC) and D-glucose were analyzed for comparison. The seasonal variation of levoglucosan concentrations shows a maximum in the winter, which is consistent with the enhanced Asian outflow to the Pacific indicated by backward air-mass trajectories. The concentration levels of levoglucosan estimated from global aerosol model outputs in the winter are, on average, comparable to the observed levels, suggesting that a considerable fraction of levoglucosan did not decompose during long-range transport from the Asian continent by westerly/northwesterly winds. This result is supported by comparable ratios of levoglucosan to EC in Chichi-jima and the East Asian coastal region. Conversely, the measured concentrations of levoglucosan in the summer are significantly lower than the modeled one. This implies a degradation of levoglucosan in the air masses that stagnated over the Pacific, although uncertainties in the model estimate may also be partly responsible for this discrepancy. One possible degradation pathway is oxidation by OH radicals; the contribution of acid-catalyzed reactions needs further investigation
On the interpretation of "Chiki" and "Kakubutsu"
No full textThe Daigaku, reported to be a work of Soshi, is the book that gives us the most systematic and accurate idea on the philosophy of Confusianism. Shushi, a\nconfucianist of the So era, believing the Daigaku to be the most important canon of Confucianism, wrote his Daigaku Shoku, in which he added his interpretation of "chichi" and "kakubutsu", two of the eight articles of the: Daigaku. for these two articles had been left unexplained by the original author of the Daigaku. However, Oyomei, a scholas of the Min era, maintained the opinion that such interpretation by Shushi was a superfluity. This difference in the theories of these two scholars appears to show the difference in their philosophies and thinking approaches.\nThe purpose of this paper is to clarify the difference of the philosophies and hinking approaches of Shushi and Oyomei, by way of annalyzing their interpretations of "chichi" and "kakubutsu".\n(1) Clarified the contents of the Daigaku and the evaluation of its role in Confucianism.\n(2) Clarified the philosophy of Shushi in his "kakubutsu" and "kyuri" thought.\n(3) Clarified the philosophy of Oyomei's "shin shoku ri" thought.\n(4) Through analyses of these two scholars' interpretations of "kakubutsu" and "chichi" of the Daigaku. it was clarified that Shushi stood on the basis of positivism or empiricism while Oyomei on that of idealism.紀要論
The C-Propeptide in Collagen Proteostasis
No full textCollagen folding is initiated at the C-terminal propeptide (C-Pro) domain, a globular domain wholly distinct from the collagen’s characteristic triple helix. The C-Pro domain is responsible for assembling three collagen strands into the correct orientation and stoichiometry and nucleating folding of the most abundant protein in the human body. While the function of the C-Pro domain in guiding collagen assembly is well accepted, its role in proteostasis has only recently been appreciated. In Chapter 2, we demonstrate that the highly-conserved N-glycan in the collagen-I C-Pro domain is critical for maintaining collagen proteostasis under challenging conditions. Specifically, the N-glycan facilitates interaction between procollagen and ER lectin chaperones to ensure proper folding of misfolding-prone collagen variants or wild-type collagen under proteostatic stress. In Chapter 3, we present progress towards understanding the molecular mechanisms of collagen assembly. We previously showed that collagen-I C-Pro assembly patterns are guided by Ca2+ -dependent non-covalent assembly of all C-Pro trimers, followed by covalent immortalization by interchain disulfide bonds. While prior work focused on the C-Pro domains in isolation, Chapter 3 explores unanswered questions about collagen assembly using full-length procollagen constructs. We show that regions of procollagen beyond the C-Pro domain play an unexpected role in defining the ability of triple-helical domains to homotrimerize. These results also yield fresh insights into the still unknown molecular features that promote procollagen heterotrimerization. Collectively, the work described in this thesis advance our understanding of the critical roles of the C-Pro domain in collagen proteostasis.Ph.D
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